Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA

Nature Medicine

Volumn 7, Issue 8, 2001, Pages 934-940

  Nakada, Kazuto ^a,b   Inoue, Kimiko ^a   Ono, Tomoko ^a   Isobe, Kotoyo ^a   Ogura, Atsuo ^c   Goto, Yu Ichi ^b   Nonaka, Ikuya ^b   Hayashi, Jun Ichi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ARTICLE; BASE MISPAIRING; DELETION MUTANT; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; ENZYME ACTIVITY; GENE THERAPY; GENETIC COMPLEMENTATION; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; CELLS, CULTURED; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX IV; GENETIC COMPLEMENTATION TEST; MALE; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIA; PHENOTYPE;

EID: 0034881326     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/90976     Document Type: Article

References (22)

1. Molecular genetic aspects of human mitochondrial disorders
2. Mitochondrial diseases in man and mouse
3. Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression
4. Complete repopulation of mouse mitochondrial DNA-less cells with rat mitochondrial DNA restores mitochondrial translation but not mitochondrial respiratory functions
5. Mice with only rat mtDNA are required as models of mitochondrial diseases
6. Isolation and characterization of mitochondrial DNA-less mouse cell lines and their application for trapping mouse synaptosomal mitochondrial DNA with deletion mutations
7. Generation of mice with mitochondrial dysfunction by introducing mouse deletion mutant mtDNA into zygotes
8. Elimination of paternal mitochondrial DNA in intraspecific crosses during early mouse embryogenesis
9. Selective and continuous elimination of mitochondria microinjected into mouse eggs from spermatids, but not from liver cells, occurs throughout embryogenesis
10. Complementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell with distinct organelles
11. Mitochondrial encephalomyopathies
12. Mitochondria and aging
13. Mitochondrial DNA deletion: A cause of chronic tubulointerstitial nephropathy
14. Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy
15. Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction
16. Transcription of the mammalian mitochondrial genome
17. Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria
18. Human mitochondria and mitochondrial genome function as a single dynamic cellular unit
19. Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease
20. Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmophilic reagent, diaminobenzidine (DAB)
21. Cytochrome c oxidase deficiency in two siblings with Leigh encephalomyelopathy
22. Tissue specificity in cytochrome c oxidase deficient myopathy