Premature ageing in mice expressing defective mitochondrial DNA polymerase

Nature

Volumn 429, Issue 6990, 2004, Pages 417-423

  Trifunovic, Aleksandra ^a   Wredenberg, Anna ^a   Falkenberg, Maria ^a   Spelbrink, Johannes N ^b   Rovio, Anja T ^b   Bruder, Cari E ^c   Bohlooly Y, Mohammad ^c   Gldlöf, Sebastian ^a   Oldfors, Anders ^d   Wibom, Rolf ^a   Törnell, Jan ^c   Jacobs, Howard T ^b   Larsson, Nils Göran ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c ASTRAZENECA R AND D   (Sweden)

^d SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; BRAIN; CARDIOVASCULAR SYSTEM; CATALYST ACTIVITY; CELL CULTURE; DNA; MUSCLE; MUTAGENESIS;

MITOCHONTRIAL DNA; MOSAIC PATTERNS; PREMATURE AGEING;

GENETIC ENGINEERING;

DNA POLYMERASE; GENE PRODUCT; MITOCHONDRIAL DNA; PROTEIN POLGA; UNCLASSIFIED DRUG;

MEDICINE;

ALOPECIA; ANEMIA; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CARDIOMEGALY; CLONE; ENZYME SUBUNIT; FEMALE; GENE DELETION; GENE EXPRESSION; GENETIC LINKAGE; INFERTILITY; KYPHOSIS; LIFESPAN; MALE; MAMMAL; MOUSE; NONHUMAN; OSTEOPOROSIS; PHENOTYPE; POINT MUTATION; PREMATURE AGING; PRIORITY JOURNAL; RESPIRATORY CHAIN; SOMATIC MUTATION; SUBCUTANEOUS FAT; WEIGHT REDUCTION;

ADIPOSE TISSUE; AGING, PREMATURE; ALOPECIA; ANIMALS; BODY COMPOSITION; BODY WEIGHT; BONE DENSITY; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; HOMOZYGOTE; KYPHOSIS; MICE; MITOCHONDRIA; MUTAGENESIS; MUTATION; PHENOTYPE; TRANSGENES;

ANIMALIA; MAMMALIA; RODENTIA; TRIXIS;

EID: 2642580016     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02517     Document Type: Article

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