Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis

Genomics

Volumn 69, Issue 2, 2000, Pages 151-161

  Zhang, Dekui ^a   Mott, Justin L ^a   Chang, Shin Wen ^a   Denniger, Grace ^a   Feng, Zehua ^a   Zassenhaus, Hans Peter ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; MYOSIN HEAVY CHAIN;

ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; GENE MUTATION; MOLECULAR CLONING; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONTENT; PROTEIN EXPRESSION; TISSUE SPECIFICITY; TRANSGENE; TRANSGENIC MOUSE;

MUS MUSCULUS; RODENTIA;

EID: 0034667349     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2000.6333     Document Type: Article

References (41)

1. Oxidants, antioxidants, and the degenerative diseases of aging
2. Deleterious mitochondrial DNA mutations accumulate in aging human tissues
3. Multi-stage proofreading in DNA replication
4. A general structure for DNA-dependent DNA polymerases
5. Purification and properties of wild-type and exonuclease-deficient DNA polymerase II from Escherichia coli
6. PCR fidelity of Pfu DNA polymerase and other thermostable DNA polymerases
7. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains
8. Hypoxemia is associated with mitochondrial DNA damage and gene induction. Implications for cardiac disease
9. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
10. Mitochondria in organismal aging and degeneration
11. Structure - Function analysis of 3' → 5' exonuclease of DNA polymerases
12. Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrlal DNA
13. Yeast mitochondrial DNA mutators with deficient proofreading exonucleolytic activity
14. Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit
15. Purification and identification of subunit structure of the human mitochondrial DNA polymerase
16. Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phospholipids in the tissues of the rat
17. Isolation and characterization of ten mutator alleles of the mitochondrial DNA polymerase-encoding MIP1 gene from Saccharomyces cerevisiae
18. Mitochondrial DNA mutations in cardiomyopathy
19. Human aging is associated with stochastic somatic mutations of mitochondrial DNA
20. Structural features in eukaryotic mRNAs that modulate the initiation of translation
21. DNA replication fidelity
22. Rapid and efficient site-specific mutagenesis without phenotypic selection
23. Mutations in mitochondrial DNA accumulate differentially in three different human tissues during aging
24. Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle
25. The 3' → 5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiae
26. Low frequencies of mitochondrial DNA mutations cause cardiac disease in the mouse
27. Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA
28. The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages
29. Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging
30. Regional heterogeneity of mtDNA heteroplasmy in parkinsonian brain
31. Spontaneous Kearns-Sayre/ chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: A slip-replication model and metabolic therapy
32. Accumulation of deletions in human mitochondrial DNA during normal aging: Analysis by quantitative PCR
33. Tissue-specific regulation of the alphamyosin heavy chain gene promoter in transgenic mice
34. Relationship of phosphoenolpyruvate transport, acyl coenzyme A inhibition of adenine nucleotide translocase and calcium ion efflux in guinea pig heart mitochondria
35. Multiple deletions are detectable in mitochondrial DNA of aging mice
36. Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines
37. Diseases of the mitochondrial DNA
38. Rapid electroelution of nucleic acids from agarose and acrylamide gels
39. Multiple mitochondrial DNA deletions in an elderly human individual
40. Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of aging humans