Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

Nature Genetics

Volumn 38, Issue 5, 2006, Pages 518-520

  Kraytsberg, Yevgenya ^a   Kudryavtseva, Elena ^a   McKee, Ann C ^b,c   Geula, Changiz ^a   Kowall, Neil W ^b,c   Khrapko, Konstantin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA;

ARTICLE; CELL DEATH; CELL RESPIRATION; CLONAL VARIATION; FUNCTIONAL DISEASE; GENE DELETION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MITOCHONDRIAL DNA DISORDER; NERVE CELL; NERVE DEGENERATION; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC MUTATION; SUBSTANTIA NIGRA;

AGING; ANIMALS; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX IV; MICE; MICE, TRANSGENIC; NEURONS; SUBSTANTIA NIGRA;

EID: 33646351299     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1778     Document Type: Article

References (15)

1. Harman, D. J. Am. Geriatr. Soc. 20, 145-147 (1972).
2. Linnane, A.W., Marzuki, S., Ozawa, T. & Tanaka, M. Lancet 1, 642-645 (1989).
3. Khrapko, K., Kraytsberg, Y., de Grey, A., Vijg, J. & Schon, E.A. Aging Cell (in the press).
4. Jacobs, H.T. Aging Cell 2, 11-17 (2003).
5. Corral-Debrinski, M. et al. Nat. Genet. 2, 324-329 (1992).
6. Soong, N.W., Hinton, D.R., Cortopassi, G. & Arnheim, N. Nat. Genet. 2, 318-323 (1992).
7. Itoh, K., Weis, S., Mehraein, P. & Muller-Hocker, J. Neurobiol. Aging 17, 843-848 (1996).
8. Nekhaeva, E., Kraytsberg, Y. & Khrapko, K. Mech. Ageing Dev. 123, 891-898 (2002).
9. Kraytsberg, Y. & Khrapko, K. Expert Rev. Mol. Diagn. 5, 809-815 (2005).
10. Rossignol, R. et al. Biochem. J. 370, 751-762 (2003).
11. Bender, A. et al. Nat. Genet., advance online publication 9 April 2006 (doi:10.1038/ ng1769).
12. Khrapko, K. et al. Nucleic Acids Res. 27, 2434-2441 (1999).
13. Bennett, D.A. et al. N. Engl. J. Med. 334, 71-76 (1996).
14. Ross, G.W. et al. Ann. Neurol. 56, 532-539 (2004).
15. Khrapko, K. Rejuvenation Res. 8, 6-8 (2005).