Caloric restriction and genomic stability

Nucleic Acids Research

Volumn 35, Issue 22, 2007, Pages 7485-7496

  Heydari, Ahmad R ^a   Unnikrishnan, Archana ^a   Lucente, Lisa Ventrella ^a   Richardson, Arlan ^b  

^a WAYNE STATE UNIVERSITY   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; MITOCHONDRIAL DNA; SINGLE STRANDED DNA;

AGING; ARTICLE; CALORIC RESTRICTION; CANCER INHIBITION; CANCER PREVENTION; CELL FUNCTION; DNA REPAIR; DNA STRAND BREAKAGE; EXCISION REPAIR; GENE DELETION; GENE REPLICATION; GENETIC TRANSCRIPTION; GENOMIC INSTABILITY; HUMAN; LONGEVITY; MISMATCH REPAIR; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

AGING; ANIMALS; CALORIC RESTRICTION; DNA DAMAGE; DNA REPAIR; GENOMIC INSTABILITY; MICE; RATS;

RODENTIA;

EID: 38049016464     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkm860     Document Type: Article

References (118)

1. McCay,C.M., Crowell,M.F. and Maynard,L.A. (1935) The effect of retarded growth upon the length of life span and upon the ultimate body size. J. Nutr., 10, 63-79.
2. Yu,B.P., Masoro,E.J., Murata,I., Bertrand,H.A. and Lynd,F.T. (1982) Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, growth, lean body mass and disease. J. Gerontol. 37, 130-141.
3. Weindruch,R., Walford,R.L., Fligiel,S. and Guthrie,D. (1986) The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake. J. Nutr., 116, 654.
4. Masoro,E.J. (1988) Food restriction in rodents: An evaluation of its role in the study of aging. J. Gerontol., 43, B59-B64.
5. Masoro,E.J., Shirnokawa,I. and Yu,B.P. (1991) Retardation of the aging processes in rats by food restriction. Ann. N. Y. Acad. Sci., 621, 337-352.
6. Masoro,E.J. (2001) Dietary restriction: An experimental approach to the study of the biology of aging. In: Masoro, EJ. and Austad, SN., eds. Handbook of the Biology of Aging, 5th edn. Academic Press, San Diego, CA. pp. 396-420.
7. Masoro,E.J. (1990) Assessment of nutritional components in prolongation of life and health by diet. Proc. Soc. Exp. Biol. Med., 193, 31-34.
8. Kubo,C., Johnson,B.C., Gajjar,A. and Good,R.A. (1987) Crucial Dietary Factors in Maximizing Life Span and Longevity in Autoimmune-Prone Mice. J. Nutr., 117, 1129-1135.
9. Masoro,E.J. (1985) Nutrition and aging: A current assessment. J. Nutr., 115, 842-848.
10. Yu,B.P., Masoro,E.J. and Maman,C.A. (1985) Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics. J. Gerontol., 40, 657-670.
11. Zimmerman,J.A., Malloy,V., Krajck,R. and Orentreich,N. (2003) Nutritional control of aging. Exp. Gerontol., 38, 47-52.
12. Miller,R. A., Buehner,G., Chang,Y., Harper,J. M., Sigler,R. and Smith-Wheelock,M. (2005) Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-1 and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell, 4, 119-125.
13. Masoro,E.J., Iwasaki,L., Gleiser,C.A., MeMahan,C.A., Seo,E. and Yu.,B.P. (1989) Dietary modulation of the progression of nephropathy in aging rats: An evaluation of the importance of protein. Am. J. Clin, Nutr. 49, 217-227.
14. Masoro,E.J. (2005) Overview of caloric restriction and ageing. Mech. Ageing Dev., 126, 913-922.
15. Masoro,E.J. (1992) Potential role of the modulation of fuel use in the antiaging action of dietary restriction. Ann. N. Y. Acad. Sci., 663, 403-411.
16. Masoro,E.J. (1992) Retardation of aging processes by food restriction: An experimental tool. Am. J. Clin. Nutr., 55.
17. Heydari,A.R. and Richardson,A. (1992) Does gene expression play any role in the mechanism of the antiaging effect of dietary restriction. Ann. N. Y. Acad. Sci., 663, 384-395.
18. Masoro,E.J. (1995) Antiaging action of caloric restriction: Endocrine and metabolic aspects. Obes. Res., 3.
19. Heydari,A.R., You,S., Takahashi,R., Gutsman n,A., Sarge,K.D. and Richardson,A. (1996) Effect of caloric restriction on the expression of beat shock protein 70 and the activation of heat shock transcription factor 1. Dev. Genet., 18, 114-124.
20. Berg,B.N. and Simms,H.S. (1960) Nutrition and longevity in the rat: II. Longevity and onset of disease with different levels of food intake. J. Nutr., 71, 255-263.
21. Sacher,G.A. (1977) Life table modification and life prolongation. In Finch,C.E. and Hayflick,L. (eds), Handbook of the biology of aging Van Nostrand Reinhold, New York, pp. 582-638.
22. McCarter,R.J., Masoro,E.J. and Yu,B.P. (1985) Does food restriction retard aging by reducing the metabolic rate? Am. J. Physiol., 248, E488-E490.
23. McCarter,R.J. and McGee,J.R. (1989) Transient reduction of metabolic rate by food restriction. Am. J. Physiol., 257, E175-E179.
24. Yu,B.P. (1996) Aging and oxidative stress: Modulation by dietary restriction. Free Radic. Biol. Med., 21, 651-668.
25. Zainal,T.A., Oberley,T.D., Allison,D.B., Szweda,L.I. and Weindruch,R. (2000) Caloric0 restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB, 14, 1825-1836.
26. Feuers,R.J., Weindruch,R. and Hart,R.W. (1993) Caloric restriction, aging, and antioxidant enzymes. Mutat. Res., 295, 191-200.
27. Hyun,D-H., Emerson,S.S., Jo,D-G., Mattson,M.P. and De Cabo,R. (2006) Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc. Nad Acad Sci., 103, 19908-19912.
28. De Cabo,R., Cabello,R., Rios,M., Lopez-Lluch,G., Ingram,D.K., Lane,M.A. and Navas,P. (2004) Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver. Exp. Gerontol., 39, 297-304.
29. Gou,Z.M., Yang,H., Hamilton,M.L., VanRemmen,H. and Richardson,A. (2001) Effects of age and food restriction on oxidative DNA damage and antioxidant enzyme activities in the mouse aorta. Mech. Ageing Dev. 122, 1771-1786.
30. Armeni,T., Pieri,C., Marra,M., Sacucci,F. and Principato,G. (1998) Studies on the life prolonging effects of food restriction: Glutathione levels and glyoxylase enzymes in rat liver. Mech. Ageing Dev., 101, 101-110.
31. Xia,E., Rao,G., VanRernmen,H., Heydari,A.R. and Richardson,A. (1995) Activities of antioxidant enzymes in various tissues of male Fischer 344 ratas are altered by food restriction. J. Nutt., 125, 195-201.
32. Guo,Z.M., Heydari,A.R. and Richardson,A. (1998) Nucleotide excision repair of actively transcribed versus nontranscribed DNA in rat hepatocytes. Exp. Cell. Res., 245, 228-238.
33. Cabelof,D.C., Yanamadala,S., Raffoul,J.J., Guo,Z., Soofi,A. and Heydari,A.R. (2003) Caloric restriction promotes genomic stability by induction of base excision repair and reversal of its age-related decline. DNA Repair, 2, 295-307.
34. Stuart,J.A., Karahalil,B., Hogue,B.A., Souza-Pinto,N.C. and Bohr,V.A. (2004) Mitochondrial and nuclear DNA base excision. repair are affected differently by caloric restriction. FASEB J., 18, 595-597.
35. Masoro,E.J., McCarter,R.J.M., Katz,M.S. and MeMahan,C.A. (1992) Dietary restriction alters the characterize of glucose fuel use. J. Gerontol. Biol. Sci., 47, 208.
36. Kemnitz,J.W., Roecker,E.B., Weindruch,R., Elson,D.F., Baum,S.T. and Bergmann,R.N. (1994) Dietary restriction increases insulin sensitivity and lowers blood glucose in Rhesus monkeys. Am. J. Physiol., 266, E540-E547.
37. Cefalu,W.T., Wagner,J.D., Wang,Z.Q., Bell-Farrow,A.D., Collins,J., Haskell,D., Bechtold,R. and Morgan,T. (1997) A study of caloric restriction and cardiovascular aging in cynomolgus monkeys (macaca facicularis): A potential model for aging research. J. Gerontol. Biol. Sci., 52A, 19.
38. Bluher,M., Kahn,B.B. and Kahn,R.C. (2003) Extended longetivity in mice lacking the insulin receptor in adipose tissue. Science, 299 572-574.
39. Ingram,D.K., Zhu,M., Mamczarz,J., Zou,S., Lane,M.A., Roth,G.S. and DeCabo,R. (2006) Calorie restriction memetics: An emerging research field. Aging Cell, 5, 97-108.
40. D'costa,A.P., Lenham,J.E., Ingram,R.L. and Sonntag,W.E. (1993) Moderate caloric restriction increases type I IGF receptors and protein synthesis in aging rats. Mech. Ageing. Dev., 71, 59-71.
41. Coschigano,K.T., Clemmons,D., Bellush,M.E. and Kopchick,J.J. (2000) Assessment of growth parameters and lifespan of GHR/BP gene-disrupted mice. Endocrinology, 141, 2608-2613.
42. Heydari,A.R., Wu,B., Takahashi,R., Strong,R. and Richardson,A. (1993) Expression of heat shock protein 70 is altered by age and diet at the level of transcription. Mol. Cell. Biol., 13, 410-418.
43. Picard,F., Kurtev,M., Chung,N., Topark-Ngarm,A., Senawong,L. De Oliveira,K.M., Leid,M., McBurney,M.W. and Guarente,L. (2004) Sirtl promotes fat mobilization in white adipocytes by repressing PPAR-γy. Nature, 429, 771-776.
44. Lin,S.J., Defossez,P.A. and Guarente,L. (2000) Requirement of NAD and Sir 2 for life-span extension by caloric restriction in Saccharomyces cerevisiae. Science, 289, 2126-2128.
45. Anderson,R.M., Bitterman,K.J., Wood,J.G., Medvedik,O. and Sinclair,D.A. (2003) Nicotinamide and PNCI govern lifespan extension by caloric restriction in Saccharomyces cervisiae. Nature, 423, 181-185.
46. Um,J.H., Kim,S.J., Kim,D.W., Ha,M.Y., Jang,J.H., Kim,D.W., Chung,B.S., Kang,C.D. and Kim,S.H. (2003) Tissue-specific changes of DNA repair protein Ku and mtHSP70 in aging rats and their retardation by caloric restriction. Mech. Ageing Dev., 124, 967-975.
47. Raffoul,J.J., Guo,Z., Soofi,A. and Heydari,A.R. (1993) Caloric restriction and genomic stability. J. Nutr. Health Aging, 3, 102-110.
48. Haley-Zitlin,V. and Richardson,A. (1993) Effect of dietary restriction on DNA repair and DNA damage. Mutat. Res., 295, 237-245.
49. Tannenbaum,A. (1940) The initiation and growth of tumors. Introduction. I. Effects of underfeeding. Am. J. Cancer, 38, 335-350.
50. Tannenbaum,A. (1942) The initiation and growth of tumors. II. Effects of caloric restriction per se. Cancer Res., 2, 460-467.
51. Saxton,J.A.Jr., Boon,M.C. and Furth,J. (1944) Observations on the inhibition of development of spontaneous leukemia in mice by underfeeding. Cancer Res., 4, 401-409.
52. Visscher,R.L., Ball,Z.B., Barnes,R.H. and Sivertsen,I. (1942) The influence of caloric restriction upon the incidence of spontaneous mammary carcinoma in mice. Surgery, 11, 48-55.
53. Weraarchakul,N., Strong,R., Wood,W.G. and Richardson,A. (1989) The effect of aging and dietary restriction on DNA repair. Exp. Cell Res. 181, 204.
54. Szilard,L. (1959) On the nature of aging process. Proc. Natl. Acad. Sci. USA, 45, 30-45.
55. Alexander,P. (1967) The role of DNA lesions in processes leading to aging in mice. Sym. Soc. Exp. Biol., 21, 29-51.
56. Mullaart,E., Lohman,P.H., Berends,F. and Vijg,J. (1990) DNA damage metabolism and aging. Mutat. Res., 37, 189-210.
57. Bohr,V.A. and Anson,R.M. (1995) DNA damage, mutation, and fine structure DNA repair in aging. Mutat. Res., 338, 25-34.
58. Koshland,D.E.Jr. (1994) Molecule of the year: The DNA repair enzyme. Science, 266, 1925.
59. Sancar,A., Lindsey-Boltz,L.A., Unsal-Kacmaz,K. and Linn,S. (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Ann. Rev. Biochem., 73, 39-85.
60. Sancar,A. (1994) Mechanisms of DNA excision repair. Science, 266, 1954-1956.
61. Hanawalt,P.C. (1994) Evolution of concepts in DNA repair. Environ. Mol. Mutagen., 23 (Suppl. 24), 78-85.
62. Hanawalt,P.C., Donahue,B.A. and Sweder,K.S. (1994) Repair and transcription. Collision or collusion? Current Biol., 4, 518-521.
63. Modrich,P. (1994). Mismatch repair, genetic stability, and cancer. Science, 266, 1959-1960.
64. Holmquist,F.P. (1998) Endogenous lesions, S-phase-independent spontaneous mutations, and evolutionary strategies for base excision repair. Mutat. Res., 400, 59-68.
65. Lindahl,T. (2000) Suppression of spontaneous mutagenesis in human cells by DNA base excision- repair. Mutat. Res., 462, 129-135.
66. Wiebauer,K. and Jiricny,J. (1990) Mismatch-specific thymine DNA glycosylase and DNA polymerase β mediate the correction of G.T mispairs in nuclear extracts from human cells. Proc. Natl. Acad. Sci. USA, 87, 5842-5845.
67. Matsumoto,Y. and Bogenhagen,D.F. (1991) Repair of a synthetic abasic site involves concerted reactions of DNA synthesis followed by excision and ligation. Mol. Cell. Biol., 11, 4441-4447.
68. Dianov,G., Price,A. and Lindahl,T. (1992) Generation of single-nucleotide repair patches following excision of uracil residues from DNA. Mol. Cell. Biol., 12-1612.
69. Sancar,A. (1996) DNA excision repair. Ann. Rev. Biochem., 65 43-81.
70. Hart,R.W. and Setlow,R.B. (1974) Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proc. Natl. Acad. Sci. USA, 71, 2169-2173.
71. Hall,K.Y., Hart,R.W., Benirschke,A.K. and Walford,R.L. (1984) Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span. Mech. Ageing Dev., 24, 163-173.
72. Kato,H., Hasoda,M., Tsuchiya,K. and Mariwaki,K. (1980) Absence of correlation between DNA repair in ultraviolet irradiated mammalian cells and life span of donor species. Jpn. J. Genet., 55, 99-108.
73. Walter,C.A., Grabowski,D.T., Street,K.A., Conrad,C.C. and Richardson,A. (1997) Analysis and modulation of DNA repair in aging. Mech. Ageing Dev., 98, 203-222.
74. Sobol,R.W., Horton,J.K., Kuhn,R, Hua,G., Singhal,R.K., Prasad,R., Rajewsky,K. and Wilson,S.H. (1996) Requirement of mammalian DNA polymerase β in base-excision repair. Nature, 379, 183-186.
75. Cabelof,D.C., Ikeno,Y., Nyska,A., Busuttil,R.A., Anyangwe,N., Vijg,J., Matherly,L.H., Tucker,J.D., Wilson,S.H. et al. (2006) Haploinsufficiency in DNA polymerase β increases cancer risk with age and alters mortality rate. Cancer Res., 66, 7460-7465.
76. Giese,H., Dolle,M.E.T., Hezel,A., Van Steeg,H. and Vijg,J. (1999) Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA. Oncogene, 18, 1257-1260.
77. De Vries,A., Van Oostrom,C.T.M., Dortant,P.M., Beems,R.M., Van Kreijl,C.F., Capel,P.J.A. and Van Steeg,H. (1997) Spontaneous liver tumors and benzo[a]pyrene-induced lymphomas in XPA-deficient mice. Carcinogenesis, 19, 46-53.
78. Wijnhoven,S.W.P., Kool,H.J.M., Mullenders,L.H.F., Van Zeeland,A.A, Friedberg,E.C., Van der Horst,G.T.J, Van Steeg,H. and Vrieling,H. (2000) Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair. Oncogene, 19, 5037.
79. Friedberg,E.C., Bond,J.P., Burns,D.K., Cheo,D.L., Greenblatt,M.S., Meira,L.B., Nahari,D. and Reis,A.M. (2000) Defective nucleotide excision repair in Xpc mutant mice and its association with cancer predisposition. Mutat. Res., 459, 99-108.
80. Hasty,P., Campisi,J., Hoeijmakers,J., Van steeg,H. and Vijg,J. (2003) Aging and Genome maintenance: Lessons from the mouse? Science, 299, 1355-1359.
81. Dolle,M.E.T., Busuttil,R.A., Garcia,A.M., Wijnhoven,S., Van Drunen,E., Niedernhofer,L.J., Van der Horst,G., Hoeijmakers,J.H.J., Van Steeg,H. et al. (2006) Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat. Res., 596, 22-35.
82. Licastro,F., Weindruch,R., Davis,L.J. and Walford,R.L. (1988) Effect of dietary restriction upon the age-associated decline of lymphocyte DNA repair activity in mice. Age, 11, 48-52.
83. Srivastava,V.K. and Busbee,D.L. (1992) Decreased fidelity of DNA polymerases and decreased DNA excision repair in aging mice: Effects of caloric restriction. Biochem. Biophys. Res. Commun., 182, 712-721.
84. Tilley,R., Miller,S., Srivastava,V. and Busbee,D. (1992) Enhanced unscheduled DNA synthesis by secondary cultures of lung cells established from calorically restricted aged rats. Mech. Ageing Dev. 63, 165-176.
85. Lipman,J.M., Turturro,A. and Hart,R.W. (1989) The influence of dietary restriction on DNA repair in rodents: A preliminary study. Mech Ageing Dev., 48, 135-143.
86. Asakura,S., Sawada,S., Daimon,H., Fukuda,T., Ogura,K., Yamatsu,K. and Furihata,C. (1994) Effects of dietary restriction on induction of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) in rat liver. Mutation Res., 322, 257-264.
87. Shaddock,J.G., Feuers,R.J., Chou,M.W. and Casciano,D.A. (1993) Evidence that DNA repair may not be modified by age or chronic caloric restriction. Mutation Res., 301, 261-266.
88. Bohr,V.A. (1991) Carcinogenesis, 12, 1983-1992.
89. Bohr,V.A., Smith,C.A., Okumoto,D.S. and Hanawalt,P.C. (1985) DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell, 40, 359-369.
90. Mellon,I. and Hanawalt,P.C. (1989) Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand. Nature, 342, 95-98.
91. Sweder,K.S. and Hanawalt,PC. (1992) Preferential repair of cyclobutane pyrimidine dimers in the transcribed strand of a gene in yeast chromosomes and plasmids is dependent on transcription. Proc. Natl. Acad. Sci. USA, 89, 10696-10700.
92. Guo,Z., Heydari,A.R., Wu,W., Yang,H., Sabia,M.R. and Richardson,A. (1998) Characterization of gene-specific DNA repair by primary cultures of rat hepatocytes. J Cell Physiol., 176, 314-322.
93. Mellon,I., Spivak,G. and Hanawalt,P.C. (1987) Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene. Cell, 51, 241-249.
94. Mellon,I., Bohr,V.A., Smith,C.A. and Hanawalt,P.C. (1986) Preferential DNA repair of an active gene in human cells. Proc. Natl. Acad. Sci. USA, 83, 8878-8882.
95. Venema,J., Van Hoffen,A., Karkagi,V., Natarajan,A.T., van Zeeland,A.A. and Mullender,L.H.F. (1991) Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes. Mol. Cell. Biol., 11, 4128-4134.
96. Srivastava,V.K., Miller,S., Schroeder,M.D., Hart,R.W. and Busbee,D. (1993) Age-related changes in expression and activity of DNA polymerase: Some effects of dietary restriction. Mutation Res., 295, 265-280.
97. Prapurna,D.R. and Rao,K.S. (2003) Long-term effects of caloric restriction initiated at different ages on DNA polymerases in rat brain. Mech. Ageing Dev., 92, 133-142.
98. Hasty,P. (2001) The impact energy metabolism and genome maintenance have on longevity and senescence: Lessons from yeast to mammals. Mech. Ageing Dev., 122, 1651-1662.
99. Tsao,J.L., Dudley,S., Kwok,B., Nickel,A.E., Laird,P.W., Siegmund,K.D., Liskay,R.M. and Shibata,D. (2002) Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis, 23, 1807-1810.
100. Dempsey,J.L., Pfeiffer,M. and Morley,A.A. (1993) Effect of dietary restriction on in vivo somatic mutation in mice. Mutat. Res., 291, 141-145.
101. Casciano,D.A., Chou,M., Lyn-Cook,L.E. and Aidoo,A. (1996) Calorie restriction modulates chemically induced in vivo somatic mutation frequency. Environ. Mol. Mutagen., 27, 162-164.
102. Chung,M.H., Kasai,H., Nishimura,S. and Yu,B.P. (1992) Protection of DNA damage by dietary restriction. Free Radic. Biol. Med., 12, 523-525.
103. Djuric,Z., Lu,M.H., Lewis,S.M., Luongo,D.A., Chen,X.W., Heilbrun,L.K., Reading,B.A., Duffy,P.H. and Hart,R.W. (1992) Oxidative DNA damage levels in rats fed low-fat, high-fat, or calorie-restricted diets. Toxicol. Appl. Pharmacol., 115, 156-160.
104. Sohal,R.S., Agarwal,S., Candas,M., Forster,M.J. and Lal,H. (1994) Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev., 76, 215-224.
105. Kaneko,T., Tahara,S. and Matsuo,M. (1997) Retarding effect of dietary restriction on the accumulation of 8-hydroxy-2′-deoxyguanosine in organs of Fischer 344 rats during aging. Free. Radic. Biol. Med., 23, 76-81.
106. Simic,M.G. and Bergtold,D.S. (1991) Dietary modulation of DNA damage in human. Mutat. Res., 250, 17-24.
107. Simic,M.G. (1994) DNA markers of oxidative processes in vivo: Relevance to carcinogenesis and anticarcinogenesis. Cancer Res., 54, 1918-1923.
108. Fu,C.S., Harris,S.B., Wilhelmi,P. and Walford,R.L. (1991) Lack of effect of age and dietary restriction on DNA single-stranded breaks in brain, liver, and kidney of (C3H x C57BL/10)F1 mice. J. Gerontol., 46 B78-B80.
109. Wolf,F.I., Fasanella,S., Tedesco,B., Cavallin,G., Donati,A., Bergamini,E. and Cittadini,A. (2005) Peripheral lymphocyte 8-OHdG levels correlate with age-associated increase of tissue oxidative DNA damage in Sprague-Dawley rats. Protective effects of caloric restriction. Exp. Gerontol., 40, 181-188.
110. Hamilton,M.L., Guo,Z.M., Fuller,C.D., Van Remmen,H., Ward,W.F., Austad,S.N., Troyer,D.A., Thompson,I. and Richardson,A. (2001) A reliable assessment of 8-Oxo-3-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA. Nucleic Acids Res., 29, 2117-2126.
111. Hamilton,M.L., Van Remmen,H., Drake,J.A., Yang,H., Guo,Z.M., Kewitt,K., Walter,C.A. and Richardson,A. (2001) Does oxidative damage to DNA increase with age? Proc. Natl Acad. Sci., USA, 98, 10469-10474.
112. Ward,W.F., Qi,W., Van Remmen,H., Zackert,W.E., Roberts,L.JII and Richardson,A. (2005) Effects of age and caloric restriction on lipid peroxidation: Measurement of oxidative stress by F2-isoprostane levels. J. Gerontol., 60, 847-851.
113. Melov,S., Hinerfeld,D., Esposito,L. and Wallace,D.C. (1997) Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age. Nucleic Acids Res., 25, 974-982.
114. Kang,C.M., Kristal,B.S. and Yu,BP. (1998) Age-related mitochondrial DNA deletions: Effect of dietary restriction. Free Radic. Biol. Med., 24, 148-154.
115. Lopez-Torres,M., Gredilla,R., Sanz,A. and Barjo,G. (2002) Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria. Free Radic. Biol. Med., 32, 882-889.
116. Timiras,P.S., Yaghmaie,F., Saeed,O., Thung,E. and Chinn,G. (2005) The ageing phenome: Caloric restriction and hormones promote neural cell survival, growth and de-differentiation. Mech. Ageing Dev., 126 3-9.
117. Shima,N., Swiger,R.R. and Heddle,J.A. (2000) Dietary restriction during murine development provides protection against MNU-induced mutations. Mutat. Res., 470, 189-200.
118. Cao,S.X., Dhahbi,J.M., Mote,P.L. and Spindler,S.R. (2001) Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc. Natl Acad. Sci. USA, 98, 10630-10635.