Parkinson's disease: Clinical features and diagnosis

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 79, Issue 4, 2008, Pages 368-376

  Jankovic, J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVODOPA;

ANOSMIA; ATAXIA; AUTONOMIC DYSFUNCTION; BRADYKINESIA; CLINICAL FEATURE; COGNITIVE DEFECT; DEMENTIA; DIFFERENTIAL DIAGNOSIS; DRUG RESPONSE; DYSARTHRIA; DYSPHAGIA; GAIT DISORDER; HALLUCINATION; HUMAN; HYPERSALIVATION; OPHTHALMOPLEGIA; PARESTHESIA; PARKINSON DISEASE; PARKINSONISM; PRIORITY JOURNAL; REFLEX DISORDER; REVIEW; RIGIDITY; SLEEP DISORDER; TREMOR;

EID: 41149163183     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2007.131045     Document Type: Review

References (144)

1. Parkinson J. An essay on the shaking palsy. J Neuropsychiatry Clin Neurosci 2002;14:223-36.
2. Kempster PA, Hurwitz B, Lees AJ. A new look at James Parkinson's essay on the shaking palsy. Neurology 2007;69:482-5.
3. Bjorklund A, Dunnett SB. Dopamine neuron systems in the brain: an update. Trends Neurosci 2007;30:194-202.
4. Hornykiewicz O. The discovery of dopamine deficiency in the parkinsonian brain. J Neural Transm 2006;70:9-15.
5. Birkmayer W, Hornykiewicz O. The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia. Wien Klin Wochenschr 1961;73:787-8.
6. Birkmayer W, Hornykiewicz O. The effect of L-3, 4-dihydroxyphenylalanine (L-DOPA) on akinesia in parkinsonism. Parkinsonism Relat Disord 1998;4:59-60.
7. Cotzias GC, Papavasiliou PS, Gellene R. Modification of parkinsonism: chronic treatment with L-DOPA. N Engl J Med 1969;280:337-45.
8. McNaught KSP, Jenner P, Olanow CW. Protein mishandling: Role of the ubiquitin proteasome system in the pathogenesis of Parkinson's disease. In: Jankovic J, Tolosa E, eds. Parkinson's disease and movement disorders. Philadelphia: Lippincott Williams and Wilkins, 2007:33-49.
9. Pan T, Kondo S, Le W, et al. The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 2008 (Epub ahead of print).
10. Jankovic J, Tolosa E. Parkinson's disease and movement disorders. Philadelphia: Lippincott Williams and Wilkins, 2007.
11. Fahn S, Jankovic J. Principles and practice of movement disorders. Philadelphia: Elsevier, 2007.
12. Jankovic J. Pathophysiology and assessment of parkinsonian symptoms and signs. In: Pahwa R, Lyons K, Koller WC, eds. Handbook of Parkinson's disease. New York: Taylor and Francis Group, LLC, 2007:79-104.
13. Ramaker C, Marinus J, Stiggelbout AM, et al. Systematic evaluation of rating scales for impairment and disability in Parkinson's disease. Mov Disord 2002;17:867-76.
14. Ebersbach G, Baas H, Csoti I, et al. Scales in Parkinson's disease. J Neurol 2006;253:iv32-5.
15. Goetz CG, Fahn S, Martinez-Martin P, et al. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): process, format, and clinimetric testing plan. Mov Disord 2007;22:41-7.
16. Jankovic J, Kapadia AS. Functional decline in Parkinson disease. Arch Neurol 2001;58:1611-5.
17. Lang AE. The progression of Parkinson disease: a hypothesis. Neurology 2007;68:948-52.
18. Post B, Merkus MP, Haan RJ, et al. Prognostic factors for the progression of Parkinson's disease: A systematic review. Mov Disord 2007;22:1839-51.
19. Jankovic J, Stacy M. Medical management of levodopa-associated motor complications in patients with Parkinson's disease. CNS Drugs 2007;21:677-92.
20. Schrag A, Dodel R, Spottke A, et al. Rate of clinical progression in Parkinson's disease. A prospective study. Mov Disord 2007;22:938-45.
21. Schrag A, Barone P, Brown RG, et al. Depression rating scales in Parkinson's disease: critique and recommendations. Mov Disord 2007;22:1077-92.
22. Berardelli A, Rothwell JC, Thompson PD, et al. Pathophysiology of bradykinesia in Parkinson's disease. Brain 2001;124:2131-46.
23. Cooper JA, Sagar HJ, Tidswell P, et al. Slowed central processing in simple and go/no-go reaction time tasks in Parkinson's disease. Brain 1994;117:517-29.
24. Giovannoni G, van Schalkwyk J, Fritz VU, et al. Bradykinesia akinesia incoordination test (BRAIN TEST): an objective computerised assessment of upper limb motor function. J Neurol Neurosurg Psychiatry 1999;67:624-9.
25. Bagheri H, Damase-Michel C, Lapeyre-Mestre M, et al. A study of salivary secretion in Parkinson's disease. Clin Neuropharmacol 1999;22:213-15.
26. Vingerhoets FJG, Schulzer M, Calne DB, et al. Which clinical sign of Parkinson's disease best reflects the nigrostriatal lesion? Ann Neurol 1997;41:58-64.
27. Ross GW, Petrovitch H, Abbott RD, et al. Parkinsonian signs and substantia nigra neuron density in decendents elders without PD. Ann Neurol 2004;56:532-9.
28. Lozza C, Marie RM, Baron JC. The metabolic substrates of bradykinesia and tremor in uncomplicated Parkinson's disease. Neuroimage 2002;17:688-99.
29. 2 receptor blockade is associated with reduced motor cortex activity in the rat. J Neurosci 2005;25:5700-9.
30. Turner RS, Grafton ST, McIntosh AR, et al. The functional anatomy of parkinsonian bradykinesia. Neuroimage 2003;19:163-79.
31. Hallett M, Khoshbin S. A physiological mechanism of bradykinesia. Brain 1980;103:301-14.
32. Shulman LM, Singer C, Bean JA, et al. Internal tremor in patients with Parkinson's disease. Mov Disord 1996;11:3-7.
33. Shahed J, Jankovic J. Exploring the relationship between essential tremor and Parkinson's disease. Parkinsonism Relat Disord 2007;13:67-76.
34. Jankovic J, Schwartz KS, Ondo W. Re-emergent tremor of Parkinson's disease. J Neurol Neurosurg Psychiatry 1999;67:646-50.
35. Jankovic J. Essential tremor: a heterogenous disorder. Mov Disord 2002;17:638-44.
36. Hughes AJ, Daniel SE, Blankson S, et al. A clinicopathologic study of 100 cases of Parkinson's disease. Arch Neurol 1993;50:140-8.
37. Martin WE, Loewenson RB, Resch JA, et al. Parkinson's disease: clinical analysis of 100 patients. Neurology 1973;23:783-90.
38. Rajput AH, Rozdilsky B, Rajput A. Accuracy of clinical diagnosis in parkinsonism: a prospective study. Can J Neurol Sci 1991;18:275-8.
39. Broussolle E, Krack P, Thobois S, et al. Contribution of Jules Froment to the study of parkinsonian rigidity. Mov Disord 2007;22:909-14.
40. Riley D, Lang AE, Blair RD, et al. Frozen shoulder and other shoulder disturbances in Parkinson's disease. J Neurol Neurosurg Psychiatry 1989;52:63-6.
41. Stamey WP, Jankovic J. Shoulder pain in Parkinson's disease. Mov Disord 2007;22:S247-8.
42. de Lau LML, Koudstaal PJ, Hofman A, et al. Subjective complaints precede Parkinson disease: the Rotterdam study. Arch Neurol 2006;63:362-5.
43. Ashour R, Tintner R, Jankovic J. Striatal deformities of the hand and foot in Parkinson's disease. Lancet Neurol 2005;4:423-31.
44. Ashour R, Jankovic J. Joint and skeletal deformities in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Mov Disord 2006;21:1856-63.
45. Winkler AS, Reuter I, Harwood G, et al. The frequency and significance of 'striatal toe' in parkinsonism. Parkinsonism Relat Disord 2002;9:97-101.
46. Askmark H, Eeg-Olofsson KE, Johansson A, et al. Parkinsonism and neck extensor myopathy: a new syndrome or coincidental findings? Arch Neurol 2001;58:232-7.
47. Djaldetti R, Melamed E. Camptocormia in Parkinson's disease: new insights. J Neurol Neurosurg Psychiatry 2006;77:1205.
48. Azher SN, Jankovic J. Camptocormia: pathogenesis, classification, and response to therapy. Neurology 2005;65:355-9.
49. Bloch F, Houeto JL, Tezenas du MS, et al. Parkinson's disease with camptocormia. J Neurol Neurosurg Psychiatry 2006;77:1223-8.
50. Djaldetti R, Mosberg-Galili R, Sroka H, et al. Camptocormia (bent spine) in patients with Parkinson's disease - characterization and possible pathogenesis of an unusual phenomenon. Mov Disord 1999;14:443-7.
51. Villarejo A, Camacho A, Garcia-Ramos R, et al. Cholinergic-dopaminergic imbalance in Pisa syndrome. Clin Neuropharmacol 2003;26:119-21.
52. Williams DR, Watt HC, Lees AJ. Predictors of falls and fractures in bradykinetic rigid syndromes: a retrospective study. J Neurol Neurosurg Psychiatry 2006;77:468-73.
53. Wenning GK, Ebersbach G, Verny M, et al. Progression of falls in postmortemconfirmed parkinsonian disorders. Mov Disord 1999;14:947-50.
54. Bloem BR. Postural instability in Parkinson's disease. Clin Neurol Neurosurg 1992;94:S41-5.
55. Bronte-Stewart HM, Minn AY, Rodrigues K, et al. Postural instability in idiopathic Parkinson's disease: the role of medication and unilateral pallidotomy. Brain 2002;125:2100-14.
56. Adkin AL, Frank JS, Jog MS. Fear of falling and postural control in Parkinson's disease. Mov Disord 2003;18:496-502.
57. Koller WC, Glatt S, Vetere-Overfield B, et al. Falls and Parkinson's disease. Clin Neuropharmacol 1989;12:98-105.
58. Roberts-Warrior D, Overby A, Jankovic J, et al. Postural control in Parkinson's disease after unilateral posteroventral pallidotomy. Brain 2000;123:2141-9.
59. Maurer C, Mergner T, Xie J, et al. Effect of chronic bilateral subthalamic nucleus (STN) stimulation on postural control in Parkinson's disease. Brain 2003;126:1146-63.
60. Stefani A, Lozano AM, Peppe A, et al. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain 2007;130:1596-607.
61. Giladi N, McDermott MP, Fahn S, et al. Freezing of gait in PD: prospective assessment in the DATATOP cohort. Neurology 2001;56:1712-21.
62. Bloem BR, Hausdorff JM, Visser JE, et al. Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomena. Mov Disord 2004;19:871-84.
63. Macht M, Kaussner Y, Moller JC, et al. Predictors of freezing in Parkinson's disease: a survey of 6,620 patients. Mov Disord 2007;22:953-6.
64. Boghen D. Apraxia of lid opening: a review. Neurology 1997;48:1491-4.
65. Schaafsma JD, Balash Y, Gurevich T, et al. Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson's disease. Eur J Neurol 2003;10:391-8.
66. Dietz MA, Goetz CG, Stebbins GT. Evaluation of a modified inverted walking stick as a treatment for parkinsonian freezing episodes. Mov Disord 1990;5:243-7.
67. Arias P, Cudeiro J. Effects of rhythmic sensory stimulation (auditory, visual) on gait in Parkinson's disease patients. Exp Brain Res 2008 (Epub ahead of print 23 Jan).
68. Marchese R, Diverio M, Zucchi F, et al. The role of sensory cues in the rehabilitation of parkinsonian patients: a comparison of two physical therapy protocols. Mov Disord 2000;15:879-83.
69. Giladi N, Kao R, Fahn S. Freezing phenomenon in patients with parkinsonian syndromes. Mov Disord 1997;12:302-5.
70. Sheffield JK, Jankovic J. Botulinum toxin in the treatment of tremors, dystonias, sialorrhea and other symptoms associated with Parkinson's disease. Exp Rev Neurother 2007;7:637-47.
71. Singh R, Pentland B, Hunter J, et al. Parkinson's disease and driving ability. J Neurol Neurosurg Psychiatry 2007;78:363-6.
72. Thomas RJ. Blinking and the release reflexes: are they clinically useful? J Am Geriatr Soc 1994;42:609-13.
73. Vreeling FW, Jolles J, Verhey FRJ, et al. Primitive reflexes in healthy, adult volunteers and neurological patients: methodological issues. J Neurol 1993;240:495-504.
74. Brodsky H, Dat Vuong K, Thomas M, et al. Glabellar and palmomental reflexes in Parkinsonian disorders. Neurology 2004;63:1096-8.
75. Wu J, Sitburana O, Jankovic J. The specificity and sensitivity of "applause sign" in differentiating PSP and other parkinsonian syndromes. Mov Disord 2007;22:S254-5.
76. Li JY, Espay AJ, Gunraj CA, et al. Interhemispheric and ipsilateral connections in Parkinson's disease: relation to mirror movements. Mov Disord 2007;22:813-21.
77. Hunker CJ, Abbs JH, Barlow SM. The relationship between parkinsonian rigidity and hypokinesia in the orofacial system: a quantitative analysis. Neurology 1982;32:749-54.
78. Matison R, Mayeux R, Rosen J, et al. "Tip-of-the- tongue" phenomenon in Parkinson disease. Neurology 1982;32:567-70.
79. Critchley EMR. Speech disorders of Parkinsonism: a review. J Neurol Neurosurg Psychiatry 1981;44:751-8.
80. Sapir S, Spielman JL, Ramig LO, et al. Effects of intensive voice treatment (the Lee Silverman Voice Treatment [LSVT]) on vowel articulation in dysarthric individuals with idiopathic Parkinson disease: acoustic and perceptual findings. J Speech Lang Hear Res 2007;50:899-912.
81. Potulska A, Friedman A, Krolicki L, et al. Swallowing disorders in Parkinson's disease. Parkinsonism Relat Disord 2003;9:349-53.
82. Biousse V, Skibell BC, Watts RL, et al. Ophthalmologic features of Parkinson's disease. Neurology 2004;62:177-80.
83. Hood AJ, Amador SC, Cain AE, et al. Levodopa slows prosaccades and improves antisaccades: an eye movement study in Parkinson's disease. J Neurol Neurosurg Psychiatry 2007;78:565-70.
84. Rascol O, Clanet M, Montastruc JL, et al. Abnormal ocular movements in Parkinson's disease: evidence for involvement of dopaminergic systems. Brain 1989;112:1193-214.
85. Sharpe JA, Fletcher WA, Lang AE, et al. Smooth pursuit during dose-related on-off fluctuations in Parkinson's disease. Neurology 1987;37:1389-92.
86. Zadikoff C, Lang AE. Apraxia in movement disorders. Brain 2005;128:1480-97.
87. Linazasoro G, Van Blercom N, Lasa A. Levodopa-induced ocular dyskinesias in Parkinson's disease. Mov Disord 2002;17:186-7.
88. Sabate M, Gonzalez I, Ruperez F, et al. Obstructive and restrictive pulmonary dysfunctions in Parkinson's disease. J Neurol Sci 1996;138:114-19.
89. Fernandez HH, Lapane KL. Predictors of mortality among nursing home residents with a diagnosis of Parkinson's disease. Med Sci Monit 2002;8:CR241-6.
90. Shill H, Stacy M. Respiratory function in Parkinson's disease. Clin Neurosci 1998;5:131-5.
91. Jankovic J, Nour F. Respiratory dyskinesia in Parkinson's disease. Neurology 1986;36:303-4.
92. Zesiewicz TA, Sullivan KL, Hauser RA. Nonmotor symptoms of Parkinson's disease. Exp Rev Neurother 2006;6:1811-22.
93. Pursiainen V, Haapaniemi TH, Korpelainen JT, et al. Sweating in Parkinsonian patients with wearing-off. Mov Disord 2007;22:828-32.
94. Senard JM, Rai S, Lapeyre-Mestre M, et al. Prevalence of orthostatic hypotension in Parkinson's disease. J Neurol Neurosurg Psychiatry 1997;63:584-9.
95. Swinn L, Schrag A, Viswanathan R, et al. Sweating dysfunction in Parkinson's disease. Mov Disord 2003;18:1459-63.
96. Allcock LM, Ullyart K, Kenny RA, et al. Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 2004;75:1470-1.
97. Hely MA, Morris JGL, Reid WGJ, et al. Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years. Mov Disord 2005;20:190-9.
98. Aarsland D, Andersen K, Larsen JP, et al. Risk of dementia in Parkinson's disease: a community-based, prospective study. Neurology 2001;56:730-6.
99. Aarsland D, Bronnick K, Ehrt U, et al. Neuropsychiatric symptoms in patients with Parkinson's disease and dementia: frequency, profile and associated care giver stress. J Neurol Neurosurg Psychiatry 2007;78:36-42.
100. Ravina B, Camicioli R, Como PG, et al. The impact of depressive symptoms in early Parkinson disease. Neurology 2007;69:342-7.
101. Palmiter RD. Is dopamine a physiologically relevant mediator of feeding behavior? Trends Neurosci 2007;30:375-81.
102. Miyasaki JM, Al HK, Lang AE, et al. Punding prevalence in Parkinson's disease. Mov Disord 2007;22:1179-81.
103. Weintraub D, Siderowf AD, Potenza MN, et al. Association of dopamine agonist use with impulse control disorders in Parkinson disease. Arch Neurol 2006;63:969-73.
104. Sawamoto N, Honda M, Hanakawa T, et al. Cognitive slowing in Parkinson disease is accompanied by hypofunctioning of the striatum. Neurology 2007;68:1062-8.
105. Ondo WG, Dat Vuong K, Khan H, et al. Daytime sleepiness and other sleep disorders in Parkinson's disease. Neurology 2001;57:1392-6.
106. Gjerstad MD, Alves G, Wentzel-Larsen T, et al. Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease? Neurology 2006;67:853-8.
107. Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder. Neurology 1996;46:388-93.
108. Plazzi G, Corsini R, Provini F, et al. REM sleep behavior disorders in multiple system atrophy. Neurology 1997;48:1094-7.
109. Gagnon J-F, Postuma RB, Mazza S, et al. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. Lancet Neurol 2006;5:424-32.
110. Borek LL, Kohn R, Friedman JH. Phenomenology of dreams in Parkinson's disease. Mov Disord 2007;22:198-202.
111. Gjerstad MD, Wentzel-Larsen T, Aarsland D, et al. Insomnia in Parkinson's disease: frequency and progression over time. J Neurol Neurosurg Psychiatry 2007;78:476-9.
112. Boeve BF, Silber MH, Saper CB, et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain 2007;130(Pt 11):2770-88.
113. Fronczek R, Overeem S, Lee SY, et al. Hypocretin (orexin) loss in Parkinson's disease. Brain 2007;130:1577-85.
114. Thannickal TC, Lai YY, Siegel JM. Hypocretin (orexin) cell loss in Parkinson's disease. Brain 2007;130:1586-95.
115. Friedman JH, Brown RG, Cornelia C, et al. Fatigue in Parkinson's disease: a review. Mov Disord 2007;22:297-308.
116. Stern MB, Doty RL, Dotti M, et al. Olfactory function in Parkinson's disease subtypes. Neurology 1994;44:266-8.
117. 123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy. Mov Disord 2006;21:1975-7.
118. Comella CL, Goetz CG. Akathisia in Parkinson's disease. Mov Disord 1994;9:545-9.
119. Ford B, Louis ED, Greene P, et al. Oral and genital pain syndromes in Parkinson's disease. Mov Disord 1996;11:421-6.
120. Djaldetti R, Shifrin A, Rogowski Z, et al. Quantitative measurement of pain sensation in patients with Parkinson disease. Neurology 2004;62:2171-5.
121. Tinazzi M, Del Vesco C, Fincati E, et al. Pain and motor complications in Parkinson's disease. J Neurol Neurosurg Psychiatry 2006;77:822-5.
122. Ponsen MM, Stoffers D, Booij J, et al. Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann Neurol 2004;56:173-81.
123. Marras C, Goldman S, Smith A, et al. Smell identification ability in twin pairs discordant for Parkinson's disease. Mov Disord 2005;20:687-93.
124. Harding AJ, Stimson E, Henderson JM, et al. Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease. Brain 2002;125:2431-45.
125. Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988;51:745-52.
126. Rao G, Fisch L, Srinivasan S, et al. Does this patient have Parkinson disease? JAMA 2003;289:347-53.
127. Tolosa E, Wenning G, Poewe W. The diagnosis of Parkinson's disease. Lancet Neurol 2006;5:75-86.
128. Gelb DJ, Oliver E, Gilman S. Diagnostic criteria for Parkinson disease. Arch Neurol 1999;56:33-9.
129. de Rijk MC, Rocca WA, Anderson DW, et al. A population perspective on diagnostic criteria for Parkinson's disease. Neurology 1997;48:1277-81.
130. Hughes AJ, Ben-Shlomo Y, Daniel SE, et al. What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study. Neurology 1992;42:1142-6.
131. Hughes AJ, Daniel SE, Lees AJ. Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology 2001;57:1497-9.
132. Jankovic J, Rajput AH, McDermott MP, et al. The evolution of diagnosis in early Parkinson disease. Arch Neurol 2000;57:369- 72.
133. Meara J, Bhowmick BK, Hobson P. Accuracy of diagnosis in patients with presumed Parkinson's disease. Age Ageing 1999;28:99-102.
134. Arvanitakis Z, Wilson RS, Schneider JA, et al. Diabetes mellitus and progression of rigidity and gait disturbance in older persons. Neurology 2004;63:996-1001.
135. Inzelberg R, Jankovic J. Are Parkinson disease patients protected from some but not all cancers? Neurology 2007;69:1542-50.
136. Warren NM, Piggott MA, Greally E, et al. Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy. Mov Disord 2007;22:1594-1600.
137. Parati EA, Fetoni V, Geminiani GC, et al. Response to L-DOPA in multiple system atrophy. Clin Neuropharmacol 1993;16:139-44.
138. Clarke CE, Davies P. Systematic review of acute levodopa and apomorphine challenge tests in the diagnosis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 2000;69:590-4.
139. Piccini P, Brooks DJ. New developments of brain imaging for Parkinson's disease and related disorders. Mov Disord 2006;21:2035-41.
140. 11C-raclopride and positron emission tomography. Ann Neurol 1992;31:184-92.
141. 123I] beta-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease. Neurology 1996;46:231-7.
142. Walter U, Niehaus L, Probst T, et al. Brain parenchyma sonography discriminates Parkinson's disease and atypical parkinsonian syndromes. Neurology 2003;60:74-7.
143. Stockner H, Sojer M, KS K, et al. Midbrain sonography in patients with essential tremor. Mov Disord 2007;22:414-7.
144. Ishihara LS, Cheesbrough A, Brayne C, et al. Estimated life expectancy of Parkinson's patients compared with the UK population. J Neurol Neurosurg Psychiatry 2007;78:1304-9.