New insights into the role of mitochondria in aging: Mitochondrial dynamics and more

Journal of Cell Science

Volumn 123, Issue 15, 2010, Pages 2533-2542

  Seo, Arnold Y ^a   Joseph, Anna Maria ^a   Dutta, Debapriya ^a   Hwang, Judy C Y ^a   Aris, John P ^a   Leeuwenburgh, Christiaan ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; Fission; Fusion; Mammalian aging; Mitochondria; Mitophagy; mtDNA

Indexed keywords

MITOFUSIN 1; MITOFUSIN 2;

AGING; APOPTOSIS; AUTOPHAGY; DEGENERATIVE DISEASE; MITOCHONDRION; NONHUMAN; NOTE; PRIORITY JOURNAL;

AGING; ANIMALS; APOPTOSIS; DNA, MITOCHONDRIAL; HUMANS; MITOCHONDRIA; MODELS, BIOLOGICAL;

MAMMALIA;

EID: 77955351652     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.070490     Document Type: Note

References (153)

1. Adhihetty, P. J., O'Leary, M. F., Chabi, B., Wicks, K. L. and Hood, D. A. (2007). Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle. J. Appl. Physiol. 102, 1143-1151.
2. Alexander, C., Votruba, M., Pesch, U. E., Thiselton, D. L., Mayer, S., Moore, A., Rodriguez, M., Kellner, U., Leo-Kottler, B., Auburger, G. et al. (2000). OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. Nat. Genet. 26, 211-215.
3. Alirol, E., James, D., Huber, D., Marchetto, A., Vergani, L., Martinou, J. C. and Scorrano, L. (2006). The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis. Mol. Biol. Cell 17, 4593-4605.
4. Alvers, A. L., Fishwick, L. K., Wood, M. S., Hu, D., Chung, H. S., Dunn, W. A., Jr and Aris, J. P. (2009). Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell 8, 353-369.
5. Arnoult, D., Grodet, A., Lee, Y. J., Estaquier, J. and Blackstone, C. (2005a). Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation. J. Biol. Chem. 280, 35742-35750.
6. Arnoult, D., Rismanchi, N., Grodet, A., Roberts, R. G., Seeburg, D. P., Estaquier, J., Sheng, M. and Blackstone, C. (2005b). Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death. Curr. Biol. 15, 2112-2118.
7. Attaix, D., Mosoni, L., Dardevet, D., Combaret, L., Mirand, P. P. and Grizard, J. (2005). Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods. Int. J. Biochem. Cell Biol. 37, 1962-1973.
8. Bach, D., Pich, S., Soriano, F. X., Vega, N., Baumgartner, B., Oriola, J., Daugaard, J. R., Lloberas, J., Camps, M., Zierath, J. R. et al. (2003). Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J. Biol. Chem. 278, 17190-17197.
9. Bach, D., Naon, D., Pich, S., Soriano, F. X., Vega, N., Rieusset, J., Laville, M., Guillet, C., Boirie, Y., Wallberg-Henriksson, H. et al. (2005). Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Diabetes 54, 2685-2693. (Pubitemid 41233591)
10. Bakeeva, L. E., Chentsov, Yu, S. and Skulachev, V. P. (1978). Mitochondrial framework (reticulum mitochondriale) in rat diaphragm muscle. Biochim. Biophys. Acta 501, 349-369.
11. Bandy, B. and Davison, A. J. (1990). Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? Free Radic. Biol. Med. 8, 523-539.
12. Benchoua, A., Trioulier, Y., Zala, D., Gaillard, M. C., Lefort, N., Dufour, N., Saudou, F., Elalouf, J. M., Hirsch, E., Hantraye, P. et al. (2006). Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin. Mol. Biol. Cell 17, 1652-1663.
13. Bereiter-Hahn, J. and Voth, M. (1994). Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria. Microsc. Res. Tech. 27, 198-219.
14. Berman, S. B., Chen, Y. B., Qi, B., McCaffery, J. M., Rucker, E. B., 3rd, Goebbels, S., Nave, K. A., Arnold, B. A., Jonas, E. A., Pineda, F. J. et al. (2009). Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons. J. Cell Biol. 184, 707-719.
15. Bibb, M. J., Van Etten, R. A., Wright, C. T., Walberg, M. W. and Clayton, D. A. (1981). Sequence and gene organization of mouse mitochondrial DNA. Cell 26, 167-180.
16. Bogenhagen, D. F. (2010). Does mtDNA nucleoid organization impact aging? Exp. Gerontol. 45, 473-477.
17. Bossy-Wetzel, E., Petrilli, A. and Knott, A. B. (2008). Mutant huntingtin and mitochondrial dysfunction. Trends Neurosci. 31, 609-616.
18. Breckenridge, D. G., Stojanovic, M., Marcellus, R. C. and Shore, G. C. (2003). Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J. Cell Biol. 160, 1115-1127.
19. Brooks, C., Wei, Q., Feng, L., Dong, G., Tao, Y., Mei, L., Xie, Z. J. and Dong, Z. (2007). Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc. Natl. Acad. Sci. USA 104, 11649-11654.
20. Brooks, C., Wei, Q., Cho, S. G. and Dong, Z. (2009). Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J. Clin. Invest. 119, 1275-1285.
21. Cartoni, R., Leger, B., Hock, M. B., Praz, M., Crettenand, A., Pich, S., Ziltener, J. L., Luthi, F., Deriaz, O., Zorzano, A. et al. (2005). Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J. Physiol. 567, 349-358.
22. Chang, C. R. and Blackstone, C. (2007). Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. J. Biol. Chem. 282, 21583-21587.
23. Chen, H. and Chan, D. C. (2004). Mitochondrial dynamics in mammals. Curr. Top. Dev. Biol. 59, 119-144.
24. Chen, H. and Chan, D. C. (2009). Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Hum. Mol. Genet. 18, R169-R176.
25. Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E. and Chan, D. C. (2003). Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 160, 189-200. (Pubitemid 36254953)
26. Chen, H., Chomyn, A. and Chan, D. C. (2005). Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J. Biol. Chem. 280, 26185-26192.
27. Chen, H., McCaffery, J. M. and Chan, D. C. (2007). Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130, 548-562.
28. Chen, H., Vermulst, M., Wang, Y. E., Chomyn, A., Prolla, T. A., McCaffery, J. M. and Chan, D. C. (2010). Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 141, 280-289.
29. Cho, D. H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z. and Lipton, S. A. (2009). S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324, 102-105.
30. Chomyn, A. and Attardi, G. (2003). MtDNA mutations in aging and apoptosis. Biochem. Biophys. Res. Commun. 304, 519-529.
31. Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P. and Leeuwenburgh, C. (2009). Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res. Rev. 8, 18-30.
32. Chung, J. H., Seo, A. Y., Chung, S. W., Kim, M. K., Leeuwenburgh, C., Yu, B. P. and Chung, H. Y. (2008). Molecular mechanism of PPAR in the regulation of age-related inflammation. Ageing Res. Rev. 7, 126-136.
33. Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R. and Ravussin, E. (2007). Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 4, e76.
34. Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A. and Guo, M. (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441, 1162-1166.
35. Combaret, L., Dardevet, D., Bechet, D., Taillandier, D., Mosoni, L. and Attaix, D. (2009). Skeletal muscle proteolysis in aging. Curr. Opin. Clin. Nutr. Metab. Care 12, 37-41.
36. Crane, J. D., Devries, M. C., Safdar, A., Hamadeh, M. J. and Tarnopolsky, M. A. (2010). The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure. J. Gerontol. A Biol. Sci. Med. Sci. 65, 119-128.
37. Cribbs, J. T. and Strack, S. (2007). Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep. 8, 939-944. (Pubitemid 47500477)
38. Cuervo, A. M. and Dice, J. F. (2000). Regulation of lamp2a levels in the lysosomal membrane. Traffic 1, 570-583.
39. Dagda, R. K., Cherra, S. J., 3rd, Kulich, S. M., Tandon, A., Park, D. and Chu, C. T. (2009). Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem. 284, 13843-13855.
40. de Brito, O. M. and Scorrano, L. (2008). Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456, 605-610.
41. Delettre, C., Griffoin, J. M., Kaplan, J., Dollfus, H., Lorenz, B., Faivre, L., Lenaers, G., Belenguer, P. and Hamel, C. P. (2001). Mutation spectrum and splicing variants in the OPA1 gene. Hum. Genet. 109, 584-591.
42. Delivani, P., Adrain, C., Taylor, R. C., Duriez, P. J. and Martin, S. J. (2006). Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics. Mol. Cell 21, 761-773.
43. Deng, H., Dodson, M. W., Huang, H. and Guo, M. (2008). The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. Natl. Acad. Sci. USA 105, 14503-14508.
44. Dinsdale, D., Zhuang, J. and Cohen, G. M. (1999). Redistribution of cytochrome c precedes the caspase-dependent formation of ultracondensed mitochondria, with a reduced inner membrane potential, in apoptotic monocytes. Am. J. Pathol. 155, 607-618.
45. Dirks, A. J. and Leeuwenburgh, C. (2005). The role of apoptosis in age-related skeletal muscle atrophy. Sports Med. 35, 473-483.
46. Dodson, M. W. and Guo, M. (2007). Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease. Curr. Opin. Neurobiol. 17, 331-337.
47. Donati, A., Cavallini, G., Paradiso, C., Vittorini, S., Pollera, M., Gori, Z. and Bergamini, E. (2001). Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes. J. Gerontol. A Biol. Sci. Med. Sci. 56, B288-B293.
48. Dupont-Versteegden, E. E. (2005). Apoptosis in muscle atrophy: relevance to sarcopenia. Exp. Gerontol. 40, 473-481.
49. Duvezin-Caubet, S., Jagasia, R., Wagener, J., Hofmann, S., Trifunovic, A., Hansson, A., Chomyn, A., Bauer, M. F., Attardi, G., Larsson, N. G. et al. (2006). Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology. J. Biol. Chem. 281, 37972-37979.
50. Elmore, S. P., Qian, T., Grissom, S. F. and Lemasters, J. J. (2001). The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J. 15, 2286-2287.
51. Eura, Y., Ishihara, N., Yokota, S. and Mihara, K. (2003). Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion. J. Biochem. 134, 333-344. (Pubitemid 37288331)
52. Exner, N., Treske, B., Paquet, D., Holmstrom, K., Schiesling, C., Gispert, S., Carballo-Carbajal, I., Berg, D., Hoepken, H. H., Gasser, T. et al. (2007). Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J. Neurosci. 27, 12413-12418.
53. Fannin, S. W., Lesnefsky, E. J., Slabe, T. J., Hassan, M. O. and Hoppel, C. L. (1999). Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria. Arch. Biochem. Biophys. 372, 399-407.
54. Frank, S., Gaume, B., Bergmann-Leitner, E. S., Leitner, W. W., Robert, E. G., Catez, F., Smith, C. L. and Youle, R. J. (2001). The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev. Cell 1, 515-525.
55. Frezza, C., Cipolat, S., Martins de Brito, O., Micaroni, M., Beznoussenko, G. V., Rudka, T., Bartoli, D., Polishuck, R. S., Danial, N. N., De Strooper, B. et al. (2006). OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell 126, 177-189.
56. Gao, W., Pu, Y., Luo, K. Q. and Chang, D. C. (2001). Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells. J. Cell Sci. 114, 2855-2862. (Pubitemid 32785463)
57. Germain, M., Mathai, J. P., McBride, H. M. and Shore, G. C. (2005). Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis. EMBO J. 24, 1546-1556.
58. Gomes, L. C. and Scorrano, L. (2008). High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim. Biophys. Acta 1777, 860-866.
59. Green, D. R. (1998). Apoptosis. Death deceiver. Nature 396, 629-630.
60. Green, D. R. and Kroemer, G. (2004). The pathophysiology of mitochondrial cell death. Science 305, 626-629.
61. Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B. and Pallanck, L. J. (2003). Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc. Natl. Acad. Sci. USA 100, 4078-4083.
62. Harman, D. (1956). Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11, 298-300.
63. Harman, D. (1972). The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20, 145-147.
64. Hermann, G. J., Thatcher, J. W., Mills, J. P., Hales, K. G., Fuller, M. T., Nunnari, J. and Shaw, J. M. (1998). Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J. Cell Biol. 143, 359-373.
65. Hiona, A. and Leeuwenburgh, C. (2008). The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging. Exp. Gerontol. 43, 24-33.
66. Holloszy, J. O. (1967). Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J. Biol. Chem. 242, 2278-2282.
67. Holloszy, J. O. and Booth, F. W. (1976). Biochemical adaptations to endurance exercise in muscle. Annu. Rev. Physiol. 38, 273-291.
68. Hood, D. A. (2001). Invited Review: contractile activity-induced mitochondrial biogenesis in skeletal muscle. J. Appl. Physiol. 90, 1137-1157.
69. Hoppins, S., Lackner, L. and Nunnari, J. (2007). The machines that divide and fuse mitochondria. Annu. Rev. Biochem. 76, 751-780.
70. Hutter, E., Skovbro, M., Lener, B., Prats, C., Rabol, R., Dela, F. and Jansen-Durr, P. (2007). Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle. Aging Cell 6, 245-256. (Pubitemid 46455068)
71. Ishihara, N., Eura, Y. and Mihara, K. (2004). Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J. Cell Sci. 117, 6535-6546.
72. James, A. M., Wei, Y. H., Pang, C. Y. and Murphy, M. P. (1996). Altered mitochondrial function in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations. Biochem. J. 318, 401-407.
73. Karbowski, M., Lee, Y. J., Gaume, B., Jeong, S. Y., Frank, S., Nechushtan, A., Santel, A., Fuller, M., Smith, C. L. and Youle, R. J. (2002). Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J. Cell Biol. 159, 931-938.
74. Karbowski, M., Jeong, S. Y. and Youle, R. J. (2004). Endophilin B1 is required for the maintenance of mitochondrial morphology. J. Cell Biol. 166, 1027-1039. (Pubitemid 39304766)
75. Karbowski, M., Norris, K. L., Cleland, M. M., Jeong, S. Y. and Youle, R. J. (2006). Role of Bax and Bak in mitochondrial morphogenesis. Nature 443, 658-662.
76. Kelley, D. E., He, J., Menshikova, E. V. and Ritov, V. B. (2002). Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51, 2944-2950.
77. Kim, I., Rodriguez-Enriquez, S. and Lemasters, J. J. (2007). Selective degradation of mitochondria by mitophagy. Arch Biochem. Biophys. 462, 245-253.
78. Kirkwood, S. P., Munn, E. A. and Brooks, G. A. (1986). Mitochondrial reticulum in limb skeletal muscle. Am. J. Physiol. 251, C395-C402.
79. Klingenspor, M. (2003). Cold-induced recruitment of brown adipose tissue thermogenesis. Exp. Physiol. 88, 141-148.
80. Kroemer, G., Galluzzi, L. and Brenner, C. (2007). Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 87, 99-163.
81. Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A. et al. (2005). Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309, 481-484.
82. Kujoth, G. C., Leeuwenburgh, C. and Prolla, T. A. (2006). Mitochondrial DNA mutations and apoptosis in mammalian aging. Cancer Res. 66, 7386-7389. (Pubitemid 44289188)
83. Lee, S., Jeong, S. Y., Lim, W. C., Kim, S., Park, Y. Y., Sun, X., Youle, R. J. and Cho, H. (2007). Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J. Biol. Chem. 282, 22977-22983.
84. Lee, Y. J., Jeong, S. Y., Karbowski, M., Smith, C. L. and Youle, R. J. (2004). Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol. Biol. Cell 15, 5001-5011.
85. Legros, F., Malka, F., Frachon, P., Lombes, A. and Rojo, M. (2004). Organization and dynamics of human mitochondrial DNA. J. Cell Sci. 117, 2653-2662. (Pubitemid 38997249)
86. Liesa, M., Palacin, M. and Zorzano, A. (2009). Mitochondrial dynamics in mammalian health and disease. Physiol. Rev. 89, 799-845.
87. Liu, X., Kim, C. N., Yang, J., Jemmerson, R. and Wang, X. (1996). Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86, 147-157.
88. Lu, B. (2009). Mitochondrial dynamics and neurodegeneration. Curr. Neurol. Neurosci. Rep. 9, 212-219.
89. Malena, A., Loro, E., Di Re, M., Holt, I. J. and Vergani, L. (2009). Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA. Hum. Mol. Genet. 18, 3407-3416.
90. Marzetti, E., Lawler, J. M., Hiona, A., Manini, T., Seo, A. Y. and Leeuwenburgh, C. (2008). Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle. Free Radic. Biol. Med. 44, 160-168.
91. Merz, S., Hammermeister, M., Altmann, K., Durr, M. and Westermann, B. (2007). Molecular machinery of mitochondrial dynamics in yeast. Biol. Chem. 388, 917-926.
92. Mingrone, G., Manco, M., Calvani, M., Castagneto, M., Naon, D. and Zorzano, A. (2005). Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity? Diabetologia 48, 2108-2114.
93. Mootha, V. K., Handschin, C., Arlow, D., Xie, X., St Pierre, J., Sihag, S., Yang, W., Altshuler, D., Puigserver, P., Patterson, N. et al. (2004). Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc. Natl. Acad. Sci. USA 101, 6570-6575.
94. Moyes, C. D., Mathieu-Costello, O. A., Tsuchiya, N., Filburn, C. and Hansford, R. G. (1997). Mitochondrial biogenesis during cellular differentiation. Am. J. Physiol. 272, C1345-C1351.
95. Mukamel, Z. and Kimchi, A. (2004). Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death. J. Biol. Chem. 279, 36732-36738.
96. Murakoshi, M., Osamura, Y. and Watanabe, K. (1985). Mitochondrial alterations in aged rat adrenal cortical cells. Tokai J. Exp. Clin. Med. 10, 531-536.
97. Narendra, D., Tanaka, A., Suen, D. F. and Youle, R. J. (2008). Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803.
98. Neuspiel, M., Zunino, R., Gangaraju, S., Rippstein, P. and McBride, H. (2005). Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization. J. Biol. Chem. 280, 25060-25070.
99. Niemann, A., Ruegg, M., La Padula, V., Schenone, A. and Suter, U. (2005). Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease. J. Cell Biol. 170, 1067-1078.
100. Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E. et al. (2005). Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310, 314-317.
101. Okamoto, K. and Shaw, J. M. (2005). Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Annu. Rev. Genet. 39, 503-536.
102. Olichon, A., Baricault, L., Gas, N., Guillou, E., Valette, A., Belenguer, P. and Lenaers, G. (2003). Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J. Biol. Chem. 278, 7743-7746.
103. Panov, A. V., Gutekunst, C. A., Leavitt, B. R., Hayden, M. R., Burke, J. R., Strittmatter, W. J. and Greenamyre, J. T. (2002). Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines. Nat. Neurosci. 5, 731-736.
104. Parone, P. A., James, D. I., Da Cruz, S., Mattenberger, Y., Donze, O., Barja, F. and Martinou, J. C. (2006). Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis. Mol. Cell. Biol. 26, 7397-7408.
105. Parone, P. A., Da Cruz, S., Tondera, D., Mattenberger, Y., James, D. I., Maechler, P., Barja, F. and Martinou, J. C. (2008). Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS One 3, e3257.
106. Pich, S., Bach, D., Briones, P., Liesa, M., Camps, M., Testar, X., Palacin, M. and Zorzano, A. (2005). The Charcot-Marie-Tooth type 2A gene product, Mfn2, upregulates fuel oxidation through expression of OXPHOS system. Hum. Mol. Genet. 14, 1405-1415.
107. Pitts, K. R., Yoon, Y., Krueger, E. W. and McNiven, M. A. (1999). The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells. Mol. Biol. Cell 10, 4403-4417.
108. Poole, A. C., Thomas, R. E., Andrews, L. A., McBride, H. M., Whitworth, A. J. and Pallanck, L. J. (2008). The PINK1/Parkin pathway regulates mitochondrial morphology. Proc. Natl. Acad. Sci. USA 105, 1638-1643.
109. Qiang, W., Weiqiang, K., Qing, Z., Pengju, Z. and Yi, L. (2007). Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha. Exp. Mol. Med. 39, 535-543.
110. Rapaport, D., Brunner, M., Neupert, W. and Westermann, B. (1998). Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J. Biol. Chem. 273, 20150-20155.
111. Reznick, R. M., Zong, H., Li, J., Morino, K., Moore, I. K., Yu, H. J., Liu, Z. X., Dong, J., Mustard, K. J., Hawley, S. A. et al. (2007). Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab. 5, 151-156.
112. Rojo, M., Legros, F., Chateau, D. and Lombes, A. (2002). Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. J. Cell Sci. 115, 1663-1674. (Pubitemid 34520596)
113. Romanello, V., Guadagnin, E., Gomes, L., Roder, I., Sandri, C., Petersen, Y., Milan, G., Masiero, E., Del Piccolo, P., Foretz, M. et al. (2010). Mitochondrial fission and remodelling contributes to muscle atrophy. EMBO J. 29, 1774-1785.
114. Rube, D. A. and van der Bliek, A. M. (2004). Mitochondrial morphology is dynamic and varied. Mol. Cell Biochem. 256-257, 331-339.
115. Sandri, M., Lin, J., Handschin, C., Yang, W., Arany, Z. P., Lecker, S. H., Goldberg, A. L. and Spiegelman, B. M. (2006). PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc. Natl. Acad. Sci. USA 103, 16260-16265.
116. Santel, A., Frank, S., Gaume, B., Herrler, M., Youle, R. J. and Fuller, M. T. (2003). Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J. Cell Sci. 116, 2763-2774.
117. Sato, A., Nakada, K. and Hayashi, J. (2006). Mitochondrial dynamics and aging: mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA. Biochim. Biophys. Acta 1763, 473-481.
118. Sato, A., Nakada, K. and Hayashi, J. (2009). Mitochondrial complementation preventing respiratory dysfunction caused by mutant mtDNA. Biofactors 35, 130-137.
119. Scarpulla, R. C. (2008). Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator. Ann. NY Acad. Sci. 1147, 321-334.
120. Schafer, A. and Reichert, A. S. (2009). Emerging roles of mitochondrial membrane dynamics in health and disease. Biol. Chem. 390, 707-715.
121. Scorrano, L., Ashiya, M., Buttle, K., Weiler, S., Oakes, S. A., Mannella, C. A. and Korsmeyer, S. J. (2002). A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev. Cell 2, 55-67.
122. Seo, A. Y., Hofer, T., Sung, B., Judge, S., Chung, H. Y. and Leeuwenburgh, C. (2006). Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise. Antioxid. Redox. Signal. 8, 529-538.
123. Seo, A. Y., Xu, J., Servais, S., Hofer, T., Marzetti, E., Wohlgemuth, S. E., Knutson, M. D., Chung, H. Y. and Leeuwenburgh, C. (2008). Mitochondrial iron accumulation with age and functional consequences. Aging Cell 7, 706-716.
124. Sesaki, H. and Jensen, R. E. (1999). Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J. Cell Biol. 147, 699-706.
125. Skulachev, V. P. (2001). Mitochondrial filaments and clusters as intracellular power-transmitting cables. Trends Biochem. Sci. 26, 23-29.
126. Smirnova, E., Griparic, L., Shurland, D. L. and van der Bliek, A. M. (2001). Dynaminrelated protein Drp1 is required for mitochondrial division in mammalian cells. Mol. Biol. Cell 12, 2245-2256.
127. Soriano, F. X., Liesa, M., Bach, D., Chan, D. C., Palacin, M. and Zorzano, A. (2006). Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2. Diabetes 55, 1783-1791.
128. Squitieri, F., Cannella, M., Sgarbi, G., Maglione, V., Falleni, A., Lenzi, P., Baracca, A., Cislaghi, G., Saft, C., Ragona, G. et al. (2006). Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation. Mech. Ageing Dev. 127, 217-220.
129. Sugiyama, S., Takasawa, M., Hayakawa, M. and Ozawa, T. (1993). Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages. Biochem. Mol. Biol. Int. 30, 937-944.
130. Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M. et al. (1999). Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397, 441-446.
131. Suzuki, M., Jeong, S. Y., Karbowski, M., Youle, R. J. and Tjandra, N. (2003). The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. J. Mol. Biol. 334, 445-458.
132. Takahashi, Y., Karbowski, M., Yamaguchi, H., Kazi, A., Wu, J., Sebti, S. M., Youle, R. J. and Wang, H. G. (2005). Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol. Cell. Biol. 25, 9369-9382.
133. Tandler, B. and Hoppel, C. L. (1986). Studies on giant mitochondria. Ann. NY Acad. Sci. 488, 65-81.
134. Terman, A. (1995). The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. Gerontology 41, 319-326.
135. Terman, A. and Brunk, U. T. (2005). The aging myocardium: roles of mitochondrial damage and lysosomal degradation. Heart Lung Circ. 14, 107-114. (Pubitemid 40895299)
136. Terman, A., Kurz, T., Navratil, M., Arriaga, E. A. and Brunk, U. T. (2010). Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid. Redox Signal. 12, 503-535.
137. Tondera, D., Czauderna, F., Paulick, K., Schwarzer, R., Kaufmann, J. and Santel, A. (2005). The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells. J. Cell Sci. 118, 3049-3059.
138. Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly, Y. M., Gidlof, S., Oldfors, A., Wibom, R. et al. (2004). Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429, 417-423.
139. Twig, G., Elorza, A., Molina, A. J., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G. et al. (2008). Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 27, 433-446.
140. Wallace, D. C. and Fan, W. (2009). The pathophysiology of mitochondrial disease as modeled in the mouse. Genes Dev. 23, 1714-1736.
141. Wang, X., Su, B., Siedlak, S. L., Moreira, P. I., Fujioka, H., Wang, Y., Casadesus, G. and Zhu, X. (2008). Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc. Natl. Acad. Sci. USA 105, 19318-19323.
142. Wasiak, S., Zunino, R. and McBride, H. M. (2007). Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J. Cell Biol. 177, 439-450. (Pubitemid 46718273)
143. Wasilewski, M. and Scorrano, L. (2009). The changing shape of mitochondrial apoptosis. Trends Endocrinol. Metab. 20, 287-294.
144. Westermann, B. (2008). Molecular machinery of mitochondrial fusion and fission. J. Biol. Chem. 283, 13501-13505.
145. Wohlgemuth, S. E., Seo, A. Y., Marzetti, E., Lees, H. A. and Leeuwenburgh, C. (2010). Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise. Exp. Gerontol. 45, 138-148.
146. Wood-Kaczmar, A., Gandhi, S., Yao, Z., Abramov, A. Y., Miljan, E. A., Keen, G., Stanyer, L., Hargreaves, I., Klupsch, K., Deas, E. et al. (2008). PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One 3, e2455.
147. Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C. et al. (1999). Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98, 115-124.
148. Yamaguchi, R. and Perkins, G. (2009). Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1. Biochim. Biophys. Acta 1787, 963-972.
149. Yoon, Y., Krueger, E. W., Oswald, B. J. and McNiven, M. A. (2003). The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol. Cell. Biol. 23, 5409-5420.
150. Yoon, Y. S., Yoon, D. S., Lim, I. K., Yoon, S. H., Chung, H. Y., Rojo, M., Malka, F., Jou, M. J., Martinou, J. C. and Yoon, G. (2006). Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1. J. Cell Physiol. 209, 468-480.
151. Yorimitsu, T. and Klionsky, D. J. (2005). Autophagy: molecular machinery for selfeating. Cell Death Differ. 12, 1542-1552.
152. Zhang, Y. and Chan, D. C. (2007). New insights into mitochondrial fusion. FEBS Lett. 581, 2168-2173.
153. Zhuang, J., Dinsdale, D. and Cohen, G. M. (1998). Apoptosis, in human monocytic THP.1 cells, results in the release of cytochrome c from mitochondria prior to their ultracondensation, formation of outer membrane discontinuities and reduction in inner membrane potential. Cell Death Differ. 5, 953-962. (Pubitemid 28510698)