Microengineered Liver Tissues for Drug Testing

Journal of Laboratory Automation

Volumn 20, Issue 3, 2015, Pages 216-250

  Khetani, Salman R ^a   Berger, Dustin R ^a   Ballinger, Kimberly R ^a   Davidson, Matthew D ^a   Lin, Christine ^a   Ware, Brenton R ^a  

^a Engineering Research Center and Hydraulics Laboratory   (United States)

Author keywords

cocultures; drug development; drug induced liver injury; hepatocytes; microfabrication

Indexed keywords

CELL CULTURE; DIAGNOSIS; DRUG PRODUCTS; MICROFABRICATION; SEMICONDUCTOR DEVICE MANUFACTURE; STEM CELLS; TISSUE;

CO-CULTURES; DRUG DEVELOPMENT; HEPATOCYTES; HUMAN LIVER MODEL; LIVER INJURIES; NEW CHEMICAL ENTITIES; PATIENT POPULATION; SEMICONDUCTOR INDUSTRY;

CELL ENGINEERING;

CYTOCHROME P450;

BIOREACTOR; CELL FATE; CELL LINE; CLINICAL TRIAL (TOPIC); COMPUTER MODEL; DRUG EFFECT; DRUG METABOLISM; DRUG RESEARCH; DRUG SCREENING; EXTRACELLULAR MATRIX; HUMAN; LIVER CELL; LIVER FUNCTION; LIVER PERFUSION; MICROENGINEERED LIVER TISSUE; MICROENVIRONMENT; MICROFLUIDICS; NONHUMAN; PLURIPOTENT STEM CELL; REVIEW; SPHEROID CELL; TISSUE ENGINEERING; TOXIC HEPATITIS; TOXICITY; ANIMAL; CYTOLOGY; DRUG-INDUCED LIVER INJURY; HIGH THROUGHPUT SCREENING; LAB ON A CHIP; LIVER; MINIATURIZATION; PHYSIOLOGY; PRECLINICAL STUDY; PROCEDURES; STEM CELL; SYSTEMS BIOLOGY;

ANIMALS; DRUG EVALUATION, PRECLINICAL; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LAB-ON-A-CHIP DEVICES; LIVER; MINIATURIZATION; STEM CELLS; SYSTEMS BIOLOGY; TISSUE ENGINEERING;

EID: 84928337511     PISSN: 22110682     EISSN: 22110690     Source Type: Journal    
DOI: 10.1177/2211068214566939     Document Type: Review

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