메뉴 건너뛰기




Volumn 106, Issue SUPPL. 2, 1998, Pages 511-532

Liver cell models in in vitro toxicology

Author keywords

Animal hepatocytes; Cytotoxicity; Genotoxicity; Human hepatocytes; In vitro liver models; In vitro toxicology; Mechanism of toxicity; Primary cultures; Screening; Xenobiotic metabolism

Indexed keywords

XENOBIOTIC AGENT;

EID: 0031832805     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106511     Document Type: Conference Paper
Times cited : (351)

References (292)
  • 1
    • 0020609247 scopus 로고
    • The effect of size on the portal circulation of hepatic nodules from carcinogen treated rats
    • Conway JP, Popp JA, Thurman RG. The effect of size on the portal circulation of hepatic nodules from carcinogen treated rats. Cancer Res 43:3374-3379 (1983).
    • (1983) Cancer Res , vol.43 , pp. 3374-3379
    • Conway, J.P.1    Popp, J.A.2    Thurman, R.G.3
  • 2
    • 0006869089 scopus 로고
    • Mécanismes des atteintes hépatiques d'origine chimique
    • Ballet F, Thurman RG, eds. Paris:Les Editions INSERM and John Libbey, Eurotext
    • Plaa GL. Mécanismes des atteintes hépatiques d'origine chimique. In: Foie isolé perfusé (Ballet F, Thurman RG, eds). Paris:Les Editions INSERM and John Libbey, Eurotext, 1993;411-426.
    • (1993) Foie Isolé Perfusé , pp. 411-426
    • Plaa, G.L.1
  • 3
    • 0021352008 scopus 로고
    • Rates of allyl alcohol metabolism in periportal andpericentral regions of the liver lobule
    • Belinsky SA, Kauffman FC, Ji S, Lemasters JJ, Thurman RG. Rates of allyl alcohol metabolism in periportal andpericentral regions of the liver lobule. Mol Pharmacol 25:158-164 (1984).
    • (1984) Mol Pharmacol , vol.25 , pp. 158-164
    • Belinsky, S.A.1    Kauffman, F.C.2    Ji, S.3    Lemasters, J.J.4    Thurman, R.G.5
  • 6
    • 0027960498 scopus 로고
    • Use of human organ slices to evaluate the biotransformation anddrug-induced side-effects of pharmaceuticals
    • Vickers AEM. Use of human organ slices to evaluate the biotransformation anddrug-induced side-effects of pharmaceuticals. Cell Biol Toxicol 10:407-414 (1994).
    • (1994) Cell Biol Toxicol , vol.10 , pp. 407-414
    • Vickers, A.E.M.1
  • 7
    • 0027478959 scopus 로고
    • Culture of precision-cut liver slices: Effect of some peroxisome proliferators
    • Beamand JA, Price RJ, Cunninghame ME, Lake BG. Culture of precision-cut liver slices: effect of some peroxisome proliferators. Food Chem Toxicol 31:137-147 (1993).
    • (1993) Food Chem Toxicol , vol.31 , pp. 137-147
    • Beamand, J.A.1    Price, R.J.2    Cunninghame, M.E.3    Lake, B.G.4
  • 8
    • 0014178252 scopus 로고
    • The enzymatic preparation of isolated intact parenchymal cells from rat liver
    • Howard RB, Christensen AK, Gibbs AF, Pesch LA. The enzymatic preparation of isolated intact parenchymal cells from rat liver. J Cell Biol 35:675-684 (1967).
    • (1967) J Cell Biol , vol.35 , pp. 675-684
    • Howard, R.B.1    Christensen, A.K.2    Gibbs, A.F.3    Pesch, L.A.4
  • 9
    • 0014645531 scopus 로고
    • High-yield preparation of isolated rat liver parenchymal cells. A biochemical andfine structural study
    • Berry MN, Friend DS. High-yield preparation of isolated rat liver parenchymal cells. A biochemical andfine structural study. J Cell Biol 43:506-520 (1969).
    • (1969) J Cell Biol , vol.43 , pp. 506-520
    • Berry, M.N.1    Friend, D.S.2
  • 10
    • 0017101039 scopus 로고
    • Preparation of isolated rat liver cells
    • Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 13:29-83 (1975).
    • (1975) Methods Cell Biol , vol.13 , pp. 29-83
    • Seglen, P.O.1
  • 12
    • 2642589831 scopus 로고
    • Digitonin perfusion of rat liver. A new approach in the study of intracellular compartmentation in the liver
    • Quistorff B, Grunner N, Cornell NW. Digitonin perfusion of rat liver. A new approach in the study of intracellular compartmentation in the liver. Biochem J 226:2189-297 (1985).
    • (1985) Biochem J , vol.226 , pp. 2189-2297
    • Quistorff, B.1    Grunner, N.2    Cornell, N.W.3
  • 13
    • 0021801314 scopus 로고
    • Digitonin-collagenase perfusion for efficient separation of periportal andperivenous hepatocytes
    • Lindros KO, Penttilä KE. Digitonin-collagenase perfusion for efficient separation of periportal andperivenous hepatocytes. Biochem J 228:560-575 (1985).
    • (1985) Biochem J , vol.228 , pp. 560-575
    • Lindros, K.O.1    Penttilä, K.E.2
  • 14
    • 0020507588 scopus 로고
    • Albumin secretion andprotein synthesis by cultured diploid andtetraploid rat hepatocytes separated by elutriation
    • Le Rumeur E, Guguen-Guillouzo C, Beaumont C, Saunier A, Guillouzo A. Albumin secretion andprotein synthesis by cultured diploid andtetraploid rat hepatocytes separated by elutriation. Exp Cell Res 147:247-254 (1983).
    • (1983) Exp Cell Res , vol.147 , pp. 247-254
    • Le Rumeur, E.1    Guguen-Guillouzo, C.2    Beaumont, C.3    Saunier, A.4    Guillouzo, A.5
  • 15
    • 0023266056 scopus 로고
    • Isolated rat hepatocyte couplets in short term culture, structural characteristics andplasma membrane reorganization
    • Gautam A, Ng OC, Boyer JL. Isolated rat hepatocyte couplets in short term culture, structural characteristics andplasma membrane reorganization. Hepatology 7:216-223 (1987).
    • (1987) Hepatology , vol.7 , pp. 216-223
    • Gautam, A.1    Ng, O.C.2    Boyer, J.L.3
  • 17
    • 0022365063 scopus 로고
    • Isolation of rat hepatocytes with EDTA andtheir metabolic functions in primary culture
    • Wang SR, Renaud G, Infante J, Catala D, Infante R. Isolation of rat hepatocytes with EDTA andtheir metabolic functions in primary culture, In Vitro Cell Dev Biol 21:526-530 (1985).
    • (1985) In Vitro Cell Dev Biol , vol.21 , pp. 526-530
    • Wang, S.R.1    Renaud, G.2    Infante, J.3    Catala, D.4    Infante, R.5
  • 19
    • 0024241875 scopus 로고
    • Rat hepatocytes prepared without collagenase: Prolonged retention or differentiated characteristics in culture
    • Meredith MJ. Rat hepatocytes prepared without collagenase: prolonged retention or differentiated characteristics in culture. Cell Biol Toxicol 4:405-425 (1988).
    • (1988) Cell Biol Toxicol , vol.4 , pp. 405-425
    • Meredith, M.J.1
  • 20
    • 0026516652 scopus 로고
    • Evidence that the loss of rat liver cytochrome P-450 in vitro is not solely associated with the use of collagenase, the loss of cell-cell contacts and/or the absence of an extracellular matrix
    • Wright MC, Paine AJ. Evidence that the loss of rat liver cytochrome P-450 in vitro is not solely associated with the use of collagenase, the loss of cell-cell contacts and/or the absence of an extracellular matrix. Biochem Pharmacol 43:2337-2343 (1992).
    • (1992) Biochem Pharmacol , vol.43 , pp. 2337-2343
    • Wright, M.C.1    Paine, A.J.2
  • 21
    • 0003054992 scopus 로고
    • Methods for preparation of adult andfetal hepatocytes
    • Guillouzo A, Guguen-Guillouzo C, eds. Paris:Les Editions INSERM and John Libbey Eurotext
    • Guguen-Guillouzo C, Guillouzo A. Methods for preparation of adult andfetal hepatocytes. In:Isolated and Cultured Hepacocytes (Guillouzo A, Guguen-Guillouzo C, eds). Paris:Les Editions INSERM and John Libbey Eurotext, 1986;1-12.
    • (1986) Isolated and Cultured Hepacocytes , pp. 1-12
    • Guguen-Guillouzo, C.1    Guillouzo, A.2
  • 23
    • 0006807074 scopus 로고
    • Isolation andculture of hepatocytes from different laboratory species
    • Tyson CA, Frazier JM, eds. San Diego, CA:Academic Press
    • McQueen CA. Isolation andculture of hepatocytes from different laboratory species. In:In Vitro Biological Systems. Methods in Toxicology. Vol I (Tyson CA, Frazier JM, eds). San Diego, CA:Academic Press, 1993;255-270.
    • (1993) In Vitro Biological Systems. Methods in Toxicology , vol.1 , pp. 255-270
    • McQueen, C.A.1
  • 24
    • 0023737890 scopus 로고
    • Characterization of midazolam metabolism using human hepatic microsomal fractions andhepatocytes in suspension ootained by perfusing whole human livers
    • Fabre G, Rahmani R, Placidi M, Combalbert J, Covo J, Cano JP, Coulange C, Ducros M, Rampal M. Characterization of midazolam metabolism using human hepatic microsomal fractions andhepatocytes in suspension ootained by perfusing whole human livers. Biochem Pharmacol 37:4389-4397 (1988).
    • (1988) Biochem Pharmacol , vol.37 , pp. 4389-4397
    • Fabre, G.1    Rahmani, R.2    Placidi, M.3    Combalbert, J.4    Covo, J.5    Cano, J.P.6    Coulange, C.7    Ducros, M.8    Rampal, M.9
  • 26
    • 0024217256 scopus 로고
    • Transient expression of c-fos andconstant expression of c-myc in freshly isolated andcultured normal adult rat hepatocytes
    • Etienne PL, Baffet G, Desvergne B, Boisnard-Rissel M, Glaise D, Guguen-Guillouzo C. Transient expression of c-fos andconstant expression of c-myc in freshly isolated andcultured normal adult rat hepatocytes. Oncogene Res 3:255-262 (1988).
    • (1988) Oncogene Res , vol.3 , pp. 255-262
    • Etienne, P.L.1    Baffet, G.2    Desvergne, B.3    Boisnard-Rissel, M.4    Glaise, D.5    Guguen-Guillouzo, C.6
  • 27
    • 0027389277 scopus 로고
    • Altered expression of cytochrome P-450 mRNAs, and potentially of other transcripts encoding key hepatic functions, are triggered during the isolation of rat hepatocytes
    • Padgham CRW, Paine AJ. Altered expression of cytochrome P-450 mRNAs, and potentially of other transcripts encoding key hepatic functions, are triggered during the isolation of rat hepatocytes. Biochem J 289:621-624 (1993).
    • (1993) Biochem J , vol.289 , pp. 621-624
    • Padgham, C.R.W.1    Paine, A.J.2
  • 31
    • 0025026967 scopus 로고
    • Comparison of cultured human hepatocytes isolated from surgical biopsies or cold-stored organ donor livers
    • Vons C, Pegorier JP, Ivanov MA, Girard J, Melcion C, Cordier A, Franco D. Comparison of cultured human hepatocytes isolated from surgical biopsies or cold-stored organ donor livers. Toxicol In Vitro 4:432-434 (1990).
    • (1990) Toxicol in Vitro , vol.4 , pp. 432-434
    • Vons, C.1    Pegorier, J.P.2    Ivanov, M.A.3    Girard, J.4    Melcion, C.5    Cordier, A.6    Franco, D.7
  • 32
    • 0017367458 scopus 로고
    • Protein-catabolic state of isolated rat hepatocytes
    • Seglen PO. Protein-catabolic state of isolated rat hepatocytes. Biochim Biophys Acta 496:182-191 (1977).
    • (1977) Biochim Biophys Acta , vol.496 , pp. 182-191
    • Seglen, P.O.1
  • 33
    • 0027424602 scopus 로고
    • Correction of bilirubin conjugation in the Gunn rat using hepatocytes immobilized in alginate gel beads as an extracorporeal bioartificial liver
    • Frémond B, Malandain C, Guyomard C, Chesné C, Guillouzo A, Campion JP. Correction of bilirubin conjugation in the Gunn rat using hepatocytes immobilized in alginate gel beads as an extracorporeal bioartificial liver. Cell Transplant 2:453-460 (1993).
    • (1993) Cell Transplant , vol.2 , pp. 453-460
    • Frémond, B.1    Malandain, C.2    Guyomard, C.3    Chesné, C.4    Guillouzo, A.5    Campion, J.P.6
  • 34
    • 0025744686 scopus 로고
    • Functional andmorphological features of isolated hepatocytes preserved in University of Wisconsin solution
    • Sorrentino D, Van Ness K, Ribeiro J, Miller CM. Functional andmorphological features of isolated hepatocytes preserved in University of Wisconsin solution. Hepatology 14:331-339 (1991).
    • (1991) Hepatology , vol.14 , pp. 331-339
    • Sorrentino, D.1    Van Ness, K.2    Ribeiro, J.3    Miller, C.M.4
  • 35
    • 0026517058 scopus 로고
    • Drug transport, viability andmorphology of isolated rat hepatocytes preserved for 24 hours in University of Wisconsin solution
    • Sandker GW, Slooff MJH, Groothuis GMM. Drug transport, viability andmorphology of isolated rat hepatocytes preserved for 24 hours in University of Wisconsin solution. Biochem Pharmacol 43:1479-1485 (1992).
    • (1992) Biochem Pharmacol , vol.43 , pp. 1479-1485
    • Sandker, G.W.1    Slooff, M.J.H.2    Groothuis, G.M.M.3
  • 36
    • 0026515627 scopus 로고
    • Viability andprimary culture of rat hepatocytes after hypothermic preservation: The superiority of the Leibovitz medium over the UW solution for cold storage
    • Poullain MG, Fautrel A, Guyomard C, Chesné C, Grislain L, Guillouzo A. Viability andprimary culture of rat hepatocytes after hypothermic preservation: the superiority of the Leibovitz medium over the UW solution for cold storage. Hepatology 15:97-106 (1992).
    • (1992) Hepatology , vol.15 , pp. 97-106
    • Poullain, M.G.1    Fautrel, A.2    Guyomard, C.3    Chesné, C.4    Grislain, L.5    Guillouzo, A.6
  • 37
    • 0023787984 scopus 로고
    • Cryopreservation of isolated rat hepatocytes: A critical evaluation or freezing and thawing conditions
    • Chesń C, Guillouzo A. Cryopreservation of isolated rat hepatocytes: a critical evaluation or freezing and thawing conditions. Cryobiology 25:323-330 (1988).
    • (1988) Cryobiology , vol.25 , pp. 323-330
    • Chesń, C.1    Guillouzo, A.2
  • 38
    • 0024551516 scopus 로고
    • Optimization of cryopreservation procedures for rat andhuman hepatocytes
    • Loretz LJ, Li AP, Flye MW, Wilson AGE. Optimization of cryopreservation procedures for rat andhuman hepatocytes. Xenobiotica 19:489-498 (1989).
    • (1989) Xenobiotica , vol.19 , pp. 489-498
    • Loretz, L.J.1    Li, A.P.2    Flye, M.W.3    Wilson, A.G.E.4
  • 39
    • 0025969415 scopus 로고
    • Development of an optimal method for the Cryopreservation of hepatocytes andtheir subsequent monolayer culture
    • Lawrence JN, Benford DJ. Development of an optimal method for the Cryopreservation of hepatocytes andtheir subsequent monolayer culture. Toxicol In Vitro 5:39-51 (1991).
    • (1991) Toxicol in Vitro , vol.5 , pp. 39-51
    • Lawrence, J.N.1    Benford, D.J.2
  • 40
    • 0027218230 scopus 로고
    • Viability andfunction in primary culture of adult hepatocytes from various animal species andhuman beings after cryopreservacion
    • Chesné C, Guyomard C, Fautrel A, Poullain MG, Fŕmond B, De Jong H, Guillouzo A. Viability andfunction in primary culture of adult hepatocytes from various animal species andhuman beings after cryopreservacion. Hepatology 18:406-414 (1993).
    • (1993) Hepatology , vol.18 , pp. 406-414
    • Chesné, C.1    Guyomard, C.2    Fautrel, A.3    Poullain, M.G.4    Fŕmond, B.5    De Jong, H.6    Guillouzo, A.7
  • 42
    • 0026654736 scopus 로고
    • Characterization of cryopreserved rat liver parenchymal cells by metabolism of diagnostic substrates andactivities of related enzymes
    • Utesch D, Diener B, Molitor E, Oesch F, Platt KL. Characterization of cryopreserved rat liver parenchymal cells by metabolism of diagnostic substrates andactivities of related enzymes. Biochem Pharmacol 44:309-315 (1992).
    • (1992) Biochem Pharmacol , vol.44 , pp. 309-315
    • Utesch, D.1    Diener, B.2    Molitor, E.3    Oesch, F.4    Platt, K.L.5
  • 44
    • 0023603597 scopus 로고
    • Cryopreservation of rat anddog hepatocytes for studies of xenobiotic metabolism andactivation
    • Powis G, Santone KS, Melder DC, Thomas L, Moore DJ. Wilke TJ. Cryopreservation of rat anddog hepatocytes for studies of xenobiotic metabolism andactivation. Drug Metab Disp 15:826-832 (1987).
    • (1987) Drug Metab Disp , vol.15 , pp. 826-832
    • Powis, G.1    Santone, K.S.2    Melder, D.C.3    Thomas, L.4    Moore, D.J.5    Wilke, T.J.6
  • 45
    • 0030685776 scopus 로고    scopus 로고
    • Long-term maintenance of drug metabolizing enzyme activities in rat hepatocytes after Cryopreservation
    • Fautrel A, Joly B, Guyomard C, Guillouzo A. Long-term maintenance of drug metabolizing enzyme activities in rat hepatocytes after Cryopreservation. Toxicol Appl Pharmacol 147:110-114 (1997).
    • (1997) Toxicol Appl Pharmacol , vol.147 , pp. 110-114
    • Fautrel, A.1    Joly, B.2    Guyomard, C.3    Guillouzo, A.4
  • 46
    • 0030460927 scopus 로고    scopus 로고
    • Influence of alginate gel entrapment andcryopreservation on survival andxenobiotic metabolism capacity of rat hepatocytes
    • Guyomard C, Rialland L, Frémond B, Chesné C, Guillouzo A. Influence of alginate gel entrapment andcryopreservation on survival andxenobiotic metabolism capacity of rat hepatocytes. Toxicol Appl Pharmacol 141:349-356 (1996).
    • (1996) Toxicol Appl Pharmacol , vol.141 , pp. 349-356
    • Guyomard, C.1    Rialland, L.2    Frémond, B.3    Chesné, C.4    Guillouzo, A.5
  • 47
    • 0018519489 scopus 로고
    • Drug metabolism andeffects of carcinogens in cultured hepatic cells
    • Sirica AE, Pitot HC. Drug metabolism andeffects of carcinogens in cultured hepatic cells. Pharmacol Rev 31:205-228 (1980).
    • (1980) Pharmacol Rev , vol.31 , pp. 205-228
    • Sirica, A.E.1    Pitot, H.C.2
  • 48
    • 0020688509 scopus 로고
    • Modulation of functional activities in cultured rat hepatocytes
    • Guguen-Guillouzo C, Guillouzo A. Modulation of functional activities in cultured rat hepatocytes. Mol Cell Biochem 53/54:35-56 (1983).
    • (1983) Mol Cell Biochem , vol.53-54 , pp. 35-56
    • Guguen-Guillouzo, C.1    Guillouzo, A.2
  • 49
    • 0017686599 scopus 로고
    • Drug metabolism in adult rat hepatocytes in primary monolayer culture
    • Guzelian PS, Bissell DM, Meyer UA. Drug metabolism in adult rat hepatocytes in primary monolayer culture. Gastroenteroloey 72:1232-1239 (1977).
    • (1977) Gastroenteroloey , vol.72 , pp. 1232-1239
    • Guzelian, P.S.1    Bissell, D.M.2    Meyer, U.A.3
  • 51
    • 0020336393 scopus 로고
    • Primary cultures andthe levels of cytochrome P-450 in hepatocytes from mouse, rat, hamster andrabbit liver
    • Maslansky CJ, Williams GM. Primary cultures andthe levels of cytochrome P-450 in hepatocytes from mouse, rat, hamster andrabbit liver. In Vitro 18:663-693 (1982).
    • (1982) In Vitro , vol.18 , pp. 663-693
    • Maslansky, C.J.1    Williams, G.M.2
  • 52
    • 0021126053 scopus 로고
    • Prolonged maintenance of active cytochrome P-450 in adult rat heparocyres co-cultured with another liver cell type
    • Bégué JM, Guguen-Guillouzo C, Pasdeloup N, Guillouzo A. Prolonged maintenance of active cytochrome P-450 in adult rat heparocyres co-cultured with another liver cell type. Heparology 4:839-842 (1984).
    • (1984) Heparology , vol.4 , pp. 839-842
    • Bégué, J.M.1    Guguen-Guillouzo, C.2    Pasdeloup, N.3    Guillouzo, A.4
  • 53
    • 0022000618 scopus 로고
    • Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes
    • Steward AR, Dannan GA, Guzelian PS, Guengerich FP. Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes. Mol Pharmacol 27:125-132 (1985).
    • (1985) Mol Pharmacol , vol.27 , pp. 125-132
    • Steward, A.R.1    Dannan, G.A.2    Guzelian, P.S.3    Guengerich, F.P.4
  • 55
    • 0027460346 scopus 로고
    • Expression of multiple forms of cytochrome P-450s in primary cultures of rat hepatocytes maintained on matrigel
    • Kocarek TA, Schuetz EG, Guzelian PS. Expression of multiple forms of cytochrome P-450s in primary cultures of rat hepatocytes maintained on matrigel. Mol Pharmacol 43:328-334 (1993).
    • (1993) Mol Pharmacol , vol.43 , pp. 328-334
    • Kocarek, T.A.1    Schuetz, E.G.2    Guzelian, P.S.3
  • 56
    • 0023571719 scopus 로고
    • Expression of five forms of microsomal cytochrome P-450 in primary cultures of rabbit hepatocytes treated with various classes of inducers
    • Daujat M, Pichard L, Dalet C, Larroque C, Bonfils C, Pompon D, Li D, Guzelian PS, Maurel P. Expression of five forms of microsomal cytochrome P-450 in primary cultures of rabbit hepatocytes treated with various classes of inducers. Biochem Pharmacol 36:3597-3606 (1987).
    • (1987) Biochem Pharmacol , vol.36 , pp. 3597-3606
    • Daujat, M.1    Pichard, L.2    Dalet, C.3    Larroque, C.4    Bonfils, C.5    Pompon, D.6    Li, D.7    Guzelian, P.S.8    Maurel, P.9
  • 57
    • 0024789951 scopus 로고
    • Changes in the quantity andactivity of cytochrome P-450 isozymes in primary cultured rat hepatocytes
    • Namiki M, Degawa M, Masuki T, Hashimoto Y. Changes in the quantity andactivity of cytochrome P-450 isozymes in primary cultured rat hepatocytes. Jpn J Cancer Res 80:126-131 (1989).
    • (1989) Jpn J Cancer Res , vol.80 , pp. 126-131
    • Namiki, M.1    Degawa, M.2    Masuki, T.3    Hashimoto, Y.4
  • 58
    • 0025870495 scopus 로고
    • Effects of ethanol andclofibrate on expression of cytochrome P-450 enzymes andepoxide hydrolase in cultures andcocultures of rat hepatocytes
    • Perrot N, Chesné C, de Waziers I, Conner J, Beaune P, Guillouzo A. Effects of ethanol andclofibrate on expression of cytochrome P-450 enzymes andepoxide hydrolase in cultures andcocultures of rat hepatocytes. Eur J Biochem 200:255-262 (1991).
    • (1991) Eur J Biochem , vol.200 , pp. 255-262
    • Perrot, N.1    Chesné, C.2    De Waziers, I.3    Conner, J.4    Beaune, P.5    Guillouzo, A.6
  • 59
    • 0019979215 scopus 로고
    • Stimulation of de novo synthesis of cytochrome P-450 by phenobarbital in primary nonproliferating cultures of adult rat hepatocytes
    • Newman S, Guzelian PS. Stimulation of de novo synthesis of cytochrome P-450 by phenobarbital in primary nonproliferating cultures of adult rat hepatocytes. Proc Natl Acad Sci USA 79:2922-2926 (1982).
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 2922-2926
    • Newman, S.1    Guzelian, P.S.2
  • 60
    • 0019407028 scopus 로고
    • Induction of cytochrome P-450 by pregnenolone-16α-carbonitrile in primary monolayer cultures of adult rat hepatocytes andin a cellfree translation system
    • Elshourbagy NA, Barwick JL, Guzelian PS. Induction of cytochrome P-450 by pregnenolone-16α-carbonitrile in primary monolayer cultures of adult rat hepatocytes andin a cellfree translation system. J Biol Chem 256:6060-6068 (1981).
    • (1981) J Biol Chem , vol.256 , pp. 6060-6068
    • Elshourbagy, N.A.1    Barwick, J.L.2    Guzelian, P.S.3
  • 61
    • 0020546517 scopus 로고
    • Induction of lauric acid hydroxylation andmaintenance of cytochrome P-450 content by clofibrate in primary cultures of rat hepatocytes
    • Lake BG, Gray TJB, Stubberfield CR, Beamand JA, Gangolli SD. Induction of lauric acid hydroxylation andmaintenance of cytochrome P-450 content by clofibrate in primary cultures of rat hepatocytes. Life Sci 33:249-254 (1983).
    • (1983) Life Sci , vol.33 , pp. 249-254
    • Lake, B.G.1    Gray, T.J.B.2    Stubberfield, C.R.3    Beamand, J.A.4    Gangolli, S.D.5
  • 62
    • 0023024338 scopus 로고
    • Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo andin primary monolayer culture
    • Watkins PB, Wrighton SA, Schuetz EG, Maurel P, Guzelian PS. Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo andin primary monolayer culture. J Biol Chem 261:6264-2671 (1986).
    • (1986) J Biol Chem , vol.261 , pp. 6264-12671
    • Watkins, P.B.1    Wrighton, S.A.2    Schuetz, E.G.3    Maurel, P.4    Guzelian, P.S.5
  • 63
    • 0022550848 scopus 로고
    • Induction of monooxygenase andUDP-glucuronyltransferase activities in primary cultures of rat hepatocytes
    • Forster U, Luippold G, Schwartz LR. Induction of monooxygenase andUDP-glucuronyltransferase activities in primary cultures of rat hepatocytes. Drug Metab Dispos 4:353-360 (1986).
    • (1986) Drug Metab Dispos , vol.4 , pp. 353-360
    • Forster, U.1    Luippold, G.2    Schwartz, L.R.3
  • 66
    • 85045533706 scopus 로고    scopus 로고
    • A comparison of the effect of inducers on the expression of glutathione S-transferases in the liver of the intact rat andin hepatocytes in primary culture
    • Langouët S, Morel F, Meyer DJ, Fardel O, Corcos L, Ketterer B, Guillouzo A. A comparison of the effect of inducers on the expression of glutathione S-transferases in the liver of the intact rat andin hepatocytes in primary culture. Hepatology 43:881-887 (1996).
    • (1996) Hepatology , vol.43 , pp. 881-887
    • Langouët, S.1    Morel, F.2    Meyer, D.J.3    Fardel, O.4    Corcos, L.5    Ketterer, B.6    Guillouzo, A.7
  • 67
    • 0030598389 scopus 로고    scopus 로고
    • Sulfotransferase gene expression in primary cultures of rat hepatocytes
    • Liu L, LeCluyse EL, Liu J, Klaassen CD. Sulfotransferase gene expression in primary cultures of rat hepatocytes. Biocnem Pharmacol 52:1621-1630 (1996).
    • (1996) Biocnem Pharmacol , vol.52 , pp. 1621-1630
    • Liu, L.1    LeCluyse, E.L.2    Liu, J.3    Klaassen, C.D.4
  • 68
    • 0020822437 scopus 로고
    • Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes
    • Clayton DF, Darnell JE. Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes. Mol Cell Biol 3:1552-1561 (1983).
    • (1983) Mol Cell Biol , vol.3 , pp. 1552-1561
    • Clayton, D.F.1    Darnell, J.E.2
  • 69
    • 0022133333 scopus 로고
    • Dependence of hepatocyte specific gene expression on cell-cell interactions in primary culture
    • Fraslin JM, Kneip B, Vaulont S, Glaise D, Munnich A, Guguen-Guillouzo C. Dependence of hepatocyte specific gene expression on cell-cell interactions in primary culture. EMBO J 4:2487-2491 (1985).
    • (1985) EMBO J , vol.4 , pp. 2487-2491
    • Fraslin, J.M.1    Kneip, B.2    Vaulont, S.3    Glaise, D.4    Munnich, A.5    Guguen-Guillouzo, C.6
  • 70
    • 0026503191 scopus 로고
    • Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture
    • Fardel O, Ratanasavanh D, Loyer P, Ketterer B, Guillouzo A. Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture. Eur J Biochem 205:847-852 (1992).
    • (1992) Eur J Biochem , vol.205 , pp. 847-852
    • Fardel, O.1    Ratanasavanh, D.2    Loyer, P.3    Ketterer, B.4    Guillouzo, A.5
  • 71
    • 0021246273 scopus 로고
    • Long-term co-cultures of adult human hepatocytes with rat liver epithelial cells: Modulation of active albumin secretion and accumulation of extracellular material
    • Clément B, Guguen-Guillouzo C, Campion JP, Glaise D, Bourel M, Guillouzo A. Long-term co-cultures of adult human hepatocytes with rat liver epithelial cells: modulation of active albumin secretion and accumulation of extracellular material. Hepatology 4:373-38 (1984).
    • (1984) Hepatology , vol.4 , pp. 373-438
    • Clément, B.1    Guguen-Guillouzo, C.2    Campion, J.P.3    Glaise, D.4    Bourel, M.5    Guillouzo, A.6
  • 74
    • 0025134337 scopus 로고
    • Cyclosporin A drug interactions. Screening for inducers andinhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes andin liver microsomes
    • Pichard L, Fabre I, Fabre G, Domergue J, Saint Aubert B, Mourad G, Maurel P. Cyclosporin A drug interactions. Screening for inducers andinhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes andin liver microsomes. Drug Metab Dispos 18:595-606 (1990).
    • (1990) Drug Metab Dispos , vol.18 , pp. 595-606
    • Pichard, L.1    Fabre, I.2    Fabre, G.3    Domergue, J.4    Saint Aubert, B.5    Mourad, G.6    Maurel, P.7
  • 76
    • 0027074986 scopus 로고
    • Anti-liver microsomes autoantibodies anddihydralazine-induced hepatitis: Specificity of autoantibodies and inductive capacity of the drug
    • Bourdi M, Gautier JC, Mircheva J, Larrey D, Guillouzo A, Andre C, Belloc C, Beaune P. Anti-liver microsomes autoantibodies anddihydralazine-induced hepatitis: specificity of autoantibodies and inductive capacity of the drug. Mol Pharmacol 42:280-285 (1992).
    • (1992) Mol Pharmacol , vol.42 , pp. 280-285
    • Bourdi, M.1    Gautier, J.C.2    Mircheva, J.3    Larrey, D.4    Guillouzo, A.5    Andre, C.6    Belloc, C.7    Beaune, P.8
  • 77
    • 0000996823 scopus 로고
    • Inducibility andexpression of class IA andIIIA cytochromes P-450 in primary cultures of adult human hepatocytes
    • Daujat M, Fabre I, Diaz D, Pichard L, Fabre G, Fabre JM, Saint-Aubert B, Maurel P. Inducibility andexpression of class IA andIIIA cytochromes P-450 in primary cultures of adult human hepatocytes. Life Sci Adv 9:315-326 (1991).
    • (1991) Life Sci Adv , vol.9 , pp. 315-326
    • Daujat, M.1    Fabre, I.2    Diaz, D.3    Pichard, L.4    Fabre, G.5    Fabre, J.M.6    Saint-Aubert, B.7    Maurel, P.8
  • 78
    • 0023197883 scopus 로고
    • Human adult hepatocytes in primary monolayer cultures. Maintenance of mixed function oxidase andconjugation pathways of drug metabolism
    • Grant MH, Burke MD, Hawksworth GM, Duthie SJ, Engeset J, Petrie JC. Human adult hepatocytes in primary monolayer cultures. Maintenance of mixed function oxidase andconjugation pathways of drug metabolism. Biochem Pharmacol 36:2311-2316 (1987).
    • (1987) Biochem Pharmacol , vol.36 , pp. 2311-2316
    • Grant, M.H.1    Burke, M.D.2    Hawksworth, G.M.3    Duthie, S.J.4    Engeset, J.5    Petrie, J.C.6
  • 80
    • 0027497708 scopus 로고
    • Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene anddithiolethiones
    • Morel F, Fardel O, Meyer DJ, Langouët S, Gilmore KS, Meunier B, Tu CPD, Kensler TW, Ketterer B, Guillouzo A. Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene anddithiolethiones. Cancer Res 53:230-234 (1993).
    • (1993) Cancer Res , vol.53 , pp. 230-234
    • Morel, F.1    Fardel, O.2    Meyer, D.J.3    Langouët, S.4    Gilmore, K.S.5    Meunier, B.6    Tu, C.P.D.7    Kensler, T.W.8    Ketterer, B.9    Guillouzo, A.10
  • 81
    • 0027300475 scopus 로고
    • P-Glycoprotein expression in human, mouse, hamster andrat hepatocytes in primary culture
    • Fardel O, Morel F, Guillouzo A. p-Glycoprotein expression in human, mouse, hamster andrat hepatocytes in primary culture. Carcinogenesis 14:781-783 (1993).
    • (1993) Carcinogenesis , vol.14 , pp. 781-783
    • Fardel, O.1    Morel, F.2    Guillouzo, A.3
  • 83
    • 0002323123 scopus 로고
    • Role of homotypic andhererotypic cell interactions in expression of specific functions by cultured hepatocytes
    • Guillouzo A, Guguen-Guillouzo C, eds. Paris:Les Editions INSERM and John Libbey Eurotext
    • Guguen-Guillouzo C. Role of homotypic andhererotypic cell interactions in expression of specific functions by cultured hepatocytes. In:Isolated and Cultured Hepatocytes (Guillouzo A, Guguen-Guillouzo C, eds). Paris:Les Editions INSERM and John Libbey Eurotext, 1986;271-296.
    • (1986) Isolated and Cultured Hepatocytes , pp. 271-296
    • Guguen-Guillouzo, C.1
  • 84
    • 84909879065 scopus 로고
    • Hormonal control of amino acid transport systems in cultured periportal andperivenous hepatocytes
    • Petzinger E, Kinne RKH, Sies H, eds. Berlim:Springer-Verlag
    • Gebhardt R. Hormonal control of amino acid transport systems in cultured periportal andperivenous hepatocytes. In:Hepatic Transport in Organic Substances (Petzinger E, Kinne RKH, Sies H, eds). Berlim:Springer-Verlag, 1989;177-187.
    • (1989) Hepatic Transport in Organic Substances , pp. 177-187
    • Gebhardt, R.1
  • 85
    • 0026691558 scopus 로고
    • Evidence for cytochrome P-450 2E1-mediated toxicity of N-nitrosodimethylamine in cultured perivenous hepatocytes from ethanol treated rats
    • Anundi J, Lindros KO. Evidence for cytochrome P-450 2E1-mediated toxicity of N-nitrosodimethylamine in cultured perivenous hepatocytes from ethanol treated rats. Pharmacol Toxicol 70:453-458 (1992).
    • (1992) Pharmacol Toxicol , vol.70 , pp. 453-458
    • Anundi, J.1    Lindros, K.O.2
  • 87
    • 0001362997 scopus 로고
    • Isolation andculture of animal andhuman hepatocytes
    • Freshney RI, ed. Glasgow:Alan R. Liss
    • Guguen-Guillouzo C. Isolation andculture of animal andhuman hepatocytes. In:Culture of Epithelial Cells. Vol 1 (Freshney RI, ed). Glasgow:Alan R. Liss, 1991;197-223.
    • (1991) Culture of Epithelial Cells , vol.1 , pp. 197-223
    • Guguen-Guillouzo, C.1
  • 88
    • 0016525968 scopus 로고
    • Etude ultrastructurale de monocouches d'hépatocytes de rat adulte cultivés en présence d'hémisuccinate d'hydrocortisone
    • Guguen-Guillouzo C, Guillouzo A, Boisnard M, Le Cam A, Bourel M. Etude ultrastructurale de monocouches d'hépatocytes de rat adulte cultivés en présence d'hémisuccinate d'hydrocortisone. Biol Gastroenterol 8:223-231 (1975).
    • (1975) Biol Gastroenterol , vol.8 , pp. 223-231
    • Guguen-Guillouzo, C.1    Guillouzo, A.2    Boisnard, M.3    Le Cam, A.4    Bourel, M.5
  • 89
    • 0017166204 scopus 로고
    • Conditions affecting primary cell cultures of functional adult rat hepatocytes. I: The effect of insulin
    • Laishes BA, Williams GM. Conditions affecting primary cell cultures of functional adult rat hepatocytes. I: The effect of insulin. In Vitro 12:521-532 (1967).
    • (1967) In Vitro , vol.12 , pp. 521-532
    • Laishes, B.A.1    Williams, G.M.2
  • 90
    • 0025249973 scopus 로고
    • The maintenance of cytochrome P-450 in rat hepatocyte culture: Some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system
    • Paine AJ. The maintenance of cytochrome P-450 in rat hepatocyte culture: some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system. Chem Biol Interact 74:1-31 (1990).
    • (1990) Chem Biol Interact , vol.74 , pp. 1-31
    • Paine, A.J.1
  • 91
    • 0024566545 scopus 로고
    • Nicotinamide prolongs survival of primary cultured hepatocytes without involving loss of hepatocyte-specific functions
    • Inoue C, Yamamoto H, Nakamura T, Ichihara A, Okamoto H. Nicotinamide prolongs survival of primary cultured hepatocytes without involving loss of hepatocyte-specific functions. J Biol Chem 264:4747-4750 (1989).
    • (1989) J Biol Chem , vol.264 , pp. 4747-4750
    • Inoue, C.1    Yamamoto, H.2    Nakamura, T.3    Ichihara, A.4    Okamoto, H.5
  • 93
    • 0028208243 scopus 로고
    • Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen andperoxisome proliferator nafenopin
    • Bayly AC, Roberts RA, Dive C. Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen andperoxisome proliferator nafenopin. J Cell Biol 125:197-203 (1994).
    • (1994) J Cell Biol , vol.125 , pp. 197-203
    • Bayly, A.C.1    Roberts, R.A.2    Dive, C.3
  • 94
    • 0028965718 scopus 로고
    • Long-term maintenance of functional rat hepatocytes in primary culture by additions of pyruvate andvarious hormones
    • Tomita Y, Yuasa C, Ni R, Ishimura K, Ichihara A. Long-term maintenance of functional rat hepatocytes in primary culture by additions of pyruvate andvarious hormones. Biochim Biophys Acta 1243:329-335 (1995).
    • (1995) Biochim Biophys Acta , vol.1243 , pp. 329-335
    • Tomita, Y.1    Yuasa, C.2    Ni, R.3    Ishimura, K.4    Ichihara, A.5
  • 95
    • 0029928703 scopus 로고    scopus 로고
    • Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF andTGFα in a chemically defined (HGM) medium
    • Block GD, Locker J, Bowen WC, Petersen BE, Katyal S, Strom SC, Riley T, Howard TA, Michalopoulos GK. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF andTGFα in a chemically defined (HGM) medium. J Cell Biol 132:1133-1149 (1996).
    • (1996) J Cell Biol , vol.132 , pp. 1133-1149
    • Block, G.D.1    Locker, J.2    Bowen, W.C.3    Petersen, B.E.4    Katyal, S.5    Strom, S.C.6    Riley, T.7    Howard, T.A.8    Michalopoulos, G.K.9
  • 97
    • 0022388760 scopus 로고
    • Long-term survival of functional hepatocytes from adult rat in the presence of phenobarbital in primary culture
    • Miyazaki M, Handa Y, Oda M, Yabe T, Miyano K, Sato J. Long-term survival of functional hepatocytes from adult rat in the presence of phenobarbital in primary culture. Exp Cell Res 159:176-190 (1985).
    • (1985) Exp Cell Res , vol.159 , pp. 176-190
    • Miyazaki, M.1    Handa, Y.2    Oda, M.3    Yabe, T.4    Miyano, K.5    Sato, J.6
  • 98
    • 0021364171 scopus 로고
    • Hepatocyte proliferation in vitro: Its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix
    • Enar R, Jefferson DM, Ruiz-Opazo N, Gatmaitan Z, Leinwand L, Reid LM. Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix. Proc Natl Acad Sci USA 81:1411-1415 (1984).
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 1411-1415
    • Enar, R.1    Jefferson, D.M.2    Ruiz-Opazo, N.3    Gatmaitan, Z.4    Leinwand, L.5    Reid, L.M.6
  • 99
    • 0000253582 scopus 로고
    • Matrix andhormonal regulation of differentiation in liver cultures
    • Guillouzo A, Guguen-Guillouzo C, eds. Paris:Les Editions INSERM and John Libbey Eurotext
    • Reid LM, Narita M, Fujita M, Murray Z, Liverpool C, Rosenbere, L. Matrix andhormonal regulation of differentiation in liver cultures. In:Isolated and Cultured Hepatocytes (Guillouzo A, Guguen-Guillouzo C, eds). Paris:Les Editions INSERM and John Libbey Eurotext, 1986;226-258.
    • (1986) Isolated and Cultured Hepatocytes , pp. 226-258
    • Reid, L.M.1    Narita, M.2    Fujita, M.3    Murray, Z.4    Liverpool, C.5    Rosenbere, L.6
  • 101
    • 0029973363 scopus 로고    scopus 로고
    • Growth factor-dependence of entry andprogression through G1 andS phases of adult rat hepatocytes in vitro
    • Loyer P, Cariou S, Glaise D, Bilodeau M, Baffet G, Guguen-Guillouzo C. Growth factor-dependence of entry andprogression through G1 andS phases of adult rat hepatocytes in vitro. J Biol Chem 271:11484-11492 (1996).
    • (1996) J Biol Chem , vol.271 , pp. 11484-11492
    • Loyer, P.1    Cariou, S.2    Glaise, D.3    Bilodeau, M.4    Baffet, G.5    Guguen-Guillouzo, C.6
  • 102
    • 0001870863 scopus 로고
    • Hepatocytc proliferation in culture
    • Guillouzo A, Guguen-Guillouzo C, eds. Paris:Les Editions INSERM and John Libbey Eurotext
    • McGowan JA. Hepatocytc proliferation in culture. In:Isolated and Cultured Hepatocytes (Guillouzo A, Guguen-Guillouzo C, eds). Paris:Les Editions INSERM and John Libbey Eurotext, 1986;13-38.
    • (1986) Isolated and Cultured Hepatocytes , pp. 13-38
    • McGowan, J.A.1
  • 105
    • 0023620085 scopus 로고
    • Effects of EGF andcalcium on adult parenchymal hepatocyte proliferation
    • Eckl PM, Whitcomb WR, Michalopoulos GK, Jirde RL. Effects of EGF andcalcium on adult parenchymal hepatocyte proliferation. J Cell Physiol 132:363-366 (1987).
    • (1987) J Cell Physiol , vol.132 , pp. 363-366
    • Eckl, P.M.1    Whitcomb, W.R.2    Michalopoulos, G.K.3    Jirde, R.L.4
  • 106
    • 0026019312 scopus 로고
    • Multiple cell cycles occur in rat hepatocytes cultured in the presence of nicotinamide andepidermal growth factor
    • Mitaka T, Sattler CA, Sattler GL, Sargent LM, Pitot HC. Multiple cell cycles occur in rat hepatocytes cultured in the presence of nicotinamide andepidermal growth factor. Hepatology 13:21-30 (1991).
    • (1991) Hepatology , vol.13 , pp. 21-30
    • Mitaka, T.1    Sattler, C.A.2    Sattler, G.L.3    Sargent, L.M.4    Pitot, H.C.5
  • 107
  • 108
    • 0026352219 scopus 로고
    • Growth of normal human hepatocytes in primary culture: Effects of hormones and growth factors on DNA synthesis
    • Ismail T, Howl J, Wheatley M, McMaster P, Neuberger JM, Strain AJ. Growth of normal human hepatocytes in primary culture: effects of hormones and growth factors on DNA synthesis. Hepatology 14:1076-1082 (1991).
    • (1991) Hepatology , vol.14 , pp. 1076-1082
    • Ismail, T.1    Howl, J.2    Wheatley, M.3    McMaster, P.4    Neuberger, J.M.5    Strain, A.J.6
  • 111
    • 0021350062 scopus 로고
    • Substrate adhesion of rat hepatocytes: On the mechanism of attachment of fibronectin
    • Johansson S, Hook M. Substrate adhesion of rat hepatocytes: on the mechanism of attachment of fibronectin. J Cell Biol 98:810-817 (1984).
    • (1984) J Cell Biol , vol.98 , pp. 810-817
    • Johansson, S.1    Hook, M.2
  • 112
    • 0016710260 scopus 로고
    • Primary culture of parenchymal liver cells on collagen membranes
    • Michalopoulos G, Pitot HC. Primary culture of parenchymal liver cells on collagen membranes. Exp Cell Res 94:70-78 (1975).
    • (1975) Exp Cell Res , vol.94 , pp. 70-78
    • Michalopoulos, G.1    Pitot, H.C.2
  • 114
    • 0027529529 scopus 로고
    • Proline-mediated enhancement of hepatocyte function in a collagen gel sandwich culture configuration
    • Lee J, Morgan JR, Tompkins RG, Yarmush MI. Proline-mediated enhancement of hepatocyte function in a collagen gel sandwich culture configuration. FASEB J 7:586-591 (1993).
    • (1993) FASEB J , vol.7 , pp. 586-591
    • Lee, J.1    Morgan, J.R.2    Tompkins, R.G.3    Yarmush, M.I.4
  • 115
    • 0028209259 scopus 로고
    • Collagen gel immobilization: A useful cell culture technique for long-term metabolic studies on human hepatocytes
    • Koebe HG, Pahernik S, Eyer P, Schildberg FW. Collagen gel immobilization: a useful cell culture technique for long-term metabolic studies on human hepatocytes. Xenobiotica 24:95-107 (1994).
    • (1994) Xenobiotica , vol.24 , pp. 95-107
    • Koebe, H.G.1    Pahernik, S.2    Eyer, P.3    Schildberg, F.W.4
  • 116
    • 0019069761 scopus 로고
    • Connective tissue biomatrix: Its isolation and utilization for long-term cultures of normal rat hepatocytes
    • Rojkind M, Gatmaitan Z, Mackensen S, Giambrone MA, Ponce P, Reid LM. Connective tissue biomatrix: its isolation and utilization for long-term cultures of normal rat hepatocytes. J Cell Biol 87:255-263 (1980).
    • (1980) J Cell Biol , vol.87 , pp. 255-263
    • Rojkind, M.1    Gatmaitan, Z.2    Mackensen, S.3    Giambrone, M.A.4    Ponce, P.5    Reid, L.M.6
  • 118
    • 0026701412 scopus 로고
    • Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components
    • Vukicevic S, Kleinman HK, Luyten FP, Roberts AB, Roche NS, Reddi AH. Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Exp Cell Res 202:1-8 (1992).
    • (1992) Exp Cell Res , vol.202 , pp. 1-8
    • Vukicevic, S.1    Kleinman, H.K.2    Luyten, F.P.3    Roberts, A.B.4    Roche, N.S.5    Reddi, A.H.6
  • 120
    • 0024502767 scopus 로고
    • Hepatocyte function andextracellular matrix geometry: Long-term culture in a sandwich configuration
    • Dunn JY, Yarmush ML, Koebe HG, Tompkins RG. Hepatocyte function andextracellular matrix geometry: long-term culture in a sandwich configuration. FASEB J 3:174-177 (1989).
    • (1989) FASEB J , vol.3 , pp. 174-177
    • Dunn, J.Y.1    Yarmush, M.L.2    Koebe, H.G.3    Tompkins, R.G.4
  • 121
    • 0025058804 scopus 로고
    • Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins
    • Caron JM, Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins. Mol Cell Biol 10:1239-1243 (1990).
    • (1990) Mol Cell Biol , vol.10 , pp. 1239-1243
    • Caron, J.M.1
  • 122
    • 0027419759 scopus 로고
    • Crude liver membrane factions as substrate preserve liver specific functions in long-term, serum-free rat hepatocyte cultures
    • Saad B, Schawalder H, Maier P. Crude liver membrane factions as substrate preserve liver specific functions in long-term, serum-free rat hepatocyte cultures. In Vitro Cell Dev Biol 29A:32-40 (1993).
    • (1993) In Vitro Cell Dev Biol , vol.29 A , pp. 32-40
    • Saad, B.1    Schawalder, H.2    Maier, P.3
  • 123
    • 0027285199 scopus 로고
    • Crude liver membrane fractions andextracellular matrix components as substrata regulate differentially the preservation andinducibility of cytochrome P-450 isoenzymes in cultured rat hepatocytes
    • Saad B, Scholl FA, Thomas H, Schwalder H, Streit V, Waechter F, Maier P. Crude liver membrane fractions andextracellular matrix components as substrata regulate differentially the preservation andinducibility of cytochrome P-450 isoenzymes in cultured rat hepatocytes. Eur J Biochem 46:805-814 (1993).
    • (1993) Eur J Biochem , vol.46 , pp. 805-814
    • Saad, B.1    Scholl, F.A.2    Thomas, H.3    Schwalder, H.4    Streit, V.5    Waechter, F.6    Maier, P.7
  • 124
    • 0018568131 scopus 로고
    • Interaction of adult rat hepatocytes andsinusoidal cells in co-culture
    • Wanson JC, Mosselmans R, Brouwer A, Knook DL. Interaction of adult rat hepatocytes andsinusoidal cells in co-culture. Biol Cell 56:7-16 (1979).
    • (1979) Biol Cell , vol.56 , pp. 7-16
    • Wanson, J.C.1    Mosselmans, R.2    Brouwer, A.3    Knook, D.L.4
  • 125
    • 0018640579 scopus 로고
    • Primary cultures of hepatocytes on human fibroblasts
    • Michalopoulos G, Russel F, Biles C. Primary cultures of hepatocytes on human fibroblasts. In Vitro 15:796-806 (1979).
    • (1979) In Vitro , vol.15 , pp. 796-806
    • Michalopoulos, G.1    Russel, F.2    Biles, C.3
  • 126
    • 0020660763 scopus 로고
    • Maintenance andreversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type
    • Guguen-Guillouzo C, Clément B, Baffet G, Beaumont C, Morel-Chany E, Glaise D, Guillouzo A. Maintenance andreversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type. Exp Cell Res 143:47-54 (1983).
    • (1983) Exp Cell Res , vol.143 , pp. 47-54
    • Guguen-Guillouzo, C.1    Clément, B.2    Baffet, G.3    Beaumont, C.4    Morel-Chany, E.5    Glaise, D.6    Guillouzo, A.7
  • 128
    • 0021211284 scopus 로고
    • Modulation of human fetal hepatocyte survival anddifferentiation by interactions with a rat liver epithelial cell line
    • Guguen-Guillouzo C, Clément B, Lescoat G, Glaise D, Guillouzo A. Modulation of human fetal hepatocyte survival anddifferentiation by interactions with a rat liver epithelial cell line. Dev Biol 105:211-220 (1984).
    • (1984) Dev Biol , vol.105 , pp. 211-220
    • Guguen-Guillouzo, C.1    Clément, B.2    Lescoat, G.3    Glaise, D.4    Guillouzo, A.5
  • 129
    • 0021342865 scopus 로고
    • Long-term production of acute-phase proteins by adult rat hepatocytes co-cultured with another liver cell type in serum-free medium
    • Guillouzo A, Delers F, Clément B, Bernard N, Engler R. Long-term production of acute-phase proteins by adult rat hepatocytes co-cultured with another liver cell type in serum-free medium. Biochem Biophys Res Commun 120:311-317 (1984).
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 311-317
    • Guillouzo, A.1    Delers, F.2    Clément, B.3    Bernard, N.4    Engler, R.5
  • 130
    • 0021963846 scopus 로고
    • Long-term maintenance of taurocholate uptake by adult rat hepatocytes co-cultured with a liver epithelial cell line
    • Foliot A, Glaise D, Erlinger S, Guguen-Guillouzo C. Long-term maintenance of taurocholate uptake by adult rat hepatocytes co-cultured with a liver epithelial cell line. Hepatology 16:215-219 (1985).
    • (1985) Hepatology , vol.16 , pp. 215-219
    • Foliot, A.1    Glaise, D.2    Erlinger, S.3    Guguen-Guillouzo, C.4
  • 131
    • 0021795422 scopus 로고
    • Control of albumin andα-fetoprotein secretion by fetal andneonatal rat hepatocytes maintained in co-culture
    • Lescoat G, Thézé N, Clément B, Guillouzo A, Guguen-Guillouzo C. Control of albumin andα-fetoprotein secretion by fetal andneonatal rat hepatocytes maintained in co-culture. Cell Diff 16:259-268 (1985).
    • (1985) Cell Diff , vol.16 , pp. 259-268
    • Lescoat, G.1    Thézé, N.2    Clément, B.3    Guillouzo, A.4    Guguen-Guillouzo, C.5
  • 132
    • 0022479022 scopus 로고
    • Long-term biosynthesis of complement component C3 andalpha-1 glycoprotein by adult rat hepatocytes in a co-culture system with an epithelial liver cell-type
    • Lebreton JP, Daveau M, Hiron M, Fontaine M, Biou M, Gilbert D, Guguen-Guillouzo C. Long-term biosynthesis of complement component C3 andalpha-1 glycoprotein by adult rat hepatocytes in a co-culture system with an epithelial liver cell-type. Biochem J 235:421-427 (1986).
    • (1986) Biochem J , vol.235 , pp. 421-427
    • Lebreton, J.P.1    Daveau, M.2    Hiron, M.3    Fontaine, M.4    Biou, M.5    Gilbert, D.6    Guguen-Guillouzo, C.7
  • 133
    • 0025359854 scopus 로고
    • Acute phase response induction in rat hepatocytes co-cultured with rat liver epithelial cells
    • Conner J, Vallet-Collom I, Daveau M, Delers F, Lebreton JP, Guillouzo A. Acute phase response induction in rat hepatocytes co-cultured with rat liver epithelial cells. Biochem J 266:683-688 (1990).
    • (1990) Biochem J , vol.266 , pp. 683-688
    • Conner, J.1    Vallet-Collom, I.2    Daveau, M.3    Delers, F.4    Lebreton, J.P.5    Guillouzo, A.6
  • 134
    • 0025859883 scopus 로고
    • Rat adult hepatocytes in primary pure andmixed monolayer culture. Comparison of the maintenance of mixed function oxidase andconjugation pathways of drug metabolism
    • Niemann C, Gauthier JC, Richert L, Ivanov MA, Melcion C, Cordier A. Rat adult hepatocytes in primary pure andmixed monolayer culture. Comparison of the maintenance of mixed function oxidase andconjugation pathways of drug metabolism. Biochem Pharmacol 42:373-379 (1991).
    • (1991) Biochem Pharmacol , vol.42 , pp. 373-379
    • Niemann, C.1    Gauthier, J.C.2    Richert, L.3    Ivanov, M.A.4    Melcion, C.5    Cordier, A.6
  • 135
    • 12644302207 scopus 로고    scopus 로고
    • Regulation of the major detoxication functions by phenobarbital and3-methylcholanthrene in co-cultures of rat hepatocytes andliver epithelial cells
    • Lerche C, Fautrel A, Shaw PM, Glaise D, Ballet F, Guillouzo A, Corcos L. Regulation of the major detoxication functions by phenobarbital and3-methylcholanthrene in co-cultures of rat hepatocytes andliver epithelial cells. Eur J Biochem 244:98-106 (1997).
    • (1997) Eur J Biochem , vol.244 , pp. 98-106
    • Lerche, C.1    Fautrel, A.2    Shaw, P.M.3    Glaise, D.4    Ballet, F.5    Guillouzo, A.6    Corcos, L.7
  • 136
    • 0023621552 scopus 로고
    • Cell contact but not junctional communication (dye coupling) with biliary epithelial cells is required for hepatocytes to maintain differentiated functions
    • Mesnil M, Fraslin JM, Piccoli C, Yamasaki H, Guguen-Guillouzo C. Cell contact but not junctional communication (dye coupling) with biliary epithelial cells is required for hepatocytes to maintain differentiated functions. Exp Cell Res 173:524-533 (1987).
    • (1987) Exp Cell Res , vol.173 , pp. 524-533
    • Mesnil, M.1    Fraslin, J.M.2    Piccoli, C.3    Yamasaki, H.4    Guguen-Guillouzo, C.5
  • 138
    • 0022982255 scopus 로고
    • Long-term maintenance of hepatocyte functional activity in co-culture: Requirements for sinusoidal endothelial cells and dexamethasone
    • Morin O, Normand C. Long-term maintenance of hepatocyte functional activity in co-culture: requirements for sinusoidal endothelial cells and dexamethasone. J Cell Physiol 129:103-110 (1986).
    • (1986) J Cell Physiol , vol.129 , pp. 103-110
    • Morin, O.1    Normand, C.2
  • 139
    • 0024843377 scopus 로고
    • Synthesis of alpha-fetoprotein in hepatocytes is coordinately regulated with cell-cell andcell-matrix interactions
    • Gleiberman AS, Kudrjavtseva EI, Sharovskaya UY, Abelev GI. Synthesis of alpha-fetoprotein in hepatocytes is coordinately regulated with cell-cell andcell-matrix interactions. Mol Biol Med 6:95-107 (1989).
    • (1989) Mol Biol Med , vol.6 , pp. 95-107
    • Gleiberman, A.S.1    Kudrjavtseva, E.I.2    Sharovskaya, U.Y.3    Abelev, G.I.4
  • 140
    • 0025131373 scopus 로고
    • Induction of glutamine synthetase in periportal hepatocytes by co-cultivation with a liver epithelial cell line
    • Schrode W, Mecke D, Gebhardt R. Induction of glutamine synthetase in periportal hepatocytes by co-cultivation with a liver epithelial cell line. Europ J Cell Biol 53:35-41 (1990).
    • (1990) Europ J Cell Biol , vol.53 , pp. 35-41
    • Schrode, W.1    Mecke, D.2    Gebhardt, R.3
  • 142
    • 0025870255 scopus 로고
    • Coculrures of hepatocytes with epithelia-like cell lines: Expression of drug biotransformation activities by hepatocytes
    • Donato MT, Castell JV, Gomez-Lechon MJ. Coculrures of hepatocytes with epithelia-like cell lines: expression of drug biotransformation activities by hepatocytes. Cell Biol Toxicol 7:1-14 (1991).
    • (1991) Cell Biol Toxicol , vol.7 , pp. 1-14
    • Donato, M.T.1    Castell, J.V.2    Gomez-Lechon, M.J.3
  • 143
    • 0026333754 scopus 로고
    • Differential stabilization of cytochrome P-450 isoenzymes in primary cultures of adult rat liver parenchymal cells
    • Utesch D, Molitor E, Platt KL, Oesch F. Differential stabilization of cytochrome P-450 isoenzymes in primary cultures of adult rat liver parenchymal cells. In Vitro Cell Dev Biol 27A:858-863 (1991).
    • (1991) In Vitro Cell Dev Biol , vol.27 A , pp. 858-863
    • Utesch, D.1    Molitor, E.2    Platt, K.L.3    Oesch, F.4
  • 145
    • 0023689952 scopus 로고
    • Intracytoplasmic triglyceride accumulation produced by dexamethasone in adult rat hepatocytes cultivated on 3T3 cells
    • Mendoza-Figueroa T, Hernandez A, Lopez ML, Kuharcuch W. Intracytoplasmic triglyceride accumulation produced by dexamethasone in adult rat hepatocytes cultivated on 3T3 cells. Toxicology 52:273-286 (1988).
    • (1988) Toxicology , vol.52 , pp. 273-286
    • Mendoza-Figueroa, T.1    Hernandez, A.2    Lopez, M.L.3    Kuharcuch, W.4
  • 146
    • 0023729096 scopus 로고
    • Cellular interactions promote tissue-specific function, biomatrix deposition andjunctional communication of primary cultured hepatocytes
    • Goulet F, Normand C, Morin O. Cellular interactions promote tissue-specific function, biomatrix deposition andjunctional communication of primary cultured hepatocytes. Hepatology 8:1010-1018 (1988).
    • (1988) Hepatology , vol.8 , pp. 1010-1018
    • Goulet, F.1    Normand, C.2    Morin, O.3
  • 147
    • 0025153166 scopus 로고
    • Prolonged expression of biotransformation activities of rat hepatocytes co-cultured with established cell lines
    • Donato MT, Castell JV, Gomez-Lechon MJ. Prolonged expression of biotransformation activities of rat hepatocytes co-cultured with established cell lines. Toxicol In Vitro 4:461-466 (1990).
    • (1990) Toxicol in Vitro , vol.4 , pp. 461-466
    • Donato, M.T.1    Castell, J.V.2    Gomez-Lechon, M.J.3
  • 148
    • 0025987629 scopus 로고
    • A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes
    • Corlu A, Kneip B, Lhadi C, Leray G, Glaise D, Baffet G, Bourel D, Guguen-Guillouzo C. A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes. J Cell Biol 115:505-515 (1991).
    • (1991) J Cell Biol , vol.115 , pp. 505-515
    • Corlu, A.1    Kneip, B.2    Lhadi, C.3    Leray, G.4    Glaise, D.5    Baffet, G.6    Bourel, D.7    Guguen-Guillouzo, C.8
  • 149
    • 0028111087 scopus 로고
    • Tissue distribution of liver regulating protein: Evidence for a cell recognition signal common to liver, pancreas, gonads, and hemopoetic tissues
    • Corlu A, Ilyin GP, Gérard N, Kneip B, Rissel M, Jégou B, Guguen-Guillouzo C. Tissue distribution of liver regulating protein: evidence for a cell recognition signal common to liver, pancreas, gonads, and hemopoetic tissues. Am J Pathol 145:715-727 (1994).
    • (1994) Am J Pathol , vol.145 , pp. 715-727
    • Corlu, A.1    Ilyin, G.P.2    Gérard, N.3    Kneip, B.4    Rissel, M.5    Jégou, B.6    Guguen-Guillouzo, C.7
  • 150
    • 0023917839 scopus 로고
    • Influence of medium composition andculture conditions on glutathione S-transferase activity in adult hepatocytes during culture
    • Vandenberghe Y, Ratanasavanh D, Glaise D, Guillouzo A. Influence of medium composition andculture conditions on glutathione S-transferase activity in adult hepatocytes during culture. In Vitro Cell Dev Biol 24:281-288 (1988).
    • (1988) In Vitro Cell Dev Biol , vol.24 , pp. 281-288
    • Vandenberghe, Y.1    Ratanasavanh, D.2    Glaise, D.3    Guillouzo, A.4
  • 151
    • 0020282949 scopus 로고
    • Hydrocortisone modulates the production of extracellular material andalbumin in long-term cocultures of adult rat hepatocytes with other liver epithelial cells
    • Baffet G, Clément B, Glaise D, Guillouzo A, Guguen-Guillouzo C. Hydrocortisone modulates the production of extracellular material andalbumin in long-term cocultures of adult rat hepatocytes with other liver epithelial cells. Biochem Biophys Res Commun 109:507-512 (1982).
    • (1982) Biochem Biophys Res Commun , vol.109 , pp. 507-512
    • Baffet, G.1    Clément, B.2    Glaise, D.3    Guillouzo, A.4    Guguen-Guillouzo, C.5
  • 152
    • 0023512683 scopus 로고
    • Aggregate cultures of foetal rat liver cells: Development and maintenance of liver gene expression
    • Guigoz Y, Werffeli P, Favre D, Juillerat M, Wellinger R, Honegger P. Aggregate cultures of foetal rat liver cells: development and maintenance of liver gene expression. Biol Cell 60:163-172 (1987).
    • (1987) Biol Cell , vol.60 , pp. 163-172
    • Guigoz, Y.1    Werffeli, P.2    Favre, D.3    Juillerat, M.4    Wellinger, R.5    Honegger, P.6
  • 153
    • 0022204028 scopus 로고
    • Spheroidal aggregate culture of rat liver cells: Historypic reorganization, biomatrix deposition, and maintenance of functional activities
    • Landry J, Bernier D, Quellet C, Goyette R, Marceau N. Spheroidal aggregate culture of rat liver cells: historypic reorganization, biomatrix deposition, and maintenance of functional activities. J Cell Biol 101:914-923 (1985).
    • (1985) J Cell Biol , vol.101 , pp. 914-923
    • Landry, J.1    Bernier, D.2    Quellet, C.3    Goyette, R.4    Marceau, N.5
  • 154
    • 0025135443 scopus 로고
    • Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces andunder other non adherent environments
    • Koide KS, Sakaguchi K, Koide Y, Asano K, Kawaguchi M, Matsushima H, Takenami T, Shinji T, Mori M, Tsuji T. Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces andunder other non adherent environments. Exp Cell Res 186:227-235 (1990).
    • (1990) Exp Cell Res , vol.186 , pp. 227-235
    • Koide, K.S.1    Sakaguchi, K.2    Koide, Y.3    Asano, K.4    Kawaguchi, M.5    Matsushima, H.6    Takenami, T.7    Shinji, T.8    Mori, M.9    Tsuji, T.10
  • 156
    • 0017651546 scopus 로고
    • Isolation andcharacterization of Kupffer andendothelial cells from the rat liver
    • Knook DL, Blansjaar N, Sleyster E. Isolation andcharacterization of Kupffer andendothelial cells from the rat liver. Exp Cell Res 109:317-329 (1977).
    • (1977) Exp Cell Res , vol.109 , pp. 317-329
    • Knook, D.L.1    Blansjaar, N.2    Sleyster, E.3
  • 157
    • 0002815920 scopus 로고
    • Sinusoidal endothelial cells andperisinusoidal fat-storing cells
    • Arias IM, Jakoby WB, Popper H, Schachter D, Shafrirz DA, eds. New York:Raven Press
    • Brouwer A, Wisse E, Knook DL. Sinusoidal endothelial cells andperisinusoidal fat-storing cells. In; The Liver Biology andPathobiology (Arias IM, Jakoby WB, Popper H, Schachter D, Shafrirz DA, eds). New York:Raven Press, 1988;665-680.
    • (1988) The Liver Biology AndPathobiology , pp. 665-680
    • Brouwer, A.1    Wisse, E.2    Knook, D.L.3
  • 158
    • 0021275006 scopus 로고
    • Purified rat liver fat-storing cells in culture divide andcontain collagen
    • De Leeuw AM, McCarthy SP, Geerts A, Knook DL. Purified rat liver fat-storing cells in culture divide andcontain collagen. Hepatology 4:392-403 (1984).
    • (1984) Hepatology , vol.4 , pp. 392-403
    • De Leeuw, A.M.1    McCarthy, S.P.2    Geerts, A.3    Knook, D.L.4
  • 159
    • 0024829161 scopus 로고
    • Immunoisolation andculture of biliary epithelial cells from normal human liver
    • Joplin R, Strain AJ, Neuberger JM. Immunoisolation andculture of biliary epithelial cells from normal human liver. In Vitro Cell Dev Biol 25:1189-1192 (1989).
    • (1989) In Vitro Cell Dev Biol , vol.25 , pp. 1189-1192
    • Joplin, R.1    Strain, A.J.2    Neuberger, J.M.3
  • 160
    • 0026583401 scopus 로고
    • Biological characteristics of primary cultures of human gallbladder epithelial cells
    • Hoerl BJ, Vroman BT, Kasperbauer JL, LaRusso NF, Scott RE. Biological characteristics of primary cultures of human gallbladder epithelial cells. Lab Invest 66:243-250 (1992).
    • (1992) Lab Invest , vol.66 , pp. 243-250
    • Hoerl, B.J.1    Vroman, B.T.2    Kasperbauer, J.L.3    LaRusso, N.F.4    Scott, R.E.5
  • 161
    • 0028830154 scopus 로고
    • UW-preservation of cultured human gallbladder epithelial cells:
    • Campion JP, Porchet N, Aubert JP, L'Helgoualc'h A, Clément B. UW-preservation of cultured human gallbladder epithelial cells: phenotypic alterations and differential mucin gene expression in the presence of bile. Hepatoiogy 21:223-231 (1995).
    • (1995) Hepatoiogy , vol.21 , pp. 223-231
    • Campion, J.P.1    Porchet, N.2    Aubert, J.P.3    L'Helgoualc'h, A.4    Clément, B.5
  • 162
    • 0023393350 scopus 로고
    • Demonstration andmaintenance of mucus secretion in cultured human gallbladder epithelial cells
    • Yoshitomi S, Miyazaki K, Nakayama F. Demonstration andmaintenance of mucus secretion in cultured human gallbladder epithelial cells. In Vitro Cell Dev Biol 23:559-566 (1987).
    • (1987) In Vitro Cell Dev Biol , vol.23 , pp. 559-566
    • Yoshitomi, S.1    Miyazaki, K.2    Nakayama, F.3
  • 164
    • 0016685233 scopus 로고
    • Methods for detecting carcinogens andmutagens with the Salmonella/mammalian-microsome mutagenicity test
    • Ames BN, McCann J, Yamasaki E. Methods for detecting carcinogens andmutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res 31:347-364 (1975).
    • (1975) Mutat Res , vol.31 , pp. 347-364
    • Ames, B.N.1    McCann, J.2    Yamasaki, E.3
  • 165
    • 0001285525 scopus 로고    scopus 로고
    • Drug metabolism andcarcinogen activation studies with human genetically engineered cells
    • Castell JV, Gomez-Lechon MJ eds. San Diego, CA:Academic Press
    • Macé K, Offord EA, Pfeifer AMA. Drug metabolism andcarcinogen activation studies with human genetically engineered cells. In:In Vitro Methods in Pharmaceutical Research (Castell JV, Gomez-Lechon MJ eds). San Diego, CA:Academic Press, 1997;433-456.
    • (1997) In Vitro Methods in Pharmaceutical Research , pp. 433-456
    • Macé, K.1    Offord, E.A.2    Pfeifer, A.M.A.3
  • 166
    • 0026699138 scopus 로고
    • Distinct oxidoresistance phenotypic of human T47D cells transfected by rat glutathione S-transferase Yc expression vectors
    • Lavoie L, Tremblay A, Mirault ME. Distinct oxidoresistance phenotypic of human T47D cells transfected by rat glutathione S-transferase Yc expression vectors. J Biol Chem 267:3632-3636 (1992).
    • (1992) J Biol Chem , vol.267 , pp. 3632-3636
    • Lavoie, L.1    Tremblay, A.2    Mirault, M.E.3
  • 167
    • 0029852566 scopus 로고    scopus 로고
    • New applications of bacterial systems to problems in toxicology
    • Guengerich FP, Gillam EM, Shimada T. New applications of bacterial systems to problems in toxicology. Crit Rev Toxicol 26:551-583 (1996).
    • (1996) Crit Rev Toxicol , vol.26 , pp. 551-583
    • Guengerich, F.P.1    Gillam, E.M.2    Shimada, T.3
  • 169
  • 170
    • 2642656145 scopus 로고
    • Les hépatocytes en culture: Utilisation en pharmacotoxicologie
    • Adolphe M, Guillouzo A, eds. Paris:Les Editions INSERM
    • Ratanasavanh D, Riché C, Bégué J, Guillouzo A. Les hépatocytes en culture: utilisation en pharmacotoxicologie. In: Méthodes In Vitro en Pharmacotoxicologie. Vol 170 (Adolphe M, Guillouzo A, eds). Paris:Les Editions INSERM, 1988;11-16.
    • (1988) Méthodes in Vitro en Pharmacotoxicologie , vol.170 , pp. 11-16
    • Ratanasavanh, D.1    Riché, C.2    Bégué, J.3    Guillouzo, A.4
  • 171
    • 0023684933 scopus 로고
    • Different cytotoxicity andmetabolism of doxorubicin, daunorubicin, epirubicin, esorubicin andidarubicin in cultured human andrat hepatocytes
    • Le Bot MA, Bégué JM, Kernaleguen D, Robert J, Ratanasavanh D, Airiau J, Riché C, Guillouzo A. Different cytotoxicity andmetabolism of doxorubicin, daunorubicin, epirubicin, esorubicin andidarubicin in cultured human andrat hepatocytes. Biochem Pharmacol 37:3877-3887 (1988).
    • (1988) Biochem Pharmacol , vol.37 , pp. 3877-3887
    • Le Bot, M.A.1    Bégué, J.M.2    Kernaleguen, D.3    Robert, J.4    Ratanasavanh, D.5    Airiau, J.6    Riché, C.7    Guillouzo, A.8
  • 175
    • 0002444133 scopus 로고
    • The importance of exposure period andcell type in in vitro cytotoxicity tests
    • Riddell RJ, Panacer DS, Wilde SM, Clothier PH, Balls M. The importance of exposure period andcell type in in vitro cytotoxicity tests. ATLA 14:86-92 (1986).
    • (1986) ATLA , vol.14 , pp. 86-92
    • Riddell, R.J.1    Panacer, D.S.2    Wilde, S.M.3    Clothier, P.H.4    Balls, M.5
  • 176
    • 0026515929 scopus 로고
    • Evaluation of the cytotoxicity of ten chemicals on human cultured hepatocytes: Predictability of human toxicity and comparison with rodent cell culture systems
    • Jover R, Ponsoda X, Castell JV, Gomez-Lechon MJ. Evaluation of the cytotoxicity of ten chemicals on human cultured hepatocytes: predictability of human toxicity and comparison with rodent cell culture systems. Toxicol In Vitro 6:47-52 (1992).
    • (1992) Toxicol in Vitro , vol.6 , pp. 47-52
    • Jover, R.1    Ponsoda, X.2    Castell, J.V.3    Gomez-Lechon, M.J.4
  • 177
    • 0023888314 scopus 로고
    • Use of hepatocyte co-cultures in assessment of drug toxicity from chronic exposure
    • Ratanasavanh D, Baffet G, Latinier MF, Rissel M, Guillouzo A. Use of hepatocyte co-cultures in assessment of drug toxicity from chronic exposure. Xenobiotica 18:765-771 (1988).
    • (1988) Xenobiotica , vol.18 , pp. 765-771
    • Ratanasavanh, D.1    Baffet, G.2    Latinier, M.F.3    Rissel, M.4    Guillouzo, A.5
  • 178
    • 0342474025 scopus 로고
    • Predictive value of the in vitro test for hepatotoxicity of xenobiotics
    • Guillouzo A, ed. Paris:Les Editions INSERM and John Libbey Eurotext
    • Gomez-Lechon MJ, Larrauri A, Donate T, Lopez P, Montoya A, Castell JV. Predictive value of the in vitro test for hepatotoxicity of xenobiotics. In:Liver Cells and Drugs. Vol 164 (Guillouzo A, ed). Paris:Les Editions INSERM and John Libbey Eurotext, 1988;371-377.
    • (1988) Liver Cells and Drugs , vol.164 , pp. 371-377
    • Gomez-Lechon, M.J.1    Larrauri, A.2    Donate, T.3    Lopez, P.4    Montoya, A.5    Castell, J.V.6
  • 180
    • 0024199629 scopus 로고
    • Oxy radical-initiated S-thiolation andenzymic dethiolatton
    • Thomas JA, Park EM. Oxy radical-initiated S-thiolation andenzymic dethiolatton. Basic Life Sci 49:365-368 (1988).
    • (1988) Basic Life Sci , vol.49 , pp. 365-368
    • Thomas, J.A.1    Park, E.M.2
  • 181
    • 0015759166 scopus 로고
    • Fuscin, an inhibitor of mitochondrial SH-dependent transport-linked functions
    • Vienais PM, Vignais PV. Fuscin, an inhibitor of mitochondrial SH-dependent transport-linked functions. Biochim Biophys Acta 325:357-374 (1973).
    • (1973) Biochim Biophys Acta , vol.325 , pp. 357-374
    • Vienais, P.M.1    Vignais, P.V.2
  • 182
    • 0001371769 scopus 로고    scopus 로고
    • In vitro investigation of the molecular mechanisms of hepatoroxicity
    • Castell JV, Gomez-Lechon MJ, eds. San Diego, CA:Academic Press
    • Castell JV, Gomez-Lechon MJ, Ponsoda X, Bort R. In vitro investigation of the molecular mechanisms of hepatoroxicity. In:In Vitro Methods in Pharmaceutical Research (Castell JV, Gomez-Lechon MJ, eds). San Diego, CA:Academic Press, 1997;375-410.
    • (1997) In Vitro Methods in Pharmaceutical Research , pp. 375-410
    • Castell, J.V.1    Gomez-Lechon, M.J.2    Ponsoda, X.3    Bort, R.4
  • 183
    • 0001557130 scopus 로고
    • Lipid peroxidation: Mechanisms, analysis, enzymoloey and biological relevance
    • Sies H, ed. London:Academic Press
    • Kappus H. Lipid peroxidation: mechanisms, analysis, enzymoloey and biological relevance. In: Oxidative stress (Sies H, ed). London:Academic Press, 1985;273-310.
    • (1985) Oxidative Stress , pp. 273-310
    • Kappus, H.1
  • 184
    • 0027292908 scopus 로고
    • Simultaneous measurements of conjugated dienes andfree malondialdehyde, used as a micromethod for the evaluation of lipid peroxidation in rat hepatocyte cultures
    • Sergent O, Morel I, Cogrel P, Chevanne M, Pasdeloup N, Brissot P, Lescoat G, Cillard P, Cillard J. Simultaneous measurements of conjugated dienes andfree malondialdehyde, used as a micromethod for the evaluation of lipid peroxidation in rat hepatocyte cultures. Chem Phys Lipids 65:133-139 (1993).
    • (1993) Chem Phys Lipids , vol.65 , pp. 133-139
    • Sergent, O.1    Morel, I.2    Cogrel, P.3    Chevanne, M.4    Pasdeloup, N.5    Brissot, P.6    Lescoat, G.7    Cillard, P.8    Cillard, J.9
  • 185
    • 0028873550 scopus 로고
    • EPR study of antioxidant activity of the iron chelators pyoverdin andhyaroxypyrid-4-ones in iron loaded hepatocyte cultures
    • Morel I, Sergent O, Cogrel P, Lescoat G, Pasdeloup N, Brissot P, Cillard P, Cillard J. EPR study of antioxidant activity of the iron chelators pyoverdin andhyaroxypyrid-4-ones in iron loaded hepatocyte cultures. Free Radic Biol Med 18:303-310 (1995).
    • (1995) Free Radic Biol Med , vol.18 , pp. 303-310
    • Morel, I.1    Sergent, O.2    Cogrel, P.3    Lescoat, G.4    Pasdeloup, N.5    Brissot, P.6    Cillard, P.7    Cillard, J.8
  • 186
    • 0016210161 scopus 로고
    • A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I: Correlation of changes in covalent binding of reactive metabolites with changes in the incidence and severity of toxicity
    • Gillette JR. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I: Correlation of changes in covalent binding of reactive metabolites with changes in the incidence and severity of toxicity. Biochem Pharmacol 23:2927-2938 (1974).
    • (1974) Biochem Pharmacol , vol.23 , pp. 2927-2938
    • Gillette, J.R.1
  • 187
    • 0021177280 scopus 로고
    • Metabolism andcytotoxicity of acetaminophen in hepatocytes isolated from resistant andsusceptible species
    • Green CE, Dabbs JE, Tyson CA. Metabolism andcytotoxicity of acetaminophen in hepatocytes isolated from resistant andsusceptible species. Toxicol Appl Pharmacol 76:139-149 (1984).
    • (1984) Toxicol Appl Pharmacol , vol.76 , pp. 139-149
    • Green, C.E.1    Dabbs, J.E.2    Tyson, C.A.3
  • 188
    • 0021159819 scopus 로고
    • Critical biochemical functions of isolated hepatocytes as sensitive indicators of chemical toxicity
    • Goethals F, Krack G, Deboyser D, Vossen P, Roberfroid M. Critical biochemical functions of isolated hepatocytes as sensitive indicators of chemical toxicity. Fundam Appl Toxicol 4:441-450 (1984).
    • (1984) Fundam Appl Toxicol , vol.4 , pp. 441-450
    • Goethals, F.1    Krack, G.2    Deboyser, D.3    Vossen, P.4    Roberfroid, M.5
  • 189
    • 2642661271 scopus 로고
    • Measurement of functional metabolic activity as a sensitive parameter of cytotoxicity in cultured hepatocytes
    • Santone KS, Acosta D. Measurement of functional metabolic activity as a sensitive parameter of cytotoxicity in cultured hepatocytes. J Tissue Cult Meth 7:137-142 (1982).
    • (1982) J Tissue Cult Meth , vol.7 , pp. 137-142
    • Santone, K.S.1    Acosta, D.2
  • 190
    • 0021672952 scopus 로고
    • Effects of erythromycin derivatives on cultured rat hepatocytes
    • Villa P, Bégué JM, Guillouzo A, Effects of erythromycin derivatives on cultured rat hepatocytes. Biochem Pharmacol 33:4098-4101 (1984).
    • (1984) Biochem Pharmacol , vol.33 , pp. 4098-4101
    • Villa, P.1    Bégué, J.M.2    Guillouzo, A.3
  • 191
    • 0021051308 scopus 로고
    • Carcinogenesis by peroxisome proliferators: Evaluation of the risk of hypolipidaemic drugs and industrial plasticizers to humans
    • Reddy JK, Lalwani ND. Carcinogenesis by peroxisome proliferators: evaluation of the risk of hypolipidaemic drugs and industrial plasticizers to humans. CRC Crit Rev Toxicol 12:1-58 (1983).
    • (1983) CRC Crit Rev Toxicol , vol.12 , pp. 1-58
    • Reddy, J.K.1    Lalwani, N.D.2
  • 192
    • 0018353996 scopus 로고
    • The interrelationship between ureogenesis andprotein synthesis in isolated rat liver cells
    • Hensgens HESJ, Meijer AJ. The interrelationship between ureogenesis andprotein synthesis in isolated rat liver cells. Biochim Biophys Acta 582:525-532 (1979).
    • (1979) Biochim Biophys Acta , vol.582 , pp. 525-532
    • Hensgens, H.E.S.J.1    Meijer, A.J.2
  • 193
    • 0021261819 scopus 로고
    • Comparative metabolism of tolbutamide by isolated hepatocytes from rat, rabbit, dog andsquirrel monkey
    • Gee SJ, Green CE, Tyson CA. Comparative metabolism of tolbutamide by isolated hepatocytes from rat, rabbit, dog andsquirrel monkey. Drug Metab Dispos 12:174-178 (1984).
    • (1984) Drug Metab Dispos , vol.12 , pp. 174-178
    • Gee, S.J.1    Green, C.E.2    Tyson, C.A.3
  • 194
    • 0021189846 scopus 로고
    • The application of hepatocyte culture to the identification of pathways of drug metabolism. Studies with pindolol andfluperlapine
    • Paine AJ, Maurer G, Von Wartburg BR. The application of hepatocyte culture to the identification of pathways of drug metabolism. Studies with pindolol andfluperlapine. Biochem Pharmacol 33:3111-3114 (1984).
    • (1984) Biochem Pharmacol , vol.33 , pp. 3111-3114
    • Paine, A.J.1    Maurer, G.2    Von Wartburg, B.R.3
  • 195
    • 0022506192 scopus 로고
    • Comparison of amphetamine metabolism using isolated hepatocytes from five species including human
    • Green CE, Levalley SE, Tyson CA. Comparison of amphetamine metabolism using isolated hepatocytes from five species including human. J Pharmacol Exp Ther 237:931-396 (1986).
    • (1986) J Pharmacol Exp Ther , vol.237 , pp. 931-1396
    • Green, C.E.1    Levalley, S.E.2    Tyson, C.A.3
  • 196
    • 0022537979 scopus 로고
    • Sex differences in the biotransformation of 2-acetyl-aminofluorene in cultured rat hepatocytes
    • McQueen CA, Miller MJ, Williams GM. Sex differences in the biotransformation of 2-acetyl-aminofluorene in cultured rat hepatocytes. Cell Biol Toxicol 2:271-281 (1986).
    • (1986) Cell Biol Toxicol , vol.2 , pp. 271-281
    • McQueen, C.A.1    Miller, M.J.2    Williams, G.M.3
  • 198
    • 0023136742 scopus 로고
    • Species differences in metabolism of ketotifen in rat, rabbit andman: Demonstration of similar pathways in vivo and in cultured hepatocytes
    • Le Bigot JF, Bégué JM, Kiechel JR, Guillouzo A. Species differences in metabolism of ketotifen in rat, rabbit andman: demonstration of similar pathways in vivo and in cultured hepatocytes. Life Sci 40:883-890 (1987).
    • (1987) Life Sci , vol.40 , pp. 883-890
    • Le Bigot, J.F.1    Bégué, J.M.2    Kiechel, J.R.3    Guillouzo, A.4
  • 199
    • 0023930576 scopus 로고
    • Identification of metabolic pathways of pindolol andfluperlapine in adult human hepatocyte cultures
    • Guillouzo A, Bégué JM, Maurer G, Koch P. Identification of metabolic pathways of pindolol andfluperlapine in adult human hepatocyte cultures. Xenobiotica 18:131-139 (1988).
    • (1988) Xenobiotica , vol.18 , pp. 131-139
    • Guillouzo, A.1    Bégué, J.M.2    Maurer, G.3    Koch, P.4
  • 200
    • 0023836861 scopus 로고
    • Extrapolation of preclinical pharmacokinetic data to therapeutic drug use
    • Rahmani R, Richard B, Fabre G, Cano JP. Extrapolation of preclinical pharmacokinetic data to therapeutic drug use. Xenobiotica 18:71-88 (1988).
    • (1988) Xenobiotica , vol.18 , pp. 71-88
    • Rahmani, R.1    Richard, B.2    Fabre, G.3    Cano, J.P.4
  • 202
    • 0026065773 scopus 로고
    • Metabolism of minaprine in human andanimal hepatocytes andliver microsomes-prediction of metabolism in vivo
    • Lacarelle B, Marre F, Durand A, Davi H, Rahmani R. Metabolism of minaprine in human andanimal hepatocytes andliver microsomes-prediction of metabolism in vivo. Xenobiotica 21:317-329 (1991).
    • (1991) Xenobiotica , vol.21 , pp. 317-329
    • Lacarelle, B.1    Marre, F.2    Durand, A.3    Davi, H.4    Rahmani, R.5
  • 203
    • 0027436155 scopus 로고
    • Maintenance of the bio transformation capacity by cultured human hepatocytes after several dally exposures to drugs
    • Bégué JM, Koch P, Maurer G, Guillouzo A. Maintenance of the bio transformation capacity by cultured human hepatocytes after several dally exposures to drugs. Toxicol In Vitro 7:493-498 (1993).
    • (1993) Toxicol in Vitro , vol.7 , pp. 493-498
    • Bégué, J.M.1    Koch, P.2    Maurer, G.3    Guillouzo, A.4
  • 204
    • 0023681409 scopus 로고
    • Caffeine andtheophylline metabolism in newborn andadult human hepatocytes: Comparison with adult rat hepatocytes
    • Berthou F, Ratanasavanh D, Alix D, Carhlant D, Riché C, Guillouzo A. Caffeine andtheophylline metabolism in newborn andadult human hepatocytes: comparison with adult rat hepatocytes. Biochem Pharmacol 37:3691-3700 (1988).
    • (1988) Biochem Pharmacol , vol.37 , pp. 3691-3700
    • Berthou, F.1    Ratanasavanh, D.2    Alix, D.3    Carhlant, D.4    Riché, C.5    Guillouzo, A.6
  • 205
    • 0343305094 scopus 로고
    • Primary cultures of rat andhuman hepatocytes as a model system for the evaluation of cytotoxicity andmetabolic pathways of a new drug S-3341
    • Guillouzo A, ed. Paris:Les Editions INSERM and John Libbey Eurotext
    • Grislain L, Ratanasavanh D, Moquard MT, Raquillet L, Bégué JM, Du Vignaud P, Génissel P, Guillouzo A, Bromet N. Primary cultures of rat andhuman hepatocytes as a model system for the evaluation of cytotoxicity andmetabolic pathways of a new drug S-3341. In:Liver Cells and Drugs. Vol 164 (Guillouzo A, ed). Paris:Les Editions INSERM and John Libbey Eurotext, 1988;357-363.
    • (1988) Liver Cells and Drugs , vol.164 , pp. 357-363
    • Grislain, L.1    Ratanasavanh, D.2    Moquard, M.T.3    Raquillet, L.4    Bégué, J.M.5    Du Vignaud, P.6    Génissel, P.7    Guillouzo, A.8    Bromet, N.9
  • 206
    • 0025746296 scopus 로고
    • In vitro assessment of stereoselective hepatic metabolism of disopyramide in humans - Comparison with in vivo data
    • Le Corre P, Ratanasavanh D, Chevanne F, Gibassier D, Sado P, Le Verge R, Guillouzo A. In vitro assessment of stereoselective hepatic metabolism of disopyramide in humans - comparison with in vivo data. Chirality 3:405-411 (1991).
    • (1991) Chirality , vol.3 , pp. 405-411
    • Le Corre, P.1    Ratanasavanh, D.2    Chevanne, F.3    Gibassier, D.4    Sado, P.5    Le Verge, R.6    Guillouzo, A.7
  • 207
    • 0025134337 scopus 로고
    • Cyclosporin A drug interactions. Screening for inducers andinhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes andliver microsomes
    • Pichard L, Fabre I, Fabre G, Domergue J, Saint-Aubert B, Mourad G, Maurel P. Cyclosporin A drug interactions. Screening for inducers andinhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes andliver microsomes. Drug Metab Disp 18:595-606 (1990).
    • (1990) Drug Metab Disp , vol.18 , pp. 595-606
    • Pichard, L.1    Fabre, I.2    Fabre, G.3    Domergue, J.4    Saint-Aubert, B.5    Mourad, G.6    Maurel, P.7
  • 209
    • 2642623416 scopus 로고
    • Cultured human hepatocytes as a model system for man in pharmacotoxicological research
    • Dayan AD, Paine AJ eds. London:Taylor & Francis
    • Guillouzo A, Gripon P, Ratanasavanh D, Clement B, Guguen-Guillouzo C. Cultured human hepatocytes as a model system for man in pharmacotoxicological research. In:Advances in Applied Toxicology. Vol 1 (Dayan AD, Paine AJ eds). London:Taylor & Francis, 1988;77-103.
    • (1988) Advances in Applied Toxicology , vol.1 , pp. 77-103
    • Guillouzo, A.1    Gripon, P.2    Ratanasavanh, D.3    Clement, B.4    Guguen-Guillouzo, C.5
  • 210
    • 0021948060 scopus 로고
    • Erythromycin toxicity in primary cultures of rat hepatocytes
    • Villa P, Bégué JM, Guillouzo A. Erythromycin toxicity in primary cultures of rat hepatocytes. Xenobiotica 15:767-773 (1985).
    • (1985) Xenobiotica , vol.15 , pp. 767-773
    • Villa, P.1    Bégué, J.M.2    Guillouzo, A.3
  • 211
    • 0025138589 scopus 로고
    • Methylcholanthrene but not phenobarbital enhances caffeine andtheophylline metabolism in cultured adult human hepatocytes
    • Ratanasavanh D, Berthou F, Dreano Y, Mondine P, Guillouzo A, Riché C. Methylcholanthrene but not phenobarbital enhances caffeine andtheophylline metabolism in cultured adult human hepatocytes. Biochem Pharmacol 39:85-94 (1990).
    • (1990) Biochem Pharmacol , vol.39 , pp. 85-94
    • Ratanasavanh, D.1    Berthou, F.2    Dreano, Y.3    Mondine, P.4    Guillouzo, A.5    Riché, C.6
  • 213
    • 0018636340 scopus 로고
    • Calcium dependence of toxic death: A final common pathway
    • Schanne FA, Kane AB, Young EE, Farber JL. Calcium dependence of toxic death: a final common pathway. Science 206:700-702 (1979).
    • (1979) Science , vol.206 , pp. 700-702
    • Schanne, F.A.1    Kane, A.B.2    Young, E.E.3    Farber, J.L.4
  • 214
    • 0019813623 scopus 로고
    • Dependence of the carbon tetrachloride-induced cell death of cultured hepatocytes on the extracellular calcium concentration
    • Casini AF, Farber JL. Dependence of the carbon tetrachloride-induced cell death of cultured hepatocytes on the extracellular calcium concentration. Am J Pathol 105:138-148 (1981).
    • (1981) Am J Pathol , vol.105 , pp. 138-148
    • Casini, A.F.1    Farber, J.L.2
  • 215
    • 0019442134 scopus 로고
    • The effect of ionophore A 23187 andcalcium on carbon tetrachloride induced toxicity in cultured rat hepatocytes
    • Chenery RM, George M, Krishna G. The effect of ionophore A 23187 andcalcium on carbon tetrachloride induced toxicity in cultured rat hepatocytes. Toxicol Appl Pharmacol 60:241-252 (1981).
    • (1981) Toxicol Appl Pharmacol , vol.60 , pp. 241-252
    • Chenery, R.M.1    George, M.2    Krishna, G.3
  • 216
    • 0019830651 scopus 로고
    • Toxic injury to isolated hepatocytes is not dependent on extracellular calcium
    • Smith MT, Thor H, Orrienus S. Toxic injury to isolated hepatocytes is not dependent on extracellular calcium. Science 213:1257-1259 (1981).
    • (1981) Science , vol.213 , pp. 1257-1259
    • Smith, M.T.1    Thor, H.2    Orrienus, S.3
  • 217
    • 0019596801 scopus 로고
    • Deleterious effects of calcium deprivation on freshly isolated hepatocytes
    • Edmonson JW, Bang NO. Deleterious effects of calcium deprivation on freshly isolated hepatocytes. Am J Physiol 241:63-68 (1981).
    • (1981) Am J Physiol , vol.241 , pp. 63-68
    • Edmonson, J.W.1    Bang, N.O.2
  • 218
    • 0020044777 scopus 로고
    • Lack of protection against chemically induced injury to isolated hepatocytes by omission of calcium from the incubation medium
    • Stacey NH, Klaassen CJJ. Lack of protection against chemically induced injury to isolated hepatocytes by omission of calcium from the incubation medium. J Toxicol Environ Health 9:267-276 (1982).
    • (1982) J Toxicol Environ Health , vol.9 , pp. 267-276
    • Stacey, N.H.1    Klaassen, C.J.J.2
  • 219
    • 0025964030 scopus 로고
    • Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroxyperoxide
    • Sakaida I, Thomas AP, Farber JL. Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroxyperoxide. J Biol Chem 266:717-722 (1991).
    • (1991) J Biol Chem , vol.266 , pp. 717-722
    • Sakaida, I.1    Thomas, A.P.2    Farber, J.L.3
  • 220
    • 0027102507 scopus 로고
    • Level of cytosolic free calcium during acetaminophen toxicity in mouse hepatocytes
    • Harman AW, Mahar SO, Burcham PC, Madsen BW. Level of cytosolic free calcium during acetaminophen toxicity in mouse hepatocytes. Mol Pharmacol 41:665-670 (1992).
    • (1992) Mol Pharmacol , vol.41 , pp. 665-670
    • Harman, A.W.1    Mahar, S.O.2    Burcham, P.C.3    Madsen, B.W.4
  • 221
    • 0020382160 scopus 로고
    • The maintenance of cytochrome P-450 in liver cell culture: Recent studies on P-450-mediated mechanisms of toxicity
    • Paine AJ, Hockin LJ. The maintenance of cytochrome P-450 in liver cell culture: recent studies on P-450-mediated mechanisms of toxicity. Toxicology 25:41-45 (1982).
    • (1982) Toxicology , vol.25 , pp. 41-45
    • Paine, A.J.1    Hockin, L.J.2
  • 222
    • 0020393568 scopus 로고
    • In vitro comparative toxicity of selected drugs andchemicals in HeLa cells, Chang liver cells andrat hepatocytes
    • Ekwall B, Acosta D. In vitro comparative toxicity of selected drugs andchemicals in HeLa cells, Chang liver cells andrat hepatocytes. Drug Chem Toxicol 5:219-231 (1982).
    • (1982) Drug Chem Toxicol , vol.5 , pp. 219-231
    • Ekwall, B.1    Acosta, D.2
  • 223
    • 0018843441 scopus 로고
    • Evaluation of hepatocytes isolated by a nonperfusion technique in a prescreen for cytotoxicity
    • Tyson CA, Mitoma C, Kalivoda J. Evaluation of hepatocytes isolated by a nonperfusion technique in a prescreen for cytotoxicity. J Toxicol Environ Health 6:197-205 (1980).
    • (1980) J Toxicol Environ Health , vol.6 , pp. 197-205
    • Tyson, C.A.1    Mitoma, C.2    Kalivoda, J.3
  • 225
  • 226
    • 2642665298 scopus 로고
    • Use of hepatocytes for studies of mutagenesis andcarcinogenesis
    • Guillouzo A, Guguen-Guillouzo C, eds. Paris-. Les Editions INSERM and John Libbey, Eurotext
    • Michalopoulos GK, Strom SC, Jirtle RL. Use of hepatocytes for studies of mutagenesis andcarcinogenesis. In:Isolated and Cultured Hepatocytes (Guillouzo A, Guguen-Guillouzo C, eds). Paris-. Les Editions INSERM and John Libbey, Eurotext, 1986;333-352.
    • (1986) Isolated and Cultured Hepatocytes , pp. 333-352
    • Michalopoulos, G.K.1    Strom, S.C.2    Jirtle, R.L.3
  • 228
    • 0023394070 scopus 로고
    • Induction of sister chromatid exchanges in cultured adult rat hepatocytes by directly andindirectly acting mutagens/carcinogens
    • Eckl P, Strom SC, Michalopoulos G, Jirtle RL. Induction of sister chromatid exchanges in cultured adult rat hepatocytes by directly andindirectly acting mutagens/carcinogens. Carcinogenesis 8:1077-1083 (1987).
    • (1987) Carcinogenesis , vol.8 , pp. 1077-1083
    • Eckl, P.1    Strom, S.C.2    Michalopoulos, G.3    Jirtle, R.L.4
  • 229
    • 0022629183 scopus 로고
    • A study of the potential senotoxicity of cimetidine using human hepatocyte primary cultures: Discrepancy from results obtained in rat hepatocytes
    • Martelli A, Robbiano L, Ghia M, Giuliano L, Angelini G, Brambilla G. A study of the potential senotoxicity of cimetidine using human hepatocyte primary cultures: discrepancy from results obtained in rat hepatocytes. Cancer Lett 30:11-16 (1986).
    • (1986) Cancer Lett , vol.30 , pp. 11-16
    • Martelli, A.1    Robbiano, L.2    Ghia, M.3    Giuliano, L.4    Angelini, G.5    Brambilla, G.6
  • 231
    • 0007195970 scopus 로고
    • The detection of genotoxic chemicals in the hepatocyte primary culture:DNA repair test
    • Imui N, Kuruki T, Yamada MA, Heidelburger C, eds. Gann Monogr Cancer Res
    • Williams GM. The detection of genotoxic chemicals in the hepatocyte primary culture:DNA repair test. In: Mutation, Promotion and Transformation. Vol 21 (Imui N, Kuruki T, Yamada MA, Heidelburger C, eds). Gann Monogr Cancer Res 1981;47-57.
    • (1981) Mutation, Promotion and Transformation. , vol.21 , pp. 47-57
    • Williams, G.M.1
  • 232
    • 0020644897 scopus 로고
    • Genotoxic effects of 2-acetylaminofluorene on rat andhuman hepatocytes
    • Strom SC, Jirtle RL, Michalopoulos G. Genotoxic effects of 2-acetylaminofluorene on rat andhuman hepatocytes. Environ Health Perspect 49:165-170 (1983).
    • (1983) Environ Health Perspect , vol.49 , pp. 165-170
    • Strom, S.C.1    Jirtle, R.L.2    Michalopoulos, G.3
  • 233
    • 0010113957 scopus 로고
    • Induction of unscheduled DNA synthesis in primary cultures of hamster, rat, mouse andhuman hepatocytes
    • Steinmetz KL, Spak DK, Green CE, Mirsalis JC. Induction of unscheduled DNA synthesis in primary cultures of hamster, rat, mouse andhuman hepatocytes. [Abstract]. Toxicologist 5:20 (1985).
    • (1985) Toxicologist , vol.5 , pp. 20
    • Steinmetz, K.L.1    Spak, D.K.2    Green, C.E.3    Mirsalis, J.C.4
  • 235
    • 0021714817 scopus 로고
    • Metabolism of benzo[a]pyrene by cultured human hepatocytes from multiple donors
    • Moore CJ, Gould MN. Metabolism of benzo[a]pyrene by cultured human hepatocytes from multiple donors. Carcinogenesis 5:1577-1582 (1984).
    • (1984) Carcinogenesis , vol.5 , pp. 1577-1582
    • Moore, C.J.1    Gould, M.N.2
  • 236
    • 0023793673 scopus 로고
    • 1-induced cytotoxicity and protection by the nepatoprotective agent (+)-Cyanidanol-3
    • 1-induced cytotoxicity and protection by the nepatoprotective agent (+)-Cyanidanol-3. Biol Cell 63:327-333 (1988).
    • (1988) Biol Cell , vol.63 , pp. 327-333
    • Bégué, J.M.1    Baffet, G.2    Campion, J.P.3    Guillouzo, A.4
  • 237
    • 0021182748 scopus 로고
    • Antihepatotoxic actions of lignoids from Scnizandra chinesis fruits
    • Hikino H, Kiso Y, Taguchi H, Ikeya Y. Antihepatotoxic actions of lignoids from Scnizandra chinesis fruits. Planta Med 50:213-218 (1984).
    • (1984) Planta Med , vol.50 , pp. 213-218
    • Hikino, H.1    Kiso, Y.2    Taguchi, H.3    Ikeya, Y.4
  • 238
    • 24244450607 scopus 로고
    • Effects of malotilate on human andrat hepatocytes in short-term andlong-term primary culture
    • Guillouzo A, ed. Paris:Les Editions INSERM and John Libbey Eurotext
    • Clément B, Dumont JM, Ratanasavanh D, Latinier MF, Brissot P, Guillouzo A. Effects of malotilate on human andrat hepatocytes in short-term andlong-term primary culture. In:Liver Cells and Drugs. Vol 164 (Guillouzo A, ed). Paris:Les Editions INSERM and John Libbey Eurotext, 1988;417-421.
    • (1988) Liver Cells and Drugs , vol.164 , pp. 417-421
    • Clément, B.1    Dumont, J.M.2    Ratanasavanh, D.3    Latinier, M.F.4    Brissot, P.5    Guillouzo, A.6
  • 239
    • 0027404134 scopus 로고
    • The results of a randomized double blind controlled trial evaluating malotilate in primary biliary cirrhosis
    • European Multicentre Study Group. The results of a randomized double blind controlled trial evaluating malotilate in primary biliary cirrhosis. J Hepatol 17:277-235 (1993).
    • (1993) J Hepatol , vol.17 , pp. 277-1235
  • 241
    • 0030852501 scopus 로고    scopus 로고
    • Inhibition of cytochromes P-450 andinduction of elutathione S transferases by sulforaphane in primary human andrat hepatocytes
    • Mahéo K, Morel F, Langouet S, Kramer H, Le Ferrée E, Ketterer B, Guillouzo A. Inhibition of cytochromes P-450 andinduction of elutathione S transferases by sulforaphane in primary human andrat hepatocytes. Cancer Res 57:3649-3652 (1997).
    • (1997) Cancer Res , vol.57 , pp. 3649-3652
    • Mahéo, K.1    Morel, F.2    Langouet, S.3    Kramer, H.4    Le Ferrée, E.5    Ketterer, B.6    Guillouzo, A.7
  • 242
    • 0024549203 scopus 로고
    • Investigation into the mechanism of tetracycline-induced steatosis. Study in isolated hepatocytes
    • Deboyser D, Krack G, Roberfroid M. Investigation into the mechanism of tetracycline-induced steatosis. Study in isolated hepatocytes. Toxicol Appl Pharmacol 97:473-479 (1989).
    • (1989) Toxicol Appl Pharmacol , vol.97 , pp. 473-479
    • Deboyser, D.1    Krack, G.2    Roberfroid, M.3
  • 243
    • 0026590008 scopus 로고
    • Biochemical effects on methothrexate in isolated hepatocytes in relation to its steatogenic activity
    • Deboyser D, Goethals F, Roberfroid M. Biochemical effects on methothrexate in isolated hepatocytes in relation to its steatogenic activity. Biochem Pharmacol 6:129-132 (1992).
    • (1992) Biochem Pharmacol , vol.6 , pp. 129-132
    • Deboyser, D.1    Goethals, F.2    Roberfroid, M.3
  • 244
    • 0002980402 scopus 로고
    • Use of isolated andcultured hepatocytes in studies on bile formation
    • Guillouzo A, Guguen-Guillouzo C, eds. Paris:Les Editions INSERM and John Libbey Eurotext
    • Gebhardt R. Use of isolated andcultured hepatocytes in studies on bile formation. In:Isolated and Cultured Hepatocytes (Guillouzo A, Guguen-Guillouzo C, eds). Paris:Les Editions INSERM and John Libbey Eurotext, 1986;353-376.
    • (1986) Isolated and Cultured Hepatocytes , pp. 353-376
    • Gebhardt, R.1
  • 245
    • 0030881576 scopus 로고    scopus 로고
    • Isolated hepatocyte couplets andbile duct units. Novel preparations for the in vitro study of bile secretory function
    • Boyer JL. Isolated hepatocyte couplets andbile duct units. Novel preparations for the in vitro study of bile secretory function. Cell Biol Toxicol 13:289-300 (1997).
    • (1997) Cell Biol Toxicol , vol.13 , pp. 289-300
    • Boyer, J.L.1
  • 246
    • 0028150950 scopus 로고
    • Scanning laser cytometry: Alterations induced by cholestatic agents in isolated rat hepatocyte couplets
    • Thibault N. Scanning laser cytometry: alterations induced by cholestatic agents in isolated rat hepatocyte couplets. Cell Biol Toxicol 10:323-328 (1994).
    • (1994) Cell Biol Toxicol , vol.10 , pp. 323-328
    • Thibault, N.1
  • 247
    • 0021079659 scopus 로고
    • Mechanisms of bile formation andcholestasis
    • Boyer JL. Mechanisms of bile formation andcholestasis. Scand J Gastroenterol 18:51-56 (1978).
    • (1978) Scand J Gastroenterol , vol.18 , pp. 51-56
    • Boyer, J.L.1
  • 248
    • 0022348935 scopus 로고
    • Primary culture of rat hepatocytes as a model system of canalicular development, bilary secretion andbile canalicular ultrastructure induced by chlorpromazine
    • Jung W, Gebhardt R, Robenek H. Primary culture of rat hepatocytes as a model system of canalicular development, bilary secretion andbile canalicular ultrastructure induced by chlorpromazine. Virchows Arch (Cell Pathol) 49:349-363 (1985).
    • (1985) Virchows Arch (Cell Pathol) , vol.49 , pp. 349-363
    • Jung, W.1    Gebhardt, R.2    Robenek, H.3
  • 249
    • 0020031555 scopus 로고
    • Tauroursodeoxycholate prevents taurocholate-induced cholestasis
    • Kitani K, Kanai S Tauroursodeoxycholate prevents taurocholate-induced cholestasis. Life Sci 30:515-523 (1982).
    • (1982) Life Sci , vol.30 , pp. 515-523
    • Kitani, K.1    Kanai, S.2
  • 250
    • 0027398769 scopus 로고
    • Effect of bile acids on intracellular calcium in isolated rat hepatocyte couplets
    • Thibault N, Ballet F. Effect of bile acids on intracellular calcium in isolated rat hepatocyte couplets. Biochem Pharmacol 45:289-293 (1993).
    • (1993) Biochem Pharmacol , vol.45 , pp. 289-293
    • Thibault, N.1    Ballet, F.2
  • 251
    • 0023254528 scopus 로고
    • Amiodarone-induced lysosomal inclusions in primary cultures of human hepatocytes
    • Yap SH, Rijntjes PJM, Moshage HJ. Amiodarone-induced lysosomal inclusions in primary cultures of human hepatocytes, Gastroenrerology 92:272-273 (1987).
    • (1987) Gastroenrerology , vol.92 , pp. 272-273
    • Yap, S.H.1    Rijntjes, P.J.M.2    Moshage, H.J.3
  • 252
    • 0025096979 scopus 로고
    • Amiodarone- Anddesethylamiodarone-induced myelinoid inclusion bodies andtoxicity in cultured rat hepatocytes
    • Somani P, Bandyopadhyay S, Klaunig JE, Gross SA. Amiodarone- anddesethylamiodarone-induced myelinoid inclusion bodies andtoxicity in cultured rat hepatocytes. Hepatology 11:81-92 (1990).
    • (1990) Hepatology , vol.11 , pp. 81-92
    • Somani, P.1    Bandyopadhyay, S.2    Klaunig, J.E.3    Gross, S.A.4
  • 253
    • 2642686450 scopus 로고
    • Acute hepatocellular changes elicited by various antibiotics in the perfused liver andcultured hepatocytes from the rat
    • Guillouzo A, ed. Paris:Les Editions INSERM and John Libbey Eurotext
    • Ulrich R, Cox JW. Acute hepatocellular changes elicited by various antibiotics in the perfused liver andcultured hepatocytes from the rat. In:Liver Cells and Drugs. Vol 164 (Guillouzo A, ed). Paris:Les Editions INSERM and John Libbey Eurotext, 1988;391-396.
    • (1988) Liver Cells and Drugs. , vol.164 , pp. 391-396
    • Ulrich, R.1    Cox, J.W.2
  • 255
    • 0021220669 scopus 로고
    • Use of primary cultures of adult rat hepatocytes to investigate mechanisms of actions of nafenopin, a hepatocarcinogenic peroxisome proliferator
    • Bieri F, Bentley P, Waechter F, Staubli W. Use of primary cultures of adult rat hepatocytes to investigate mechanisms of actions of nafenopin, a hepatocarcinogenic peroxisome proliferator. Carcinogenesis 5:1033-1039 (1984).
    • (1984) Carcinogenesis , vol.5 , pp. 1033-1039
    • Bieri, F.1    Bentley, P.2    Waechter, F.3    Staubli, W.4
  • 257
  • 258
    • 0021345926 scopus 로고
    • N-acetyl-p-benzoquinone imine: A cytochrome P-450 product of acetamjnophen
    • Dahlin DC, Miwa GJ, Lu AYH, Nelson SD. N-acetyl-p-benzoquinone imine: a cytochrome P-450 product of acetamjnophen. Proc Natl Acad Sci USA 81:1327-1331 (1984).
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 1327-1331
    • Dahlin, D.C.1    Miwa, G.J.2    Lu, A.Y.H.3    Nelson, S.D.4
  • 259
    • 0023031916 scopus 로고
    • Freshly isolated hepatocytes as a model for studying the toxicity of paracetamol
    • Boobis AR, Tee LBG, Hamyden CE, Davies DS. Freshly isolated hepatocytes as a model for studying the toxicity of paracetamol. Food Chem Toxicol 24:731-736 (1986).
    • (1986) Food Chem Toxicol , vol.24 , pp. 731-736
    • Boobis, A.R.1    Tee, L.B.G.2    Hamyden, C.E.3    Davies, D.S.4
  • 260
    • 0024202767 scopus 로고
    • Immunochemical analysis or acetaminophen covalent binding to proteins. Partial characterization of the major acetaminophen binding liver proteins
    • Bartolome JB, Birge RB, Sparks K, Cohen SD, Khairalla EA. Immunochemical analysis or acetaminophen covalent binding to proteins. Partial characterization of the major acetaminophen binding liver proteins. Biochem Pharmacol 37:4763-4774 (1988).
    • (1988) Biochem Pharmacol , vol.37 , pp. 4763-4774
    • Bartolome, J.B.1    Birge, R.B.2    Sparks, K.3    Cohen, S.D.4    Khairalla, E.A.5
  • 261
    • 0023859021 scopus 로고
    • Biochemical evaluation of rat hepatocyte primary cultures as a model for carbon tetrachloride hepatotoxicity: Comparative studies in vivo and in vitro
    • Long RM, Moore L. Biochemical evaluation of rat hepatocyte primary cultures as a model for carbon tetrachloride hepatotoxicity: comparative studies in vivo and in vitro. Toxicol Appl Pharmacol 92:295-306 (1988).
    • (1988) Toxicol Appl Pharmacol , vol.92 , pp. 295-306
    • Long, R.M.1    Moore, L.2
  • 262
    • 0021969635 scopus 로고
    • Carbon tetrachloride induced inhibition of hepatocyte lipoprotein secretion: Functional impairment of Golgi apparatus in the early phases of such injury
    • Poli G, Chiarpotto E, Albano E, Cottalasso D, Nanni G, Marinari UM, Bassi AM, Dianzani MU. Carbon tetrachloride induced inhibition of hepatocyte lipoprotein secretion: functional impairment of Golgi apparatus in the early phases of such injury. Life Sci 36:533-539 (1984).
    • (1984) Life Sci , vol.36 , pp. 533-539
    • Poli, G.1    Chiarpotto, E.2    Albano, E.3    Cottalasso, D.4    Nanni, G.5    Marinari, U.M.6    Bassi, A.M.7    Dianzani, M.U.8
  • 263
    • 0020003996 scopus 로고
    • 4-induced lipid peroxidation in isolated rat hepatocytes with different oxygen concentrations
    • 4-induced lipid peroxidation in isolated rat hepatocytes with different oxygen concentrations. Toxicol Appl Pharmacol 62:421-427 (1982).
    • (1982) Toxicol Appl Pharmacol , vol.62 , pp. 421-427
    • Stacey, N.H.1    Ottenwalder, H.2    Kappus, H.3
  • 264
    • 77957180738 scopus 로고
    • Potentiation of chlorinated hydrocarbon toxicity by 2,5-hexanedione in primary cultures of adult rat hepatocytes
    • Jernigan JD, Pounds JG, Harbison RD. Potentiation of chlorinated hydrocarbon toxicity by 2,5-hexanedione in primary cultures of adult rat hepatocytes. Fundam Appl Toxicol 3:22-26 (1983).
    • (1983) Fundam Appl Toxicol , vol.3 , pp. 22-26
    • Jernigan, J.D.1    Pounds, J.G.2    Harbison, R.D.3
  • 265
    • 0021960659 scopus 로고
    • Isopropanol andchlordecone potentiation of carbon tetrachloride liver injury: Retention of potentiating action in hepatocyte suspensions prepared from rats given isopropanol or chlordecone
    • Glende EA, Lee PY. Isopropanol andchlordecone potentiation of carbon tetrachloride liver injury: retention of potentiating action in hepatocyte suspensions prepared from rats given isopropanol or chlordecone. Exp Mol Pathol 42:167-174 (1985).
    • (1985) Exp Mol Pathol , vol.42 , pp. 167-174
    • Glende, E.A.1    Lee, P.Y.2
  • 267
    • 0022560719 scopus 로고
    • 4-induced toxicity in isolated hepatocytes. the importance of direct solvent injury
    • 4-induced toxicity in isolated hepatocytes. The importance of direct solvent injury. Hepatology 36-45 (1986).
    • (1986) Hepatology , pp. 36-45
    • Berger, M.D.1    Bhatt, H.2    Combes, B.3    Estabrook, R.W.4
  • 268
    • 0023947169 scopus 로고
    • Comparative toxicity of halothane, isoflurane, hypoxia andphenobarbital induction in monolayer cultures of rat hepatocytes
    • Schieble TM, Costa AK, Heffel DF, Trudell JR. Comparative toxicity of halothane, isoflurane, hypoxia andphenobarbital induction in monolayer cultures of rat hepatocytes. Anesthesiology 68:485-494 (1988).
    • (1988) Anesthesiology , vol.68 , pp. 485-494
    • Schieble, T.M.1    Costa, A.K.2    Heffel, D.F.3    Trudell, J.R.4
  • 270
    • 0027136078 scopus 로고
    • Halothane-induced cytotoxicity to rat centrilobular hepatocytes in primary culture is not increased under low oxygen concentration
    • Wodey E, Fautrel A, Rissel M, Tanguy M, Guillouzo A, Mallédant Y. Halothane-induced cytotoxicity to rat centrilobular hepatocytes in primary culture is not increased under low oxygen concentration. Anesthesiology 79:1296-1303 (1993).
    • (1993) Anesthesiology , vol.79 , pp. 1296-1303
    • Wodey, E.1    Fautrel, A.2    Rissel, M.3    Tanguy, M.4    Guillouzo, A.5    Mallédant, Y.6
  • 272
    • 0021784546 scopus 로고
    • Characterization of halothane-induced antigens by immunoblotting
    • Kenna JG, Neuberger J, Williams R. Characterization of halothane-induced antigens by immunoblotting. Biochem Soc Trans 13:910-911 (1985).
    • (1985) Biochem Soc Trans , vol.13 , pp. 910-911
    • Kenna, J.G.1    Neuberger, J.2    Williams, R.3
  • 273
    • 0028030973 scopus 로고
    • Human hepatocytes express trifluoroacetylated neoantigens after in vitro exposure to halothane
    • Ilyin GP, Rissel M, Mallédant Y, Tanguy M, Guillouzo A. Human hepatocytes express trifluoroacetylated neoantigens after in vitro exposure to halothane. Biochem Pharmacol 48:561-567 (1994).
    • (1994) Biochem Pharmacol , vol.48 , pp. 561-567
    • Ilyin, G.P.1    Rissel, M.2    Mallédant, Y.3    Tanguy, M.4    Guillouzo, A.5
  • 274
    • 0029786269 scopus 로고    scopus 로고
    • Cytochrome P-450 2E1 is a cell surface antoantigen in halothane hepatitis
    • Eliasson E, Kenna JG. Cytochrome P-450 2E1 is a cell surface antoantigen in halothane hepatitis. Mol Pharmacol 50:573-582 (1996).
    • (1996) Mol Pharmacol , vol.50 , pp. 573-582
    • Eliasson, E.1    Kenna, J.G.2
  • 277
    • 0019436045 scopus 로고
    • Comparison of the effects of metals on cellular injury andlipid peroxidation in isolated rat hepatocytes
    • Stacey NH, Klaassen CD. Comparison of the effects of metals on cellular injury andlipid peroxidation in isolated rat hepatocytes. J Toxicol Environ Health 7:139-147 (1981).
    • (1981) J Toxicol Environ Health , vol.7 , pp. 139-147
    • Stacey, N.H.1    Klaassen, C.D.2
  • 278
    • 0027096724 scopus 로고
    • Cadmium-2-acetylaminofluorene interaction in isolated rat hepatocytes
    • Moffatt P, Michel M, Denizeau F. Cadmium-2-acetylaminofluorene interaction in isolated rat hepatocytes. Cell Biol Toxicol 8:277-290 (1992).
    • (1992) Cell Biol Toxicol , vol.8 , pp. 277-290
    • Moffatt, P.1    Michel, M.2    Denizeau, F.3
  • 279
    • 0019486533 scopus 로고
    • Interactions of metal ions with cadmium-induced cellular toxicity
    • Stacey NH, Klaassen CD. Interactions of metal ions with cadmium-induced cellular toxicity. J Toxicol Environ Health 7:149-158 (1981).
    • (1981) J Toxicol Environ Health , vol.7 , pp. 149-158
    • Stacey, N.H.1    Klaassen, C.D.2
  • 280
    • 0020034214 scopus 로고
    • Comparison of methods of assessment of metal-induced lipid peroxidation in isolated rat hepatocytes
    • Stacey NH, Kappus H. Comparison of methods of assessment of metal-induced lipid peroxidation in isolated rat hepatocytes. J Toxicol Environ Health 9:277-285 (1985).
    • (1985) J Toxicol Environ Health , vol.9 , pp. 277-285
    • Stacey, N.H.1    Kappus, H.2
  • 281
    • 0025290814 scopus 로고
    • Kinetic evaluation of free malondialdehyde andenzyme leakage as indices of iron damage in rat hepatocyte cultures: Involvement of free radicals
    • Morel I, Lescoat G, Cillard J, Pasdeloup N, Brissot P, Cillard P. Kinetic evaluation of free malondialdehyde andenzyme leakage as indices of iron damage in rat hepatocyte cultures: involvement of free radicals. Biochem Pharmacol 39:1647-1655 (1990).
    • (1990) Biochem Pharmacol , vol.39 , pp. 1647-1655
    • Morel, I.1    Lescoat, G.2    Cillard, J.3    Pasdeloup, N.4    Brissot, P.5    Cillard, P.6
  • 282
    • 0023811903 scopus 로고
    • Iron mobilization from hepatocyte monolayer cultures by chelators: The importance of membrane permeability and the iron-binding constant
    • Porter JB, Gyparaki M, Burke LC, Huehns ER, Sarpone P, Saez V, Hider RC. Iron mobilization from hepatocyte monolayer cultures by chelators: the importance of membrane permeability and the iron-binding constant. Blood 72:1497-1503 (1988).
    • (1988) Blood , vol.72 , pp. 1497-1503
    • Porter, J.B.1    Gyparaki, M.2    Burke, L.C.3    Huehns, E.R.4    Sarpone, P.5    Saez, V.6    Hider, R.C.7
  • 284
    • 0026562611 scopus 로고
    • Inhibition of iron overload toxicity in rat hepatocyte cultures by pyoverdin Pf, the siderophore of Pseudomonas fluorescent
    • Jego P, Hubert N, Morel I, Pasdeloup N, Ocaktan A, Abdallah M, Brissot P, Lescoat G. Inhibition of iron overload toxicity in rat hepatocyte cultures by pyoverdin Pf, the siderophore of Pseudomonas fluorescent. Biochem Pharmacol 43:1275-1280 (1992).
    • (1992) Biochem Pharmacol , vol.43 , pp. 1275-1280
    • Jego, P.1    Hubert, N.2    Morel, I.3    Pasdeloup, N.4    Ocaktan, A.5    Abdallah, M.6    Brissot, P.7    Lescoat, G.8
  • 285
    • 0006462474 scopus 로고    scopus 로고
    • Experimental in vitro models to evaluate hepatotoxicity
    • Castell JV, Gomez-Lechon MJ, eds. San Diego, CA:Academic Press
    • Vickers AEM. Experimental in vitro models to evaluate hepatotoxicity. In:In Vitro Methods in Pharmaceutical Research (Castell JV, Gomez-Lechon MJ, eds). San Diego, CA:Academic Press, 1997;103-127.
    • (1997) In Vitro Methods in Pharmaceutical Research , pp. 103-127
    • Vickers, A.E.M.1
  • 286
    • 2642628535 scopus 로고
    • Hépatotoxicité in vitro
    • Adolphe M, Guillouzo A, Marano F, eds. Paris:Les Editions INSERM
    • Guillouzo A. Hépatotoxicité in vitro. In:Toxicologie Cellulaire in vitro (Adolphe M, Guillouzo A, Marano F, eds). Paris:Les Editions INSERM, 1995;69-120.
    • (1995) Toxicologie Cellulaire in Vitro , pp. 69-120
    • Guillouzo, A.1
  • 287
    • 0001371769 scopus 로고    scopus 로고
    • In vitro investigation of the molecular mechanisms of hepatotoxicity
    • Castell JV, Gomez-Lechon MJ, eds. San Diego, CA:Academic Press
    • Castell JV, Gomez-Lechon MJ, Ponsoda X, Bort R. In vitro investigation of the molecular mechanisms of hepatotoxicity. In:In vitro Methods in Pharmaceutical Research (Castell JV, Gomez-Lechon MJ, eds). San Diego, CA:Academic Press, 1997;376-410.
    • (1997) In Vitro Methods in Pharmaceutical Research , pp. 376-410
    • Castell, J.V.1    Gomez-Lechon, M.J.2    Ponsoda, X.3    Bort, R.4
  • 290
    • 0023945227 scopus 로고
    • Immortalized differentiated hepatocyte lines derived from transgenic mice harboring SV40 T-antigen genes
    • Paul D, Höhne M, Pinkert C, Piasecki A, Ummelmann E, Brinster R. Immortalized differentiated hepatocyte lines derived from transgenic mice harboring SV40 T-antigen genes. Exp Cell Res 175:354-362 (1988).
    • (1988) Exp Cell Res , vol.175 , pp. 354-362
    • Paul, D.1    Höhne, M.2    Pinkert, C.3    Piasecki, A.4    Ummelmann, E.5    Brinster, R.6
  • 291
    • 0025183819 scopus 로고
    • Validation of alternative toxicity tests: Principles, practices and cases
    • Clothier RH, Balls M. Validation of alternative toxicity tests: principles, practices and cases. Toxicol In Vitro 4:692-693 (1990).
    • (1990) Toxicol in Vitro , vol.4 , pp. 692-693
    • Clothier, R.H.1    Balls, M.2
  • 292
    • 0029884296 scopus 로고    scopus 로고
    • Perifusion of co-cultured hepatocytes: Optimization of studies on drug metabolism and cytotoxicity in vitro
    • Gebhardt R, Wegner H, Alber J. Perifusion of co-cultured hepatocytes: optimization of studies on drug metabolism and cytotoxicity in vitro. Cell Biol Toxicol 12:57-68 (1996).
    • (1996) Cell Biol Toxicol , vol.12 , pp. 57-68
    • Gebhardt, R.1    Wegner, H.2    Alber, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.