Cryopreserved human hepatocytes: Characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential

Chemico-Biological Interactions

Volumn 121, Issue 1, 1999, Pages 17-35

  Li, Albert P ^a   Lu, Chuang ^a   Brent, Julie A ^a   Pham, Chuong ^a   Fackett, Andrew ^a   Ruegg, Charles E ^a   Silber, Paul M ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

Cryopreservation; Cytochromes P450; Cytotoxicity; Drug interactions; Drug metabolism; Drug drug interactions; Hepatocytes; Hepatotoxicity; High throughput screening; Human; Human hepatocytes; In vitro; Monkey hepatocytes; Mouse hepatocytes; Rabbit hepatocytes; Rat hepatocytes; Species differences; Sulfotransferase; UDP glucuronyltransferase

Indexed keywords

7 ETHOXYCOUMARIN; AMIODARONE; CADMIUM; CLOZAPINE; CYTOCHROME P450 ISOENZYME; DEBRISOQUINE 4 HYDROXYLASE; DEXTROMETHORPHAN; DICLOFENAC; DIETHYLDITHIOCARBAMIC ACID; FURAFYLLINE; GLUCURONOSYLTRANSFERASE; KETOCONAZOLE; PHENACETIN O DEETHYLASE; QUINIDINE; SULFAPHENAZOLE; SULFOTRANSFERASE; TAMOXIFEN; THIOURACIL; TRANYLCYPROMINE;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CRYOPRESERVATION; CYTOTOXICITY; DOG; DOSE RESPONSE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; MALE; MONKEY; NONHUMAN; RABBIT; RAT; SPECIES DIFFERENCE; STORAGE;

ADULT; AGED; ANIMALS; CELL SURVIVAL; CRYOPRESERVATION; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; ENZYME STABILITY; FORMAZANS; HUMANS; LIVER; MACACA FASCICULARIS; MALE; MIDDLE AGED; ORGAN PRESERVATION; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; TETRAZOLIUM SALTS; TOXICITY TESTS;

ANIMALIA; CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS;

EID: 0032968777     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(99)00088-5     Document Type: Article

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