Primary rat hepatocytes as in vitro system for gene expression studies: Comparison of sandwich, Matrigel and 2D cultures

Archives of Toxicology

Volumn 82, Issue 12, 2008, Pages 923-931

  Schug, M ^a   Heise, T ^b   Bauer, A ^a   Storm, D ^b   Blaszkewicz, M ^a   Bedawy, E ^a   Brulport, M ^a   Geppert, B ^a   Hermes, M ^a   Follmann W ^a   Rapp, K ^a   MacCoux, L ^a   Schormann, W ^a   Appel, K E ^b   Oberemm, A ^b   Gundert Remy, U ^b   Hengstler, J G ^a  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^b FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

In vitro system; Methapyrilene; Nongenotoxic carcinogen; Primary rat hepatocytes; Sandwich culture; Toxicogenomics

Indexed keywords

ANTIHISTAMINIC AGENT; CARCINOGEN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; MATRIGEL; METHAPYRILENE; PROTEIN ABAT; PROTEIN GSK3B; PROTEIN MYD116; PROTEIN SULTLA1; UNCLASSIFIED DRUG; ARYL SULFOTRANSFERASE; COLLAGEN; DIFFERENTIATION ANTIGEN; LAMININ; MYD116 PROTEIN, RAT; ONCOPROTEIN; PROTEOGLYCAN; REPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; GENE EXPRESSION; GENETIC ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD; CELL CULTURE; COMPARATIVE STUDY; CULTURE MEDIUM; CULTURE TECHNIQUE; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECT; ENZYMOLOGY; EXTRACELLULAR MATRIX; METABOLISM; METHODOLOGY; TIME; TOXICOGENETICS; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

ANIMALS; ANTIGENS, DIFFERENTIATION; ARYLSULFOTRANSFERASE; CARCINOGENS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; COLLAGEN; CULTURE MEDIA, SERUM-FREE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; EXTRACELLULAR MATRIX; GENE EXPRESSION; HEPATOCYTES; LAMININ; MALE; METHAPYRILENE; PROTEOGLYCANS; PROTO-ONCOGENE PROTEINS; RATS; RATS, WISTAR; REPRESSOR PROTEINS; TIME FACTORS; TOXICOGENETICS;

EID: 59849100943     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0375-x     Document Type: Article

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