Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

Biochemical Pharmacology

Volumn 78, Issue 6, 2009, Pages 625-632

  Chao, P ^a   Maguire, T ^a   Novik, E ^a   Cheng, K C ^b   Yarmush, M L ^c  

^a Hurel Corporation   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

Hepatic clearance; Human hepatocyte; Microfluidic

Indexed keywords

BUSPIRONE; CAFFEINE; CARBAMAZEPINE; IMIPRAMINE; SILDENAFIL; TIMOLOL;

AREA UNDER THE CURVE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CRYOPRESERVATION; DRUG CLEARANCE; FEASIBILITY STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER CLEARANCE; MICROFLUIDIC ANALYSIS; MICROFLUIDICS; PREDICTION; PRIORITY JOURNAL;

ANIMALS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; HEPATOCYTES; HUMANS; LIVER; METABOLIC CLEARANCE RATE; MICROFLUIDICS; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS;

EID: 67749115964     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.05.013     Document Type: Article

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