Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 301, Issue 1, 2011, Pages

  Olsen, Abby L ^a,c   Bloomer, Steven A ^a   Chan, Erick P ^a   Gaça, Marianna D A ^a   Georges, Penelope C ^c,d   Sackey, Bridget ^c   Uemura, Masayuki ^a   Janmey, Paul A ^a,c,d   Wells, Rebecca G ^a,b,c,d  

^a Department of Medicine ^*  (United States)

^b Laboratory Medicine   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Liver fibrosis; Matrigel; Matrix stiffness; Myofibroblast; Transforming growth factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; MATRIGEL; MATRIX PROTEIN; NPC 34016; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; DISEASE COURSE; EXTRACELLULAR MATRIX; GENE EXPRESSION; IMMUNOFLUORESCENCE; LIVER FIBROSIS; LIVER STIFFNESS; MALE; MATERIAL COATING; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; RIGIDITY; STELLATE CELL;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN; DRUG COMBINATIONS; EXTRACELLULAR MATRIX; HEPATIC STELLATE CELLS; LAMININ; LIVER CIRRHOSIS; MALE; MYOFIBROBLASTS; POLYLYSINE; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; TRANSFORMING GROWTH FACTOR BETA;

EID: 79959893918     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00412.2010     Document Type: Article

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