Fluorometric assessment of acetaminophen-induced toxicity in rat hepatocyte spheroids seeded on micro-space cell culture plates

Toxicology in Vitro

Volumn 28, Issue 6, 2014, Pages 1176-1182

  Sanoh, Seigo ^a   Santoh, Masataka ^a   Takagi, Masashi ^b   Kanayama, Tatsuya ^a   Sugihara, Kazumi ^c   Kotake, Yaichiro ^a   Ejiri, Yoko ^d   Horie, Toru ^e   Kitamura, Shigeyuki ^f   Ohta, Shigeru ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

^d KURARAY CO LTD   (Japan)

^e D Three Research Laboratories   (Japan)

^f NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Acetaminophen; Hepatocytes; Imaging; Micro space cell culture plate; Spheroids

Indexed keywords

1 AMINOBENZOTRIAZOLE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2C6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 2B1; GLUTATHIONE; MESSENGER RNA; PARACETAMOL; SULFOTRANSFERASE 1A1; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; ARYL SULFOTRANSFERASE; GLUCURONOSYLTRANSFERASE; SULT1A1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL LEVEL; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; FLUORESCENCE; INFANT; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER TOXICITY; METABOLIC ACTIVATION; METABOLITE; MICRO SPACE CELL CULTURE; MICROFLUOROMETRY; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT; SPHEROID TOXICITY; TANDEM MASS SPECTROMETRY; ANIMAL; DRUG EFFECTS; FLUOROMETRY; GENETICS; METABOLISM; MULTICELLULAR SPHEROID; TOXICITY;

ACETAMINOPHEN; ADENOSINE TRIPHOSPHATE; ANIMALS; ARYLSULFOTRANSFERASE; CYTOCHROME P-450 ENZYME SYSTEM; FLUOROMETRY; GLUCURONOSYLTRANSFERASE; GLUTATHIONE; HEPATOCYTES; RATS; RNA, MESSENGER; SPHEROIDS, CELLULAR;

EID: 84903188498     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.05.007     Document Type: Article

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