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Volumn 9, Issue 1, 2014, Pages 16-27

Physiologically relevant organs on chips

Author keywords

Microengineering; Microfluidics; Organs on chips; Physiologically relevant microenvironment; Tissue engineering

Indexed keywords

BIOCHEMICAL STIMULI; HUMAN DISEASE MODELS; MICRO-ENGINEERING; MICROENVIRONMENTS; MICROFLUIDIC CELL CULTURE; ORGANS-ON-CHIPS; PHARMACEUTICAL RESEARCH; PHYSIOLOGICAL SYSTEMS;

EID: 84891930814     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201300187     Document Type: Article
Times cited : (107)

References (106)
  • 1
    • 0028998479 scopus 로고
    • A cell culture analogue of rodent physiology: Application to naphthalene toxicology.
    • Sweeney, L. M., Shuler, M. L., Babish, J. G., Ghanem, A., A cell culture analogue of rodent physiology: Application to naphthalene toxicology. Toxicol. In Vitro 1995, 9, 307-316.
    • (1995) Toxicol. In Vitro , vol.9 , pp. 307-316
    • Sweeney, L.M.1    Shuler, M.L.2    Babish, J.G.3    Ghanem, A.4
  • 2
    • 0030571207 scopus 로고    scopus 로고
    • A self-regulating cell culture analog device to mimic animal and human toxicological responses.
    • Shuler, M. L., Ghanem, A., Quick, D., Wong, M. C. et al., A self-regulating cell culture analog device to mimic animal and human toxicological responses. Biotechnol. Bioeng. 1996, 52, 45-60.
    • (1996) Biotechnol. Bioeng. , vol.52 , pp. 45-60
    • Shuler, M.L.1    Ghanem, A.2    Quick, D.3    Wong, M.C.4
  • 3
    • 0037357723 scopus 로고    scopus 로고
    • Integration of cell culture and microfabrication technology.
    • Park, T. H., Shuler, M. L., Integration of cell culture and microfabrication technology. Biotechnol. Prog. 2003, 19, 243-253.
    • (2003) Biotechnol. Prog. , vol.19 , pp. 243-253
    • Park, T.H.1    Shuler, M.L.2
  • 4
    • 54349096920 scopus 로고    scopus 로고
    • Cell culture models in microfluidic systems.
    • Meyvantsson, I., Beebe, D. J., Cell culture models in microfluidic systems. Annu. Rev. Anal. Chem. 2008, 1, 423-449.
    • (2008) Annu. Rev. Anal. Chem. , vol.1 , pp. 423-449
    • Meyvantsson, I.1    Beebe, D.J.2
  • 5
    • 84860481842 scopus 로고    scopus 로고
    • Organs-on-chips: Breaking the in vitro impasse.
    • van der Meer, A. D., Berg, A. v. d., Organs-on-chips: Breaking the in vitro impasse. Integr. Biol. 2012, 4, 461-470.
    • (2012) Integr. Biol. , vol.4 , pp. 461-470
    • van der Meer, A.D.1    Berg, A.v.d.2
  • 6
    • 79960527448 scopus 로고    scopus 로고
    • The role of body-on-a-chip devices in drug and toxicity studies.
    • Esch, M. B., King, T. L., Shuler, M. L., The role of body-on-a-chip devices in drug and toxicity studies. Annu. Rev. Biomed. Eng. 2011, 13, 55-72.
    • (2011) Annu. Rev. Biomed. Eng. , vol.13 , pp. 55-72
    • Esch, M.B.1    King, T.L.2    Shuler, M.L.3
  • 7
    • 84864559173 scopus 로고    scopus 로고
    • Modeling life.
    • Shuler, M., Modeling life. Ann. Biomed. Eng. 2012, 40, 1399-1407.
    • (2012) Ann. Biomed. Eng. , vol.40 , pp. 1399-1407
    • Shuler, M.1
  • 8
    • 84862140907 scopus 로고    scopus 로고
    • Microtechnology for mimicking in vivo tissue environment.
    • Sung, J., Shuler, M., Microtechnology for mimicking in vivo tissue environment. Ann. Biomed. Eng. 2012, 40, 1289-1300.
    • (2012) Ann. Biomed. Eng. , vol.40 , pp. 1289-1300
    • Sung, J.1    Shuler, M.2
  • 9
    • 81355146382 scopus 로고    scopus 로고
    • From 3D cell culture to organs-on-chips.
    • Huh, D., Hamilton, G. A., Ingber, D. E., From 3D cell culture to organs-on-chips. Trends Cell Biol. 2011, 21, 745-754.
    • (2011) Trends Cell Biol. , vol.21 , pp. 745-754
    • Huh, D.1    Hamilton, G.A.2    Ingber, D.E.3
  • 11
    • 34648834682 scopus 로고    scopus 로고
    • The third dimension bridges the gap between cell culture and live tissue.
    • Pampaloni, F., Reynaud, E. G., Stelzer, E. H. K., The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell Biol. 2007, 8, 839-845.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 839-845
    • Pampaloni, F.1    Reynaud, E.G.2    Stelzer, E.H.K.3
  • 12
    • 84862186471 scopus 로고    scopus 로고
    • Microengineered physiological biomimicry: Organs-on-chips.
    • Huh, D., Torisawa, Y.-S., Hamilton, G. A., Kim, H. J. et al., Microengineered physiological biomimicry: Organs-on-chips. Lab Chip 2012, 12, 2156-2164.
    • (2012) Lab Chip , vol.12 , pp. 2156-2164
    • Huh, D.1    Torisawa, Y.-S.2    Hamilton, G.A.3    Kim, H.J.4
  • 15
    • 33747117373 scopus 로고    scopus 로고
    • The origins and the future of microfluidics.
    • Whitesides, G. M., The origins and the future of microfluidics. Nature 2006, 442, 368-373.
    • (2006) Nature , vol.442 , pp. 368-373
    • Whitesides, G.M.1
  • 17
    • 0030953763 scopus 로고    scopus 로고
    • Geometric control of cell life and death.
    • Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M. et al., Geometric control of cell life and death. Science 1997, 276, 1425-1428.
    • (1997) Science , vol.276 , pp. 1425-1428
    • Chen, C.S.1    Mrksich, M.2    Huang, S.3    Whitesides, G.M.4
  • 18
    • 0034578083 scopus 로고    scopus 로고
    • Microengineering of cellular interactions.
    • Folch, A., Toner, M., Microengineering of cellular interactions. Annu. Rev. Biomed. Eng. 2000, 2, 227-256.
    • (2000) Annu. Rev. Biomed. Eng. , vol.2 , pp. 227-256
    • Folch, A.1    Toner, M.2
  • 19
    • 35748941950 scopus 로고    scopus 로고
    • Microfluidic scaffolds for tissue engineering.
    • Choi, N. W., Cabodi, M., Held, B., Gleghorn, J. P. et al., Microfluidic scaffolds for tissue engineering. Nat. Mater. 2007, 6, 908-915.
    • (2007) Nat. Mater. , vol.6 , pp. 908-915
    • Choi, N.W.1    Cabodi, M.2    Held, B.3    Gleghorn, J.P.4
  • 20
    • 84888094853 scopus 로고    scopus 로고
    • Vascularized perfused microtissue/micro-organ arrays
    • US Patent 6197575
    • Griffith, L. G., Tannenbaum, S., Powers, M. J., Domansky, K. et al. Vascularized perfused microtissue/micro-organ arrays. US Patent 6197575, 2001.
    • (2001)
    • Griffith, L.G.1    Tannenbaum, S.2    Powers, M.J.3    Domansky, K.4
  • 22
    • 0035768206 scopus 로고    scopus 로고
    • Sin, A., Baxter, G. T., Shuler, M. L., Animal on a chip: A microscale cell culture analog device for evaluating toxicological and pharmacological profiles. Proc. SPIE-Int. Soc. Opt. Eng. 2001, 4560, 98-101.
    • Sin, A., Baxter, G. T., Shuler, M. L., Animal on a chip: A microscale cell culture analog device for evaluating toxicological and pharmacological profiles. Proc. SPIE-Int. Soc. Opt. Eng. 2001, 4560, 98-101.
  • 23
    • 1142293800 scopus 로고    scopus 로고
    • The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors.
    • Sin, A., Chin, K. C., Jamil, M. F., Kostov, Y. et al., The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors. Biotechnol. Prog. 2004, 20, 338-345.
    • (2004) Biotechnol. Prog. , vol.20 , pp. 338-345
    • Sin, A.1    Chin, K.C.2    Jamil, M.F.3    Kostov, Y.4
  • 24
    • 12144263348 scopus 로고    scopus 로고
    • Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays.
    • Hung, P. J., Lee, P. J., Sabounchi, P., Lin, R. et al., Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays. Biotechnol. Bioeng. 2005, 89, 1-8.
    • (2005) Biotechnol. Bioeng. , vol.89 , pp. 1-8
    • Hung, P.J.1    Lee, P.J.2    Sabounchi, P.3    Lin, R.4
  • 25
    • 34547581758 scopus 로고    scopus 로고
    • An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture.
    • Lee, P. J., Hung, P. J., Lee, L. P., An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture. Biotechnol. Bioeng. 2007, 97, 1340-1346.
    • (2007) Biotechnol. Bioeng. , vol.97 , pp. 1340-1346
    • Lee, P.J.1    Hung, P.J.2    Lee, L.P.3
  • 26
    • 77954038080 scopus 로고    scopus 로고
    • Reconstituting organ-level lung functions on a chip.
    • Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M. et al., Reconstituting organ-level lung functions on a chip. Science 2010, 328, 1662-1668.
    • (2010) Science , vol.328 , pp. 1662-1668
    • Huh, D.1    Matthews, B.D.2    Mammoto, A.3    Montoya-Zavala, M.4
  • 27
    • 0041695170 scopus 로고    scopus 로고
    • Cell culture in 3-dimensional microfluidic structure of PDMS (polydimethylsiloxane).
    • Leclerc, E., Sakai, Y., Fujii, T., Cell culture in 3-dimensional microfluidic structure of PDMS (polydimethylsiloxane). Biomed. Microdevices 2003, 5, 109-114.
    • (2003) Biomed. Microdevices , vol.5 , pp. 109-114
    • Leclerc, E.1    Sakai, Y.2    Fujii, T.3
  • 28
    • 3042614049 scopus 로고    scopus 로고
    • Perfusion culture of fetal human hepatocytes in microfluidic environments.
    • Leclerc, E., Sakai, Y., Fujii, T., Perfusion culture of fetal human hepatocytes in microfluidic environments. Biochem. Eng. J. 2004, 20, 143-148.
    • (2004) Biochem. Eng. J. , vol.20 , pp. 143-148
    • Leclerc, E.1    Sakai, Y.2    Fujii, T.3
  • 29
    • 2942709867 scopus 로고    scopus 로고
    • Microfluidic PDMS (polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes.
    • Leclerc, E., Sakai, Y., Fujii, T., Microfluidic PDMS (polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes. Biotechnol. Prog. 2004, 20, 750-755.
    • (2004) Biotechnol. Prog. , vol.20 , pp. 750-755
    • Leclerc, E.1    Sakai, Y.2    Fujii, T.3
  • 30
    • 78650334218 scopus 로고    scopus 로고
    • Microenvironment array chip for cell culture environment screening.
    • Hattori, K., Sugiura, S., Kanamori, T., Microenvironment array chip for cell culture environment screening. Lab Chip 2011, 11, 212-214.
    • (2011) Lab Chip , vol.11 , pp. 212-214
    • Hattori, K.1    Sugiura, S.2    Kanamori, T.3
  • 31
    • 37349067768 scopus 로고    scopus 로고
    • Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments.
    • King, K. R., Wang, S., Jayaraman, A., Yarmush, M. L. et al., Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments. Lab Chip 2008, 8, 107-116.
    • (2008) Lab Chip , vol.8 , pp. 107-116
    • King, K.R.1    Wang, S.2    Jayaraman, A.3    Yarmush, M.L.4
  • 32
    • 84868204184 scopus 로고    scopus 로고
    • Biomimetic perfusion and electrical stimulation applied in concert improved the assembly of engineered cardiac tissue.
    • Maidhof, R., Tandon, N., Lee, E. J., Luo, J. et al., Biomimetic perfusion and electrical stimulation applied in concert improved the assembly of engineered cardiac tissue. J. Tissue Eng. Regenerative Med. 2012, 6, e12-e23.
    • (2012) J. Tissue Eng. Regenerative Med. , vol.6
    • Maidhof, R.1    Tandon, N.2    Lee, E.J.3    Luo, J.4
  • 33
    • 73149086151 scopus 로고    scopus 로고
    • Macro- and microscale fluid flow systems for endothelial cell biology.
    • Young, E. W. K., Simmons, C. A., Macro- and microscale fluid flow systems for endothelial cell biology. Lab Chip 2010, 10, 143-160.
    • (2010) Lab Chip , vol.10 , pp. 143-160
    • Young, E.W.K.1    Simmons, C.A.2
  • 34
    • 80053086676 scopus 로고    scopus 로고
    • Fluid forces control endothelial sprouting.
    • Song, J. W., Munn, L. L., Fluid forces control endothelial sprouting. Proc. Natl. Acad. Sci. USA 2011, 108, 15342-15347.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 15342-15347
    • Song, J.W.1    Munn, L.L.2
  • 35
    • 4544288097 scopus 로고    scopus 로고
    • Microfluidic shear devices for quantitative analysis of cell adhesion.
    • Lu, H., Koo, L. Y., Wang, W. M., Lauffenburger, D. A. et al., Microfluidic shear devices for quantitative analysis of cell adhesion. Anal. Chem. 2004, 76, 5257-5264.
    • (2004) Anal. Chem. , vol.76 , pp. 5257-5264
    • Lu, H.1    Koo, L.Y.2    Wang, W.M.3    Lauffenburger, D.A.4
  • 36
    • 9144257910 scopus 로고    scopus 로고
    • Endothelialized networks with a vascular geometry in microfabricated poly(dimethyl siloxane).
    • Shin, M., Matsuda, K., Ishii, O., Terai, H. et al., Endothelialized networks with a vascular geometry in microfabricated poly(dimethyl siloxane). Biomed. Microdevices 2004, 6, 269-278.
    • (2004) Biomed. Microdevices , vol.6 , pp. 269-278
    • Shin, M.1    Matsuda, K.2    Ishii, O.3    Terai, H.4
  • 37
    • 21644489338 scopus 로고    scopus 로고
    • Computer-controlled microcirculatory support system for endothelial cell culture and shearing.
    • Song, J. W., Gu, W., Futai, N., Warner, K. A. et al., Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal. Chem. 2005, 77, 3993-3999.
    • (2005) Anal. Chem. , vol.77 , pp. 3993-3999
    • Song, J.W.1    Gu, W.2    Futai, N.3    Warner, K.A.4
  • 38
    • 33644648070 scopus 로고    scopus 로고
    • Microfluidic arrays for logarithmically perfused embryonic stem cell culture.
    • Kim, L., Vahey, M. D., Lee, H.-Y., Voldman, J., Microfluidic arrays for logarithmically perfused embryonic stem cell culture. Lab Chip 2006, 6, 394-406.
    • (2006) Lab Chip , vol.6 , pp. 394-406
    • Kim, L.1    Vahey, M.D.2    Lee, H.-Y.3    Voldman, J.4
  • 39
    • 80052487439 scopus 로고    scopus 로고
    • Shear stress regulates adhesion and rolling of CD44+ leukemic and hematopoietic progenitor cells on hyaluronan.
    • Christophis, C., Taubert, I., Meseck, Georg R., Schubert, M. et al., Shear stress regulates adhesion and rolling of CD44+ leukemic and hematopoietic progenitor cells on hyaluronan. Biophys. J. 2011, 101, 585-593.
    • (2011) Biophys. J. , vol.101 , pp. 585-593
    • Christophis, C.1    Taubert, I.2    Meseck, G.R.3    Schubert, M.4
  • 41
    • 37649009647 scopus 로고    scopus 로고
    • Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems.
    • Huh, D., Fujioka, H., Tung, Y.-C., Futai, N. et al., Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems. Proc. Natl. Acad. Sci. USA 2007, 104, 18886-18891.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 18886-18891
    • Huh, D.1    Fujioka, H.2    Tung, Y.-C.3    Futai, N.4
  • 42
    • 77951884924 scopus 로고    scopus 로고
    • A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells.
    • Jang, K.-J., Suh, K.-Y., A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab Chip 2010, 10, 36-42.
    • (2010) Lab Chip , vol.10 , pp. 36-42
    • Jang, K.-J.1    Suh, K.-Y.2
  • 43
    • 79951474125 scopus 로고    scopus 로고
    • Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells.
    • Jang, K.-J., Cho, H. S., Kang, D. H., Bae, W. G. et al., Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells. Integr. Biol. 2011, 3, 134-141.
    • (2011) Integr. Biol. , vol.3 , pp. 134-141
    • Jang, K.-J.1    Cho, H.S.2    Kang, D.H.3    Bae, W.G.4
  • 44
    • 79551635268 scopus 로고    scopus 로고
    • Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model.
    • Douville, N. J., Zamankhan, P., Tung, Y.-C., Li, R. et al., Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model. Lab Chip 2011, 11, 609-619.
    • (2011) Lab Chip , vol.11 , pp. 609-619
    • Douville, N.J.1    Zamankhan, P.2    Tung, Y.-C.3    Li, R.4
  • 46
    • 0033837424 scopus 로고    scopus 로고
    • Deformation-induced injury of alveolar epithelial cells: Effect of frequency, duration, and amplitude.
    • Tschumperlin, D. J., Oswari, J., Margulies, S. S., Deformation-induced injury of alveolar epithelial cells: Effect of frequency, duration, and amplitude. Am. J. Respir. Crit. Care Med. 2000, 162, 357-362.
    • (2000) Am. J. Respir. Crit. Care Med. , vol.162 , pp. 357-362
    • Tschumperlin, D.J.1    Oswari, J.2    Margulies, S.S.3
  • 47
    • 0037308661 scopus 로고    scopus 로고
    • Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening.
    • Bilek, A. M., Dee, K. C., Gaver, D. P., Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening. J. Appl. Physiol. 2003, 94, 770-783.
    • (2003) J. Appl. Physiol. , vol.94 , pp. 770-783
    • Bilek, A.M.1    Dee, K.C.2    Gaver, D.P.3
  • 48
    • 35648940703 scopus 로고    scopus 로고
    • Influence of airway diameter and cell confluence on epithelial cell injury in an in vitro model of airway reopening.
    • Yalcin, H. C., Perry, S. F., Ghadiali, S. N., Influence of airway diameter and cell confluence on epithelial cell injury in an in vitro model of airway reopening. J. Appl. Physiol. 2007, 103, 1796-1807.
    • (2007) J. Appl. Physiol. , vol.103 , pp. 1796-1807
    • Yalcin, H.C.1    Perry, S.F.2    Ghadiali, S.N.3
  • 49
    • 84869126274 scopus 로고    scopus 로고
    • A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice.
    • 159ra147.
    • Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P. et al., A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci. Transl. Med. 2012, 4, 159ra147.
    • (2012) Sci. Transl. Med. , vol.4
    • Huh, D.1    Leslie, D.C.2    Matthews, B.D.3    Fraser, J.P.4
  • 50
    • 84857964726 scopus 로고    scopus 로고
    • Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip.
    • Grosberg, A., Alford, P. W., McCain, M. L., Parker, K. K., Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip. Lab Chip 2011, 11, 4165-4173.
    • (2011) Lab Chip , vol.11 , pp. 4165-4173
    • Grosberg, A.1    Alford, P.W.2    McCain, M.L.3    Parker, K.K.4
  • 51
    • 84861482079 scopus 로고    scopus 로고
    • Muscle on a chip: In vitro contractility assays for smooth and striated muscle.
    • Grosberg, A., Nesmith, A. P., Goss, J. A., Brigham, M. D. et al., Muscle on a chip: In vitro contractility assays for smooth and striated muscle. J. Pharmacol. Toxicol. Methods 2012, 65, 126-135.
    • (2012) J. Pharmacol. Toxicol. Methods , vol.65 , pp. 126-135
    • Grosberg, A.1    Nesmith, A.P.2    Goss, J.A.3    Brigham, M.D.4
  • 52
    • 37349027919 scopus 로고    scopus 로고
    • Biomolecular gradients in cell culture systems.
    • Keenan, T. M., Folch, A., Biomolecular gradients in cell culture systems. Lab Chip 2008, 8, 34-57.
    • (2008) Lab Chip , vol.8 , pp. 34-57
    • Keenan, T.M.1    Folch, A.2
  • 53
    • 78149268198 scopus 로고    scopus 로고
    • Biological applications of microfluidic gradient devices.
    • Kim, S., Kim, H. J., Jeon, N. L., Biological applications of microfluidic gradient devices. Integr. Biol. 2010, 2, 584-603.
    • (2010) Integr. Biol. , vol.2 , pp. 584-603
    • Kim, S.1    Kim, H.J.2    Jeon, N.L.3
  • 54
    • 0034293766 scopus 로고    scopus 로고
    • Generation of solution and surface gradients using microfluidic systems.
    • Jeon, N. L., Dertinger, S. K. W., Chiu, D. T., Choi, I. S. et al., Generation of solution and surface gradients using microfluidic systems. Langmuir 2000, 16, 8311-8316.
    • (2000) Langmuir , vol.16 , pp. 8311-8316
    • Jeon, N.L.1    Dertinger, S.K.W.2    Chiu, D.T.3    Choi, I.S.4
  • 55
    • 0035866594 scopus 로고    scopus 로고
    • Generation of gradients having complex shapes using microfluidic networks.
    • Dertinger, S. K. W., Chiu, D. T., Jeon, N. L., Whitesides, G. M., Generation of gradients having complex shapes using microfluidic networks. Anal. Chem. 2001, 73, 1240-1246.
    • (2001) Anal. Chem. , vol.73 , pp. 1240-1246
    • Dertinger, S.K.W.1    Chiu, D.T.2    Jeon, N.L.3    Whitesides, G.M.4
  • 56
    • 0036022527 scopus 로고    scopus 로고
    • Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device.
    • Jeon, N. L., Baskaran, H., Dertinger, S. K. W., Whitesides, G. M. et al., Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nat. Biotechnol. 2002, 20, 826-830.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 826-830
    • Jeon, N.L.1    Baskaran, H.2    Dertinger, S.K.W.3    Whitesides, G.M.4
  • 57
    • 33847356130 scopus 로고    scopus 로고
    • A novel 3D mammalian cell perfusion-culture system in microfluidic channels.
    • Toh, Y.-C., Zhang, C., Zhang, J., Khong, Y. M. et al., A novel 3D mammalian cell perfusion-culture system in microfluidic channels. Lab Chip 2007, 7, 302-309.
    • (2007) Lab Chip , vol.7 , pp. 302-309
    • Toh, Y.-C.1    Zhang, C.2    Zhang, J.3    Khong, Y.M.4
  • 58
    • 34548354876 scopus 로고    scopus 로고
    • Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber.
    • Saadi, W., Rhee, S., Lin, F., Vahidi, B. et al., Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber. Biomed. Microdevices 2007, 9, 627-635.
    • (2007) Biomed. Microdevices , vol.9 , pp. 627-635
    • Saadi, W.1    Rhee, S.2    Lin, F.3    Vahidi, B.4
  • 59
    • 52649129923 scopus 로고    scopus 로고
    • Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging.
    • Vickerman, V., Blundo, J., Chung, S., Kamm, R., Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging. Lab Chip 2008, 8, 1468-1477.
    • (2008) Lab Chip , vol.8 , pp. 1468-1477
    • Vickerman, V.1    Blundo, J.2    Chung, S.3    Kamm, R.4
  • 60
    • 68549115534 scopus 로고    scopus 로고
    • Transport-mediated angiogenesis in 3D epithelial coculture.
    • Sudo, R., Chung, S., Zervantonakis, I. K., Vickerman, V. et al., Transport-mediated angiogenesis in 3D epithelial coculture. FASEB J. 2009, 23, 2155-2164.
    • (2009) FASEB J. , vol.23 , pp. 2155-2164
    • Sudo, R.1    Chung, S.2    Zervantonakis, I.K.3    Vickerman, V.4
  • 61
    • 73949099714 scopus 로고    scopus 로고
    • Surface-treatment-induced three-dimensional capillary morphogenesis in a microfluidic platform.
    • Chung, S., Sudo, R., Zervantonakis, I. K., Rimchala, T. et al., Surface-treatment-induced three-dimensional capillary morphogenesis in a microfluidic platform. Adv. Mater. 2009, 21, 4863-4867.
    • (2009) Adv. Mater. , vol.21 , pp. 4863-4867
    • Chung, S.1    Sudo, R.2    Zervantonakis, I.K.3    Rimchala, T.4
  • 62
    • 84862157431 scopus 로고    scopus 로고
    • Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels.
    • Shin, Y., Han, S., Jeon, J. S., Yamamoto, K. et al., Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels. Nat. Protocols 2012, 7, 1247-1259.
    • (2012) Nat. Protocols , vol.7 , pp. 1247-1259
    • Shin, Y.1    Han, S.2    Jeon, J.S.3    Yamamoto, K.4
  • 63
    • 79958787923 scopus 로고    scopus 로고
    • In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients.
    • Shin, Y., Jeon, J. S., Han, S., Jung, G.-S. et al., In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients. Lab Chip 2011, 11, 2175-2181.
    • (2011) Lab Chip , vol.11 , pp. 2175-2181
    • Shin, Y.1    Jeon, J.S.2    Han, S.3    Jung, G.-S.4
  • 64
    • 81255144070 scopus 로고    scopus 로고
    • Sprouting angiogenesis under a chemical gradient regulated by interactions with an endothelial monolayer in a microfluidic platform.
    • Jeong, G. S., Han, S., Shin, Y., Kwon, G. H. et al., Sprouting angiogenesis under a chemical gradient regulated by interactions with an endothelial monolayer in a microfluidic platform. Anal. Chem. 2011, 83, 8454-8459.
    • (2011) Anal. Chem. , vol.83 , pp. 8454-8459
    • Jeong, G.S.1    Han, S.2    Shin, Y.3    Kwon, G.H.4
  • 65
    • 78149278006 scopus 로고    scopus 로고
    • Microfluidic platform for chemotaxis in gradients formed by CXCL2 source-sink cells.
    • Torisawa, Y.-S., Mosadegh, B., Bersano-Begey, T., Steele, J. M. et al., Microfluidic platform for chemotaxis in gradients formed by CXCL2 source-sink cells. Integr. Biol. 2010, 2, 680-686.
    • (2010) Integr. Biol. , vol.2 , pp. 680-686
    • Torisawa, Y.-S.1    Mosadegh, B.2    Bersano-Begey, T.3    Steele, J.M.4
  • 66
    • 84875258119 scopus 로고    scopus 로고
    • Assembly of complex cell microenvironments using geometrically docked hydrogel shapes.
    • Eng, G., Lee, B. W., Parsa, H., Chin, C. D. et al., Assembly of complex cell microenvironments using geometrically docked hydrogel shapes. Proc. Natl. Acad. Sci. USA 2013, 110, 4551-4556.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 4551-4556
    • Eng, G.1    Lee, B.W.2    Parsa, H.3    Chin, C.D.4
  • 67
    • 14844320510 scopus 로고    scopus 로고
    • In vitro zonation and toxicity in a hepatocyte bioreactor.
    • Allen, J. W., Khetani, S. R., Bhatia, S. N., In vitro zonation and toxicity in a hepatocyte bioreactor. Toxicol. Sci. 2005, 84, 110-119.
    • (2005) Toxicol. Sci. , vol.84 , pp. 110-119
    • Allen, J.W.1    Khetani, S.R.2    Bhatia, S.N.3
  • 68
    • 78649509613 scopus 로고    scopus 로고
    • Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants.
    • Goral, V. N., Hsieh, Y.-C., Petzold, O. N., Clark, J. S. et al., Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants. Lab Chip 2010, 10, 3380-3386.
    • (2010) Lab Chip , vol.10 , pp. 3380-3386
    • Goral, V.N.1    Hsieh, Y.-C.2    Petzold, O.N.3    Clark, J.S.4
  • 69
  • 71
    • 79953270125 scopus 로고    scopus 로고
    • Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments.
    • Zervantonakis, I. K., Kothapalli, C. R., Chung, S., Sudo, R. et al., Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments. Biomicrofluidics 2011, 5, 013406-013414.
    • (2011) Biomicrofluidics , vol.5 , pp. 013406-013414
    • Zervantonakis, I.K.1    Kothapalli, C.R.2    Chung, S.3    Sudo, R.4
  • 72
    • 62749175785 scopus 로고    scopus 로고
    • Cell migration into scaffolds under co-culture conditions in a microfluidic platform.
    • Chung, S., Sudo, R., Mack, P. J., Wan, C.-R. et al., Cell migration into scaffolds under co-culture conditions in a microfluidic platform. Lab Chip 2009, 9, 269-275.
    • (2009) Lab Chip , vol.9 , pp. 269-275
    • Chung, S.1    Sudo, R.2    Mack, P.J.3    Wan, C.-R.4
  • 73
    • 79953731991 scopus 로고    scopus 로고
    • Transition to invasion in breast cancer: A microfluidic in vitro model enables examination of spatial and temporal effects.
    • Sung, K. E., Yang, N., Pehlke, C., Keely, P. J. et al., Transition to invasion in breast cancer: A microfluidic in vitro model enables examination of spatial and temporal effects. Integr. Biol. 2011, 3, 439-450.
    • (2011) Integr. Biol. , vol.3 , pp. 439-450
    • Sung, K.E.1    Yang, N.2    Pehlke, C.3    Keely, P.J.4
  • 74
    • 79953747798 scopus 로고    scopus 로고
    • Breast on-a-chip: Mimicry of the channeling system of the breast for development of theranostics.
    • Grafton, M. M. G., Wang, L., Vidi, P.-A., Leary, J. et al., Breast on-a-chip: Mimicry of the channeling system of the breast for development of theranostics. Integr. Biol. 2011, 3, 451-459.
    • (2011) Integr. Biol. , vol.3 , pp. 451-459
    • Grafton, M.M.G.1    Wang, L.2    Vidi, P.-A.3    Leary, J.4
  • 75
    • 23144439234 scopus 로고    scopus 로고
    • A microfluidic culture platform for CNS axonal injury, regeneration and transport.
    • Taylor, A. M., Blurton-Jones, M., Rhee, S. W., Cribbs, D. H. et al., A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat. Methods 2005, 2, 599-605.
    • (2005) Nat. Methods , vol.2 , pp. 599-605
    • Taylor, A.M.1    Blurton-Jones, M.2    Rhee, S.W.3    Cribbs, D.H.4
  • 76
    • 70549105100 scopus 로고    scopus 로고
    • Microfluidic compartmentalized co-culture platform for CNS axon myelination research.
    • Park, J., Koito, H., Li, J., Han, A., Microfluidic compartmentalized co-culture platform for CNS axon myelination research. Biomed. Microdevices 2009, 11, 1145-1153.
    • (2009) Biomed. Microdevices , vol.11 , pp. 1145-1153
    • Park, J.1    Koito, H.2    Li, J.3    Han, A.4
  • 77
    • 72049098211 scopus 로고    scopus 로고
    • Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture.
    • Puleo, C. M., McIntosh Ambrose, W., Takezawa, T., Elisseeff, J. et al., Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture. Lab Chip 2009, 9, 3221-3227.
    • (2009) Lab Chip , vol.9 , pp. 3221-3227
    • Puleo, C.M.1    McIntosh Ambrose, W.2    Takezawa, T.3    Elisseeff, J.4
  • 78
    • 77951883483 scopus 로고    scopus 로고
    • Microfluidic local perfusion chambers for the visualization and manipulation of synapses.
    • Taylor, A. M., Dieterich, D. C., Ito, H. T., Kim, S. A. et al., Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron 2010, 66, 57-68.
    • (2010) Neuron , vol.66 , pp. 57-68
    • Taylor, A.M.1    Dieterich, D.C.2    Ito, H.T.3    Kim, S.A.4
  • 79
    • 77957019165 scopus 로고    scopus 로고
    • Micro-scale and microfluidic devices for neurobiology.
    • Taylor, A. M., Jeon, N. L., Micro-scale and microfluidic devices for neurobiology. Curr. Opin. Neurobiol. 2010, 20, 640-647.
    • (2010) Curr. Opin. Neurobiol. , vol.20 , pp. 640-647
    • Taylor, A.M.1    Jeon, N.L.2
  • 80
    • 80054035696 scopus 로고    scopus 로고
    • Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers.
    • Peyrin, J.-M., Deleglise, B., Saias, L., Vignes, M. et al., Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers. Lab Chip 2011, 11, 3663-3673.
    • (2011) Lab Chip , vol.11 , pp. 3663-3673
    • Peyrin, J.-M.1    Deleglise, B.2    Saias, L.3    Vignes, M.4
  • 81
    • 84862117005 scopus 로고    scopus 로고
    • Organs-on-a-chip: A focus on compartmentalized microdevices.
    • Moraes, C., Mehta, G., Lesher-Perez, S., Takayama, S., Organs-on-a-chip: A focus on compartmentalized microdevices. Ann. Biomed. Eng. 2012, 40, 1211-1227.
    • (2012) Ann. Biomed. Eng. , vol.40 , pp. 1211-1227
    • Moraes, C.1    Mehta, G.2    Lesher-Perez, S.3    Takayama, S.4
  • 82
    • 66849138510 scopus 로고    scopus 로고
    • Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells.
    • Song, J. W., Cavnar, S. P., Walker, A. C., Luker, K. E. et al., Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells. PLoS One 2009, 4, e5756.
    • (2009) PLoS One , vol.4
    • Song, J.W.1    Cavnar, S.P.2    Walker, A.C.3    Luker, K.E.4
  • 83
    • 77954502719 scopus 로고    scopus 로고
    • Microfluidic culture models of tumor angiogenesis.
    • Stroock, A. D., Fischbach, C., Microfluidic culture models of tumor angiogenesis. Tissue Eng. Part A 2010, 16, 2143-2146.
    • (2010) Tissue Eng. Part A , vol.16 , pp. 2143-2146
    • Stroock, A.D.1    Fischbach, C.2
  • 84
    • 34548073601 scopus 로고    scopus 로고
    • Microfabrication of three-dimensional engineered scaffolds.
    • Borenstein, J. T., Weinberg, E. J., Orrick, B. K., Sundback, C. et al., Microfabrication of three-dimensional engineered scaffolds. Tissue Eng. 2007, 13, 1837-1844.
    • (2007) Tissue Eng. , vol.13 , pp. 1837-1844
    • Borenstein, J.T.1    Weinberg, E.J.2    Orrick, B.K.3    Sundback, C.4
  • 85
    • 77953837789 scopus 로고    scopus 로고
    • Principles of biomimetic vascular network design applied to a tissue-engineered liver scaffold.
    • Hoganson, D. M., Pryor, H. I., Spool, I. D., Burns, O. H. et al., Principles of biomimetic vascular network design applied to a tissue-engineered liver scaffold. Tissue Eng. Part A 2010, 16, 1469-1477.
    • (2010) Tissue Eng. Part A , vol.16 , pp. 1469-1477
    • Hoganson, D.M.1    Pryor, H.I.2    Spool, I.D.3    Burns, O.H.4
  • 86
    • 84866355664 scopus 로고    scopus 로고
    • Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues.
    • Miller, J. S., Stevens, K. R., Yang, M. T., Baker, B. M. et al., Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nat. Mater. 2012, 11, 768-774.
    • (2012) Nat. Mater. , vol.11 , pp. 768-774
    • Miller, J.S.1    Stevens, K.R.2    Yang, M.T.3    Baker, B.M.4
  • 87
    • 84862197029 scopus 로고    scopus 로고
    • In vitro microvessels for the study of angiogenesis and thrombosis.
    • Zheng, Y., Chen, J., Craven, M., Choi, N. W. et al., In vitro microvessels for the study of angiogenesis and thrombosis. Proc. Natl. Acad. Sci. USA 2012, 109, 9342-9347.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 9342-9347
    • Zheng, Y.1    Chen, J.2    Craven, M.3    Choi, N.W.4
  • 88
    • 67650481611 scopus 로고    scopus 로고
    • A microfluidic 3D hepatocyte chip for drug toxicity testing.
    • Toh, Y.-C., Lim, T. C., Tai, D., Xiao, G. et al., A microfluidic 3D hepatocyte chip for drug toxicity testing. Lab Chip 2009, 9, 2026-2035.
    • (2009) Lab Chip , vol.9 , pp. 2026-2035
    • Toh, Y.-C.1    Lim, T.C.2    Tai, D.3    Xiao, G.4
  • 89
    • 79959866368 scopus 로고    scopus 로고
    • Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device.
    • Nakao, Y., Kimura, H., Sakai, Y., Fujii, T., Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device. Biomicrofluidics 2011, 5, 022212-022217.
    • (2011) Biomicrofluidics , vol.5 , pp. 022212-022217
    • Nakao, Y.1    Kimura, H.2    Sakai, Y.3    Fujii, T.4
  • 90
    • 0035964350 scopus 로고    scopus 로고
    • Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip.
    • Zeck, G., Fromherz, P., Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip. Proc. Natl. Acad. Sci. USA 2001, 98, 10457-10462.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10457-10462
    • Zeck, G.1    Fromherz, P.2
  • 91
    • 12344267714 scopus 로고    scopus 로고
    • An endothelial and astrocyte co-culture model of the blood-brain barrier utilizing an ultra-thin, nanofabricated silicon nitride membrane.
    • Ma, S. H., Lepak, L. A., Hussain, R. J., Shain, W. et al., An endothelial and astrocyte co-culture model of the blood-brain barrier utilizing an ultra-thin, nanofabricated silicon nitride membrane. Lab Chip 2005, 5, 74-85.
    • (2005) Lab Chip , vol.5 , pp. 74-85
    • Ma, S.H.1    Lepak, L.A.2    Hussain, R.J.3    Shain, W.4
  • 92
    • 60649095211 scopus 로고    scopus 로고
    • Microfluidics: A new cosset for neurobiology.
    • Wang, J., Ren, L., Li, L., Liu, W. et al., Microfluidics: A new cosset for neurobiology. Lab Chip 2009, 9, 644-652.
    • (2009) Lab Chip , vol.9 , pp. 644-652
    • Wang, J.1    Ren, L.2    Li, L.3    Liu, W.4
  • 93
    • 42549115139 scopus 로고    scopus 로고
    • An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models.
    • Kimura, H., Yamamoto, T., Sakai, H., Sakai, Y. et al., An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models. Lab Chip 2008, 8, 741-746.
    • (2008) Lab Chip , vol.8 , pp. 741-746
    • Kimura, H.1    Yamamoto, T.2    Sakai, H.3    Sakai, Y.4
  • 94
    • 84862207235 scopus 로고    scopus 로고
    • Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow.
    • Kim, H. J., Huh, D., Hamilton, G., Ingber, D. E., Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip 2012, 12, 2165-2174.
    • (2012) Lab Chip , vol.12 , pp. 2165-2174
    • Kim, H.J.1    Huh, D.2    Hamilton, G.3    Ingber, D.E.4
  • 95
    • 79952521585 scopus 로고    scopus 로고
    • Application of microfluidic technology to pancreatic islet research: First decade of endeavor.
    • Wang, Y., Lo, J. F., Mendoza-Elias, J. E., Adewola, A. F. et al., Application of microfluidic technology to pancreatic islet research: First decade of endeavor. Bioanalysis 2010, 2, 1729-1744.
    • (2010) Bioanalysis , vol.2 , pp. 1729-1744
    • Wang, Y.1    Lo, J.F.2    Mendoza-Elias, J.E.3    Adewola, A.F.4
  • 96
    • 77957754885 scopus 로고    scopus 로고
    • Tumors on chips: Oncology meets microfluidics.
    • Wlodkowic, D., Cooper, J. M., Tumors on chips: Oncology meets microfluidics. Curr. Opin. Chem. Biol. 2010, 14, 556-567.
    • (2010) Curr. Opin. Chem. Biol. , vol.14 , pp. 556-567
    • Wlodkowic, D.1    Cooper, J.M.2
  • 97
    • 65649133932 scopus 로고    scopus 로고
    • A micro cell culture analog (μCCA) with 3D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs.
    • Sung, J. H., Shuler, M. L., A micro cell culture analog (μCCA) with 3D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. Lab Chip 2009, 9, 1385-1394.
    • (2009) Lab Chip , vol.9 , pp. 1385-1394
    • Sung, J.H.1    Shuler, M.L.2
  • 98
    • 75749153235 scopus 로고    scopus 로고
    • A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip.
    • Sung, J. H., Kam, C., Shuler, M. L., A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Lab Chip 2010, 10, 446-455.
    • (2010) Lab Chip , vol.10 , pp. 446-455
    • Sung, J.H.1    Kam, C.2    Shuler, M.L.3
  • 99
    • 7444259030 scopus 로고    scopus 로고
    • A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: Comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells.
    • Li, A. P., Bode, C., Sakai, Y., A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: Comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells. Chem.-Biol. Interact. 2004, 150, 129-136.
    • (2004) Chem.-Biol. Interact. , vol.150 , pp. 129-136
    • Li, A.P.1    Bode, C.2    Sakai, Y.3
  • 100
    • 70449574700 scopus 로고    scopus 로고
    • The use of the integrated discrete multiple organ co-culture (IdMOC®) system for the evaluation of multiple organ toxicity.
    • Li, A. P., The use of the integrated discrete multiple organ co-culture (IdMOC®) system for the evaluation of multiple organ toxicity. ATLA, Altern. Lab. Anim. 2009, 37, 377-385.
    • (2009) ATLA, Altern. Lab. Anim. , vol.37 , pp. 377-385
    • Li, A.P.1
  • 101
    • 79551610758 scopus 로고    scopus 로고
    • Cardiotoxicity of kinase inhibitors: The prediction and translation of preclinical models to clinical outcomes.
    • Force, T., Kolaja, K. L., Cardiotoxicity of kinase inhibitors: The prediction and translation of preclinical models to clinical outcomes. Nat Rev Drug Discov 2011, 10, 111-126.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 111-126
    • Force, T.1    Kolaja, K.L.2
  • 102
    • 63049090064 scopus 로고    scopus 로고
    • A fresh look at iPS cells.
    • Yamanaka, S., A fresh look at iPS cells. Cell 2009, 137, 13-17.
    • (2009) Cell , vol.137 , pp. 13-17
    • Yamanaka, S.1
  • 103
    • 70349301819 scopus 로고    scopus 로고
    • Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.
    • Lee, G., Papapetrou, E. P., Kim, H., Chambers, S. M. et al., Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 2009, 461, 402-406.
    • (2009) Nature , vol.461 , pp. 402-406
    • Lee, G.1    Papapetrou, E.P.2    Kim, H.3    Chambers, S.M.4
  • 104
    • 79958260092 scopus 로고    scopus 로고
    • The human brain in a dish: The promise of iPSC-derived neurons.
    • Dolmetsch, R., Geschwind, Daniel H., The human brain in a dish: The promise of iPSC-derived neurons. Cell 2011, 145, 831-834.
    • (2011) Cell , vol.145 , pp. 831-834
    • Dolmetsch, R.1    Geschwind, D.H.2
  • 105
    • 84862849950 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells derived hepatocytes: Rising promise for disease modeling, drug development and cell therapy.
    • Yi, F., Liu, G.-H., Belmonte, J., Human induced pluripotent stem cells derived hepatocytes: Rising promise for disease modeling, drug development and cell therapy. Protein Cell 2012, 3, 246-250.
    • (2012) Protein Cell , vol.3 , pp. 246-250
    • Yi, F.1    Liu, G.-H.2    Belmonte, J.3
  • 106
    • 84882247304 scopus 로고    scopus 로고
    • The future of the patient-specific body-on-a-chip.
    • Williamson, A., Singh, S., Fernekorn, U., Schober, A., The future of the patient-specific body-on-a-chip. Lab Chip 2013, 13, 3471-3480.
    • (2013) Lab Chip , vol.13 , pp. 3471-3480
    • Williamson, A.1    Singh, S.2    Fernekorn, U.3    Schober, A.4


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