Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport

Drug Metabolism and Disposition

Volumn 34, Issue 9, 2006, Pages 1658-1665

  Bi, Yi An ^a   Kazolias, Diana ^a   Duignan, David B ^a,b  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIN; MULTIDRUG RESISTANCE PROTEIN; POLYPEPTIDE; TAUROCHOLIC ACID;

ARTICLE; CELL CULTURE; CELL STRUCTURE; CONTROLLED STUDY; CRYOPRESERVATION; HUMAN; HUMAN CELL; LIVER CELL; LIVER CLEARANCE; PRIORITY JOURNAL;

ADOLESCENT; AGED; BILE CANALICULI; BIOLOGICAL TRANSPORT; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHILD, PRESCHOOL; CRYOPRESERVATION; DIGOXIN; DRUG EVALUATION, PRECLINICAL; ESTRADIOL; FEMALE; HEPATOCYTES; HUMANS; KINETICS; MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; TAUROCHOLIC ACID;

EID: 33747841593     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.009118     Document Type: Article

References (22)

1. Angelin B, Arvidsson A, Dahlqvist R, Hedman A, and Schenck-Gustafsson K (1987) Quinidine reduces biliary clearance of digoxin in man. Eur J Clin Investig 17:262-265.
2. Corsini A, Bellosta S, Baetta R, Fumagalli R, Paoletti R, and Bernini F (1999) New insights into the pharmacodynamic and pharmacokinetic properties of statins. Pharmacol Ther 84:413-428.
3. Cowen AE, Korman MG, Hofmann AF, and Thomas PJ (1975) Plasma disappearance of radioactivity after intravenous injection of labeled bile acids in man. Gastroenterology 68:156-1573.
4. Garcia M, Rager J, Wang Q, Strab R, Hidalgo IJ, Owen A, and Li J (2003) Cryopreserved human hepatocytes as alternative in vitro model for cytochrome P450 induction studies. In Vitro Cell Dev Biol Anim 39:283-287.
5. Hoffmaster KA, Turncliff RZ, LeCluyse EL, Kim RB, Meier PJ, and Brouwer KL (2004) P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Pharm Res 21:1294-1302.
6. Houle R, Raoul J, Levesque J-F, Pang KS, Nicoll-Griffith DA, and Silva JM (2003) Retention of transporter activities in cryopreserved, isolated rat hepatocytes. Drug Metab Dispos 31:447-451.
7. Janiszewski JS, Rogers KJ, Whalen KM, Cole MJ, Liston TE, Duchoslav E, and Fouda HG (2001) A high-capacity LC/MS system for the bioanalysis of samples generated from plate-based metabolic screening. Anal Chem 73:1495-1501.
8. Jigorel E, Le Vee M, Boursier-Neyret C, Bertrand M, and Fardel O (2005) Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes. Drug Metab Dispos 33:1418-1422.
9. Lau YY, Sapidou E, Cui X, White RE, and Cheng K-C (2002) Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes. Drug Metab Dispos 30:1446-1454.
10. Laznicek M and Laznickova A (1994) Kidney and liver contributions to salicylate metabolism in rats. Eur J Drug Metab Pharmacokinet 19:21-26.
11. LeCluyse EL, Audus KL, and Hochman JH (1994) Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration. Am J Physiol 266:C1764-C1774.
12. Liu X, Brouwer KL, Gan L-S, Brouwer KR, Stieger B, Meier PJ, Audus KL, and LeCluyse EL (1998) Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration. Pharm Res 15:1533-1539.
13. Liu X, Chism JP, LeCluyse EL, Brouwer KR, and Brouwer KL (1999a) Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats. Drug Metab Dispos 27:637-644.
14. Liu X, LeCluyse EL, Brouwer KR, Gan L-S, Lemasters JJ, Stieger B, Meier PJ, and Brouwer KL (1999b) Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration. Am J Physiol 277 40:G12-G21.
15. 2+ modulation to evaluate biliary excretion in sandwich-cultured rat hepatocytes. J Pharmacol Exp Ther 289:1592-1599.
16. Martin PD, Warwick MJ, Dane AL, Hill SJ, Giles PB, Phillips PJ, and Lenz E (2003) Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers. Clin Ther 25:2822-2835.
17. Nakai D, Nakagomi R, Furuta Y, Tokui T, Abe T, Ikeda T, and Nishimura K (2001) Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes. J Pharmacol Exp Ther 297:861-867.
18. Olinga P, Merema M, Hof IH, Slooff MJH, Proost JH, Meijer DKF, and Groothuis GMM (1998) Characterization of the uptake of rocuronium and digoxin in human hepatocytes: carrier specificity and comparison with in vivo data. J Pharmacol Exp Ther 285:506-510.
19. Pahlman I, Edholm M, Kankaanranta S, and Odell M-L (1998) Pharmacokinetics of susalimod, a highly biliary-excreted sulphasalazine analog, in various species. Nonpredictable human clearance by allometric scaling. Pharm Pharmacol Comm 4:493-498.
20. Shitara Y, Li AP, Kato Y, Lu C, Ito K, Itoh T, and Sugiyama Y (2003) Function of uptake transporters for taurocholate and estradiol 17β-D-glucuronide in cryopreserved human hepatocytes. Drug Metab Pharmacokinet 18:33-41.
21. Siegers C-P and Bumann D (1991) Clinical significance of the biliary excretion of drugs. Prog Pharmacol Clin Pharmacol 8:537-549.
22. Wheeler HO, Meltzer JI, and Bradley SE (1960) Biliary transport and hepatic storage of sulfobromophthalein sodium (BSP) in the unanesthetized dog, in normal man, and in patients with hepatic disease. J Clin Investig 39:1131-1144.