Metabolic activation in drug-induced liver injury

Drug Metabolism Reviews

Volumn 44, Issue 1, 2012, Pages 18-33

  Leung, Louis ^a   Kalgutkar, Amit S ^a   Obach, R Scott ^a  

^a PFIZER INC   (United States)

Author keywords

Bioactivation; covalent binding; hepatotoxicity; idiosyncratic adverse drug reactions; risk assessment

Indexed keywords

ALCLOFENAC; AMODIAQUINE; CLOZAPINE; DAPSONE; DICLOFENAC; FELBAMATE; FLUTAMIDE; HALOTHANE; IBUFENAC; INDOMETACIN; NEFAZODONE; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OLANZAPINE; PARACETAMOL; PIOGLITAZONE; PROCAINAMIDE; QUINONE DERIVATIVE; ROSIGLITAZONE; SULFAMETHOXAZOLE; SUPROFEN; TAMOXIFEN; TIENILIC ACID; TOLCAPONE; TOLMETIN; TROGLITAZONE; UNINDEXED DRUG; ZAFIRLUKAST; ZOLPIDEM TARTRATE; ZOMEPIRAC;

ADVERSE DRUG REACTION; COVALENT BOND; DRUG ACTIVATION; DRUG DEVELOPMENT; DRUG WITHDRAWAL; HALOTHANE LIVER INJURY; HUMAN; IDIOSYNCRATIC ADVERSE DRUG REACTION; LIVER INJURY; LIVER TOXICITY; METABOLIC ACTIVATION; METABOLITE; RASH; REVIEW; RISK ASSESSMENT;

ANIMALS; BIOTRANSFORMATION; DRUG-INDUCED LIVER INJURY; HUMANS; LIVER; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; QUINONES; RISK ASSESSMENT;

EID: 84855873678     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602532.2011.605791     Document Type: Review

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