Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling

Archives of Toxicology

Volumn 87, Issue 5, 2013, Pages 807-823

  Driessen, Marja ^a,b   Kienhuis, Anne S ^a   Pennings, Jeroen L A ^a   Pronk, Tessa E ^a,c   Van De Brandhof, Evert Jan ^a   Roodbergen, Marianne ^a   Spaink, Herman P ^d   Van De Water, Bob ^b   Van Der Ven, Leo T M ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Adult zebrafish liver; Gene expression profiles; Hepatotoxicity; Next generation sequencing; Pathway analysis; Toxicogenomics; Transcription factor analysis; Whole zebrafish embryo model

Indexed keywords

CYCLOSPORIN A; RNA; TRANSCRIPTION FACTOR; TRANSCRIPTOME; CYCLOSPORIN; XENOBIOTIC AGENT;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; EMBRYO; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; IN SITU HYBRIDIZATION; LIVER TOXICITY; NEXT GENERATION SEQUENCING; NONHUMAN; PRIORITY JOURNAL; RNA SEQUENCE; SIGNAL TRANSDUCTION; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; ANIMAL TESTING ALTERNATIVE; DISEASE MODEL; DRUG EFFECT; DRUG SCREENING; FEMALE; GENE EXPRESSION; HIGH THROUGHPUT SEQUENCING; LIFE CYCLE STAGE; LIVER; LIVER CELL; MALE; METABOLISM; METHODOLOGY; MOUSE; PHYSIOLOGY; PRENATAL DEVELOPMENT; SEQUENCE ANALYSIS; SPECIES DIFFERENCE; TUMOR CELL LINE;

DANIO RERIO; MAMMALIA;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CELL LINE, TUMOR; CYCLOSPORINE; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; EMBRYO, NONMAMMALIAN; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEPATOCYTES; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; IN SITU HYBRIDIZATION; LIFE CYCLE STAGES; LIVER; MALE; MICE; SEQUENCE ANALYSIS, RNA; SPECIES SPECIFICITY; XENOBIOTICS; ZEBRAFISH;

EID: 84883242462     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1039-z     Document Type: Article

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