Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices

Xenobiotica

Volumn 43, Issue 1, 2013, Pages 41-53

  Lake, Brian G ^a   Price, Roger J ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Cytochrome P450; Hepatotoxicity; Precision cut liver slices; Species differences; Xenobiotic metabolism

Indexed keywords

XENOBIOTIC AGENT;

ENZYME INDUCTION; ENZYME INHIBITION; EVALUATION; GENOTOXICITY; HUMAN; LIVER METABOLISM; LIVER SLICE; LIVER TOXICITY; NONHUMAN; PRECISION CUT LIVER SLICE METHOD; REVIEW; SPECIES COMPARISON; SPECIES DIFFERENCE; XENOBIOTIC METABOLISM;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; HUMANS; KINETICS; LIVER; MODELS, BIOLOGICAL; ORGAN CULTURE TECHNIQUES; XENOBIOTICS;

ANIMALIA;

EID: 84870548432     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2012.734643     Document Type: Review

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