Bioactivation and toxicity of acetaminophen in a rat hepatocyte micropatterned coculture system

Journal of Biochemical and Molecular Toxicology

Volumn 27, Issue 10, 2013, Pages 471-478

  Ukairo, Okechukwu ^a   Mcvay, Michael ^a   Krzyzewski, Stacy ^a   Aoyama, Simon ^a   Rose, Kelly ^b   Andersen, Melvin E ^b   Khetani, Salman R ^c   Lecluyse, Edward L ^b  

^a Hepregen Corporation   (United States)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Acetaminophen; Bioactivation; Cocultures; Micropatterning; Rat Hepatocytes

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALBUMIN; BUTHIONINE SULFOXIMINE; CYTOCHROME P450 3A; DEXAMETHASONE; GLUTATHIONE; PARACETAMOL; UREA;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CELL VIABILITY; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA ADDUCT; DRUG CYTOTOXICITY; EXPERIMENTAL MODEL; LABORATORY DEVICE; LIVER CELL CULTURE; LIVER FUNCTION; LIVER TOXICITY; MALE; METABOLITE; NONHUMAN; OXIDATIVE STRESS; RAT; TOXICITY TESTING;

MURINAE; RATTUS;

ACETAMINOPHEN; BIOACTIVATION; COCULTURES; MICROPATTERNING; RAT HEPATOCYTES;

ACETAMINOPHEN; ADENOSINE TRIPHOSPHATE; ALBUMINS; ANALGESICS, NON-NARCOTIC; ANIMALS; BUTHIONINE SULFOXIMINE; COCULTURE TECHNIQUES; CYTOCHROME P-450 CYP3A; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GLUTATHIONE; HEPATOCYTES; MALE; MODELS, BIOLOGICAL; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION; UREA;

EID: 84884983203     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.21512     Document Type: Article

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