메뉴 건너뛰기




Volumn 16, Issue 6, 2014, Pages 800-809

Combined use of N-acetylcysteine and Liberase improves the viability and metabolic function of human hepatocytes isolated from human liver

Author keywords

Acetylcysteine; Cell transplantation; Hepatocytes; Liberase

Indexed keywords

ACETYLCYSTEINE; ALBUMIN; COLLAGENASE; LIBERASE; UREA; THERMOLYSIN;

EID: 84899921179     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2014.01.006     Document Type: Article
Times cited : (17)

References (40)
  • 1
    • 48549100695 scopus 로고    scopus 로고
    • Critical review of clinical trials of bone marrow stem cells in liver disease
    • Houlihan D.D., Newsome P.N. Critical review of clinical trials of bone marrow stem cells in liver disease. Gastroenterology 2008, 135:438-450.
    • (2008) Gastroenterology , vol.135 , pp. 438-450
    • Houlihan, D.D.1    Newsome, P.N.2
  • 2
    • 84855954616 scopus 로고    scopus 로고
    • New horizons for stem cell therapy in liver disease
    • Forbes S.J., Newsome P.N. New horizons for stem cell therapy in liver disease. J Hepatol 2012, 56:496-499.
    • (2012) J Hepatol , vol.56 , pp. 496-499
    • Forbes, S.J.1    Newsome, P.N.2
  • 3
    • 79958812975 scopus 로고    scopus 로고
    • Stem cell-based therapies for liver diseases: state of the art and new perspectives
    • Piscaglia A.C., Campanale M., Gasbarrini A., Gasbarrini G. Stem cell-based therapies for liver diseases: state of the art and new perspectives. Stem Cells Int 2010, 2010:259461.
    • (2010) Stem Cells Int , vol.2010 , pp. 259461
    • Piscaglia, A.C.1    Campanale, M.2    Gasbarrini, A.3    Gasbarrini, G.4
  • 4
    • 84859461966 scopus 로고    scopus 로고
    • State-of-the-art on basic and applied stem cell therapy: Stem Cell Research Italy-International Society for Cellular Therapy Europe, Joint Meeting, Montesilvano (PE) Italy, June 10-12, 2011
    • Siniscalco D., Pandolfi A., Galderisi U. State-of-the-art on basic and applied stem cell therapy: Stem Cell Research Italy-International Society for Cellular Therapy Europe, Joint Meeting, Montesilvano (PE) Italy, June 10-12, 2011. Stem Cells Dev 2012, 21:668-669.
    • (2012) Stem Cells Dev , vol.21 , pp. 668-669
    • Siniscalco, D.1    Pandolfi, A.2    Galderisi, U.3
  • 5
    • 39149115049 scopus 로고    scopus 로고
    • Stem cells, cell transplantation and liver repopulation
    • Oertel M., Shafritz D.A. Stem cells, cell transplantation and liver repopulation. Biochim Biophys Acta 2008, 1782:61-74.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 61-74
    • Oertel, M.1    Shafritz, D.A.2
  • 6
    • 63849125254 scopus 로고    scopus 로고
    • A fat chance for hepatocyte transplantation?
    • Thomas J.A., Forbes S.J. A fat chance for hepatocyte transplantation?. Gut 2009, 58:480-482.
    • (2009) Gut , vol.58 , pp. 480-482
    • Thomas, J.A.1    Forbes, S.J.2
  • 7
    • 0037308271 scopus 로고    scopus 로고
    • Hepatocyte transplantation: new possibilities for therapy
    • Strom S., Fisher R. Hepatocyte transplantation: new possibilities for therapy. Gastroenterology 2003, 124:568-571.
    • (2003) Gastroenterology , vol.124 , pp. 568-571
    • Strom, S.1    Fisher, R.2
  • 8
    • 65649136956 scopus 로고    scopus 로고
    • Ethical issues in stem cell research
    • Lo B., Parham L. Ethical issues in stem cell research. Endocr Rev 2009, 30:204-213.
    • (2009) Endocr Rev , vol.30 , pp. 204-213
    • Lo, B.1    Parham, L.2
  • 10
    • 70349207748 scopus 로고    scopus 로고
    • Human hepatocyte transplantation: state of the art
    • Fitzpatrick E., Mitry R.R., Dhawan A. Human hepatocyte transplantation: state of the art. J Intern Med 2009, 266:339-357.
    • (2009) J Intern Med , vol.266 , pp. 339-357
    • Fitzpatrick, E.1    Mitry, R.R.2    Dhawan, A.3
  • 12
    • 84863258782 scopus 로고    scopus 로고
    • Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London
    • Puppi J., Strom S.C., Hughes R.D., Bansal S., Castell J.V., Dagher I., et al. Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London. Cell Transplant 2012, 21:1-10.
    • (2012) Cell Transplant , vol.21 , pp. 1-10
    • Puppi, J.1    Strom, S.C.2    Hughes, R.D.3    Bansal, S.4    Castell, J.V.5    Dagher, I.6
  • 13
    • 77952091621 scopus 로고    scopus 로고
    • Human hepatocyte transplantation: current experience and future challenges
    • Dhawan A., Puppi J., Hughes R.D., Mitry R.R. Human hepatocyte transplantation: current experience and future challenges. Nat Rev Gastroenterol Hepatol 2010, 7:288-298.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 288-298
    • Dhawan, A.1    Puppi, J.2    Hughes, R.D.3    Mitry, R.R.4
  • 14
    • 34247505574 scopus 로고    scopus 로고
    • Human hepatocytes: isolation, cryopreservation and applications in drug development
    • Li A.P. Human hepatocytes: isolation, cryopreservation and applications in drug development. Chem Biol Interact 2007, 168:16-29.
    • (2007) Chem Biol Interact , vol.168 , pp. 16-29
    • Li, A.P.1
  • 15
    • 78049369209 scopus 로고    scopus 로고
    • Isolation and culture of primary hepatocytes from resected human liver tissue
    • LeCluyse E.L., Alexandre E. Isolation and culture of primary hepatocytes from resected human liver tissue. Methods Mol Biol 2010, 640:57-82.
    • (2010) Methods Mol Biol , vol.640 , pp. 57-82
    • LeCluyse, E.L.1    Alexandre, E.2
  • 17
    • 33646452424 scopus 로고    scopus 로고
    • Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation
    • Hughes R.D., Mitry R.R., Dhawan A., Lehec S.C., Girlanda R., Rela M., et al. Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation. Liver Transplant 2006, 12:713-717.
    • (2006) Liver Transplant , vol.12 , pp. 713-717
    • Hughes, R.D.1    Mitry, R.R.2    Dhawan, A.3    Lehec, S.C.4    Girlanda, R.5    Rela, M.6
  • 18
  • 19
    • 40149100649 scopus 로고    scopus 로고
    • Isolation of primary human hepatocytes after partial hepatectomy: criteria for identification of the most promising liver specimen
    • Vondran F.W., Katenz E., Schwartlander R., Morgul M.H., Raschzok N., Gong X., et al. Isolation of primary human hepatocytes after partial hepatectomy: criteria for identification of the most promising liver specimen. Artif Organs 2008, 32:205-213.
    • (2008) Artif Organs , vol.32 , pp. 205-213
    • Vondran, F.W.1    Katenz, E.2    Schwartlander, R.3    Morgul, M.H.4    Raschzok, N.5    Gong, X.6
  • 20
    • 79953166050 scopus 로고    scopus 로고
    • Isolation of primary human hepatocytes from normal and diseased liver tissue: a one hundred liver experience
    • Bhogal R.H., Hodson J., Bartlett D.C., Weston C.J., Curbishley S.M., Haughton E., et al. Isolation of primary human hepatocytes from normal and diseased liver tissue: a one hundred liver experience. PLoS One 2011, 6:e18222.
    • (2011) PLoS One , vol.6
    • Bhogal, R.H.1    Hodson, J.2    Bartlett, D.C.3    Weston, C.J.4    Curbishley, S.M.5    Haughton, E.6
  • 21
    • 0014645531 scopus 로고
    • High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study
    • Berry M.N., Friend D.S. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol 1969, 43:506-520.
    • (1969) J Cell Biol , vol.43 , pp. 506-520
    • Berry, M.N.1    Friend, D.S.2
  • 22
    • 0029619144 scopus 로고
    • Comparison of collagenase type P and Liberase during human islet isolation using the automated method
    • Linetsky E., Selvaggi G., Bottino R., Kong S.S., Qian T., Alejandro R., et al. Comparison of collagenase type P and Liberase during human islet isolation using the automated method. Transplant Proc 1995, 27:3264.
    • (1995) Transplant Proc , vol.27 , pp. 3264
    • Linetsky, E.1    Selvaggi, G.2    Bottino, R.3    Kong, S.S.4    Qian, T.5    Alejandro, R.6
  • 24
    • 0033567230 scopus 로고    scopus 로고
    • Significant progress in porcine islet mass isolation utilizing liberase HI for enzymatic low-temperature pancreas digestion
    • Brandhorst H., Brandhorst D., Hering B.J., Bretzel R.G. Significant progress in porcine islet mass isolation utilizing liberase HI for enzymatic low-temperature pancreas digestion. Transplantation 1999, 68:355-361.
    • (1999) Transplantation , vol.68 , pp. 355-361
    • Brandhorst, H.1    Brandhorst, D.2    Hering, B.J.3    Bretzel, R.G.4
  • 26
    • 77954477402 scopus 로고    scopus 로고
    • The use of N-acetylcysteine in intensive care
    • Atkinson M.C. The use of N-acetylcysteine in intensive care. Crit Care Resusc 2002, 4:21-27.
    • (2002) Crit Care Resusc , vol.4 , pp. 21-27
    • Atkinson, M.C.1
  • 27
    • 33645233816 scopus 로고    scopus 로고
    • Metabolic insights into the hepatoprotective role of N-acetylcysteine in mouse liver
    • Zwingmann C., Bilodeau M. Metabolic insights into the hepatoprotective role of N-acetylcysteine in mouse liver. Hepatology 2006, 43:454-463.
    • (2006) Hepatology , vol.43 , pp. 454-463
    • Zwingmann, C.1    Bilodeau, M.2
  • 28
    • 0028223328 scopus 로고
    • Evidence that S-adenosylmethionine and N-acetylcysteine reduce injury from sequential cold and warm ischemia in the isolated perfused rat liver
    • Dunne J.B., Davenport M., Williams R., Tredger J.M. Evidence that S-adenosylmethionine and N-acetylcysteine reduce injury from sequential cold and warm ischemia in the isolated perfused rat liver. Transplantation 1994, 57:1161-1168.
    • (1994) Transplantation , vol.57 , pp. 1161-1168
    • Dunne, J.B.1    Davenport, M.2    Williams, R.3    Tredger, J.M.4
  • 30
    • 27844514137 scopus 로고    scopus 로고
    • N-acetylcysteine ameliorates the late phase of liver ischaemia/reperfusion injury in the rabbit with hepatic steatosis
    • Fusai G., Glantzounis G.K., Hafez T., Yang W., Quaglia A., Sheth H., et al. N-acetylcysteine ameliorates the late phase of liver ischaemia/reperfusion injury in the rabbit with hepatic steatosis. Clin Sci 2005, 109:465-473.
    • (2005) Clin Sci , vol.109 , pp. 465-473
    • Fusai, G.1    Glantzounis, G.K.2    Hafez, T.3    Yang, W.4    Quaglia, A.5    Sheth, H.6
  • 31
    • 78651520743 scopus 로고    scopus 로고
    • N-acetylcysteine improves the viability of human hepatocytes isolated from severely steatotic donor liver tissue
    • Sagias F.G., Mitry R.R., Hughes R.D., Lehec S.C., Patel A.G., Rela M., et al. N-acetylcysteine improves the viability of human hepatocytes isolated from severely steatotic donor liver tissue. Cell Transplant 2010, 19:1487-1492.
    • (2010) Cell Transplant , vol.19 , pp. 1487-1492
    • Sagias, F.G.1    Mitry, R.R.2    Hughes, R.D.3    Lehec, S.C.4    Patel, A.G.5    Rela, M.6
  • 34
    • 84899919723 scopus 로고    scopus 로고
    • NHS Blood and Transplant. Transplant Activity in the UK. June 19 [cited 2012 Jul 4]. Available from: URL:
    • NHS Blood and Transplant. Transplant Activity in the UK. 2011 June 19 [cited 2012 Jul 4]. Available from: URL: http://www.organdonation.nhs.uk/ukt/statistics/transplant_activity_report/transplant_activity_report.asp.
    • (2011)
  • 35
    • 0036414487 scopus 로고    scopus 로고
    • Comparison of size, viability, and function of fetal pig islet-like cell clusters after digestion using collagenase or liberase
    • Georges P., Muirhead R.P., Williams L., Holman S., Tabiin M.T., Dean S.K., et al. Comparison of size, viability, and function of fetal pig islet-like cell clusters after digestion using collagenase or liberase. Cell Transplant 2002, 11:539-545.
    • (2002) Cell Transplant , vol.11 , pp. 539-545
    • Georges, P.1    Muirhead, R.P.2    Williams, L.3    Holman, S.4    Tabiin, M.T.5    Dean, S.K.6
  • 36
    • 31544469496 scopus 로고    scopus 로고
    • Evaluation of Liberase, a purified enzyme blend, for the isolation of human primordial and primary ovarian follicles
    • Dolmans M.M., Michaux N., Camboni A., Martinez-Madrid B., Van L.A., Nottola S.A., et al. Evaluation of Liberase, a purified enzyme blend, for the isolation of human primordial and primary ovarian follicles. Hum Reprod 2006, 21:413-420.
    • (2006) Hum Reprod , vol.21 , pp. 413-420
    • Dolmans, M.M.1    Michaux, N.2    Camboni, A.3    Martinez-Madrid, B.4    Van, L.A.5    Nottola, S.A.6
  • 37
    • 3142704439 scopus 로고    scopus 로고
    • Hepatocyte survival depends on beta1-integrin-mediated attachment of hepatocytes to hepatic extracellular matrix
    • Pinkse G.G., Voorhoeve M.P., Noteborn M., Terpstra O.T., Bruijn J.A., De H.E. Hepatocyte survival depends on beta1-integrin-mediated attachment of hepatocytes to hepatic extracellular matrix. Liver Int 2004, 24:218-226.
    • (2004) Liver Int , vol.24 , pp. 218-226
    • Pinkse, G.G.1    Voorhoeve, M.P.2    Noteborn, M.3    Terpstra, O.T.4    Bruijn, J.A.5    De, H.E.6
  • 39
    • 0036910180 scopus 로고    scopus 로고
    • Anoikis: roadblock to cell transplantation?
    • Zvibel I., Smets F., Soriano H. Anoikis: roadblock to cell transplantation?. Cell Transplant 2002, 11:621-630.
    • (2002) Cell Transplant , vol.11 , pp. 621-630
    • Zvibel, I.1    Smets, F.2    Soriano, H.3
  • 40
    • 0031005369 scopus 로고    scopus 로고
    • Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture
    • Greuet J., Pichard L., Ourlin J.C., Bonfils C., Domergue J., Le T.P., et al. Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture. Hepatology 1997, 25:1166-1175.
    • (1997) Hepatology , vol.25 , pp. 1166-1175
    • Greuet, J.1    Pichard, L.2    Ourlin, J.C.3    Bonfils, C.4    Domergue, J.5    Le, T.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.