Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 4, 2005, Pages 983-987

  Lee, Moo Yeal ^a   Park, Chan Beum ^b,c   Dordick, Jonathan S ^a   Clark, Douglas S ^b  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b University of California   (United States)

^c Arizona State University   (United States)

Author keywords

In situ drug metabolism; In vitro cytotoxicity; P450; Sol gel encapsulation

Indexed keywords

4 HYDROXYCYCLOPHOSPHAMIDE; CYCLOPHOSPHAMIDE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; PARACETAMOL; QUINOLINE; TEGAFUR;

ARTICLE; CATALYSIS; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG DEVELOPMENT; DRUG METABOLISM; ENCAPSULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIVER CELL CULTURE; LIVER MICROSOME; LIVER SLICE; MONOLAYER CULTURE; OXIDATION; PRIORITY JOURNAL;

BIOTRANSFORMATION; CATALYSIS; CYCLOPHOSPHAMIDE; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; PHASE TRANSITION; TOXICITY TESTS;

MINK CELL FOCUS-FORMING VIRUS;

EID: 12844253069     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0406755102     Document Type: Article

References (44)

1. Geysen, H. M., Schoenen, F., Wagner, D. & Wagner, R. (2003) Nat. Rev. Drug Discov. 2, 222-230.
2. Myers, P. L. (1997) Curr. Opin. Biotechnol. 2, 701-707.
3. Bleicher, K. H., Bohm, H. J., Muller, K. & Alanine, A. I. (2003) Nat. Rev. Drug Discov. 2, 369-378.
4. Petricoin, E. F., Zoon, K. C. Kohn, E. C., Barrett, J. C. & Liotta, L. A. (2002) Nat. Rev. Drug Discov. 1, 683-695.
5. Gombar, V. K., Silver, L. S. & Zhao, Z. (2003) Top. Med. Chem. 3, 1205-1225.
6. Li, A. P. (2001) Drug Discov. Today 6, 357-366.
7. MacCoss, M. & Ballie, T. A. (2004) Science 303, 1810-1813.
8. Guengerich, F. P. (2001) Chem. Res. Toxicol. 14, 611-650.
9. Lewis, D. F. (2004) Pharmacogenomics 5, 305-318.
10. Yumibe, N., Huie, K., Chen, K. J., Snow, M., Clement, R. P. & Cayen, M. N. (1996) Biochem. Pharmacol. 51, 165-172.
11. Villeneuve, J. P. & Pichette, V. (2004) Curr. Drug Metab. 5, 273-282.
12. Nelson, S. D. (1995) Drug Metab. Rev. 27, 147-177.
13. James, L. P., Mayeux, P. R. & Hinson, J. A. (2003) Drug Metab. Dispos. 31, 1499-1506.
14. Brandon, E. F. A., Raap, C. D., Meijerman, I., Beijnen, J. H. & Schellens, J. H. M. (2003) Toxicol. Appl. Pharmacol. 189, 233-246.
15. Onderwater, R. C., Commandeur, J. N. & Vermeulen, N. P. (2004) Toxicology 197, 81-91.
16. Martignoni, M., Monshouwer, M., de Kanter, R., Pezzetta, D., Moscone, A. & Grossi, P. (2004) Toxicol. In Vitro 18, 121-128.
17. McGinnity, D. F., Soars, M. G., Urbanowicz, R. & Riley, R. J. (2004) Drug Metab. Dispos. 32, 1247-1253.
18. Hewitt, N. J. & Hewitt, P. (2004) Xenobiotica 34, 243-256.
19. Urani, C, Doldi, M., Crippa, S. & Camatini, M. (1998) Chemosphere 37, 2785-2795.
20. Peng, F. C., Chaing, H. H., Tang, S. H., Chen, P. C. & Lu, S. C. (2004) J. Toxicol. Environ. Health A 67, 109-124.
21. Fabre, N., Arrivet, E., Trancard, J., Bichet, N., Roome, N. O., Prenez, A. & Vericat, J. A. (2003) Cell Biol. Toxicol. 19, 71-82.
22. Powers, M. J., Domansky, K., Kaazemour-Mofrad, M. R., Kalezi, A., Capitano, A., Upadhyaya, A., Kurzawski, P., Wack, K. E., Stolz, D. B., Kamm, R. & Griffith, L. G. (2002) Biotechnol. Bioeng. 78, 257-269.
23. Boisclair, Y. R., Wang, J., Shi, J., Hurst, K. R. & Ooi, G. T. (2000) J. Biol. Chem. 275, 3841-3847.
24. Madan, A., Dehaan, R., Mudra, D., Carroll, K., Lecluyse, E. & Parkinson, A. (1999) Drug Metab. Dispos. 27, 327-335.
25. Fardel, O., Morel, F., Ratanasavanh, D., Fautrel, A., Beaune, P. & Guillouzo, A. (1992) Cell. Mol. Aspects Cirrhosis 216, 327-330.
26. Samuel, K., Yin, W., Stearns, R. A., Tang, Y. S., Chaudhary, A. G., Jewell, J. P., Lanza, T., Lin, L. S., Hagmann, W. K., Evans, D. C. & Kumar, S. (2003) J. Mass Spectrom. 38, 211-221.
27. Smith, K. S., Smith, P. L., Heady, T. N., Trugman, J. M., Harman, W. D. & Macdonald, T. L. (2003) Chem. Res. Toxicol. 16, 123-128.
28. Ong, C. E., Coulter, S., Birkett, D. J., Bhasker, C. R. & Miners, J. O. (2000) J. Clin. Pharmacol. 50, 573-580.
29. Gut, I., Danielova, V., Holubova, J., Soucek, P. & Kluckova, H. (2000) Arch. Toxicol. 74, 437-446.
30. Ziauddin, J. & Sabatini, D. M. (2001) Nature 411, 107-110.
31. Gill, I. & Ballesteros, A. (2000) Trends Biotechnol. 18, 282-296.
32. Gill, I. (2001) Chem. Mater. 13, 3404-3421.
33. Rupcich, N., Goldstein, A. & Brennan, J. D. (2003) Chem. Mater. 15, 1803-1811.
34. Anderson, D., Bishop, J. B., Garner, R. C., Ostrosky-Wegman, P. & Selby, P. B. (1995) Mutation Res. 330, 115-181.
35. Huang, Z., Roy, P. & Waxman, D. J. (2000) Biochem. Pharmacol. 59, 961-972.
36. Simoes-Wuest, A. P., Schuerpf, T., Hall, J., Stahel, R. A. & Zangemeister-Wittke, U. (2002) Breast Cancer Res. Treat. 76, 57-166.
37. Bohnenstengel, F., Eichelbaum, M., Golbs, E. & Kroemer, H. K. (1997) J. Chromatogr. B Biomed. Sci. Appl. 692, 163-168.
38. Uchida, K., Kanematsu, M., Sakai, K., Matsuda, T., Hattori, N., Mizuno, Y., Suzuki, D., Miyata, T., Noguchi, N., Niki, E. & Osawa, T. (1998) Proc. Natl. Acad. Sci. USA 95, 4882-4887.
39. Morrow, C. S., Smitherman, P. K. & Townsend, A. J. (1998) Biochem. Pharmacol. 56, 1013-1022.
40. Struck, R. F., Thorpe, M. C., Coburn, W. C. & Laster, W. R. (1974) J. Am. Chem. Soc. 96, 313-315.
41. Komatsu, T., Yamazaki, H., Shimada, N., Nakajima, M. & Yokoi, T. (2000) Drug Metab. Dispos. 28, 1457-1463.
42. Li, D., Jang, S. H., Kim, J. H., Wientjes, M. G. & Au, J. L. S. (2003) Pharm. Res. 20, 45-50.
43. Patten, C. J., Thomas, P. E., Guy, R. L., Lee, M. J., Gonzalez, F. J., Guengerich, F. P. & Yang, C. S. (1993) Chem. Res. Toxicol. 6, 511-518.
44. Hazai, E., Vereczkey, L. & Monostory, K. (2002) Biochem. Biophys. Res. Commun. 291, 1089-1094.