From 3D cell culture to organs-on-chips

Trends in Cell Biology

Volumn 21, Issue 12, 2011, Pages 745-754

  Huh, Dongeun ^a   Hamilton, Geraldine A ^a   Ingber, Donald E ^a,b,c  

^a HARVARD UNIVERSITY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHIP; CELL CULTURE; CYTOLOGY; HUMAN; IN VITRO STUDY; MICROCHIP ANALYSIS; MICROENVIRONMENT; MICROFLUIDICS; MICROTECHNOLOGY; PRIORITY JOURNAL; REVIEW; THREE DIMENSIONAL CELL CULTURE; TISSUE DIFFERENTIATION;

ANIMALS; BIOMIMETIC MATERIALS; CELL CULTURE TECHNIQUES; HUMANS; MEMBRANES, ARTIFICIAL; MICROFLUIDICS; MODELS, BIOLOGICAL;

ANIMALIA;

EID: 81355146382     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2011.09.005     Document Type: Review

References (84)

1. Pampaloni F., et al. The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell Biol. 2007, 8:839-845.
2. Folch A., Toner M. Microengineering of cellular interactions. Annu. Rev. Biomed. Eng. 2000, 2:227-256.
3. Khademhosseini A., et al. Microscale technologies for tissue engineering and biology. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:2480-2487.
4. Whitesides G.M., et al. Soft lithography in biology and biochemistry. Annu. Rev. Biomed. Eng. 2001, 3:335-373.
5. Whitesides G.M. The origins and the future of microfluidics. Nature 2006, 442:368-373.
6. Singhvi R., et al. Engineering cell shape and function. Science 1994, 264:696-698.
7. Dike L.E., et al. Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates. In Vitro Cell. Dev. Biol. Anim. 1999, 35:441-448.
8. Polte T.R., et al. Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress. Am. J. Physiol. Cell Physiol. 2004, 286:C518-C528.
9. Chen C.S., et al. Geometric control of cell life and death. Science 1997, 276:1425-1428.
10. Feinberg A.W., et al. Muscular thin films for building actuators and powering devices. Science 2007, 317:1366-1370.
11. Alford P.W., et al. Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials 2010, 31:3613-3621.
12. Takayama S., et al. Subcellular positioning of small molecules. Nature 2001, 411:1016.
13. Li Jeon N., et al. Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nat. Biotechnol. 2002, 20:826-830.
14. Selimovic S., et al. Generating nonlinear concentration gradients in microfluidic devices for cell studies. Anal. Chem. 2011, 83:2020-2028.
15. Chung B.G., et al. Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab. Chip 2005, 5:401-406.
16. Park J.Y., et al. Gradient generation by an osmotic pump and the behavior of human mesenchymal stem cells under the fetal bovine serum concentration gradient. Lab. Chip 2007, 7:1673-1680.
17. Villa-Diaz L.G., et al. Microfluidic culture of single human embryonic stem cell colonies. Lab. Chip 2009, 9:1749-1755.
18. Lang S., et al. Growth cone response to ephrin gradients produced by microfluidic networks. Anal. Bioanal. Chem. 2008, 390:809-816.
19. Sawano A., et al. Lateral propagation of EGF signaling after local stimulation is dependent on receptor density. Dev. Cell 2002, 3:245-257.
20. Mammoto T., et al. Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev. Cell 2011, 21:758-769.
21. Lucchetta E.M., et al. Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics. Nature 2005, 434:1134-1138.
22. Seidi A., et al. A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease. Biomicrofluidics 2011, 5:22214.
23. Choi N.W., et al. Microfluidic scaffolds for tissue engineering. Nat. Mater. 2007, 6:908-915.
24. Ling Y., et al. A cell-laden microfluidic hydrogel. Lab. Chip 2007, 7:756-762.
25. Paguirigan A., Beebe D.J. Gelatin based microfluidic devices for cell culture. Lab. Chip 2006, 6:407-413.
26. Du Y., et al. Sequential assembly of cell-laden hydrogel constructs to engineer vascular-like microchannels. Biotechnol. Bioeng. 2011, 108:1693-1703.
27. Derda R., et al. Paper-supported 3D cell culture for tissue-based bioassays. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:18457-18462.
28. Derda R., et al. Multizone paper platform for 3D cell cultures. PLoS ONE 2011, 6:e18940.
29. Powers M.J., et al. A microfabricated array bioreactor for perfused 3D liver culture. Biotechnol. Bioeng. 2002, 78:257-269.
30. Powers M.J., et al. Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor. Tissue Eng. 2002, 8:499-513.
31. Leclerc E., et al. Microfluidic PDMS (polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes. Biotechnol. Prog. 2004, 20:750-755.
32. Baudoin R., et al. Development of a renal microchip for in vitro distal tubule models. Biotechnol. Prog. 2007, 23:1245-1253.
33. O'Neill A.T., et al. Characterization of microfluidic human epidermal keratinocyte culture. Cytotechnology 2008, 56:197-207.
34. Jang K., et al. Development of an osteoblast-based 3D continuous-perfusion microfluidic system for drug screening. Anal. Bioanal. Chem. 2008, 390:825-832.
35. Leclerc E., et al. Study of osteoblastic cells in a microfluidic environment. Biomaterials 2006, 27:586-595.
36. Chao P.G., et al. Dynamic osmotic loading of chondrocytes using a novel microfluidic device. J. Biomech. 2005, 38:1273-1281.
37. D'Amico Oblak T., et al. Fluorescence monitoring of ATP-stimulated, endothelium-derived nitric oxide production in channels of a poly(dimethylsiloxane)-based microfluidic device. Anal. Chem. 2006, 78:3193-3197.
38. Tkachenko E., et al. An easy to assemble microfluidic perfusion device with a magnetic clamp. Lab. Chip 2009, 9:1085-1095.
39. Chung K., et al. A microfluidic array for large-scale ordering and orientation of embryos. Nat. Methods 2011, 8:171-176.
40. Song J.W., et al. Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal. Chem. 2005, 77:3993-3999.
41. Gu W., et al. Computerized microfluidic cell culture using elastomeric channels and Braille displays. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:15861-15866.
42. Futai N., et al. Handheld recirculation system and customized media for microfluidic cell culture. Lab. Chip 2006, 6:149-154.
43. Shin M., et al. Endothelialized networks with a vascular geometry in microfabricated poly(dimethyl siloxane). Biomed. Microdevices 2004, 6:269-278.
44. Kachouie N.N., et al. Directed assembly of cell-laden hydrogels for engineering functional tissues. Organogenesis 2010, 6:234-244.
45. El-Ali J., et al. Cells on chips. Nature 2006, 442:403-411.
46. Meyvantsson I., Beebe D.J. Cell culture models in microfluidic systems. Annu. Rev. Anal. Chem. (Palo Alto Calif) 2008, 1:423-449.
47. Imura Y., et al. A microfluidic system to evaluate intestinal absorption. Anal. Sci. 2009, 25:1403-1407.
48. Kimura H., et al. An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models. Lab. Chip 2008, 8:741-746.
49. Nalayanda D.D., et al. An open-access microfluidic model for lung-specific functional studies at an air-liquid interface. Biomed. Microdevices 2009, 11:1081-1089.
50. Jang K.J., et al. Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells. Integr. Biol. (Camb) 2011, 3:134-141.
51. Jang K.J., Suh K.Y. A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab. Chip 2010, 10:36-42.
52. Puleo C.M., et al. Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture. Lab. Chip 2009, 9:3221-3227.
53. Carraro A., et al. In vitro analysis of a hepatic device with intrinsic microvascular-based channels. Biomed. Microdevices 2008, 10:795-805.
54. Kane B.J., et al. Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes. Anal. Chem. 2006, 78:4291-4298.
55. Lee P.J., et al. An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture. Biotechnol. Bioeng. 2007, 97:1340-1346.
56. Nakao Y., et al. Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device. Biomicrofluidics 2011, 5:22212.
57. You L., et al. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone 2008, 42:172-179.
58. Park J., et al. Microfluidic compartmentalized co-culture platform for CNS axon myelination research. Biomed. Microdevices 2009, 11:1145-1153.
59. Sudo R., et al. Transport-mediated angiogenesis in 3D epithelial coculture. FASEB J. 2009, 23:2155-2164.
60. Chung S., et al. Cell migration into scaffolds under co-culture conditions in a microfluidic platform. Lab. Chip 2009, 9:269-275.
61. Zervantonakis I.K., et al. Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments. Biomicrofluidics 2011, 5:13406.
62. Sung K.E., et al. Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. Integr. Biol. (Camb) 2011, 3:439-450.
63. Torisawa Y.S., et al. Efficient formation of uniform-sized embryoid bodies using a compartmentalized microchannel device. Lab. Chip 2007, 7:770-776.
64. Torisawa Y.S., et al. Microfluidic hydrodynamic cellular patterning for systematic formation of co-culture spheroids. Integr. Biol. (Camb) 2009, 1:649-654.
65. Hsiao A.Y., et al. Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids. Biomaterials 2009, 30:3020-3027.
66. Song J.W., et al. Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells. PLoS ONE 2009, 4:e5756.
67. Allen J.W., et al. In vitro zonation and toxicity in a hepatocyte bioreactor. Toxicol. Sci. 2005, 84:110-119.
68. Torisawa Y.S., et al. Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells. Integr. Biol. (Camb) 2010, 2:680-686.
69. Huh D., et al. Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:18886-18891.
70. Douville N.J., et al. Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model. Lab. Chip 2011, 11:609-619.
71. Huh D., et al. Reconstituting organ-level lung functions on a chip. Science 2010, 328:1662-1668.
72. Esch M.B., et al. The role of body-on-a-chip devices in drug and toxicity studies. Annu. Rev. Biomed. Eng. 2011, 13:55-72.
73. Sin A., et al. The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors. Biotechnol. Prog. 2004, 20:338-345.
74. Viravaidya K., et al. Development of a microscale cell culture analog to probe naphthalene toxicity. Biotechnol. Prog. 2004, 20:316-323.
75. Sung J.H., et al. A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Lab. Chip 2010, 10:446-455.
76. Sung J.H., Shuler M.L. A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. Lab. Chip 2009, 9:1385-1394.
77. Viravaidya K., Shuler M.L. Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies. Biotechnol. Prog. 2004, 20:590-597.
78. Imura Y., et al. Micro total bioassay system for ingested substances: assessment of intestinal absorption, hepatic metabolism, and bioactivity. Anal. Chem. 2010, 82:9983-9988.
79. Swinney D.C., Anthony J. How were new medicines discovered?. Nat. Rev. Drug Discov. 2011, 10:507-519.
80. Mosadegh B., et al. Integrated elastomeric components for autonomous regulation of sequential and oscillatory flow switching in microfluidic devices. Nat. Phys. 2010, 6:433-437.
81. Unger M.A., et al. Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 2000, 288:113-116.
82. Thorsen T., et al. Microfluidic large-scale integration. Science 2002, 298:580-584.
83. Grover W.H., et al. Development and multiplexed control of latching pneumatic valves using microfluidic logical structures. Lab. Chip 2006, 6:623-631.
84. Therriault D., et al. Chaotic mixing in three-dimensional microvascular networks fabricated by direct-write assembly. Nat. Mater. 2003, 2:265-271.