Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction

Molecular Therapy

Volumn 20, Issue 1, 2012, Pages 127-137

  Takayama, Kazuo ^a,b   Inamura, Mitsuru ^a,b   Kawabata, Kenji ^a,b   Katayama, Kazufumi ^a   Higuchi, Maiko ^b   Tashiro, Katsuhisa ^b   Nonaka, Aki ^b   Sakurai, Fuminori ^a   Hayakawa, Takao ^c,d   Kusuda Furue, Miho ^b,e   Mizuguchi, Hiroyuki ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^c PHARMACEUTICALS AND MEDICAL DEVICES AGENCY   (Japan)

^d KINKI UNIVERSITY   (Japan)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BIOLOGICAL MARKER; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; HEMATOPOIETICALLY EXPRESSED HOMEOBOX PROTEIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX17; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; EPITHELIAL MESENCHYMAL TRANSITION; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; HEMATOPOIETICALLY EXPRESSED HOMEOBOX GENE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA GENE; HUMAN; HUMAN CELL; LIVER DEVELOPMENT; LIVER FUNCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PROTEIN FUNCTION; SYR RELATED HMG BOX 17 GENE;

ADENOVIRIDAE;

EID: 84856974289     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.234     Document Type: Article

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