T-cadherin modulates hepatocyte functions in vitro

FASEB Journal

Volumn 22, Issue 11, 2008, Pages 3768-3775

  Khetani, Salman R ^a   Chen, Alice A ^a,b   Ranscht, Barbara ^c   Bhatia, Sangeeta N ^a,d  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c BURNHAM INSTITUTE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

CHO; Coculture; Cytochrome P450; Fibroblasts

Indexed keywords

ALBUMIN; CYTOCHROME P450 1A1; MEMBRANE PROTEIN; T CADHERIN; UNCLASSIFIED DRUG; UREA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CHO CELL; COCULTURE; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME ISOLATION; FEMALE; FIBROBLAST; GENE AMPLIFICATION; IN VITRO STUDY; LIVER CELL; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; TISSUE ENGINEERING; UREA CYCLE; WILD TYPE;

3T3 CELLS; ANIMALS; CADHERINS; CHO CELLS; COCULTURE TECHNIQUES; CRICETINAE; CRICETULUS; GENE EXPRESSION; HEPATOCYTES; LIVER; MICE; RATS; STROMAL CELLS; TISSUE ENGINEERING;

CRICETULUS GRISEUS; RATTUS;

EID: 55549087204     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-105155     Document Type: Article

References (37)

1. Allen, J. W., and Bhatia, S. N. (2002) Engineering liver therapies for the future. Tissue Eng. 8, 725-737
2. Hewitt, N. J., Lechon, M. J., Houston, J. B., Hallifax, D., Brown, H. S., Maurel, P., Kenna, J. G., Gustavsson, L., Lohmann, C., Skonberg, C., Guillouzo, A., Tuschl, G., Li, A. P., LeCluyse, E., Groothuis, G. M., and Hengstler, J. G. (2007) Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab. Rev. 39, 159-234
3. Khetani, S. R., and Bhatia, S. N. (2007) Microscale culture of human liver cells for drug development. Nat. Biotechnol. 26, 120-126
4. Bhatia, S. N., Balis, U. J., Yarmush, M. L., and Toner, M. (1999) Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J. 13, 1883-1900
5. Mesnil, M., Fraslin, J. M., Piccoli, C., Yamasaki, H., and Guguen-Guillouzo, C. (1987) Cell contact but not junctional communication (dye coupling) with biliary epithelial cells is required for hepatocytes to maintain differentiated functions. Exp. Cell Res. 173, 524-533
6. Guillouzo, A. (1998) Liver cell models in in vitro toxicology. Environ. Health Perspect. 106(Suppl. 2), 511-532
7. Khetani, S. R., Szulgit, G., Del Rio, J. A., Barlow, C., and Bhatia, S. N. (2004) Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling. Hepatology 40, 545-554
8. Guguen-Guillouzo, C., and Guillouzo, A. (1983) Modulation of functional activities in cultured rat hepatocytes. Mol. Cell. Biochem. 53-54, 35-56
9. Bissell, D. M., Arenson, D. M., Maher, J. J., and Roll, F. J. (1987) Support of cultured hepatocytes by a laminin-rich gel: evidence for a functionally significant subendothelial matrix in normal rat liver. J. Clin. Invest. 79, 801-812
10. Corlu, A., Ilyin, G., Cariou, S., Lamy, I., Loyer, P., and Guguen-Guillouzo, C. (1997) The coculture: a system for studying the regulation of liver differentiation/proliferation activity and its control. Cell Biol. Toxicol. 13, 235-242
11. Dunn, J. C., Tompkins, R. G., and Yarmush, M. L. (1991) Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol. Prog. 7, 237-245
12. Gebhardt, R., Hengstler, J. G., Muller, D., Glockner, R., Buenning, P., Laube, B., Schmelzer, E., Ullrich, M., Utesch, D., Hewitt, N., Ringel, M., Hilz, B. R., Bader, A., Langsch, A., Koose, T., Burger, H. J., Maas, J., and Oesch, F. (2003) New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures Drug Metab. Rev. 35, 145-213
13. Reid, L. M., Narita, M., Fujita, M., Murray, Z., Liverpool, Z., and Rosenberg, L. (1986) Matrix and hormonal regulation of differentiation in liver cultures. In Isolated and Cultured Hepatocytes (Guillouzo, A., and Guguen-Guillouzo, C., eds) pp. 226-258, Les Editions INSERM and John Libbey Eurotext, Paris
14. Eschbach, E., Chatterjee, S. S., Noldner, M., Gottwald, E., Dertinger, H., Weibezahn, K. F., and Knedlitschek, G. (2005) Microstructured scaffolds for liver tissue cultures of high cell density: morphological and biochemical characterization of tissue aggregates. J. Cell. Biochem. 95, 243-255
15. Sivaraman, A., Leach, J. K., Townsend, S., Iida, T., Hogan, B. J., Stolz, D. B., Fry, R., Samson, L. D., Tannenbaum, S. R., and Griffith, L. G. (2005) A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction. Curr. Drug Metab. 6, 569-591
16. Chia, S. M., Lin, P. C., and Yu, H. (2005) TGF-beta1 regulation in hepatocyte-NIH3T3 co-culture is important for the enhanced hepatocyte function in 3D microenvironment. Biotechnol. Bioeng. 89, 565-573
17. Corlu, A., Kneip, B., Lhadi, C., Leray, G., Glaise, D., Baffet, G., Bourel, D., and Guguen-Guillouzo, C. (1991) A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes. J. Cell Biol. 115, 505-515
18. Brieva, T. A., and Moghe, P. V. (2001) Functional engineering of hepatocytes via heterocellular presentation of a homoadhesive molecule, E-cadherin. Biotechnol. Bioeng. 76, 295-302
19. Goulet, F., Normand, C., and Morin, O. (1988) Cellular interactions promote tissue-specific function, biomatrix deposition and junctional communication of primary cultured hepatocytes. Hepatology 8, 1010-1018
20. Hamilton, G. A., Jolley, S. L., Gilbert, D., Coon, D. J., Barros, S., and LeCluyse, E. L. (2001) Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions. Cell Tissue Res. 306, 85-99
21. Rojkind, M., Novikoff, P. M., Greenwel, P., Rubin, J., Rojas-Valencia, L., de Carvalho, A. C., Stockert, R., Spray, D., Hertzberg, E. L., and Wolkoff, A. W. (1995) Characterization and functional studies on rat liver fat-storing cell line and freshly isolated hepatocyte coculture system. Am. J. Pathol. 146, 1508-1520
22. Marrs, J. A., and Nelson, W. J. (1996) Cadherin cell adhesion molecules in differentiation and embryogenesis. Int. Rev. Cytol. 165, 159-205
23. Ranscht, B., and Dours-Zimmermann, M. T. (1991) T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region. Neuron 7, 391-402
24. Takeuchi, T., and Ohtsuki, Y. (2001) Recent progress in Tcadherin (CDH13, H-cadherin) research. Histol. Histopathol. 16, 1287-1293
25. Vestal, D. J., and Ranscht, B. (1992) Glycosyl phosphatidylinositol- anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion. J. Cell Biol. 119, 451-461
26. Philippova, M. P., Bochkov, V. N., Stambolsky, D. V., Tkachuk, V. A., and Resink, T. J. (1998) T-cadherin and signal-transducing molecules co-localize in caveolin-rich membrane domains of vascular smooth muscle cells. FEBS Lett. 429, 207-210
27. Joshi, M. B., Philippova, M., Ivanov, D., Allenspach, R., Erne, P., and Resink, T. J. (2005) T-cadherin protects endothelial cells from oxidative stress-induced apoptosis. FASEB J. 19, 1737-1739
28. Fredette, B. J., Miller, J., and Ranscht, B. (1996) Inhibition of motor axon growth by T-cadherin substrata. Development 122, 3163-3171
29. Hug, C., Wang, J., Ahmad, N. S., Bogan, J. S., Tsao, T. S., and Lodish, H. F. (2004) T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc. Natl. Acad. Sci. U. S. A. 101, 10308-10313
30. Adachi, Y., Takeuchi, T., Sonobe, H., and Ohtsuki, Y. (2006) An adiponectin receptor, T-cadherin, was selectively expressed in intratumoral capillary endothelial cells in hepatocellular carcinoma: possible cross talk between T-cadherin and FGF-2 pathways. Virchows Arch., 4481, 311-318
31. Seglen, P. O. (1976) Preparation of isolated rat liver cells. Methods Cell Biol. 13, 29-83
32. Brieva, T. A., and Moghe, P. V. (2004) Engineering the hepatocyte differentiation-proliferation balance by acellular cadherin micropresentation. Tissue Eng. 10, 553-564
33. Hui, E. E., and Bhatia, S. N. (2007) Micromechanical control of cell-cell interactions. Proc. Natl. Acad. Sci. U. S. A. 104, 5722-5726
34. Philippova, M., Ivanov, D., Joshi, M. B., Kyriakakis, E., Rupp, K., Afonyushkin, T., Bochkov, V., Erne, P., and Resink, T. J. (2008) Identification of proteins associating with GPI-anchored T-cadherin on the surface of vascular endothelial cells: the role for Grp78/BiP in T-cadherin-dependent cell survival. Mol. Cell. Biol. 28, 4004-4017
35. Omelchenko, T., Fetisova, E., Ivanova, O., Bonder, E. M., Feder, H., Vasiliev, J. M., and Gelfand, I. M. (2001) Contact interactions between epitheliocytes and fibroblasts: formation of heterotypic cadherin-containing adhesion sites is accompanied by local cytoskeletal reorganization. Proc. Natl. Acad. Sci. U. S. A. 98, 8632-8637
36. Steinberg, M. S., and McNutt, P. M. (1999) Cadherins and their connections: adhesion junctions have broader functions. Curr. Opin. Cell Biol. 11, 554-560
37. Tkachuk, V. A., Bochkov, V. N., Philippova, M. P., Stambolsky, D. V., Kuzmenko, E. S., Sidorova, M. V., Molokoedov, A. S., Spirov, V. G., and Resink, T. J. (1998) Identification of an atypical lipoprotein-binding protein from human aortic smooth muscle as T-cadherin. FEBS Lett. 421, 208-212