Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes

European Journal of Pharmacology

Volumn 368, Issue 1, 1999, Pages 75-87

  Milosevic, Nenad ^a   Schawalder, Hanspeter ^a   Maier, Peter ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Acute phase response; Coculture; CYP1A1; CYP2B1; Hepatocyte, rat; Kupffer cell; Nitric oxide (NO); TNF (tumor necrosis factor )

Indexed keywords

ALBUMIN; CYTOCHROME P450; LIPOPOLYSACCHARIDE; NITRIC OXIDE; OROSOMUCOID; PHENOBARBITAL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL CULTURE; COCULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; IN VITRO STUDY; KUPFFER CELL; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; XENOBIOTIC METABOLISM;

ACETAMINOPHEN; ACUTE-PHASE PROTEINS; ALBUMINS; ANALGESICS, NON-NARCOTIC; ANIMALS; CARCINOGENS; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ISOENZYMES; KUPFFER CELLS; LIPOPOLYSACCHARIDES; LIVER; MALE; METHYLCHOLANTHRENE; NITRIC OXIDE; PHENOBARBITAL; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA; XENOBIOTICS;

EID: 0033047434     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00988-1     Document Type: Article

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