Tethered spheroids as an invitro hepatocyte model for drug safety screening

Biomaterials

Volumn 33, Issue 7, 2012, Pages 2165-2176

  Xia, Lei ^a   Sakban, Rashidah Binte ^a,b   Qu, Yinghua ^a,b   Hong, Xin ^a,b   Zhang, Wenxia ^a   Nugraha, Bramasta ^b,c,d   Tong, Wen Hao ^b,c   Ananthanarayanan, Abhishek ^b,c   Zheng, Baixue ^d,e   Chau, Ian Yin Yan ^f   Jia, Ruirui ^a   McMillian, Michael ^g   Silva, Jose ^g   Dallas, Shannon ^g   Yu, Hanry ^{a,b,c,d,e,h,i,j}  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e SINGAPORE MIT ALLIANCE   (Singapore)

^f UNIVERSITY OF HONG KONG   (Hong Kong)

^g JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^h NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

ⁱ SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^j USA   (United States)

more..

Author keywords

3D hepatocyte model; CYP450 enzymes; Drug safety testing; Galactose; RGD; Xenobiotics

Indexed keywords

BIOCHEMISTRY; CELL ENGINEERING; DRUG PRODUCTS; SAFETY TESTING; UREA;

3D HEPATOCYTE MODELS; CYP450 ENZYMES; DRUG SAFETY TESTING; GALACTOSE; XENOBIOTICS;

THREE DIMENSIONAL COMPUTER GRAPHICS;

ALBUMIN; CYTOCHROME P450; OXYGEN; UREA; COLLAGEN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL STRUCTURE; DRUG SAFETY; ENZYME ACTIVITY; HEALTH CARE ACCESS; IN VITRO STUDY; LIVER CELL; LIVER CELL CULTURE; MALE; MULTICELLULAR SPHEROID; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; RAT; TETHERED SPHEROID; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CYTOLOGY; DRUG SCREENING; EVALUATION; HUMAN; METABOLISM; METHODOLOGY; PHYSIOLOGY; WISTAR RAT;

ANIMALS; CELLS, CULTURED; COLLAGEN; DRUG EVALUATION, PRECLINICAL; HEPATOCYTES; HUMANS; MALE; MODELS, BIOLOGICAL; RATS; RATS, WISTAR; SPHEROIDS, CELLULAR;

EID: 84855717842     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.12.006     Document Type: Article

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