Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

Hepatology

Volumn 55, Issue 4, 2012, Pages 1227-1236

  Tostões, Rui M ^a,b   Leite, Sofia B ^a,b   Serra, Margarida ^a,b   Jensen, Janne ^c   Björquist, Petter ^c   Carrondo, Manuel J T ^a,b   Brito, Catarina ^a,b   Alves, Paula M ^a,b  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b IBET   (Portugal)

^c Cellartis AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CYTOCHROME P450 3A; CYTOKERATIN 18; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; PROTEIN KINASE C; UREA;

ARTICLE; BIOREACTOR; CELL ACTIVITY; CELL CULTURE; DRUG SCREENING; EXTENDED PERFUSION BIOREACTOR CULTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPHEROID CELL; UREA CYCLE;

ALBUMINS; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOXICITY; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; HUMANS; KERATIN-18; PERFUSION; SPHEROIDS, CELLULAR;

EID: 84859119473     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24760     Document Type: Article

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