In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsymTM: A mechanistic, mathematical model of DILI

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 39, Issue 5, 2012, Pages 527-541

  Howell, Brett A ^a   Yang, Yuching ^a   Kumar, Rukmini ^b   Woodhead, Jeffrey L ^a   Harrill, Alison H ^a   Clewell III, Harvey J ^a   Andersen, Melvin E ^a   Siler, Scott Q ^a   Watkins, Paul B ^a,c  

^a Hamner UNC Institute for Drug Safety Sciences   (United States)

^b Entelos Inc   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; Drug induced liver injury (DILI); Hepatotoxicity; In vitro to in vivo extrapolation (IVIVE); Mechanistic model; Methapyrilene; Pharmacokinetic pharmacodynamic (PKPD) model

Indexed keywords

METHAPYRILENE; PARACETAMOL;

ALGORITHM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; MALE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROCESS MODEL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; SPECIES DIFFERENCE; TOXIC HEPATITIS;

ANIMALS; DRUG-INDUCED LIVER INJURY; HUMANS; MICE; MICE, INBRED C57BL; MODELS, THEORETICAL; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

EID: 84870395485     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-012-9266-0     Document Type: Article

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