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Volumn 4, Issue 6, 2005, Pages 489-499

Idiosyncratic drug hepatotoxicity

Author keywords

[No Author keywords available]

Indexed keywords

ACARBOSE; ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALLOPURINOL; AMIODARONE; BOSENTAN; BROMFENAC; DANTROLENE; DICLOFENAC; DISULFIRAM; FELBAMATE; HALOTHANE; HERBACEOUS AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISONIAZID; ISOTRETINOIN; LABETALOL; LEFLUNOMIDE; METHYLDOPA; MINOCYCLINE; NEFAZODONE; NEVIRAPINE; NICOTINIC ACID; NITROFURANTOIN; PARACETAMOL; PEMOLINE; PHENOBARBITAL; PHENYTOIN; PYRAZINAMIDE; RIFAMPICIN; SULINDAC; TACRINE; TERBINAFINE; TOLCAPONE; TROGLITAZONE; TROVAFLOXACIN; VALPROIC ACID; XIMELAGATRAN; ZAFIRLUKAST; ZILEUTON;

EID: 20844444779     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd1750     Document Type: Review
Times cited : (937)

References (90)
  • 1
    • 0037126649 scopus 로고    scopus 로고
    • Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
    • Ostapowicz, G. et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann. Int. Med. 137, 947-954 (2002).
    • (2002) Ann. Int. Med. , vol.137 , pp. 947-954
    • Ostapowicz, G.1
  • 2
    • 0034950046 scopus 로고    scopus 로고
    • Drug-induced liver disorders: Implications for drug development and regulation
    • Kaplowitz, N. Drug-induced liver disorders: implications for drug development and regulation. Drug Saf. 24, 483-490 (2001).
    • (2001) Drug Saf. , vol.24 , pp. 483-490
    • Kaplowitz, N.1
  • 3
    • 0242463906 scopus 로고    scopus 로고
    • (eds Kaplowitz, N. & DeLeve, L.) (Marcel Dekker, New York, )
    • Obermayer-Straub, P. & Manns, M. P. in Drug-Induced Liver Disease (eds Kaplowitz, N. & DeLeve, L.) 125-149 (Marcel Dekker, New York, 2003).
    • (2003) Drug-Induced Liver Disease , pp. 125-149
    • Obermayer-Straub, P.1    Manns, M.P.2
  • 4
    • 9844252868 scopus 로고    scopus 로고
    • Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug-induced liver injury
    • Maria, V. A. & Victorino, R. M. Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug-induced liver injury. Gut 41, 534-540 (1997).
    • (1997) Gut , vol.41 , pp. 534-540
    • Maria, V.A.1    Victorino, R.M.2
  • 5
    • 0031660620 scopus 로고    scopus 로고
    • Immunological investigation in hepatic drug reactions
    • Maria, V. A. & Victorino, R. M. Immunological investigation in hepatic drug reactions. Clin. Exp. Allergy 28 (Suppl. 4), 71-77 (1998).
    • (1998) Clin. Exp. Allergy , vol.28 , Issue.SUPPL. 4 , pp. 71-77
    • Maria, V.A.1    Victorino, R.M.2
  • 6
    • 3042519582 scopus 로고    scopus 로고
    • Clinical perspectives in xenobiotic hepatotoxicity
    • Gunawan, B. & Kaplowitz, N. Clinical perspectives in xenobiotic hepatotoxicity. Drug Metab. Rev. 36, 301-312 (2004).
    • (2004) Drug Metab. Rev. , vol.36 , pp. 301-312
    • Gunawan, B.1    Kaplowitz, N.2
  • 7
    • 17944393027 scopus 로고    scopus 로고
    • The danger hypothesis applied to idiosyncratic drug reactions
    • Seguin, B. & Uetrecht, J. The danger hypothesis applied to idiosyncratic drug reactions. Curr. Opin. Allergy Clin. Immunol. 3, 235-242 (2003).
    • (2003) Curr. Opin. Allergy Clin. Immunol. , vol.3 , pp. 235-242
    • Seguin, B.1    Uetrecht, J.2
  • 9
    • 0024563279 scopus 로고
    • Amiodarone hepatotoxicity: Prevalence and clinicopathologic corelations among 104 patients
    • Lewis, J. H. et al. Amiodarone hepatotoxicity: prevalence and clinicopathologic corelations among 104 patients. Hepatology 9, 679-685 (1989).
    • (1989) Hepatology , vol.9 , pp. 679-685
    • Lewis, J.H.1
  • 10
    • 0037353404 scopus 로고    scopus 로고
    • Troglitazone-induced liver failure: A case study
    • Graham, D. J., Green, L., Senior, J. R. & Nourjah, P. Troglitazone-induced liver failure: a case study. Am. J. Med. 114, 299-306 (2003).
    • (2003) Am. J. Med. , vol.114 , pp. 299-306
    • Graham, D.J.1    Green, L.2    Senior, J.R.3    Nourjah, P.4
  • 11
    • 0034048191 scopus 로고    scopus 로고
    • Defining patient risks from expanded preventive therapies
    • Tolman, K. G. Defining patient risks from expanded preventive therapies. Am. J. Cardiol. 86, 15E-19E (2000).
    • (2000) Am. J. Cardiol. , vol.86
    • Tolman, K.G.1
  • 12
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991-1045 (1994).
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 13
    • 0036146776 scopus 로고    scopus 로고
    • Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists
    • Njoku, D. B. et al. Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists. Pediatr. Anesth. 94, 243-249 (2002).
    • (2002) Pediatr. Anesth. , vol.94 , pp. 243-249
    • Njoku, D.B.1
  • 14
    • 0031026096 scopus 로고    scopus 로고
    • Role of viral infections in the induction of adverse drug reactions
    • Levy, M. Role of viral infections in the induction of adverse drug reactions. Drug Saf. 16, 1-8 (1997).
    • (1997) Drug Saf. , vol.16 , pp. 1-8
    • Levy, M.1
  • 15
    • 0028869169 scopus 로고
    • Hepatotoxicity from isoniazid and rifampin in inner-city AIDS patients
    • Ozick, L. A. et al. Hepatotoxicity from isoniazid and rifampin in inner-city AIDS patients. Am. J. Gastroenterol. 90, 1978-1980 (1995).
    • (1995) Am. J. Gastroenterol. , vol.90 , pp. 1978-1980
    • Ozick, L.A.1
  • 16
    • 0033960045 scopus 로고    scopus 로고
    • Antituberculous drug-related liver dysfunction in chronic hepatitis B infection
    • Wong, W.-M. et al. Antituberculous drug-related liver dysfunction in chronic hepatitis B infection. Hepatology 31, 201-206 (2000).
    • (2000) Hepatology , vol.31 , pp. 201-206
    • Wong, W.-M.1
  • 17
    • 0031808038 scopus 로고    scopus 로고
    • Antituberculous drug-induced hepatotoxicity: The role of hepatitis C virus and the human immunodeficiency virus
    • Ungo, J. R. et al. Antituberculous drug-induced hepatotoxicity: the role of hepatitis C virus and the human immunodeficiency virus. Am. J. Respir. Crit Care Med. 157, 1871-1876 (1998).
    • (1998) Am. J. Respir. Crit. Care Med. , vol.157 , pp. 1871-1876
    • Ungo, J.R.1
  • 18
    • 0035804846 scopus 로고    scopus 로고
    • Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes
    • Schwartz, G. G. et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes. JAMA 285, 1711-1718 (2001).
    • (2001) JAMA , vol.285 , pp. 1711-1718
    • Schwartz, G.G.1
  • 19
    • 0024512235 scopus 로고
    • Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits
    • Kornbrust, D. J. et al. Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits. J. Pharmacol. Exp. Ther. 248, 498-505 (1989).
    • (1989) J. Pharmacol. Exp. Ther. , vol.248 , pp. 498-505
    • Kornbrust, D.J.1
  • 20
    • 0025039064 scopus 로고
    • Biochemical changes and morphological alterations of the liver in guinea-pigs after administration of simvastatin (HMG CoA reductase-inhibitor)
    • Horsmans, Y., Desager, J. P. & Harvengt, C. Biochemical changes and morphological alterations of the liver in guinea-pigs after administration of simvastatin (HMG CoA reductase-inhibitor). Pharmacol. Toxicol. 67, 336-339 (1990).
    • (1990) Pharmacol. Toxicol. , vol.67 , pp. 336-339
    • Horsmans, Y.1    Desager, J.P.2    Harvengt, C.3
  • 21
    • 0242463906 scopus 로고    scopus 로고
    • (eds Kaplowitz, N. & DeLeve, L.) (Marcel Dekker, New York, )
    • Senior, J. R. in Drug-Induced Liver Disease (eds Kaplowitz, N. & DeLeve, L.) 739-754 (Marcel Dekker, New York, 2003).
    • (2003) Drug-Induced Liver Disease , pp. 739-754
    • Senior, J.R.1
  • 23
    • 12844253684 scopus 로고    scopus 로고
    • Troglitazone and liver injury: In search of answers
    • Chojkier, M. Troglitazone and liver injury: in search of answers. Hepatology 41, 237-246 (2005).
    • (2005) Hepatology , vol.41 , pp. 237-246
    • Chojkier, M.1
  • 24
    • 0342502229 scopus 로고    scopus 로고
    • Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus
    • Menon, K., Angulo, P. & Lindor, K. D. Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus. Am. J. Gastroenterol. 96, 1631-1634 (2001).
    • (2001) Am. J. Gastroenterol. , vol.96 , pp. 1631-1634
    • Menon, K.1    Angulo, P.2    Lindor, K.D.3
  • 25
    • 15844419903 scopus 로고    scopus 로고
    • Risk of acute liver injury, associated with the combination of amoxicillin and clavulanic acid
    • Garcia-Rodriguez, L. A., Stricker, B. H. & Zimmerman, H. J. Risk of acute liver injury, associated with the combination of amoxicillin and clavulanic acid. Arch. Int. Med. 156, 1327-1332 (1996).
    • (1996) Arch. Int. Med. , vol.156 , pp. 1327-1332
    • Garcia-Rodriguez, L.A.1    Stricker, B.H.2    Zimmerman, H.J.3
  • 26
    • 0033984873 scopus 로고    scopus 로고
    • Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
    • Stieger, B. et al. Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology 118, 427-430 (2000).
    • (2000) Gastroenterology , vol.118 , pp. 427-430
    • Stieger, B.1
  • 27
    • 0035107812 scopus 로고    scopus 로고
    • Identification of a reactive metabolite of terbinafine: Insights into terbinafine-induced hepatotoxicity
    • Iverson, S. L. & Uetrecht, J. P. Identification of a reactive metabolite of terbinafine: insights into terbinafine-induced hepatotoxicity. Chem. Res. Toxicol. 14, 175-181 (2001).
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 175-181
    • Iverson, S.L.1    Uetrecht, J.P.2
  • 28
    • 0034973781 scopus 로고    scopus 로고
    • Indirect cytotoxicity of flucoxacillin toward human biliary epithelium via metabolite formation in hepatocytes
    • Lakehal, F. et al. Indirect cytotoxicity of flucoxacillin toward human biliary epithelium via metabolite formation in hepatocytes. Chem. Res. Toxicol. 14, 694-701 (2001).
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 694-701
    • Lakehal, F.1
  • 30
    • 0027199439 scopus 로고
    • Erythromycin-associated cholestatic hepatitis
    • Derby, L. E., Jick, H., Henry, D. A. & Dean, A. D. Erythromycin-associated cholestatic hepatitis. Med. J. Aust. 158, 600-602 (1993).
    • (1993) Med. J. Aust. , vol.158 , pp. 600-602
    • Derby, L.E.1    Jick, H.2    Henry, D.A.3    Dean, A.D.4
  • 31
    • 0032955557 scopus 로고    scopus 로고
    • Hepatotoxicity of psychotropic drugs
    • Selim, K. & Kaplowitz, N. Hepatotoxicity of psychotropic drugs. Hepatology 29, 1347-1351 (1999).
    • (1999) Hepatology , vol.2 , pp. 1347-1351
    • Selim, K.1    Kaplowitz, N.2
  • 32
    • 2542627509 scopus 로고    scopus 로고
    • HLA Class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease
    • Andrade, R. J. et al. HLA Class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease. Hepatology 39, 1603-1612 (2004).
    • (2004) Hepatology , vol.39 , pp. 1603-1612
    • Andrade, R.J.1
  • 33
    • 0032568261 scopus 로고    scopus 로고
    • Hepatic dysfunction associated with troglitazone
    • Watkins, P. B. & Whitcomb, R. W. Hepatic dysfunction associated with troglitazone. N. Eng. J. Med. 338, 916-917 (2001).
    • (2001) N. Eng. J. Med. , vol.338 , pp. 916-917
    • Watkins, P.B.1    Whitcomb, R.W.2
  • 34
    • 0028316959 scopus 로고
    • Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease
    • Watkins, P. B. et al. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA 271, 992-998 (1994).
    • (1994) JAMA , vol.271 , pp. 992-998
    • Watkins, P.B.1
  • 36
    • 17444396697 scopus 로고    scopus 로고
    • Hepatic findings in long-term clinical trials of ximelagatran
    • Lee, W. M. et al. Hepatic findings in long-term clinical trials of ximelagatran. Drug Saf. 28, 351-370 (2005).
    • (2005) Drug Saf. , vol.28 , pp. 351-370
    • Lee, W.M.1
  • 37
    • 0026570896 scopus 로고
    • Isoniazid-associated hepatitis deaths: A review of available information
    • Snider, D. E. & Caras, G. J. Isoniazid-associated hepatitis deaths: a review of available information. Am. Rev. Respir. Dis. 145, 494-497 (1992).
    • (1992) Am. Rev. Respir. Dis. , vol.145 , pp. 494-497
    • Snider, D.E.1    Caras, G.J.2
  • 38
    • 4344593965 scopus 로고    scopus 로고
    • Hepatotoxicity of rifampin-pyrazinamide and isoniazid preventive therapy and tuberculosis treatment
    • vanHest, R. et al. Hepatotoxicity of rifampin-pyrazinamide and isoniazid preventive therapy and tuberculosis treatment. Clin. Infect. Dis. 39, 488-496 (2004).
    • (2004) Clin. Infect. Dis. , vol.39 , pp. 488-496
    • vanHest, R.1
  • 39
    • 0036637297 scopus 로고    scopus 로고
    • A study of compliance with FDA recommendations for pemoline (Cylert)
    • Willy, M. E. et al. A study of compliance with FDA recommendations for pemoline (Cylert). J. Am. Acad. Child Adolesc. Psychiatry 41, 785-790 (2002).
    • (2002) J. Am. Acad. Child Adolesc. Psychiatry , vol.41 , pp. 785-790
    • Willy, M.E.1
  • 40
    • 0035880320 scopus 로고    scopus 로고
    • Liver enzyme monitoring in patients treated with troglitazone
    • Graham, D. J. et al. Liver enzyme monitoring in patients treated with troglitazone. JAMA 286, 831-833 (2001).
    • (2001) JAMA , vol.286 , pp. 831-833
    • Graham, D.J.1
  • 41
    • 0033577290 scopus 로고    scopus 로고
    • Hepatotoxicity associated with isoniazid preventive therapy: A 7-year survey from a public health tuberculosis clinic
    • Nolan, C. M., Goldberg, S. V. & Buskin, S. E. Hepatotoxicity associated with isoniazid preventive therapy: a 7-year survey from a public health tuberculosis clinic. JAMA 281, 1014-1018 (1999).
    • (1999) JAMA , vol.281 , pp. 1014-1018
    • Nolan, C.M.1    Goldberg, S.V.2    Buskin, S.E.3
  • 42
    • 0033771951 scopus 로고    scopus 로고
    • Concordance of the toxicity of pharmaceuticals in humans and in animals
    • Olson, H. et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharmacol. 32, 56-67 (2000).
    • (2000) Regul. Toxicol. Pharmacol. , vol.32 , pp. 56-67
    • Olson, H.1
  • 43
    • 1542361727 scopus 로고    scopus 로고
    • Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expression
    • Ulrich, R. G., Rockett, J. C., Gibson, G. G. & Pettit, S. D. Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expression. Environ. Health Perspect. 112, 423-427 (2004).
    • (2004) Environ. Health Perspect. , vol.112 , pp. 423-427
    • Ulrich, R.G.1    Rockett, J.C.2    Gibson, G.G.3    Pettit, S.D.4
  • 44
    • 1542361729 scopus 로고    scopus 로고
    • Database development in toxicogenomics: Issues and efforts
    • Mattes, W. B. et al. Database development in toxicogenomics: issues and efforts. Environ. Health Perspect. 112, 495-505 (2004).
    • (2004) Environ. Health Perspect. , vol.112 , pp. 495-505
    • Mattes, W.B.1
  • 45
    • 0037444362 scopus 로고    scopus 로고
    • Contemporary issues in toxicology: The role of metabonomics in toxicology and its evaluation by the COMET project
    • Lindon, J. C. et al. Contemporary issues in toxicology: the role of metabonomics in toxicology and its evaluation by the COMET project. Toxicol. Appl Pharmacol. 187, 137-146 (2003).
    • (2003) Toxicol. Appl. Pharmacol. , vol.187 , pp. 137-146
    • Lindon, J.C.1
  • 46
    • 0036859006 scopus 로고    scopus 로고
    • Protein expression analysis of drug-mediated hepatotoxicity in the Sprague-Dawley rat
    • Man, W. J. et al. Protein expression analysis of drug-mediated hepatotoxicity in the Sprague-Dawley rat. Proteomics 2, 1577-1585 (2002).
    • (2002) Proteomics , vol.2 , pp. 1577-1585
    • Man, W.J.1
  • 47
    • 0035831025 scopus 로고    scopus 로고
    • Toxic effect of troglitazone on cultured rat hepatocyles
    • Toyoda, Y., Tsuchida, A., Iwami, E. & Miwa, I. Toxic effect of troglitazone on cultured rat hepatocyles. Life Sci. 68, 1867-1876 (2001).
    • (2001) Life Sci. , vol.68 , pp. 1867-1876
    • Toyoda, Y.1    Tsuchida, A.2    Iwami, E.3    Miwa, I.4
  • 48
    • 0036739108 scopus 로고    scopus 로고
    • Effects of troglitazone on HepG2 viability and mitochondrial function
    • Tirmenstein, M. A. et al. Effects of troglitazone on HepG2 viability and mitochondrial function. Toxicol Sci. 69, 131-138 (2002).
    • (2002) Toxicol Sci. , vol.69 , pp. 131-138
    • Tirmenstein, M.A.1
  • 49
    • 0037058254 scopus 로고    scopus 로고
    • Differential in vitro hepatotoxicity of troglitazone and rosiglitazone among cryopreserved human hepatocytes from 37 donors
    • Lloyd, S. et al. Differential in vitro hepatotoxicity of troglitazone and rosiglitazone among cryopreserved human hepatocytes from 37 donors. Chem. Biol Interact. 142, 57-71 (2002).
    • (2002) Chem. Biol. Interact. , vol.142 , pp. 57-71
    • Lloyd, S.1
  • 50
    • 0033058105 scopus 로고    scopus 로고
    • Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: An explanation for high acetaminophen dosage in humans without hepatic injury
    • Shayiq, R. M. et al. Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury. Hepatology 29, 451-463 (1999).
    • (1999) Hepatology , vol.29 , pp. 451-463
    • Shayiq, R.M.1
  • 51
    • 0242463906 scopus 로고    scopus 로고
    • (eds Kaplowitz, N. & DeLeve, L.) (Marcel Dekker, New York,)
    • Nelson, S. D. & Bruschi, S. A. in Drug-Induced Liver Disease (eds Kaplowitz, N. & DeLeve, L.) 287-325 (Marcel Dekker, New York, 2003).
    • (2003) Drug-Induced Liver Disease , pp. 287-325
    • Nelson, S.D.1    Bruschi, S.A.2
  • 52
    • 15844419997 scopus 로고    scopus 로고
    • Role of Cyp2e1 in the hepatotoxicity of acetaminophen
    • Lee, S. S. T. et al. Role of Cyp2e1 in the hepatotoxicity of acetaminophen. J. Biol. Chem. 271, 12063-12067 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 12063-12067
    • Lee, S.S.T.1
  • 53
    • 0025300029 scopus 로고
    • Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it
    • Burk, R. F., Hill, K. E., Hunt, R. W. & Martin, A. E. Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it. Res. Commun. Chem. Pathol. Pharmacol. 69, 115-118 (1990).
    • (1990) Res. Commun. Chem. Pathol. Pharmacol. , vol.69 , pp. 115-118
    • Burk, R.F.1    Hill, K.E.2    Hunt, R.W.3    Martin, A.E.4
  • 54
    • 0034047262 scopus 로고    scopus 로고
    • Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults
    • Thummel, K. E. et al. Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults. Clin. Pharm. Ther. 67, 591-599 (2000).
    • (2000) Clin. Pharm. Ther. , vol.67 , pp. 591-599
    • Thummel, K.E.1
  • 55
    • 0030802792 scopus 로고    scopus 로고
    • Pharmakinetic consequence of induction of CYP2E1 by ligand stabilization
    • Chien, J. Y., Thummel, K. E. & Slattery J. T. Pharmakinetic consequence of induction of CYP2E1 by ligand stabilization. Drug Metab. Dispos. 25, 1165-1175 (1997).
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 1165-1175
    • Chien, J.Y.1    Thummel, K.E.2    Slattery, J.T.3
  • 56
    • 2342613543 scopus 로고    scopus 로고
    • Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice
    • Goldring, C. E. P. et al. Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice. Hepatology 39, 1267-1276 (2004).
    • (2004) Hepatology , vol.39 , pp. 1267-1276
    • Goldring, C.E.P.1
  • 57
    • 0035836698 scopus 로고    scopus 로고
    • An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
    • Chan, K., Han, X.-D. & Kan, Y. W. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl Acad. Sci. USA 98, 4611-4616 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 4611-4616
    • Chan, K.1    Han, X.-D.2    Kan, Y.W.3
  • 58
    • 0036325858 scopus 로고    scopus 로고
    • A pivotal involvement if IFN-γ in the pathogenesis of acetaminophen-induced acute liver injury
    • Ishida, Y. et al. A pivotal involvement if IFN-γ in the pathogenesis of acetaminophen-induced acute liver injury. FASEB J. 16, 1227-1236 (2002).
    • (2002) FASEB J. , vol.16 , pp. 1227-1236
    • Ishida, Y.1
  • 59
    • 9644289366 scopus 로고    scopus 로고
    • Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity
    • Liu, Z.-X., Govindarajan, S. & Kaplowitz, N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology 127, 1760-1774 (2004).
    • (2004) Gastroenterology , vol.127 , pp. 1760-1774
    • Liu, Z.-X.1    Govindarajan, S.2    Kaplowitz, N.3
  • 60
    • 0036154452 scopus 로고    scopus 로고
    • Protection against acetaminophen induced liver injury and lethality by interleukin 10: Role of inducible nitric oxide synthase
    • Bourdi, M. et al. Protection against acetaminophen induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. Hepatology 35, 289-298 (2002).
    • (2002) Hepatology , vol.35 , pp. 289-298
    • Bourdi, M.1
  • 61
    • 0345146918 scopus 로고    scopus 로고
    • Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease
    • Masubuchi. Y. et al. Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease. Biochem. Biophys. Res. Commun. 304, 207-212 (2003).
    • (2003) Biochem. Biophys. Res. Commun. , vol.304 , pp. 207-212
    • Masubuchi, Y.1
  • 62
    • 3042826208 scopus 로고    scopus 로고
    • Acetaminophen hepatotoxicity: What we know, what we don't know and where do we go?
    • Kaplowitz, N. Acetaminophen hepatotoxicity: what we know, what we don't know and where do we go? Hepatology 40, 23-26 (2004).
    • (2004) Hepatology , vol.40 , pp. 23-26
    • Kaplowitz, N.1
  • 63
    • 0036293621 scopus 로고    scopus 로고
    • Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-α-induced apoptosis in cultured mouse hepatocytes
    • Nagai, H., Matsumaru, K., Feng, G. & Kaplowitz, N. Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-α-induced apoptosis in cultured mouse hepatocytes. Hepatology 36, 55-64 (2002).
    • (2002) Hepatology , vol.36 , pp. 55-64
    • Nagai, H.1    Matsumaru, K.2    Feng, G.3    Kaplowitz, N.4
  • 64
    • 0033649270 scopus 로고    scopus 로고
    • Mechanisms of liver cell injury
    • Kaplowitz, N. Mechanisms of liver cell injury. J. Hepatol. 32, 39-47 (2000).
    • (2000) J. Hepatol. , vol.32 , pp. 39-47
    • Kaplowitz, N.1
  • 65
    • 0038618996 scopus 로고    scopus 로고
    • Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macro-phages
    • Park, D. R. et al. Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macro-phages. J. Immunol. 170, 6209-6216 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 6209-6216
    • Park, D.R.1
  • 66
    • 0035575757 scopus 로고    scopus 로고
    • Fas ligand engagement of resident peritoneal macrophages in vivo induces apoptosis and the production of neutrophil chemotactic factors
    • Hohlbaum, A. M., Gregory, M. S., Ju, S. T. & Marshak-Rothstein, A. Fas ligand engagement of resident peritoneal macrophages in vivo induces apoptosis and the production of neutrophil chemotactic factors. J. Immunol. 167, 6217-6224 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 6217-6224
    • Hohlbaum, A.M.1    Gregory, M.S.2    Ju, S.T.3    Marshak-Rothstein, A.4
  • 68
    • 0036257307 scopus 로고    scopus 로고
    • (eds Berk, P., Farrell, G. & Liddle, C.) (Thieme Medical, New York,)
    • Kaplowitz, N. in Seminars in Liver Disease Vol. 22 (eds Berk, P., Farrell, G. & Liddle, C.) 137-144 (Thieme Medical, New York, 2002).
    • (2002) Seminars in Liver Disease , vol.22 , pp. 137-144
    • Kaplowitz, N.1
  • 69
    • 0018827758 scopus 로고
    • Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis
    • Vergani, D. et al. Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis. N. Eng. J. Med. 303, 66-71 (1980).
    • (1980) N. Eng. J. Med. , vol.303 , pp. 66-71
    • Vergani, D.1
  • 70
    • 0024523867 scopus 로고
    • Immune mechanisms in tienilic acid associated hepatotoxicity
    • Neuberger, J. & Williams, R. Immune mechanisms in tienilic acid associated hepatotoxicity. Gut 30, 515-519 (1989).
    • (1989) Gut , vol.30 , pp. 515-519
    • Neuberger, J.1    Williams, R.2
  • 71
    • 7044226521 scopus 로고    scopus 로고
    • Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes
    • Kon, K., Kim, J.-S., Jaeschke, H. & Lemasters, J. J. Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 40, 1170-1179 (2004).
    • (2004) Hepatology , vol.40 , pp. 1170-1179
    • Kon, K.1    Kim, J.-S.2    Jaeschke, H.3    Lemasters, J.J.4
  • 72
    • 0038708252 scopus 로고    scopus 로고
    • A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus
    • Watanabe, I. et al. A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. Clin. Pharm. Ther. 73, 435-455 (2003).
    • (2003) Clin. Pharm. Ther. , vol.73 , pp. 435-455
    • Watanabe, I.1
  • 73
    • 0034112853 scopus 로고    scopus 로고
    • Combined glutathione S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity
    • Simon, T. et al. Combined glutathione S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Clin. Pharm. Ther. 67, 432-437 (2000).
    • (2000) Clin. Pharm. Ther. , vol.67 , pp. 432-437
    • Simon, T.1
  • 74
    • 18744384091 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicity
    • Acuna, G. et al. Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicity. The Pharmacogenomics J. 2, 327-334 (2002).
    • (2002) The Pharmacogenomics J. , vol.2 , pp. 327-334
    • Acuna, G.1
  • 75
    • 0037380862 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 genotype and the susceptibility to antituberculous drug-induced hepatitis
    • Huang, Y.-S. et al. Cytochrome P450 2E1 genotype and the susceptibility to antituberculous drug-induced hepatitis. Hepatology 37, 924-930 (2003).
    • (2003) Hepatology , vol.37 , pp. 924-930
    • Huang, Y.-S.1
  • 76
    • 2342541211 scopus 로고    scopus 로고
    • Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity
    • Aithal, G. P. et al. Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity. Hepatology 39, 1430-1440 (2004).
    • (2004) Hepatology , vol.39 , pp. 1430-1440
    • Aithal, G.P.1
  • 77
    • 0037064177 scopus 로고    scopus 로고
    • Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
    • Zhang, J. et al. Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 298, 421-424 (2002).
    • (2002) Science , vol.298 , pp. 421-424
    • Zhang, J.1
  • 78
    • 0033732323 scopus 로고    scopus 로고
    • Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi
    • Henderson, C. J. et al. Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi. Proc. Natl Acad. Sci. USA 97, 12741-12745 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12741-12745
    • Henderson, C.J.1
  • 79
    • 0033891369 scopus 로고    scopus 로고
    • Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis
    • Zhang, H. et al. Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis. Nature Biotechnol. 18, 862-867 (2000).
    • (2000) Nature Biotechnol. , vol.18 , pp. 862-867
    • Zhang, H.1
  • 80
    • 0035893045 scopus 로고    scopus 로고
    • IFN-γ-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes
    • Bone-Larson, C. L. et al. IFN-γ-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes. J. Immunol. 167, 7077-7083 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 7077-7083
    • Bone-Larson, C.L.1
  • 81
    • 0032867463 scopus 로고    scopus 로고
    • Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines
    • Hogaboam, C. M. et al. Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines. FASEB J. 13, 1565-1574 (1999).
    • (1999) FASEB J. , vol.13 , pp. 1565-1574
    • Hogaboam, C.M.1
  • 82
    • 0035007341 scopus 로고    scopus 로고
    • Protective effect of rhIL-11 in a murine model of acetaminophen-induced hepatotoxicity
    • Trepicchio, W. L., Bozza, M., Bouchard, P. & Dorner, A. J. Protective effect of rhIL-11 in a murine model of acetaminophen-induced hepatotoxicity. Toxicol. Pathol. 29, 242-249 (2001).
    • (2001) Toxicol. Pathol. , vol.29 , pp. 242-249
    • Trepicchio, W.L.1    Bozza, M.2    Bouchard, P.3    Dorner, A.J.4
  • 83
    • 19944429825 scopus 로고    scopus 로고
    • Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice
    • Su, G. L. et al. Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice. Hepatology 41, 187-195 (2005).
    • (2005) Hepatology , vol.41 , pp. 187-195
    • Su, G.L.1
  • 84
    • 0015754446 scopus 로고
    • Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo
    • Jollow, D. J. et al. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. 187, 195-202 (1973).
    • (1973) J. Pharmacol. Exp. Ther. , vol.187 , pp. 195-202
    • Jollow, D.J.1
  • 85
    • 0035663287 scopus 로고    scopus 로고
    • A protective role for cycloxygenase-2 in drug-induced liver injury in mice
    • Reilly, T. P. et al. A protective role for cycloxygenase-2 in drug-induced liver injury in mice. Chem. Res. Toxicol. 14, 1620-1628 (2001).
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 1620-1628
    • Reilly, T.P.1
  • 86
    • 0036913249 scopus 로고    scopus 로고
    • Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice
    • Ju, C. et al. Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. Chem. Res. Toxicol. 15, 1504-1513 (2002).
    • (2002) Chem. Res. Toxicol. , vol.15 , pp. 1504-1513
    • Ju, C.1
  • 87
    • 0033848060 scopus 로고    scopus 로고
    • Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2
    • Hogaboam, C. M. et al. Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2. Am. J. Pathol. 156, 1245-1252 (2000).
    • (2000) Am. J. Pathol. , vol.156 , pp. 1245-1252
    • Hogaboam, C.M.1
  • 88
    • 0032931621 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury
    • Hogaboam, C. M. et al. Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury. Gene Ther. 6, 573-584 (1999).
    • (1999) Gene Ther. , vol.6 , pp. 573-584
    • Hogaboam, C.M.1
  • 89
    • 1542515165 scopus 로고    scopus 로고
    • Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in mice
    • Tinel, M. et al. Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in mice. Hepatology 39, 655-666 (2004).
    • (2004) Hepatology , vol.39 , pp. 655-666
    • Tinel, M.1
  • 90
    • 0038241619 scopus 로고    scopus 로고
    • Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes
    • Matsumaru, K., Ji, C. & Kaplowitz, N. Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology 37, 1425-1434 (2003).
    • (2003) Hepatology , vol.37 , pp. 1425-1434
    • Matsumaru, K.1    Ji, C.2    Kaplowitz, N.3


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