Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation

European Journal of Pharmaceutical Sciences

Volumn 13, Issue 4, 2001, Pages 343-368

  LeCluyse, Edward L ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Cytochrome P450 expression; Enzyme induction; In vitro human hepatocyte model; Orphan nuclear receptors

Indexed keywords

CELL CULTURE; ENZYMES; GENES; INDUSTRIAL LABORATORIES; METABOLISM; PHYSIOLOGY;

NEW CHEMICAL ENTITIES (NCE);

DRUG PRODUCTS;

CELL NUCLEUS RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 3A; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; NEW DRUG; PREGNANE X RECEPTOR; RIFAMPICIN; RITONAVIR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

CELL DENSITY; CELL FUNCTION; CELL INTERACTION; CONCENTRATION RESPONSE; CYTOSKELETON; DRUG POTENCY; DRUG RESPONSE; ENZYME INDUCTION; ENZYME REGULATION; EVALUATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LIVER CELL CULTURE; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SPECIES DIFFERENCE; STANDARD; TECHNIQUE;

ANIMALS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS;

EID: 0034964158     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(01)00135-X     Document Type: Review

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