Advances in bioartificial liver devices

Hepatology

Volumn 34, Issue 3, 2001, Pages 447-455

  Allen, J W ^a   Hassanein, T ^a   Bhatia, S N ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTIFICIAL LIVER; BIOREACTOR; HUMAN; HUMAN CELL; LIVER CELL; LIVER FAILURE; LIVER TRANSPLANTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0034861615     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2001.26753     Document Type: Article

References (134)

1. The American experience with transplantation for acute liver failure
2. Orthotopic liver transplantation in fulminant and subfulminant hepatitis. The Paul Brousse experience
3. Liver transplantation in Europe for patients with acute liver failure
4. Liver transplantation for acute liver failure in children under 1 year of age
5. Total hepatectomy and liver transplantation as two-stage procedure
6. Indications for orthotopic liver transplantation in fulminant liver failure
7. Organ donation by unrelated donors
8. Strategies for making more organs available for transplantation
9. Delayed encephalopathy in fulminant hepatic failure in the pediatric population and the role of liver transplantation
10. Liver transplantation for fulminant hepatic failure in the pediatric patient
11. Early indicators of prognosis in fulminant hepatic failure
12. Emergency liver transplantation for acute liver failure. Evaluation of London and Clichy criteria
13. Therapeutic liver repopulation for the treatment of metabolic liver diseases
14. Transplantation of human hepatocytes
15. Tissue engineering - Toward new solutions for transplantation and reconstructive surgery
16. Serial transplantation reveals stem cell like regenerative potential in parenchymal mouse hepatocytes
17. Replacement of diseased mouse liver by hepatic cell transplantation
18. Selective cell transplantation using bioabsorbable artificial polymers as matrices
19. Integration of surface modification and 3D fabrication techniques to prepare patterned poly(L-lactide) substrates allowing regionally selective cell adhesion
20. Biodegradable sponges for hepatocyte transplantation
21. Transplantation of hepatocytes using porous, biodegradable sponges
22. Polysaccharide scaffolds for hepatocyte transplantation: Design, seeding, and functional evaluation
23. Improved function of microencapsulated hepatocytes in a hybrid bioartificial liver support system
24. Transplantation of microcarrier-attached hepatocytes into 90% partially hepatectomized rats
25. Survival, organization, and function of microcarrier-attached hepatocytes transplanted in rats
26. A new hybrid artificial liver using a combination of hepatocytes and biomatrix
27. New method of hepatocyte transplantation and extracorporeal liver support
28. Liver allo-transplantation and xenotransplantation
29. Xenotransplantation of pig organs transgenic for human DAF: An update
30. Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection
31. Expression of the human alpha 1,2-fucosyltransferase in transgenic pigs modifies the cell surface carbohydrate phenotype and confers resistance to human serum-mediated cytolysis
32. Assessment of artificial liver support technology
33. Treatment of acute liver failure: Hybrid liver support - A critical overview
34. Extracorporeal tissue engineered liver-assist devices
35. Hybrid bioartificial liver in hepatic failure: Preliminary clinical report
36. A hybrid bioartificial liver composed of multiplated hepatocyte monolayers
37. Internal bioartificial liver with xenogeneic hepatocytes prevents death from acute liver failure: An experimental study
38. Xenobiotic metabolism by cultured primary porcine hepatocytes
39. In vitro characterization of porcine hepatocyte function
40. Heterogeneity of growth potential of adult rat hepatocytes in vitro
41. The current status of primary hepatocyte culture
42. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by Hgf/Sf, Egf and Tgf-alpha in a chemically defined (Hgm) medium
43. Culture condition-dependent senescence-like growth arrest and immortalization in rodent embryo cells
44. Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system
45. The hepatix extracorporeal liver assist device - Initial clinical experience
46. Hepatocyte cell lines established from transgenic mice harboring temperature-sensitive simian virus-40 large T-antigen gene
47. Establishment of a reversibly immortalized human hepatocyte cell line by using Cre/LoxP site-specific recombination
48. Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: Reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen
49. Embryonic stem cell lines derived from human blastocysts
50. Derivation of pluripotent stem cells horn cultured human primordial germ cells
51. Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats
52. Putative liver progenitor cells: Conditions for long-term survival in culture
53. Expansion conditions for early hepatic progenitor cells from embryonal and neonatal rat livers
54. Clonogenic hepatoblasts, common precursors for hepatocytic and biliary lineages, are lacking classical major histocompatibility complex class I antigen
55. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation
56. Hepatic stem cells in liver regeneration
57. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
58. Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations
59. Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver
60. Connective tissue biomatrix: Its isolation and utilization for long-term cultures of normal rat hepatocytes
61. Spheroidal aggregate culture of rat liver cells: Histotypic reorganization, biomatrix deposition, and maintenance of functional activities
62. Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration
63. Design of hepatocyte-specific extracellular matrices for hybrid artificial liver
64. Bioartificial liver support system using porcine hepatocytes entrapped in a three-dimensional hollow fiber module with collagen gel: An evaluation in the swine acute liver failure model
65. Hepatocytes entrapped in collagen gel following 14 days of storage at 4 degrees C: Preservation of hybrid artificial liver
66. Long-term culture of hepatocytes: Effect of hormones on enzyme activities and metabolic capacity
67. Maintenance of differentiated rat hepatocytes in primary culture
68. Effect of cell-cell interactions in preservation of cellular phenotype: Cocultivation of hepatocytes and nonparenchymal cells
69. Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor
70. A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: Cell viability and tissue-specific functions
71. Transfer of porcine endogenous retrovirus across hollow fiber membranes: Significance to a bioartificial liver
72. Performance of a new hybrid artificial liver support system using hepatocytes entrapped within a hydrogel
73. The bioartificial liver: State-of-the-art
74. A new concept of bioartificial liver based on a fluidized bed bioreactor
75. Improvement of metabolic performance of hepatocytes cultured in vitro in a packed-bed reactor for use as a bioartificial liver
76. Massive culture of human liver cancer cells in a newly developed radial flow bioreactor system: Ultrafine structure of functionally enhanced hepatocarcinoma cell lines
77. Evaluation of a hybrid artificial liver using a polyurethane foam packed-bed culture system in dogs
78. Oxygen transfer in a diffusion-limited hollow fiber bioartificial liver
79. Bioreactor for a larger scale hepatocyte in vitro perfusion
80. Development of a new bioartificial liver module filled with porcine hepatocytes immobilized on non-woven fabric
81. In vitro evaluation of a novel bioreactor based on an integral oxygenator and a spirally wound nonwoven polyester matrix for hepatocyte culture as small aggregates
82. Oxygen: Modulator of metabolic zonation and disease of the liver
83. Zonal liver cell heterogeneity: Effects of oxygen on metabolic functions of hepatocytes
84. Evolution of the bioartificial liver: The need for randomized clinical trials
85. A novel bioreactor design for in vitro reconstruction of in vivo liver characteristics
86. A new bioartificial liver using porcine hepatocyte spheroids in high-cell-density suspension perfusion culture: In vitro performance in synthesized culture medium and in 100% human plasma
87. Temporary organ substitution by hemoperfusion through suspension of active donor hepatocytes in a total complex of intensive therapy in patients with acute hepatic insufficiency
88. A bioartificial liver to treat severe acute liver failure
89. Bioartificial organ support for hepatic, renal, and hematologic failure
90. Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure
91. Review of support systems used in the management of fulminant hepatic failure
92. Liver assist systems: State of the art
93. Temporary extracorporeal liver support for severe acute alcoholic hepatitis using the BioLogic-DT
94. Dialysis against a recycled albumin solution enables the removal of albumin-bound toxins
95. Xenoantibody response of patients with severe acute liver failure exposed to porcine antigens following treatment with a bioartificial liver
96. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue
97. Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice
98. Infection of human cells by an endogenous retrovirus of pigs
99. Evidence of absence of porcine endogenous retrovirus (PERV) infection in patients treated with a bioartificial liver support system
100. Reversal of toxic and anoxic induced hepatic failure by syngeneic, allogeneic, and xenogeneic hepatocyte transplantation
101. Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction
102. Effects of plasma exposure on cultured hepatocytes - Implications for bioartificial liver support
103. Novel bioartificial liver support system: Preclinical evaluation
104. Early clinical experience with a hybrid bioartificial liver
105. Improved hepatocyte in vitro maintenance in a culture model with woven multicompartment capillary systems - Electron microscopy studies
106. Cultivation of immortalized human hepatocytes HepZ on macroporous CultiSpher G microcarriers
107. Establishment of a highly differentiated immortalized human hepatocyte cell line as a source of hepatic function in the bioartificial liver
108. Characterization and evaluation of detoxification functions of a non-tumorigenic immortalized porcine hepatocyte cell line (HepLiu)
109. Augmentation of urea-synthetic capacity by inhibition of nitric oxide synthesis in butyrate-induced differentiated human hepatocytes
110. Characterization of human hepatocyte lines derived from normal liver tissue
111. Modulation of the liver specific phenotype in the human hepatoblastoma line Hep G2
112. Hepatocyte liver-assist systems - A clinical update
113. Comparison of porcine hepatocytes with human hepatoma (C3A) cells for use in a bioartificial liver support system
114. Molecular basis of transdifferentiation of pancreas to liver
115. Extracorporeal liver support. Application to fulminant hepatic failure
116. Extracorporeal application of a gel-entrapment, bioartificial liver: Demonstration of drug metabolism and other biochemical functions
117. NMR spectroscopy and MRI investigation of a potential bioartificial liver
118. Biodialysis: A new liver support system
119. Development of a bioartificial liver with sandwiched-cultured hepatocytes between two collagen gel layers
120. Long-term cultivation of immortalised mouse hepatocytes in a high cell density, fixed-bed reactor
121. Encapsulated multicellular spheroids of rat hepatocytes produce albumin and urea in a spouted bed circulating culture system
122. Performance of plasma-perfused, microencapsulated hepatocytes - Prospects for extracorporeal liver support
123. Culturing of primary hepatocytes as entrapped aggregates in a packed bed bioreactor: A potential bioartificial liver
124. Contiuous human liver support as a bridge to transplantation
125. Pilot-controlled trial of the extracorporeal liver assist device in acute liver failure
126. Clinical experience with a bioartificial liver in the treatment of severe liver failure: A phase 1 clinical trial - Discussion
127. The HepatAssist bioartificial liver support system: Clinical study and pig hepatocyte process
128. Molecular adsorbent recycling system (MARS): Clinical results of a new membrane-based blood purification system for bioartificial liver support
129. The Molecular Adsorbents Recycling System (MARS) as a liver support system based on albumin dialysis - A summary of preclinical investigations, prospective, randomized, controlled clinical trial and clinical experience from 19 centers
130. Clinical effects of a sorbent suspension dialysis system in treatment of hepatic coma (the Biologic-Dt)
131. Liver dialysis in treatment of hepatic failure and hepatorenal failure: Randomized clinical trials and recent improvements