A systems biology based integrative framework to enhance the predictivity of in vitro methods for drug-induced liver injury

Expert Opinion on Drug Safety

Volumn 7, Issue 6, 2008, Pages 647-662

  Subramanian, Kalyanasundaram ^a   Raghavan, Sowmya ^a   Bhat, Anupama Rajan ^a   Das, Sonali ^a   Dikshit, Jyoti Bajpai ^a   Kumar, Rajeev ^a   Narasimha, Mandyam Krishnakumar ^a   Nalini, Rajeswara ^a   Radhakrishnan, Rajesh ^a   Raghunathan, Srivatsan ^a  

^a Strand Life Sciences Pvt Ltd ^*  (India)

Author keywords

Drug induced liver injury; Hepatotoxicity; In silico; In vitro; Integrative; Predictive; Systems biology; Systems modelling

Indexed keywords

AMIODARONE; BUTHIONINE SULFOXIMINE; ETACRYNIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PERHEXILINE;

ARTICLE; COMPUTER MODEL; DECISION MAKING; DRUG INDUCED DISEASE; HOMEOSTASIS; HYPOTHESIS; IN VITRO STUDY; LIVER INJURY; MATHEMATICAL MODEL; PREDICTION; SYSTEMS BIOLOGY; TOXICITY TESTING;

ADVERSE DRUG REACTION REPORTING SYSTEMS; ANIMAL TESTING ALTERNATIVES; ANIMALS; DRUG EVALUATION, PRECLINICAL; HEPATITIS, TOXIC; HOMEOSTASIS; HUMANS; LIVER; MODELS, BIOLOGICAL; SYSTEMS BIOLOGY;

EID: 57049095489     PISSN: 14740338     EISSN: None     Source Type: Journal    
DOI: 10.1517/14740330802501211     Document Type: Article

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