The liver toxicity knowledge base: A systems approach to a complex end point

Clinical Pharmacology and Therapeutics

Volumn 93, Issue 5, 2013, Pages 409-412

  Chen, M ^a   Zhang, J ^a   Wang, Y ^a   Liu, Z ^a   Kelly, R ^a   Zhou, G ^a   Fang, H ^a   Borlak, J ^b   Tong, W ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOINFORMATICS; DATA BASE; DRUG LEGISLATION; FALSE NEGATIVE RESULT; FOOD AND DRUG ADMINISTRATION; HUMAN; LIVER FAILURE; LIVER FUNCTION; LIVER TOXICITY KNOWLEDGE BASE; MEDICAL RESEARCH; MOLECULAR GENETICS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; TOXIC HEPATITIS; TREATMENT OUTCOME;

BIOMEDICAL RESEARCH; DATABASES, FACTUAL; DRUG AND NARCOTIC CONTROL; DRUG DESIGN; DRUG-INDUCED LIVER INJURY; ENDPOINT DETERMINATION; HUMANS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS;

EID: 84876665555     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2013.16     Document Type: Article

References (5)

1. Chen, M., Vijay, V., Shi, Q., Liu, Z., Fang, H. & Tong, W. FDA-approved drug labeling for the study of drug-induced liver injury. Drug Discov. Today 16, 697-703 (2011).
2. Zhang, M., Chen, M. & Tong, W. Is toxicogenomics a more reliable and sensitive biomarker than conventional indicators from rats to predict drug-induced liver injury in humans? Chem. Res. Toxicol. 25, 122-129 (2012).
3. Wang, y. et al. A unifying ontology to integrate histological and clinical observations for drug-induced liver injury. Am. J. Pathol. 2013); e-pub ahead of print 5 February 2013.
4. Liu, Z., Shi, Q., Ding, D., Kelly, R., Fang, H. & Tong, W. Translating clinical fndings into knowledge in drug safety evaluation-drug induced liver injury prediction system (DILIps). PLoS Comput. Biol. 7, e1002310 (2011).
5. Chen, M., Borlak, J. & Tong, W. High lipophilicity and high daily dose of oral medications are associated with signifcant risk for drug-induced liver injury. Hepatology (2012); e-pub ahead of print 19 December 2012.