Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming

Cell Stem Cell

Volumn 14, Issue 3, 2014, Pages 394-403

  Du, Yuanyuan ^a   Wang, Jinlin ^b   Jia, Jun ^a,b   Song, Nan ^a,b   Xiang, Chengang ^a   Xu, Jun ^a   Hou, Zhiyuan ^d   Su, Xiaohua ^a   Liu, Bei ^b   Jiang, Tao ^e   Zhao, Dongxin ^a   Sun, Yingli ^f   Shu, Jian ^a   Guo, Qingliang ^e   Yin, Ming ^a   Sun, Da ^b   Lu, Shichun ^e   Shi, Yan ^b   Deng, Hongkui ^a,b,c  

^a Peking University   (China)

^b PEKING UNIVERSITY   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^d Beijing Vitalstar Biotechnology Co   (China)

^e CHINESE PLA GENERAL HOSPITAL   (China)

^f Chinese Academy of Sciences and China National Center for Bioinformation   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HEPATOCYTE NUCLEAR FACTOR 6; HUMAN ALBUMIN; ALBUMIN; RAG2 PROTEIN; TETRACYCLINE; TRANSCRIPTION FACTOR; UROKINASE;

ANIMAL EXPERIMENT; ARTICLE; CELL FUNCTION; CELL LINEAGE; CELL TYPE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; LIVER CELL; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ATF5 GENE; CEBPA GENE; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE; GENE EXPRESSION; HNF1A GENE; HNF4A GENE; HNF6 GENE; IN VIVO STUDY; PROX1 GENE;

MUS;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELL SEPARATION; CELLS, CULTURED; DNA-BINDING PROTEINS; FIBROBLASTS; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; METABOLIC DETOXICATION, DRUG; MICE; MICE, INBRED BALB C; NUCLEAR REPROGRAMMING; TETRACYCLINE; TRANSCRIPTION FACTORS; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84896132644     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2014.01.008     Document Type: Article

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