메뉴 건너뛰기




Volumn 3 MAR, Issue , 2013, Pages

p110δ PI3 kinase pathway: Emerging roles in cancer

Author keywords

Cancer; Hematologic malignancies; p110 PI3K; PTEN; Solid tumors

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; B LYMPHOCYTE RECEPTOR; CD40 LIGAND; CHEMOKINE RECEPTOR CXCR5; CXCL13 CHEMOKINE; DIACYLGLYCEROL; G PROTEIN COUPLED RECEPTOR; GUANOSINE TRIPHOSPHATE; IDELALISIB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN P110; RETINOIC ACID; TOLL LIKE RECEPTOR;

EID: 84890773406     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00040     Document Type: Review
Times cited : (49)

References (221)
  • 1
    • 38949164409 scopus 로고    scopus 로고
    • Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase
    • Aiba, Y., Kameyama, M., Yamazaki, T., Tedder, T. F., and Kurosaki, T. (2008). Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood 111, 1497-1503.
    • (2008) Blood , vol.111 , pp. 1497-1503
    • Aiba, Y.1    Kameyama, M.2    Yamazaki, T.3    Tedder, T.F.4    Kurosaki, T.5
  • 2
    • 84867713025 scopus 로고    scopus 로고
    • The p110[delta] isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
    • Aksoy, E., Taboubi, S., Torres, D., Delbauve, S., Hachani, A., Whitehead, M. A., et al. (2012). The p110[delta] isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat. Immunol. 13, 1045-1054.
    • (2012) Nat. Immunol. , vol.13 , pp. 1045-1054
    • Aksoy, E.1    Taboubi, S.2    Torres, D.3    Delbauve, S.4    Hachani, A.5    Whitehead, M.A.6
  • 3
    • 0029804116 scopus 로고    scopus 로고
    • Mechanism of activation of protein kinase B by insulin and IGF-1
    • Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., et al. (1996). Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15, 6541-6551.
    • (1996) EMBO J. , vol.15 , pp. 6541-6551
    • Alessi, D.R.1    Andjelkovic, M.2    Caudwell, B.3    Cron, P.4    Morrice, N.5    Cohen, P.6
  • 4
    • 12644301164 scopus 로고    scopus 로고
    • 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
    • Alessi, D. R., Deak, M., Casamayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., et al. (1997a). 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol. 7, 776-789.
    • (1997) Curr. Biol. , vol.7 , pp. 776-789
    • Alessi, D.R.1    Deak, M.2    Casamayor, A.3    Caudwell, F.B.4    Morrice, N.5    Norman, D.G.6
  • 5
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
    • Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., et al. (1997b). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol. 7, 261-269.
    • (1997) Curr. Biol. , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6
  • 6
    • 0033579163 scopus 로고    scopus 로고
    • Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity
    • Ali, I. U., Schriml, L. M., and Dean, M. (1999). Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J. Natl. Cancer Inst. 91, 1922-1932.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 1922-1932
    • Ali, I.U.1    Schriml, L.M.2    Dean, M.3
  • 7
    • 7244232917 scopus 로고    scopus 로고
    • Essential role for the p110[delta] phosphoinositide 3-kinase in the allergic response
    • Ali, K., Bilancio, A., Thomas, M., Pearce, W., Gilfillan, A. M., Tkaczyk, C., et al. (2004). Essential role for the p110[delta] phosphoinositide 3-kinase in the allergic response. Nature 431, 1007-1011.
    • (2004) Nature , vol.431 , pp. 1007-1011
    • Ali, K.1    Bilancio, A.2    Thomas, M.3    Pearce, W.4    Gilfillan, A.M.5    Tkaczyk, C.6
  • 8
    • 42149091691 scopus 로고    scopus 로고
    • Isoform-specific functions of phosphoinositide 3-kinases: p110{delta} but not p110{gamma} promotes optimal allergic responses in vivo
    • Ali, K., Camps, M., Pearce, W. P., Ji, H., Ruckle, T., Kuehn, N., et al. (2008). Isoform-specific functions of phosphoinositide 3-kinases: p110{delta} but not p110{gamma} promotes optimal allergic responses in vivo. J. Immunol. 180, 2538-2544.
    • (2008) J. Immunol. , vol.180 , pp. 2538-2544
    • Ali, K.1    Camps, M.2    Pearce, W.P.3    Ji, H.4    Ruckle, T.5    Kuehn, N.6
  • 9
    • 0035909313 scopus 로고    scopus 로고
    • Forkhead transcription factors contribute to execution of the mitotic programme in mammals
    • Alvarez, B., Martinez-a, C., Burgering, B. M. T., and Carrera, A. C. (2001). Forkhead transcription factors contribute to execution of the mitotic programme in mammals. Nature 413, 744-747.
    • (2001) Nature , vol.413 , pp. 744-747
    • Alvarez, B.1    Martinez-a, C.2    Burgering, B.M.T.3    Carrera, A.C.4
  • 10
    • 0035839450 scopus 로고    scopus 로고
    • A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (Trance) and CD40L-mediated Akt activation
    • Arron, J. R., Vologodskaia, M., Wong, B. R., Naramura, M., Kim, N., Gu, H., et al. (2001). A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (Trance) and CD40L-mediated Akt activation. J. Biol. Chem. 276, 30011-30017.
    • (2001) J. Biol. Chem. , vol.276 , pp. 30011-30017
    • Arron, J.R.1    Vologodskaia, M.2    Wong, B.R.3    Naramura, M.4    Kim, N.5    Gu, H.6
  • 11
    • 77953995931 scopus 로고    scopus 로고
    • The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation
    • Beer-Hammer, S., Zebedin, E., von Holleben, M., Alferink, J., Reis, B., Dresing, P., et al. (2010). The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation. J. Leukoc. Biol. 87, 1083-1095.
    • (2010) J. Leukoc. Biol. , vol.87 , pp. 1083-1095
    • Beer-Hammer, S.1    Zebedin, E.2    von Holleben, M.3    Alferink, J.4    Reis, B.5    Dresing, P.6
  • 12
    • 0032705203 scopus 로고    scopus 로고
    • SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling
    • Beitz, L. O., Fruman, D. A., Kurosaki, T., Cantley, L. C., and Scharenberg, A. M. (1999). SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling. J. Biol. Chem. 274, 32662-32666.
    • (1999) J. Biol. Chem. , vol.274 , pp. 32662-32666
    • Beitz, L.O.1    Fruman, D.A.2    Kurosaki, T.3    Cantley, L.C.4    Scharenberg, A.M.5
  • 13
    • 0032560796 scopus 로고    scopus 로고
    • Akt activation by growth factors is a multiple-step process: the role of the PH domain
    • Bellacosa, A., Chan, T. O., Ahmed, N. N., Datta, K., Malstrom, S., Stokoe, D., et al. (1998). Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 17, 313-325.
    • (1998) Oncogene , vol.17 , pp. 313-325
    • Bellacosa, A.1    Chan, T.O.2    Ahmed, N.N.3    Datta, K.4    Malstrom, S.5    Stokoe, D.6
  • 14
    • 24944582633 scopus 로고    scopus 로고
    • GAPs in growth factor signalling
    • Bernards, A., and Settleman, J. (2005). GAPs in growth factor signalling. Growth Factors 23, 143-149.
    • (2005) Growth Factors , vol.23 , pp. 143-149
    • Bernards, A.1    Settleman, J.2
  • 15
    • 1942466518 scopus 로고    scopus 로고
    • p27Kip1 modulates cell migration through the regulation of RhoA activation
    • Besson, A., Gurian-West, M., Schmidt, A., Hall, A., and Roberts, J. M. (2004). p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev. 18, 862-876.
    • (2004) Genes Dev. , vol.18 , pp. 862-876
    • Besson, A.1    Gurian-West, M.2    Schmidt, A.3    Hall, A.4    Roberts, J.M.5
  • 16
    • 0036185944 scopus 로고    scopus 로고
    • Early embryonic lethality in mice deficient in the p110b catalytic subunit of PI 3-kinase
    • Bi, L., Okabe, I., Bernard, D. J., and Nussbaum, R. L. (2002). Early embryonic lethality in mice deficient in the p110b catalytic subunit of PI 3-kinase. Mamm. Genome 13, 169-172.
    • (2002) Mamm. Genome , vol.13 , pp. 169-172
    • Bi, L.1    Okabe, I.2    Bernard, D.J.3    Nussbaum, R.L.4
  • 17
    • 0033574429 scopus 로고    scopus 로고
    • Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110a subunit of phosphoinositide 3-kinase
    • Bi, L., Okabe, I., Bernard, D. J., Wynshaw-Boris, A., and Nussbaum, R. L. (1999). Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110a subunit of phosphoinositide 3-kinase. J. Biol. Chem. 274, 10963-10968.
    • (1999) J. Biol. Chem. , vol.274 , pp. 10963-10968
    • Bi, L.1    Okabe, I.2    Bernard, D.J.3    Wynshaw-Boris, A.4    Nussbaum, R.L.5
  • 18
    • 30444439101 scopus 로고    scopus 로고
    • Key role of the p110{delta} isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110{delta} function in B cells
    • Bilancio, A., Okkenhaug, K., Camps, M., Emery, J. L., Ruckle, T., Rommel, C., et al. (2006). Key role of the p110{delta} isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110{delta} function in B cells. Blood 107, 642-650.
    • (2006) Blood , vol.107 , pp. 642-650
    • Bilancio, A.1    Okkenhaug, K.2    Camps, M.3    Emery, J.L.4    Ruckle, T.5    Rommel, C.6
  • 19
    • 59149096169 scopus 로고    scopus 로고
    • Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation
    • Billottet, C., Banerjee, L., Vanhaesebroeck, B., and Khwaja, A. (2009). Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation. Cancer Res. 69, 1027-1036.
    • (2009) Cancer Res. , vol.69 , pp. 1027-1036
    • Billottet, C.1    Banerjee, L.2    Vanhaesebroeck, B.3    Khwaja, A.4
  • 20
    • 33750459743 scopus 로고    scopus 로고
    • A selective inhibitor of the p110[delta] isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16
    • Billottet, C., Grandage, V. L., Gale, R. E., Quattropani, A., Rommel, C., Vanhaesebroeck, B., et al. (2006). A selective inhibitor of the p110[delta] isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16. Oncogene 25, 6648-6659.
    • (2006) Oncogene , vol.25 , pp. 6648-6659
    • Billottet, C.1    Grandage, V.L.2    Gale, R.E.3    Quattropani, A.4    Rommel, C.5    Vanhaesebroeck, B.6
  • 21
    • 39749195528 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase Isoform p110delta impairs growth and survival in neuroblastoma cells
    • Boller, D., Schramm, A., Doepfner, K. T., Shalaby, T., von Bueren, A. O., Eggert, A., et al. (2008). Targeting the phosphoinositide 3-kinase Isoform p110delta impairs growth and survival in neuroblastoma cells. Clin. Cancer Res. 14, 1172-1181.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 1172-1181
    • Boller, D.1    Schramm, A.2    Doepfner, K.T.3    Shalaby, T.4    von Bueren, A.O.5    Eggert, A.6
  • 22
    • 76049123027 scopus 로고    scopus 로고
    • Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
    • Brachmann, S. M., Hofmann, I., Schnell, C., Fritsch, C., Wee, S., Lane, H., et al. (2009). Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 106, 22299-22304.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 22299-22304
    • Brachmann, S.M.1    Hofmann, I.2    Schnell, C.3    Fritsch, C.4    Wee, S.5    Lane, H.6
  • 23
    • 0034194516 scopus 로고    scopus 로고
    • Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP)
    • Brauweiler, A., Tamir, I., Dal Porto, J., Benschop, R. J., Helgason, C. D., Humphries, R. K., et al. (2000). Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP). J. Exp. Med. 191, 1545-1554.
    • (2000) J. Exp. Med. , vol.191 , pp. 1545-1554
    • Brauweiler, A.1    Tamir, I.2    Dal Porto, J.3    Benschop, R.J.4    Helgason, C.D.5    Humphries, R.K.6
  • 24
    • 67650458526 scopus 로고    scopus 로고
    • Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia
    • Buchner, M., Fuchs, S., Prinz, G., Pfeifer, D., Bartholomé, K., Burger, M., et al. (2009). Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Res. 69, 5424-5432.
    • (2009) Cancer Res. , vol.69 , pp. 5424-5432
    • Buchner, M.1    Fuchs, S.2    Prinz, G.3    Pfeifer, D.4    Bartholomé, K.5    Burger, M.6
  • 25
    • 84859256604 scopus 로고    scopus 로고
    • Inhibiting B-cell receptor signaling pathways in chronic lymphocytic leukemia
    • Burger, J. (2012). Inhibiting B-cell receptor signaling pathways in chronic lymphocytic leukemia. Curr. Hematol. Malig. Rep. 7, 26-33.
    • (2012) Curr. Hematol. Malig. Rep. , vol.7 , pp. 26-33
    • Burger, J.1
  • 26
    • 0038003956 scopus 로고    scopus 로고
    • Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty
    • Burgering, B. M. T., and Medema, R. H. (2003). Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J. Leukoc. Biol. 73, 689-701.
    • (2003) J. Leukoc. Biol. , vol.73 , pp. 689-701
    • Burgering, B.M.T.1    Medema, R.H.2
  • 29
    • 84555191770 scopus 로고    scopus 로고
    • CAL-101: a phosphatidylinositol-3-kinase p110-delta inhibitor for the treatment of lymphoid malignancies
    • Castillo, J. J., Furman, M., and Winer, E. S. (2012). CAL-101: a phosphatidylinositol-3-kinase p110-delta inhibitor for the treatment of lymphoid malignancies. Expert Opin. Investig. Drugs 21, 15-22.
    • (2012) Expert Opin. Investig. Drugs , vol.21 , pp. 15-22
    • Castillo, J.J.1    Furman, M.2    Winer, E.S.3
  • 30
    • 66149141021 scopus 로고    scopus 로고
    • PTEN and the PI3-kinase pathway in cancer
    • Chalhoub, N., and Baker, S. J. (2009). PTEN and the PI3-kinase pathway in cancer. Annu. Rev. Pathol. 4, 127-150.
    • (2009) Annu. Rev. Pathol. , vol.4 , pp. 127-150
    • Chalhoub, N.1    Baker, S.J.2
  • 31
    • 0030612144 scopus 로고    scopus 로고
    • p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
    • Chantry, D., Vojtek, A., Kashishian, A., Holtzman, D. A., Wood, C., Gray, P. W., et al. (1997). p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J. Biol. Chem. 272, 19236-19241.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19236-19241
    • Chantry, D.1    Vojtek, A.2    Kashishian, A.3    Holtzman, D.A.4    Wood, C.5    Gray, P.W.6
  • 32
    • 77949672430 scopus 로고    scopus 로고
    • Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody
    • Chapuis, N., Tamburini, J. R. M., Cornillet-Lefebvre, P., Gillot, L., Bardet, V. R., Willems, L., et al. (2010). Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody. Haematologica 95, 415-423.
    • (2010) Haematologica , vol.95 , pp. 415-423
    • Chapuis, N.1    Tamburini, J.R.M.2    Cornillet-Lefebvre, P.3    Gillot, L.4    Bardet, V.R.5    Willems, L.6
  • 33
    • 14944352799 scopus 로고    scopus 로고
    • ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia
    • Chen, L., Apgar, J., Huynh, L., Dicker, F., Giago-Mcgahan, T., Rassenti, L., et al. (2005). ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood 105, 2036-2041.
    • (2005) Blood , vol.105 , pp. 2036-2041
    • Chen, L.1    Apgar, J.2    Huynh, L.3    Dicker, F.4    Giago-Mcgahan, T.5    Rassenti, L.6
  • 34
    • 41949140313 scopus 로고    scopus 로고
    • ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia
    • Chen, L., Huynh, L., Apgar, J., Tang, L., Rassenti, L., Weiss, A., et al. (2008). ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. Blood 111, 2685-2692.
    • (2008) Blood , vol.111 , pp. 2685-2692
    • Chen, L.1    Huynh, L.2    Apgar, J.3    Tang, L.4    Rassenti, L.5    Weiss, A.6
  • 35
    • 0029981025 scopus 로고    scopus 로고
    • National cancer institute-sponsored working group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment
    • Cheson, B. D., Bennett, J. M., Grever, M., Kay, N., Keating, M. J., O'Brien, S., et al. (1996). National cancer institute-sponsored working group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 87, 4990-4997.
    • (1996) Blood , vol.87 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3    Kay, N.4    Keating, M.J.5    O'Brien, S.6
  • 36
    • 55649084906 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development
    • doi: 10.1126/scisignal.1161577
    • Ciraolo, E., Iezzi, M., Marone, R., Marengo, S., Curcio, C., Costa, C., et al. (2008). Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci. Signal. 1:ra3. doi: 10.1126/scisignal.1161577
    • (2008) Sci. Signal. , vol.1
    • Ciraolo, E.1    Iezzi, M.2    Marone, R.3    Marengo, S.4    Curcio, C.5    Costa, C.6
  • 37
    • 0037119630 scopus 로고    scopus 로고
    • A crucial role for the p110{delta} subunit of phosphatidylinositol 3-kinase in B cell development and activation
    • Clayton, E., Bardi, G., Bell, S. E., Chantry, D., Downes, C. P., Gray, A., et al. (2002). A crucial role for the p110{delta} subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med. 196, 753-763.
    • (2002) J. Exp. Med. , vol.196 , pp. 753-763
    • Clayton, E.1    Bardi, G.2    Bell, S.E.3    Chantry, D.4    Downes, C.P.5    Gray, A.6
  • 38
    • 23744492188 scopus 로고    scopus 로고
    • Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
    • Condliffe, A. M., Davidson, K., Anderson, K. E., Ellson, C. D., Crabbe, T., Okkenhaug, K., et al. (2005). Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106, 1432-1440.
    • (2005) Blood , vol.106 , pp. 1432-1440
    • Condliffe, A.M.1    Davidson, K.2    Anderson, K.E.3    Ellson, C.D.4    Crabbe, T.5    Okkenhaug, K.6
  • 39
    • 20144385604 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis
    • Contri, A., Brunati, A., Trentin, L., Cabrelle, A., Miorin, M., Cesaro, L., et al. (2005). Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis. J. Clin. Invest. 115, 369-378.
    • (2005) J. Clin. Invest. , vol.115 , pp. 369-378
    • Contri, A.1    Brunati, A.2    Trentin, L.3    Cabrelle, A.4    Miorin, M.5    Cesaro, L.6
  • 40
    • 31444434588 scopus 로고    scopus 로고
    • Constitutive phosphoinositide 3-kinase activation in acute myeloid leukemia is not due to p110[delta] mutations
    • Cornillet-Lefebvre, P., Cuccuini, W., Bardet, V., Tamburini, J., Gillot, L., Ifrah, N., et al. (2005). Constitutive phosphoinositide 3-kinase activation in acute myeloid leukemia is not due to p110[delta] mutations. Leukemia 20, 374-376.
    • (2005) Leukemia , vol.20 , pp. 374-376
    • Cornillet-Lefebvre, P.1    Cuccuini, W.2    Bardet, V.3    Tamburini, J.4    Gillot, L.5    Ifrah, N.6
  • 42
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully, M., You, H., Levine, A. J., and Mak, T. W. (2006). Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat. Rev. Cancer 6, 184-192.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 43
    • 0033084143 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3, 4, 5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
    • Currie, R. A., Walker, K. S., Gray, A., Deak, M., Casamayor, A., Downes, C. P., et al. (1999). Role of phosphatidylinositol 3, 4, 5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem. J. 337, 575-583.
    • (1999) Biochem. J. , vol.337 , pp. 575-583
    • Currie, R.A.1    Walker, K.S.2    Gray, A.3    Deak, M.4    Casamayor, A.5    Downes, C.P.6
  • 44
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., et al. (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6
  • 46
    • 84858636448 scopus 로고    scopus 로고
    • The clinically active BTK inhibitor PCI-32765 targets B-cell receptor-and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
    • De Rooij, M. F. M., Kuil, A., Geest, C. R., Eldering, E., Chang, B. Y., Buggy, J. J., et al. (2012). The clinically active BTK inhibitor PCI-32765 targets B-cell receptor-and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. Blood 119, 2590-2594.
    • (2012) Blood , vol.119 , pp. 2590-2594
    • De Rooij, M.F.M.1    Kuil, A.2    Geest, C.R.3    Eldering, E.4    Chang, B.Y.5    Buggy, J.J.6
  • 47
    • 77955288855 scopus 로고    scopus 로고
    • Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus
    • Di Nicolantonio, F., Arena, S., Tabernero, J., Grosso, S., Molinari, F., Macarulla, T., et al. (2010). Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. J. Clin. Invest. 120, 2858-2866.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2858-2866
    • Di Nicolantonio, F.1    Arena, S.2    Tabernero, J.3    Grosso, S.4    Molinari, F.5    Macarulla, T.6
  • 48
    • 34548138930 scopus 로고    scopus 로고
    • Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway
    • Doepfner, K. T., Spertini, O., and Arcaro, A. (2007). Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway. Leukemia 21, 1921-1930.
    • (2007) Leukemia , vol.21 , pp. 1921-1930
    • Doepfner, K.T.1    Spertini, O.2    Arcaro, A.3
  • 49
    • 76349098519 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses
    • Durand, C. A., Hartvigsen, K., Fogelstrand, L., Kim, S., Iritani, S., Vanhaesebroeck, B., et al. (2009). Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses. J. Immunol. 183, 5673-5684.
    • (2009) J. Immunol. , vol.183 , pp. 5673-5684
    • Durand, C.A.1    Hartvigsen, K.2    Fogelstrand, L.3    Kim, S.4    Iritani, S.5    Vanhaesebroeck, B.6
  • 50
    • 76249092302 scopus 로고    scopus 로고
    • Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors
    • Edgar, K. A., Wallin, J. J., Berry, M., Lee, L. B., Prior, W. W., Sampath, D., et al. (2010). Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors. Cancer Res. 70, 1164-1172.
    • (2010) Cancer Res. , vol.70 , pp. 1164-1172
    • Edgar, K.A.1    Wallin, J.J.2    Berry, M.3    Lee, L.B.4    Prior, W.W.5    Sampath, D.6
  • 51
    • 70350506780 scopus 로고    scopus 로고
    • RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia
    • Edwards, H., Xie, C., Lafiura, K. M., Dombkowski, A. A., Buck, S. A., Boerner, J. L., et al. (2009). RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia. Blood 114, 2744-2752.
    • (2009) Blood , vol.114 , pp. 2744-2752
    • Edwards, H.1    Xie, C.2    Lafiura, K.M.3    Dombkowski, A.A.4    Buck, S.A.5    Boerner, J.L.6
  • 52
    • 79953647466 scopus 로고    scopus 로고
    • The Syk kinase as a therapeutic target in leukemia and lymphoma
    • Efremov, D., and Laurenti, L. (2011). The Syk kinase as a therapeutic target in leukemia and lymphoma. Expert. Opin. Investig. Drugs 20, 623-636.
    • (2011) Expert. Opin. Investig. Drugs , vol.20 , pp. 623-636
    • Efremov, D.1    Laurenti, L.2
  • 53
    • 41149165141 scopus 로고    scopus 로고
    • Control of axonal growth and regeneration of sensory neurons by the p110d PI 3-kinase
    • doi: 10.1371/journal.pone.0000869
    • Eickholt, B. J., Ahmed, A. I., Davies, M., Papakonstanti, E. A., Pearce, W., Starkey, M. L., et al. (2007). Control of axonal growth and regeneration of sensory neurons by the p110d PI 3-kinase. PLoS ONE 2:e869. doi: 10.1371/journal.pone.0000869
    • (2007) PLoS ONE , vol.2
    • Eickholt, B.J.1    Ahmed, A.I.2    Davies, M.3    Papakonstanti, E.A.4    Pearce, W.5    Starkey, M.L.6
  • 54
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman, J. A., Luo, J., and Cantley, L. C. (2006). The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7, 606-619.
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 55
    • 69949170092 scopus 로고    scopus 로고
    • Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a
    • Fine, B., Hodakoski, C., Koujak, S., Su, T., Saal, L. H., Maurer, M., et al. (2009). Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science 325, 1261-1265.
    • (2009) Science , vol.325 , pp. 1261-1265
    • Fine, B.1    Hodakoski, C.2    Koujak, S.3    Su, T.4    Saal, L.H.5    Maurer, M.6
  • 57
    • 33744990592 scopus 로고    scopus 로고
    • Critical role for the p110[alpha] phosphoinositide-3-OH kinase in growth and metabolic regulation
    • Foukas, L. C., Claret, M., Pearce, W., Okkenhaug, K., Meek, S., Peskett, E., et al. (2006). Critical role for the p110[alpha] phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature 441, 366-370.
    • (2006) Nature , vol.441 , pp. 366-370
    • Foukas, L.C.1    Claret, M.2    Pearce, W.3    Okkenhaug, K.4    Meek, S.5    Peskett, E.6
  • 58
    • 2342667375 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling
    • Fruman, D. A. (2004). Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling. Curr. Opin. Immunol. 16, 314-320.
    • (2004) Curr. Opin. Immunol. , vol.16 , pp. 314-320
    • Fruman, D.A.1
  • 59
    • 84857844598 scopus 로고    scopus 로고
    • PI3Kd inhibitors in cancer: rationale and serendipity merge in the clinic
    • Fruman, D. A., and Rommel, C. (2011). PI3Kd inhibitors in cancer: rationale and serendipity merge in the clinic. Cancer Discov. 1, 562-572.
    • (2011) Cancer Discov. , vol.1 , pp. 562-572
    • Fruman, D.A.1    Rommel, C.2
  • 60
    • 0033697728 scopus 로고    scopus 로고
    • CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification
    • Fujimoto, M., Fujimoto, Y., Poe, J. C., Jansen, P. J., Lowell, C. A., Defranco, A. L., et al. (2000). CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity 13, 47-57.
    • (2000) Immunity , vol.13 , pp. 47-57
    • Fujimoto, M.1    Fujimoto, Y.2    Poe, J.C.3    Jansen, P.J.4    Lowell, C.A.5    Defranco, A.L.6
  • 61
    • 0037047268 scopus 로고    scopus 로고
    • Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization
    • Fujita, N., Sato, S., Katayama, K., and Tsuruo, T. (2002). Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J. Biol. Chem. 277, 28706-28713.
    • (2002) J. Biol. Chem. , vol.277 , pp. 28706-28713
    • Fujita, N.1    Sato, S.2    Katayama, K.3    Tsuruo, T.4
  • 62
    • 0038433304 scopus 로고    scopus 로고
    • Insulin activation of rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
    • Garami, A., Zwartkruis, F. J. T., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., et al. (2003). Insulin activation of rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11, 1457-1466.
    • (2003) Mol. Cell , vol.11 , pp. 1457-1466
    • Garami, A.1    Zwartkruis, F.J.T.2    Nobukuni, T.3    Joaquin, M.4    Roccio, M.5    Stocker, H.6
  • 64
    • 33644859147 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma
    • Georgakis, G. V., Li, Y., Rassidakis, G. Z., Medeiros, L. J., Mills, G. B., and Younes, A. (2006). Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma. Br. J. Haematol. 132, 503-511.
    • (2006) Br. J. Haematol. , vol.132 , pp. 503-511
    • Georgakis, G.V.1    Li, Y.2    Rassidakis, G.Z.3    Medeiros, L.J.4    Mills, G.B.5    Younes, A.6
  • 65
    • 33847412872 scopus 로고    scopus 로고
    • ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells
    • Gobessi, S., Laurenti, L., Longo, P. G., Sica, S., Leone, G., and Efremov, D. G. (2007). ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells. Blood 109, 2032-2039.
    • (2007) Blood , vol.109 , pp. 2032-2039
    • Gobessi, S.1    Laurenti, L.2    Longo, P.G.3    Sica, S.4    Leone, G.5    Efremov, D.G.6
  • 66
    • 44349119736 scopus 로고    scopus 로고
    • Angiogenesis selectively requires the p110[alpha] isoform of PI3K to control endothelial cell migration
    • Graupera, M., Guillermet-Guibert, J., Foukas, L. C., Phng, L.-K., Cain, R. J., Salpekar, A., et al. (2008). Angiogenesis selectively requires the p110[alpha] isoform of PI3K to control endothelial cell migration. Nature 453, 662-666.
    • (2008) Nature , vol.453 , pp. 662-666
    • Graupera, M.1    Guillermet-Guibert, J.2    Foukas, L.C.3    Phng, L.-K.4    Cain, R.J.5    Salpekar, A.6
  • 67
    • 0032100506 scopus 로고    scopus 로고
    • Alterations of the MMAC1/PTEN gene in lymphoid malignancies
    • Grønbæk, K., Zeuthen, J., Guldberg, P., Ralfkiaer, E., and Hou-Jensen, K. (1998). Alterations of the MMAC1/PTEN gene in lymphoid malignancies. Blood 91, 4388-4390.
    • (1998) Blood , vol.91 , pp. 4388-4390
    • Grønbæk, K.1    Zeuthen, J.2    Guldberg, P.3    Ralfkiaer, E.4    Hou-Jensen, K.5
  • 68
    • 46149106818 scopus 로고    scopus 로고
    • The p110b isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110g
    • Guillermet-Guibert, J., Bjorklof, K., Salpekar, A., Gonella, C., Ramadani, F., Bilancio, A., et al. (2008). The p110b isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110g. Proc. Natl. Acad. Sci. U.S.A. 105, 8292-8297.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 8292-8297
    • Guillermet-Guibert, J.1    Bjorklof, K.2    Salpekar, A.3    Gonella, C.4    Ramadani, F.5    Bilancio, A.6
  • 69
  • 70
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek, M., Cheson, B. D., Catovsky, D., Caligaris-Cappio, F., Dighiero, G., Döhner, H., et al. (2008). Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 111, 5446-5456.
    • (2008) Blood , vol.111 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3    Caligaris-Cappio, F.4    Dighiero, G.5    Döhner, H.6
  • 72
    • 34447254744 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1, 2-a]pyridines as novel PI3 kinase p110alpha inhibitors
    • Hayakawa, M., Kawaguchi, K.-I., Kaizawa, H., Koizumi, T., Ohishi, T., Yamano, M., et al. (2007). Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1, 2-a]pyridines as novel PI3 kinase p110alpha inhibitors. Bioorg. Med. Chem. 15, 5837-5844.
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 5837-5844
    • Hayakawa, M.1    Kawaguchi, K.-I.2    Kaizawa, H.3    Koizumi, T.4    Ohishi, T.5    Yamano, M.6
  • 73
    • 59749099913 scopus 로고    scopus 로고
    • B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta
    • Henley, T., Kovesdi, D., and Turner, M. (2008). B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta. Eur. J. Immunol. 38, 3543-3548.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 3543-3548
    • Henley, T.1    Kovesdi, D.2    Turner, M.3
  • 74
    • 79959404661 scopus 로고    scopus 로고
    • Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
    • Herman, S. E. M., Gordon, A. L., Hertlein, E., Ramanunni, A., Zhang, X., Jaglowski, S., et al. (2011). Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood 117, 6287-6296.
    • (2011) Blood , vol.117 , pp. 6287-6296
    • Herman, S.E.M.1    Gordon, A.L.2    Hertlein, E.3    Ramanunni, A.4    Zhang, X.5    Jaglowski, S.6
  • 75
    • 77957201023 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
    • Herman, S. E. M., Gordon, A. L., Wagner, A. J., Heerema, N. A., Zhao, W., Flynn, J. M., et al. (2010). Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood 116, 2078-2088.
    • (2010) Blood , vol.116 , pp. 2078-2088
    • Herman, S.E.M.1    Gordon, A.L.2    Wagner, A.J.3    Heerema, N.A.4    Zhao, W.5    Flynn, J.M.6
  • 76
    • 0034635434 scopus 로고    scopus 로고
    • Specific requirement for the p85-p110alpha phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells
    • Hill, K., Welti, S., Yu, J., Murray, J. T., Yip, S.-C., Condeelis, J. S., et al. (2000). Specific requirement for the p85-p110alpha phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells. J. Biol. Chem. 275, 3741-3744.
    • (2000) J. Biol. Chem. , vol.275 , pp. 3741-3744
    • Hill, K.1    Welti, S.2    Yu, J.3    Murray, J.T.4    Yip, S.-C.5    Condeelis, J.S.6
  • 77
    • 80053345977 scopus 로고    scopus 로고
    • The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
    • Hoellenriegel, J., Meadows, S. A., Sivina, M., Wierda, W. G., Kantarjian, H., Keating, M. J., et al. (2011). The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 118, 3603-3612.
    • (2011) Blood , vol.118 , pp. 3603-3612
    • Hoellenriegel, J.1    Meadows, S.A.2    Sivina, M.3    Wierda, W.G.4    Kantarjian, H.5    Keating, M.J.6
  • 78
    • 0033952239 scopus 로고    scopus 로고
    • The PI 3-kinase isoforms p110a and p110b have differential roles in PDGF-and insulin-mediated signaling
    • Hooshmand-Rad, R., Hajkova, L., Klint, P., Karlsson, R., Vanhaesebroeck, B., Claesson-Welsh, L., et al. (2000). The PI 3-kinase isoforms p110a and p110b have differential roles in PDGF-and insulin-mediated signaling. J. Cell Sci. 113, 207-214.
    • (2000) J. Cell Sci. , vol.113 , pp. 207-214
    • Hooshmand-Rad, R.1    Hajkova, L.2    Klint, P.3    Karlsson, R.4    Vanhaesebroeck, B.5    Claesson-Welsh, L.6
  • 79
    • 0027361002 scopus 로고
    • Cloning of a novel ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
    • Hu, P., Mondino, A., Skolnik, E. Y., and Schlessinger, J. (1993). Cloning of a novel ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Mol. Cell. Biol. 13, 7677-7688.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7677-7688
    • Hu, P.1    Mondino, A.2    Skolnik, E.Y.3    Schlessinger, J.4
  • 80
    • 58249120506 scopus 로고    scopus 로고
    • Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic ras is a dominant predictor for resistance
    • Ihle, N. T., Lemos, R., Wipf, P., Yacoub, A., Mitchell, C., Siwak, D., et al. (2009). Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic ras is a dominant predictor for resistance. Cancer Res. 69, 143-150.
    • (2009) Cancer Res. , vol.69 , pp. 143-150
    • Ihle, N.T.1    Lemos, R.2    Wipf, P.3    Yacoub, A.4    Mitchell, C.5    Siwak, D.6
  • 81
    • 77956592891 scopus 로고    scopus 로고
    • PI3K/p110delta is a novel therapeutic target in multiple myeloma
    • Ikeda, H., Hideshima, T., Fulciniti, M., Perrone, G., Miura, N., Yasui, H., et al. (2010). PI3K/p110delta is a novel therapeutic target in multiple myeloma. Blood 116, 1460-1468.
    • (2010) Blood , vol.116 , pp. 1460-1468
    • Ikeda, H.1    Hideshima, T.2    Fulciniti, M.3    Perrone, G.4    Miura, N.5    Yasui, H.6
  • 82
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki, K., Li, Y., Xu, T., and Guan, K.-L. (2003). Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17, 1829-1834.
    • (2003) Genes Dev. , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.-L.4
  • 83
    • 77952093741 scopus 로고    scopus 로고
    • Hotspot mutations of PIK3CA and AKT1 genes are absent in multiple myeloma
    • Ismail, S. I., Mahmoud, I. S., Msallam, M. M., and Sughayer, M. A. (2010). Hotspot mutations of PIK3CA and AKT1 genes are absent in multiple myeloma. Leuk. Res. 34, 824-826.
    • (2010) Leuk. Res. , vol.34 , pp. 824-826
    • Ismail, S.I.1    Mahmoud, I.S.2    Msallam, M.M.3    Sughayer, M.A.4
  • 85
    • 49649087385 scopus 로고    scopus 로고
    • Essential roles of PI(3)K-p110ß in cell growth, metabolism and tumorigenesis
    • Jia, S., Liu, Z., Zhang, S., Liu, P., Zhang, L., Lee, S. H., et al. (2008). Essential roles of PI(3)K-p110ß in cell growth, metabolism and tumorigenesis. Nature 454, 776-779.
    • (2008) Nature , vol.454 , pp. 776-779
    • Jia, S.1    Liu, Z.2    Zhang, S.3    Liu, P.4    Zhang, L.5    Lee, S.H.6
  • 86
    • 63749106157 scopus 로고    scopus 로고
    • Should individual PI3 kinase isoforms be targeted in cancer?
    • Jia, S., Roberts, T. M., and Zhao, J. J. (2009). Should individual PI3 kinase isoforms be targeted in cancer? Curr. Opin. Cell Biol. 21, 199-208.
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 199-208
    • Jia, S.1    Roberts, T.M.2    Zhao, J.J.3
  • 87
    • 77952048131 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase pathway activation in Phosphate and Tensin Homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110b and p110d catalytic subunits
    • Jiang, X., Chen, S., Asara, J. M., and Balk, S. P. (2010). Phosphoinositide 3-kinase pathway activation in Phosphate and Tensin Homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110b and p110d catalytic subunits. J. Biol. Chem. 285, 14980-14989.
    • (2010) J. Biol. Chem. , vol.285 , pp. 14980-14989
    • Jiang, X.1    Chen, S.2    Asara, J.M.3    Balk, S.P.4
  • 88
    • 0036829983 scopus 로고    scopus 로고
    • The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras
    • Jimenez, C., Hernandez, C., Pimentel, B., and Carrera, A. C. (2002). The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras. J. Biol. Chem. 277, 41556-41562.
    • (2002) J. Biol. Chem. , vol.277 , pp. 41556-41562
    • Jimenez, C.1    Hernandez, C.2    Pimentel, B.3    Carrera, A.C.4
  • 89
    • 0442276554 scopus 로고    scopus 로고
    • The glamour and gloom of glycogen synthase kinase-3
    • Jope, R. S., and Johnson, G. V. W. (2004). The glamour and gloom of glycogen synthase kinase-3. Trends Biochem. Sci. 29, 95-102.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 95-102
    • Jope, R.S.1    Johnson, G.V.W.2
  • 90
    • 0037695593 scopus 로고    scopus 로고
    • Essential, nonredundant role for the phosphoinositide 3-kinase p110d in signaling by the B-Cell receptor complex
    • Jou, S.-T., Carpino, N., Takahashi, Y., Piekorz, R., Chao, J.-R., Carpino, N., et al. (2002). Essential, nonredundant role for the phosphoinositide 3-kinase p110d in signaling by the B-Cell receptor complex. Mol. Cell. Biol. 22, 8580-8591.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 8580-8591
    • Jou, S.-T.1    Carpino, N.2    Takahashi, Y.3    Piekorz, R.4    Chao, J.-R.5    Carpino, N.6
  • 91
    • 31944448780 scopus 로고    scopus 로고
    • Oncogenic transformation induced by the p110beta,-{gamma}, and-{delta} isoforms of class I phosphoinositide 3-kinase
    • Kang, S., Denley, A., Vanhaesebroeck, B., and Vogt, P. K. (2006). Oncogenic transformation induced by the p110beta,-{gamma}, and-{delta} isoforms of class I phosphoinositide 3-kinase. Proc. Natl. Acad. Sci. U.S.A. 103, 1289-1294.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 1289-1294
    • Kang, S.1    Denley, A.2    Vanhaesebroeck, B.3    Vogt, P.K.4
  • 92
    • 36148992966 scopus 로고    scopus 로고
    • The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion
    • Kim, N., Saudemont, A., Webb, L., Camps, M., Ruckle, T., Hirsch, E., et al. (2007). The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion. Blood 110, 3202-3208.
    • (2007) Blood , vol.110 , pp. 3202-3208
    • Kim, N.1    Saudemont, A.2    Webb, L.3    Camps, M.4    Ruckle, T.5    Hirsch, E.6
  • 93
    • 0030975196 scopus 로고    scopus 로고
    • Signaling by phosphoinositide-3, 4, 5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains
    • Klarlund, J., Guilherme, A., Holik, J., Virbasius, J., Chawla, A., and Czech, M. (1997). Signaling by phosphoinositide-3, 4, 5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science 275, 1927-1930.
    • (1997) Science , vol.275 , pp. 1927-1930
    • Klarlund, J.1    Guilherme, A.2    Holik, J.3    Virbasius, J.4    Chawla, A.5    Czech, M.6
  • 94
    • 0242499482 scopus 로고    scopus 로고
    • Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas
    • Knobbe, C. B., and Reifenberger, G. (2003). Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol. 13, 507-518.
    • (2003) Brain Pathol. , vol.13 , pp. 507-518
    • Knobbe, C.B.1    Reifenberger, G.2
  • 95
    • 62849114529 scopus 로고    scopus 로고
    • Regulation of phosphoinositide 3-kinase expression in health and disease
    • Kok, K., Geering, B., and Vanhaesebroeck, B. (2009a). Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem. Sci. 34, 115-127.
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 115-127
    • Kok, K.1    Geering, B.2    Vanhaesebroeck, B.3
  • 97
    • 0037086679 scopus 로고    scopus 로고
    • Mechanism of the regulation of type IB phosphoinositide 3OH-kinase by G-protein bg subunits
    • Krugmann, S., Cooper, M. A., Williams, D. H., Hawkins, P. T., and Stephens, L. R. (2002). Mechanism of the regulation of type IB phosphoinositide 3OH-kinase by G-protein bg subunits. Biochem. J. 362, 725-731.
    • (2002) Biochem. J. , vol.362 , pp. 725-731
    • Krugmann, S.1    Cooper, M.A.2    Williams, D.H.3    Hawkins, P.T.4    Stephens, L.R.5
  • 98
    • 0033546148 scopus 로고    scopus 로고
    • Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits
    • Krugmann, S., Hawkins, P. T., Pryer, N., and Braselmann, S. (1999). Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits. J. Biol. Chem. 274, 17152-17158.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17152-17158
    • Krugmann, S.1    Hawkins, P.T.2    Pryer, N.3    Braselmann, S.4
  • 99
    • 0028355565 scopus 로고
    • Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling
    • Kurosaki, T., Takata, M., Yamanashi, Y., Inazu, T., Taniguchi, T., Yamamoto, T., et al. (1994). Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J. Exp. Med. 179, 1725-1729.
    • (1994) J. Exp. Med. , vol.179 , pp. 1725-1729
    • Kurosaki, T.1    Takata, M.2    Yamanashi, Y.3    Inazu, T.4    Taniguchi, T.5    Yamamoto, T.6
  • 100
    • 13544274110 scopus 로고    scopus 로고
    • Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells
    • Lal, L., Li, Y., Smith, J., Sassano, A., Uddin, S., Parmar, S., et al. (2005). Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells. Blood 105, 1669-1677.
    • (2005) Blood , vol.105 , pp. 1669-1677
    • Lal, L.1    Li, Y.2    Smith, J.3    Sassano, A.4    Uddin, S.5    Parmar, S.6
  • 101
    • 78751553221 scopus 로고    scopus 로고
    • CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
    • Lannutti, B. J., Meadows, S. A., Herman, S. E. M., Kashishian, A., Steiner, B., Johnson, A. J., et al. (2011). CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood 117, 591-594.
    • (2011) Blood , vol.117 , pp. 591-594
    • Lannutti, B.J.1    Meadows, S.A.2    Herman, S.E.M.3    Kashishian, A.4    Steiner, B.5    Johnson, A.J.6
  • 102
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann, B. D., Bauer, J. A., Chen, X., Sanders, M. E., Chakravarthy, A. B., Shyr, Y., et al. (2011). Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J. Clin. Invest. 121, 2750-2767.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3    Sanders, M.E.4    Chakravarthy, A.B.5    Shyr, Y.6
  • 104
    • 0036181869 scopus 로고    scopus 로고
    • PTEN: the down side of PI 3-kinase signalling
    • Leslie, N. R., and Downes, C. P. (2002). PTEN: the down side of PI 3-kinase signalling. Cell. Signal. 14, 285-295.
    • (2002) Cell. Signal. , vol.14 , pp. 285-295
    • Leslie, N.R.1    Downes, C.P.2
  • 105
    • 4344684649 scopus 로고    scopus 로고
    • PTEN function: how normal cells control it and tumour cells lose it
    • Leslie, N. R., and Downes, C. P. (2004). PTEN function: how normal cells control it and tumour cells lose it. Biochem. J. 382, 1-11.
    • (2004) Biochem. J. , vol.382 , pp. 1-11
    • Leslie, N.R.1    Downes, C.P.2
  • 106
    • 0037393911 scopus 로고    scopus 로고
    • Disparate expression of the PTEN gene: a novel finding in B-cell chronic lymphocytic leukaemia (B-CLL)
    • Leupin, N., Cenni, B., Novak, U., Hügli, B., Graber, H. U., Tobler, A., et al. (2003). Disparate expression of the PTEN gene: a novel finding in B-cell chronic lymphocytic leukaemia (B-CLL). Br. J. Haematol. 121, 97-100.
    • (2003) Br. J. Haematol. , vol.121 , pp. 97-100
    • Leupin, N.1    Cenni, B.2    Novak, U.3    Hügli, B.4    Graber, H.U.5    Tobler, A.6
  • 107
    • 0141532180 scopus 로고    scopus 로고
    • Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages
    • Leverrier, Y., Okkenhaug, K., Sawyer, C., Bilancio, A., Vanhaesebroeck, B., and Ridley, A. J. (2003). Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages. J. Biol. Chem. 278, 38437-38442.
    • (2003) J. Biol. Chem. , vol.278 , pp. 38437-38442
    • Leverrier, Y.1    Okkenhaug, K.2    Sawyer, C.3    Bilancio, A.4    Vanhaesebroeck, B.5    Ridley, A.J.6
  • 109
    • 2342618936 scopus 로고    scopus 로고
    • Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
    • Liang, J., and Slingerland, J. M. (2003). Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2, 336-342.
    • (2003) Cell Cycle , vol.2 , pp. 336-342
    • Liang, J.1    Slingerland, J.M.2
  • 110
    • 18644376449 scopus 로고    scopus 로고
    • PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
    • Liang, J., Zubovitz, J., Petrocelli, T., Kotchetkov, R., Connor, M. K., Han, K., et al. (2002). PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat. Med. 8, 1153-1160.
    • (2002) Nat. Med. , vol.8 , pp. 1153-1160
    • Liang, J.1    Zubovitz, J.2    Petrocelli, T.3    Kotchetkov, R.4    Connor, M.K.5    Han, K.6
  • 111
    • 77957194863 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase d regulates membrane fission of Golgi carriers for selective cytokine secretion
    • Low, P. C., Misaki, R., Schroder, K., Stanley, A. C., Sweet, M. J., Teasdale, R. D., et al. (2010). Phosphoinositide 3-kinase d regulates membrane fission of Golgi carriers for selective cytokine secretion. J. Cell Biol. 190, 1053-1065.
    • (2010) J. Cell Biol. , vol.190 , pp. 1053-1065
    • Low, P.C.1    Misaki, R.2    Schroder, K.3    Stanley, A.C.4    Sweet, M.J.5    Teasdale, R.D.6
  • 112
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: rationale and promise
    • Luo, J., Manning, B. D., and Cantley, L. C. (2003). Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4, 257-262.
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 113
    • 80054108407 scopus 로고    scopus 로고
    • Signal transduction inhibitors in chronic lymphocytic leukemia
    • Ma, S., and Rosen, S. T. (2011). Signal transduction inhibitors in chronic lymphocytic leukemia. Curr. Opin. Oncol. 23, 601-608.
    • (2011) Curr. Opin. Oncol. , vol.23 , pp. 601-608
    • Ma, S.1    Rosen, S.T.2
  • 114
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate
    • Maehama, T., and Dixon, J. E. (1998). The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate. J. Biol. Chem. 273, 13375-13378.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 115
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream
    • Manning, B. D., and Cantley, L. C. (2007). AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 117
  • 119
    • 84863116183 scopus 로고    scopus 로고
    • PI3Kdelta inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma
    • Meadows, S. A., Vega, F., Kashishian, A., Johnson, D., Diehl, V., Miller, L. L., et al. (2012). PI3Kdelta inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma. Blood 119, 1897-1900.
    • (2012) Blood , vol.119 , pp. 1897-1900
    • Meadows, S.A.1    Vega, F.2    Kashishian, A.3    Johnson, D.4    Diehl, V.5    Miller, L.L.6
  • 120
    • 84863258395 scopus 로고    scopus 로고
    • PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors
    • Meric-Bernstam, F., Akcakanat, A., Chen, H., Do, K.-A., Sangai, T., Adkins, F., et al. (2012). PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors. Clin. Cancer Res. 18, 1777-1789.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1777-1789
    • Meric-Bernstam, F.1    Akcakanat, A.2    Chen, H.3    Do, K.-A.4    Sangai, T.5    Adkins, F.6
  • 121
    • 77949681661 scopus 로고    scopus 로고
    • Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor
    • Meuillet, E., Zuohe, S., Lemos, R., Ihle, N., Kingston, J., Watkins, R., et al. (2010). Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol. Cancer Ther. 9, 706-717.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 706-717
    • Meuillet, E.1    Zuohe, S.2    Lemos, R.3    Ihle, N.4    Kingston, J.5    Watkins, R.6
  • 122
    • 0037513474 scopus 로고    scopus 로고
    • Constitutive phosphorylation of Akt//PKB protein in acute myeloid leukemia: its significance as a prognostic variable
    • Min, Y. H., Eom, J. I., Cheong, J. W., Maeng, H. O., Kim, J. Y., Jeung, H. K., et al. (2003). Constitutive phosphorylation of Akt//PKB protein in acute myeloid leukemia: its significance as a prognostic variable. Leukemia 17, 995-997.
    • (2003) Leukemia , vol.17 , pp. 995-997
    • Min, Y.H.1    Eom, J.I.2    Cheong, J.W.3    Maeng, H.O.4    Kim, J.Y.5    Jeung, H.K.6
  • 123
    • 8744259822 scopus 로고    scopus 로고
    • Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas
    • Mizoguchi, M., Nutt, C. L., Mohapatra, G., and Louis, D. N. (2004). Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas. Brain Pathol. 14, 372-377.
    • (2004) Brain Pathol. , vol.14 , pp. 372-377
    • Mizoguchi, M.1    Nutt, C.L.2    Mohapatra, G.3    Louis, D.N.4
  • 124
    • 84855992592 scopus 로고    scopus 로고
    • B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K
    • Ni, M., Macfarlane, A. W., Toft, M., Lowell, C. A., Campbell, K. S., and Hamerman, J. A. (2012). B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc. Natl. Acad. Sci. U.S.A. 109, 267-272.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 267-272
    • Ni, M.1    Macfarlane, A.W.2    Toft, M.3    Lowell, C.A.4    Campbell, K.S.5    Hamerman, J.A.6
  • 125
    • 80054947365 scopus 로고    scopus 로고
    • Selective PI3Kd inhibitors, a review of the patent literature
    • Norman, P. (2011). Selective PI3Kd inhibitors, a review of the patent literature. Expert. Opin. Ther. Pat 21, 1773-1790.
    • (2011) Expert. Opin. Ther. Pat , vol.21 , pp. 1773-1790
    • Norman, P.1
  • 126
    • 77954755623 scopus 로고    scopus 로고
    • Predictive biomarkers of sensitivity to the phosphatidylinositol 3 kinase inhibitor GDC-0941 in breast cancer preclinical models
    • O'Brien, C., Wallin, J. J., Sampath, D., Guhathakurta, D., Savage, H., Punnoose, E. A., et al. (2010). Predictive biomarkers of sensitivity to the phosphatidylinositol 3 kinase inhibitor GDC-0941 in breast cancer preclinical models. Clin. Cancer Res. 16, 3670-3683.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3670-3683
    • O'Brien, C.1    Wallin, J.J.2    Sampath, D.3    Guhathakurta, D.4    Savage, H.5    Punnoose, E.A.6
  • 127
    • 0034507903 scopus 로고    scopus 로고
    • BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
    • Okada, T., Maeda, A., Iwamatsu, A., Gotoh, K., and Kurosaki, T. (2000). BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 13, 817-827.
    • (2000) Immunity , vol.13 , pp. 817-827
    • Okada, T.1    Maeda, A.2    Iwamatsu, A.3    Gotoh, K.4    Kurosaki, T.5
  • 128
    • 0037047590 scopus 로고    scopus 로고
    • Impaired B and T cell antigen receptor signaling in p110d PI 3-kinase mutant mice
    • Okkenhaug, K., Bilancio, A., Farjot, G., Priddle, H., Sancho, S., Peskett, E., et al. (2002). Impaired B and T cell antigen receptor signaling in p110d PI 3-kinase mutant mice. Science 297, 1031-1034.
    • (2002) Science , vol.297 , pp. 1031-1034
    • Okkenhaug, K.1    Bilancio, A.2    Farjot, G.3    Priddle, H.4    Sancho, S.5    Peskett, E.6
  • 130
    • 0034168362 scopus 로고    scopus 로고
    • PLC-gamma1 signaling pathway and villin activation are involved in actin cytoskeleton reorganization induced by Na+/Pi cotransport up-regulation
    • Papakonstanti, E. A., Emmanouel, D. S., Gravanis, A., and Stournaras, C. (2000). PLC-gamma1 signaling pathway and villin activation are involved in actin cytoskeleton reorganization induced by Na+/Pi cotransport up-regulation. Mol. Med. 6, 303-318.
    • (2000) Mol. Med. , vol.6 , pp. 303-318
    • Papakonstanti, E.A.1    Emmanouel, D.S.2    Gravanis, A.3    Stournaras, C.4
  • 131
    • 34447299716 scopus 로고    scopus 로고
    • The p110d isoform of PI 3-kinase negatively controls RhoA and PTEN
    • Papakonstanti, E. A., Ridley, A. J., and Vanhaesebroeck, B. (2007). The p110d isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J. 26, 3050-3061.
    • (2007) EMBO J. , vol.26 , pp. 3050-3061
    • Papakonstanti, E.A.1    Ridley, A.J.2    Vanhaesebroeck, B.3
  • 132
    • 59349095075 scopus 로고    scopus 로고
    • Distinct roles of class IA PI 3-kinase isoforms in primary and immortalised macrophages
    • Papakonstanti, E. A., Zwaenepoel, O., Bilancio, A., Burns, E., Nock, G. E., Houseman, B., et al. (2008). Distinct roles of class IA PI 3-kinase isoforms in primary and immortalised macrophages. J. Cell Sci. 121, 4124-4133.
    • (2008) J. Cell Sci. , vol.121 , pp. 4124-4133
    • Papakonstanti, E.A.1    Zwaenepoel, O.2    Bilancio, A.3    Burns, E.4    Nock, G.E.5    Houseman, B.6
  • 133
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons, D. W., Jones, S., Zhang, X., Lin, J. C., Leary, R. J., Angenendt, P., et al. (2008). An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812.
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3    Lin, J.C.4    Leary, R.J.5    Angenendt, P.6
  • 134
    • 1342342989 scopus 로고    scopus 로고
    • Human cancer, PTEN and the PI-3 kinase pathway
    • Parsons, R. (2004). Human cancer, PTEN and the PI-3 kinase pathway. Semin. Cell Dev. Biol. 15, 171-176.
    • (2004) Semin. Cell Dev. Biol. , vol.15 , pp. 171-176
    • Parsons, R.1
  • 135
    • 33750524262 scopus 로고    scopus 로고
    • BAFF controls B cell metabolic fitness through a PKC beta-and Akt-dependent mechanism
    • Patke, A., Mecklenbrauker, I., Erdjument-Bromage, H., Tempst, P., and Tarakhovsky, A. (2006). BAFF controls B cell metabolic fitness through a PKC beta-and Akt-dependent mechanism. J. Exp. Med. 203, 2551-2562.
    • (2006) J. Exp. Med. , vol.203 , pp. 2551-2562
    • Patke, A.1    Mecklenbrauker, I.2    Erdjument-Bromage, H.3    Tempst, P.4    Tarakhovsky, A.5
  • 136
    • 33750807672 scopus 로고    scopus 로고
    • Cutting edge: the phosphoinositide 3-kinase p110d is critical for the function of CD4+CD25+Foxp3+ regulatory T cells
    • Patton, D. T., Garden, O. A., Pearce, W. P., Clough, L. E., Monk, C. R., Leung, E., et al. (2006). Cutting edge: the phosphoinositide 3-kinase p110d is critical for the function of CD4+CD25+Foxp3+ regulatory T cells. J. Immunol. 177, 6598-6602.
    • (2006) J. Immunol. , vol.177 , pp. 6598-6602
    • Patton, D.T.1    Garden, O.A.2    Pearce, W.P.3    Clough, L.E.4    Monk, C.R.5    Leung, E.6
  • 137
    • 84874196138 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase signalling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions
    • doi: 10.3389/fimmu.2012.00224
    • Pauls, S. D., Lafarge, S. T., Landego, I., Zhang, T., and Marshall, A. J. (2012). The phosphoinositide 3-kinase signalling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions. Front. Immunol. 3:224. doi: 10.3389/fimmu.2012.00224
    • (2012) Front. Immunol. , vol.3 , pp. 224
    • Pauls, S.D.1    Lafarge, S.T.2    Landego, I.3    Zhang, T.4    Marshall, A.J.5
  • 138
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • Peso, L. D., González-García, M., Page, C., Herrera, R., and Nuñez, G. (1997). Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278, 687-689.
    • (1997) Science , vol.278 , pp. 687-689
    • Peso, L.D.1    González-García, M.2    Page, C.3    Herrera, R.4    Nuñez, G.5
  • 139
    • 0035835828 scopus 로고    scopus 로고
    • p27Kip1: regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer
    • Philipp-Staheli, J., Payne, S. R., and Kemp, C. J. (2001). p27Kip1: regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp. Cell Res. 264, 148-168.
    • (2001) Exp. Cell Res. , vol.264 , pp. 148-168
    • Philipp-Staheli, J.1    Payne, S.R.2    Kemp, C.J.3
  • 140
    • 84863011553 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
    • Ponader, S., Chen, S.-S., Buggy, J. J., Balakrishnan, K., Gandhi, V., Wierda, W. G., et al. (2012). The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 119, 1182-1189.
    • (2012) Blood , vol.119 , pp. 1182-1189
    • Ponader, S.1    Chen, S.-S.2    Buggy, J.J.3    Balakrishnan, K.4    Gandhi, V.5    Wierda, W.G.6
  • 142
    • 84874205694 scopus 로고    scopus 로고
    • Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies
    • doi: 10.3389/fimmu.2012.00256
    • Puri, K. D., and Gold, M. R. (2012). Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies. Front. Immunol. 3:256. doi: 10.3389/fimmu.2012.00256
    • (2012) Front. Immunol. , vol.3 , pp. 256
    • Puri, K.D.1    Gold, M.R.2
  • 143
    • 84863764147 scopus 로고    scopus 로고
    • PI3Kdelta is essential for tumor clearance mediated by cytotoxic T lymphocytes
    • doi: 10.1371/journal.pone.0040852
    • Putz, E. M., Prchal-Murphy, M., Simma, O. A., Forster, F., Koenig, X., Stockinger, H., et al. (2012). PI3Kdelta is essential for tumor clearance mediated by cytotoxic T lymphocytes. PLoS ONE 7:e40852. doi: 10.1371/journal.pone.0040852
    • (2012) PLoS ONE , vol.7
    • Putz, E.M.1    Prchal-Murphy, M.2    Simma, O.A.3    Forster, F.4    Koenig, X.5    Stockinger, H.6
  • 144
    • 77956636063 scopus 로고    scopus 로고
    • The PI3K isoforms p110{alpha} and p110{delta} are essential for Pre-B cell receptor signaling and B cell development
    • doi: 10.1126/scisignal.2001104
    • Ramadani, F., Bolland, D. J., Garcon, F., Emery, J. L., Vanhaesebroeck, B., Corcoran, A. E., et al. (2010). The PI3K isoforms p110{alpha} and p110{delta} are essential for Pre-B cell receptor signaling and B cell development. Sci. Signal. 3:ra60. doi: 10.1126/scisignal.2001104
    • (2010) Sci. Signal. , vol.3
    • Ramadani, F.1    Bolland, D.J.2    Garcon, F.3    Emery, J.L.4    Vanhaesebroeck, B.5    Corcoran, A.E.6
  • 145
    • 84860755726 scopus 로고    scopus 로고
    • The miRNA-17[sim]92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation
    • Rao, E., Jiang, C., Ji, M., Huang, X., Iqbal, J., Lenz, G., et al. (2012). The miRNA-17[sim]92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. Leukemia 26, 1064-1072.
    • (2012) Leukemia , vol.26 , pp. 1064-1072
    • Rao, E.1    Jiang, C.2    Ji, M.3    Huang, X.4    Iqbal, J.5    Lenz, G.6
  • 146
    • 4043082729 scopus 로고    scopus 로고
    • Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing
    • Reif, K., Okkenhaug, K., Sasaki, T., Penninger, J. M., Vanhaesebroeck, B., and Cyster, J. G. (2004). Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J. Immunol. 173, 2236-2240.
    • (2004) J. Immunol. , vol.173 , pp. 2236-2240
    • Reif, K.1    Okkenhaug, K.2    Sasaki, T.3    Penninger, J.M.4    Vanhaesebroeck, B.5    Cyster, J.G.6
  • 147
    • 0026750092 scopus 로고
    • Antigen receptors on B lymphocytes
    • Reth, M. (1992). Antigen receptors on B lymphocytes. Annu. Rev. Immunol. 10, 97-121.
    • (1992) Annu. Rev. Immunol. , vol.10 , pp. 97-121
    • Reth, M.1
  • 149
    • 0031725052 scopus 로고    scopus 로고
    • A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin-and lysophosphatidic acid-mediated signal transduction
    • Roche, S., Downward, J., Raynal, P., and Courtneidge, S. A. (1998). A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin-and lysophosphatidic acid-mediated signal transduction. Mol. Cell. Biol. 18, 7119-7129.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 7119-7129
    • Roche, S.1    Downward, J.2    Raynal, P.3    Courtneidge, S.A.4
  • 150
    • 0028584245 scopus 로고
    • The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors
    • Roche, S., Koegl, M., and Courtneidge, S. A. (1994). The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors. Proc. Natl. Acad. Sci. U.S.A. 91, 9185-9189.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 9185-9189
    • Roche, S.1    Koegl, M.2    Courtneidge, S.A.3
  • 152
    • 79952109496 scopus 로고    scopus 로고
    • Taking PI3Kd and PI3K? one step ahead: dual active PI3Kd/? inhibitors for the treatment of immune-mediated inflammatory diseases
    • Rommel, C. (2010). Taking PI3Kd and PI3K? one step ahead: dual active PI3Kd/? inhibitors for the treatment of immune-mediated inflammatory diseases. Curr. Top. Microbiol. Immunol. 346, 279-299.
    • (2010) Curr. Top. Microbiol. Immunol. , vol.346 , pp. 279-299
    • Rommel, C.1
  • 153
    • 33847239467 scopus 로고    scopus 로고
    • PI3K[delta] and PI3K[gamma]: partners in crime in inflammation in rheumatoid arthritis and beyond?
    • Rommel, C., Camps, M., and Ji, H. (2007). PI3K[delta] and PI3K[gamma]: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat. Rev. Immunol. 7, 191-201.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 191-201
    • Rommel, C.1    Camps, M.2    Ji, H.3
  • 154
    • 0035803371 scopus 로고    scopus 로고
    • Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
    • Rosenwald, A., Alizadeh, A. A., Widhopf, G., Simon, R., Davis, R. E., Yu, X., et al. (2001). Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J. Exp. Med. 194, 1639-1648.
    • (2001) J. Exp. Med. , vol.194 , pp. 1639-1648
    • Rosenwald, A.1    Alizadeh, A.A.2    Widhopf, G.3    Simon, R.4    Davis, R.E.5    Yu, X.6
  • 155
    • 84055192519 scopus 로고    scopus 로고
    • Dual inhibitors of PI3K/mTOR or mTOR-selective inhibitors: which way shall we go?
    • Sabbah, D. A., Brattain, M. G., and Zhong, H. (2011). Dual inhibitors of PI3K/mTOR or mTOR-selective inhibitors: which way shall we go? Curr. Med. Chem. 18, 5528-5544.
    • (2011) Curr. Med. Chem. , vol.18 , pp. 5528-5544
    • Sabbah, D.A.1    Brattain, M.G.2    Zhong, H.3
  • 156
    • 0037369696 scopus 로고    scopus 로고
    • Essential role of phosphoinositide 3-kinase d in neutrophil directional movement
    • Sadhu, C., Masinovsky, B., Dick, K., Sowell, C. G., and Staunton, D. E. (2003). Essential role of phosphoinositide 3-kinase d in neutrophil directional movement. J. Immunol. 170, 2647-2654.
    • (2003) J. Immunol. , vol.170 , pp. 2647-2654
    • Sadhu, C.1    Masinovsky, B.2    Dick, K.3    Sowell, C.G.4    Staunton, D.E.5
  • 157
    • 0032589191 scopus 로고    scopus 로고
    • p27Kip1 is abnormally expressed in Diffuse Large B-Cell Lymphomas and is associated with an adverse clinical outcome
    • Sáez, A. L., Sánchez, E., Sánchez-Beato, M., Cruz, M. A., Chacón, I., Muñoz, E., et al. (1999). p27Kip1 is abnormally expressed in Diffuse Large B-Cell Lymphomas and is associated with an adverse clinical outcome. Br. J. Cancer 80, 1427-1434.
    • (1999) Br. J. Cancer , vol.80 , pp. 1427-1434
    • Sáez, A.L.1    Sánchez, E.2    Sánchez-Beato, M.3    Cruz, M.A.4    Chacón, I.5    Muñoz, E.6
  • 159
    • 13944284494 scopus 로고    scopus 로고
    • Oncogenic mutations of PIK3CA in human cancers
    • Samuels, Y., and Velculescu, V. E. (2004). Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 3, 1221-1224.
    • (2004) Cell Cycle , vol.3 , pp. 1221-1224
    • Samuels, Y.1    Velculescu, V.E.2
  • 160
    • 84860390340 scopus 로고    scopus 로고
    • Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer
    • doi: 10.1186/bcr2833
    • Sanchez, C., Ma, C., Crowder, R., Guintoli, T., Phommaly, C., Gao, F., et al. (2011). Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer. Breast Cancer Res. 13:R21. doi: 10.1186/bcr2833
    • (2011) Breast Cancer Res. , vol.13
    • Sanchez, C.1    Ma, C.2    Crowder, R.3    Guintoli, T.4    Phommaly, C.5    Gao, F.6
  • 161
    • 4344602002 scopus 로고    scopus 로고
    • The biology and clinical relevance of the PTEN tumor suppressor pathway
    • Sansal, I., and Sellers, W. R. (2004). The biology and clinical relevance of the PTEN tumor suppressor pathway. J. Clin. Oncol. 22, 2954-2963.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2954-2963
    • Sansal, I.1    Sellers, W.R.2
  • 162
    • 79954603804 scopus 로고    scopus 로고
    • Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma
    • Santiskulvong, C., Konecny, G. E., Fekete, M., Chen, K.-Y. M., Karam, A., Mulholland, D., et al. (2011). Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma. Clin. Cancer Res. 17, 2373-2384.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2373-2384
    • Santiskulvong, C.1    Konecny, G.E.2    Fekete, M.3    Chen, K.-Y.M.4    Karam, A.5    Mulholland, D.6
  • 163
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov, D., Guertin, D., Ali, S., and Sabatini, D. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.1    Guertin, D.2    Ali, S.3    Sabatini, D.4
  • 164
    • 0034635264 scopus 로고    scopus 로고
    • Function of PI3Kg in thymocyte development, T cell activation, and neutrophil migration
    • Sasaki, T., Irie-Sasaki, J., Jones, R. G., Oliveira-Dos-Santos, A. J., Stanford, W. L., Bolon, B., et al. (2000). Function of PI3Kg in thymocyte development, T cell activation, and neutrophil migration. Science 287, 1040-1046.
    • (2000) Science , vol.287 , pp. 1040-1046
    • Sasaki, T.1    Irie-Sasaki, J.2    Jones, R.G.3    Oliveira-Dos-Santos, A.J.4    Stanford, W.L.5    Bolon, B.6
  • 165
    • 34247169493 scopus 로고    scopus 로고
    • p110d is required for innate immunity to transplantable lymphomas
    • Saudemont, A., Okkenhaug, K., and Colucci, F. (2007). p110d is required for innate immunity to transplantable lymphomas. Biochem. Soc. Trans. 35, 183-185.
    • (2007) Biochem. Soc. Trans. , vol.35 , pp. 183-185
    • Saudemont, A.1    Okkenhaug, K.2    Colucci, F.3
  • 166
    • 0037381002 scopus 로고    scopus 로고
    • Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta
    • Sawyer, C., Sturge, J., Bennett, D. C., O'Hare, M. J., Allen, W. E., Bain, J., et al. (2003). Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta. Cancer Res. 63, 1667-1675.
    • (2003) Cancer Res. , vol.63 , pp. 1667-1675
    • Sawyer, C.1    Sturge, J.2    Bennett, D.C.3    O'Hare, M.J.4    Allen, W.E.5    Bain, J.6
  • 167
    • 79958696667 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3K3, a single convergent point promoting tumor inflammation and progression
    • Schmid, M. C., Avraamides, C. J., Dippold, H. C., Franco, I., Foubert, P., Ellies, L. G., et al. (2011). Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3K3, a single convergent point promoting tumor inflammation and progression. Cancer Cell 19, 715-727.
    • (2011) Cancer Cell , vol.19 , pp. 715-727
    • Schmid, M.C.1    Avraamides, C.J.2    Dippold, H.C.3    Franco, I.4    Foubert, P.5    Ellies, L.G.6
  • 168
    • 84861344593 scopus 로고    scopus 로고
    • A phase 1 study of the selective phosphatidylinositol 3-kinase delta (PI3K delta) inhibitor, CAL-101 (GS-1101), in combination with rituximab and/or bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia (CLL)
    • Sharman, J., De Vos, S., Leonard, J. P., Furman, R. R., Coutre, S. E., Flinn, I. W., et al. (2011). A phase 1 study of the selective phosphatidylinositol 3-kinase delta (PI3K delta) inhibitor, CAL-101 (GS-1101), in combination with rituximab and/or bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia (CLL). Blood 118, 779-780.
    • (2011) Blood , vol.118 , pp. 779-780
    • Sharman, J.1    De Vos, S.2    Leonard, J.P.3    Furman, R.R.4    Coutre, S.E.5    Flinn, I.W.6
  • 169
    • 52449092107 scopus 로고    scopus 로고
    • Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling
    • doi: 10.1371/journal.pone.0003065
    • She, Q.-B., Chandarlapaty, S., Ye, Q., Lobo, J., Haskell, K. M., Leander, K. R., et al. (2008). Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. PLoS ONE 3:e3065. doi: 10.1371/journal.pone.0003065
    • (2008) PLoS ONE , vol.3
    • She, Q.-B.1    Chandarlapaty, S.2    Ye, Q.3    Lobo, J.4    Haskell, K.M.5    Leander, K.R.6
  • 170
    • 77957739848 scopus 로고    scopus 로고
    • Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia
    • Shehata, M., Schnabl, S., Demirtas, D., Hilgarth, M., Hubmann, R., Ponath, E., et al. (2010). Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia. Blood 116, 2513-2521.
    • (2010) Blood , vol.116 , pp. 2513-2521
    • Shehata, M.1    Schnabl, S.2    Demirtas, D.3    Hilgarth, M.4    Hubmann, R.5    Ponath, E.6
  • 172
    • 0034092911 scopus 로고    scopus 로고
    • Regulation of the Cdk inhibitor p27 and its deregulation in cancer
    • Slingerland, J. P. (2000). Regulation of the Cdk inhibitor p27 and its deregulation in cancer. J. Cell. Physiol. 183, 10-17.
    • (2000) J. Cell. Physiol. , vol.183 , pp. 10-17
    • Slingerland, J.P.1
  • 173
    • 84857875585 scopus 로고    scopus 로고
    • PI3K signalling in B-and T-lymphocytes: new developments and therapeutic advances
    • So, L., and Fruman, D. A. (2012). PI3K signalling in B-and T-lymphocytes: new developments and therapeutic advances. Biochem. J. 442, 465-481.
    • (2012) Biochem. J. , vol.442 , pp. 465-481
    • So, L.1    Fruman, D.A.2
  • 174
    • 77950457187 scopus 로고    scopus 로고
    • PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
    • Soond, D. R., Bjørgo, E., Moltu, K., Dale, V. Q., Patton, D. T., Torgersen, K. M., et al. (2010). PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans. Blood 115, 2203-2213.
    • (2010) Blood , vol.115 , pp. 2203-2213
    • Soond, D.R.1    Bjørgo, E.2    Moltu, K.3    Dale, V.Q.4    Patton, D.T.5    Torgersen, K.M.6
  • 175
    • 0345016875 scopus 로고    scopus 로고
    • The B cell antigen receptor controls integrin activity through Btk and PLCgamma2
    • Spaargaren, M., Beuling, E. A., Rurup, M. L., Meijer, H. P., Klok, M. D., Middendorp, S., et al. (2003). The B cell antigen receptor controls integrin activity through Btk and PLCgamma2. J. Exp. Med. 198, 1539-1550.
    • (2003) J. Exp. Med. , vol.198 , pp. 1539-1550
    • Spaargaren, M.1    Beuling, E.A.2    Rurup, M.L.3    Meijer, H.P.4    Klok, M.D.5    Middendorp, S.6
  • 176
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • Stambolic, V., Suzuki, A., Delapompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., et al. (1998). Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39.
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    Delapompa, J.L.3    Brothers, G.M.4    Mirtsos, C.5    Sasaki, T.6
  • 177
    • 51049118140 scopus 로고    scopus 로고
    • An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
    • Stemke-Hale, K., Gonzalez-Angulo, A. M., Lluch, A., Neve, R. M., Kuo, W.-L., Davies, M., et al. (2008). An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res. 68, 6084-6091.
    • (2008) Cancer Res. , vol.68 , pp. 6084-6091
    • Stemke-Hale, K.1    Gonzalez-Angulo, A.M.2    Lluch, A.3    Neve, R.M.4    Kuo, W.-L.5    Davies, M.6
  • 178
    • 0032578999 scopus 로고    scopus 로고
    • Protein kinase B kinases that mediate phosphatidylinositol 3, 4, 5-trisphosphate-dependent activation of protein kinase B
    • Stephens, L., Anderson, K., Stokoe, D., Erdjument-Bromage, H., Painter, G. F., Holmes, A. B., et al. (1998). Protein kinase B kinases that mediate phosphatidylinositol 3, 4, 5-trisphosphate-dependent activation of protein kinase B. Science 279, 710-714.
    • (1998) Science , vol.279 , pp. 710-714
    • Stephens, L.1    Anderson, K.2    Stokoe, D.3    Erdjument-Bromage, H.4    Painter, G.F.5    Holmes, A.B.6
  • 179
    • 0030887632 scopus 로고    scopus 로고
    • The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
    • Stephens, L. R., Eguinoa, A., Erdjument-Bromage, H., Lui, M., Cooke, F., Coadwell, J., et al. (1997). The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89, 105-114.
    • (1997) Cell , vol.89 , pp. 105-114
    • Stephens, L.R.1    Eguinoa, A.2    Erdjument-Bromage, H.3    Lui, M.4    Cooke, F.5    Coadwell, J.6
  • 180
    • 0030799706 scopus 로고    scopus 로고
    • Dual role of phosphatidylinositol-3, 4, 5-trisphosphate in the activation of protein kinase B
    • Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R., Reece, C. B., Painter, G. F., et al. (1997). Dual role of phosphatidylinositol-3, 4, 5-trisphosphate in the activation of protein kinase B. Science 277, 567-570.
    • (1997) Science , vol.277 , pp. 567-570
    • Stokoe, D.1    Stephens, L.R.2    Copeland, T.3    Gaffney, P.R.4    Reece, C.B.5    Painter, G.F.6
  • 181
    • 15744363780 scopus 로고    scopus 로고
    • p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma
    • Suire, S., Coadwell, J., Ferguson, G. J., Davidson, K., Hawkins, P., and Stephens, L. (2005). p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. Curr. Biol. 15, 566-570.
    • (2005) Curr. Biol. , vol.15 , pp. 566-570
    • Suire, S.1    Coadwell, J.2    Ferguson, G.J.3    Davidson, K.4    Hawkins, P.5    Stephens, L.6
  • 182
    • 22544444889 scopus 로고    scopus 로고
    • Essential role for the p110{delta} isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
    • Sujobert, P., Bardet, V., Cornillet-Lefebvre, P., Hayflick, J. S., Prie, N., Verdier, F., et al. (2005). Essential role for the p110{delta} isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. Blood 106, 1063-1066.
    • (2005) Blood , vol.106 , pp. 1063-1066
    • Sujobert, P.1    Bardet, V.2    Cornillet-Lefebvre, P.3    Hayflick, J.S.4    Prie, N.5    Verdier, F.6
  • 183
    • 0142011466 scopus 로고    scopus 로고
    • PTEN: from pathology to biology
    • Sulis, M. L., and Parsons, R. (2003). PTEN: from pathology to biology. Trends Cell Biol. 13, 478-483.
    • (2003) Trends Cell Biol. , vol.13 , pp. 478-483
    • Sulis, M.L.1    Parsons, R.2
  • 184
    • 79955983369 scopus 로고    scopus 로고
    • The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations
    • Tanaka, H., Yoshida, M., Tanimura, H., Fujii, T., Sakata, K., Tachibana, Y., et al. (2011). The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. Clin. Cancer Res. 17, 3272-3281.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 3272-3281
    • Tanaka, H.1    Yoshida, M.2    Tanimura, H.3    Fujii, T.4    Sakata, K.5    Tachibana, Y.6
  • 185
    • 34247636761 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion
    • Tazzari, P. L., Tabellini, G., Bortul, R., Papa, V., Evangelisti, C., Grafone, T., et al. (2007). The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion. Leukemia 21, 886-896.
    • (2007) Leukemia , vol.21 , pp. 886-896
    • Tazzari, P.L.1    Tabellini, G.2    Bortul, R.3    Papa, V.4    Evangelisti, C.5    Grafone, T.6
  • 186
    • 34548444625 scopus 로고    scopus 로고
    • Elucidating the altered transcriptional programs in breast cancer using independent component analysis
    • doi: 10.1371/journal.pcbi.0030161
    • Teschendorff, A. E., Journée, M., Absil, P. A., Sepulchre, R., and Caldas, C. (2007). Elucidating the altered transcriptional programs in breast cancer using independent component analysis. PLoS Comput. Biol. 3:e161. doi: 10.1371/journal.pcbi.0030161
    • (2007) PLoS Comput. Biol. , vol.3
    • Teschendorff, A.E.1    Journée, M.2    Absil, P.A.3    Sepulchre, R.4    Caldas, C.5
  • 187
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • TGCA.
    • TGCA. (2008). Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 189
    • 51349100763 scopus 로고    scopus 로고
    • A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition
    • Torbett, N. E., Luna-Moran, A., Knight, Z. A., Houk, A., Moasser, M., Weiss, W., et al. (2008). A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. Biochem. J. 415, 97-110.
    • (2008) Biochem. J. , vol.415 , pp. 97-110
    • Torbett, N.E.1    Luna-Moran, A.2    Knight, Z.A.3    Houk, A.4    Moasser, M.5    Weiss, W.6
  • 190
    • 0035847102 scopus 로고    scopus 로고
    • The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus
    • Torres, J., and Pulido, R. (2001). The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. J. Biol. Chem. 276, 993-998.
    • (2001) J. Biol. Chem. , vol.276 , pp. 993-998
    • Torres, J.1    Pulido, R.2
  • 191
    • 58149399472 scopus 로고    scopus 로고
    • Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia
    • Trentin, L., Frasson, M., Donella-Deana, A., Frezzato, F., Pagano, M. A., Tibaldi, E., et al. (2008). Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia. Blood 112, 4665-4674.
    • (2008) Blood , vol.112 , pp. 4665-4674
    • Trentin, L.1    Frasson, M.2    Donella-Deana, A.3    Frezzato, F.4    Pagano, M.A.5    Tibaldi, E.6
  • 192
    • 84856008042 scopus 로고    scopus 로고
    • Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt
    • Troutman, T. D., Hu, W., Fulenchek, S., Yamazaki, T., Kurosaki, T., Bazan, J. F., et al. (2012). Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proc. Natl. Acad. Sci. U.S.A. 109, 273-278.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 273-278
    • Troutman, T.D.1    Hu, W.2    Fulenchek, S.3    Yamazaki, T.4    Kurosaki, T.5    Bazan, J.F.6
  • 193
    • 0027169534 scopus 로고
    • CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase
    • Tuveson, D., Carter, R., Soltoff, S., and Fearon, D. (1993). CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 260, 986-989.
    • (1993) Science , vol.260 , pp. 986-989
    • Tuveson, D.1    Carter, R.2    Soltoff, S.3    Fearon, D.4
  • 194
    • 84861763406 scopus 로고    scopus 로고
    • High levels of p110d PI3K expression in solid tumor cells suppresses PTEN activity, generating cellular sensitivity to p110d inhibitors through PTEN activation
    • Tzenaki, N., Andreou, M., Stratigi, K., Vergetaki, A., Makrigiannakis, A., Vanhaesebroeck, B., et al. (2012). High levels of p110d PI3K expression in solid tumor cells suppresses PTEN activity, generating cellular sensitivity to p110d inhibitors through PTEN activation. FASEB J. 26, 2498-2508.
    • (2012) FASEB J. , vol.26 , pp. 2498-2508
    • Tzenaki, N.1    Andreou, M.2    Stratigi, K.3    Vergetaki, A.4    Makrigiannakis, A.5    Vanhaesebroeck, B.6
  • 200
    • 0033604577 scopus 로고    scopus 로고
    • Signaling by distinct classes of phosphoinisitide 3-kinases
    • Vanhaesebroeck, B., and Waterfield, M. D. (1999). Signaling by distinct classes of phosphoinisitide 3-kinases. Exp. Cell Res. 253, 239-254.
    • (1999) Exp. Cell Res. , vol.253 , pp. 239-254
    • Vanhaesebroeck, B.1    Waterfield, M.D.2
  • 201
    • 67649382929 scopus 로고    scopus 로고
    • AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
    • Vasudevan, K. M., Barbie, D. A., Davies, M. A., Rabinovsky, R., Mcnear, C. J., Kim, J. J., et al. (2009). AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer cell 16, 21-32.
    • (2009) Cancer cell , vol.16 , pp. 21-32
    • Vasudevan, K.M.1    Barbie, D.A.2    Davies, M.A.3    Rabinovsky, R.4    Mcnear, C.J.5    Kim, J.J.6
  • 202
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-Akt pathway in human cancer
    • Vivanco, I., and Sawyers, C. L. (2002). The phosphatidylinositol 3-kinase-Akt pathway in human cancer. Nat. Rev. Cancer 2, 489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 204
    • 33744518663 scopus 로고    scopus 로고
    • Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B
    • Voigt, P., Dorner, M. B., and Schaefer, M. (2006). Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B. J. Biol. Chem. 281, 9977-9986.
    • (2006) J. Biol. Chem. , vol.281 , pp. 9977-9986
    • Voigt, P.1    Dorner, M.B.2    Schaefer, M.3
  • 206
    • 84875554160 scopus 로고    scopus 로고
    • Genomic determinants of PI3K pathway inhibitor response in cancer
    • doi: 10.3389/fonc.2012.00109
    • Weigelt, B., and Downward, J. (2012). Genomic determinants of PI3K pathway inhibitor response in cancer. Front. Oncol. 2:109. doi: 10.3389/fonc.2012.00109
    • (2012) Front. Oncol. , vol.2 , pp. 109
    • Weigelt, B.1    Downward, J.2
  • 207
    • 79960732694 scopus 로고    scopus 로고
    • PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs
    • Weigelt, B., Warne, P. H., and Downward, J. (2011). PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs. Oncogene 30, 3222-3233.
    • (2011) Oncogene , vol.30 , pp. 3222-3233
    • Weigelt, B.1    Warne, P.H.2    Downward, J.3
  • 208
    • 0037155727 scopus 로고    scopus 로고
    • P-Rex1, a PtdIns(3, 4, 5)P3-and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac
    • Welch, H. C., Coadwell, W. J., Ellson, C. D., Ferguson, G. J., Andrews, S. R., Erdjument-Bromage, H., et al. (2002). P-Rex1, a PtdIns(3, 4, 5)P3-and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 108, 809-821.
    • (2002) Cell , vol.108 , pp. 809-821
    • Welch, H.C.1    Coadwell, W.J.2    Ellson, C.D.3    Ferguson, G.J.4    Andrews, S.R.5    Erdjument-Bromage, H.6
  • 209
    • 84860213415 scopus 로고    scopus 로고
    • Isoform-selective induction of human p110d PI3K expression by TNFa: identification of a new and inducible PIK3CD promoter
    • Whitehead, M. A., Bombardieri, M., Pitzalis, C., and Vanhaesebroeck, B. (2012). Isoform-selective induction of human p110d PI3K expression by TNFa: identification of a new and inducible PIK3CD promoter. Biochem. J. 443, 857-867.
    • (2012) Biochem. J. , vol.443 , pp. 857-867
    • Whitehead, M.A.1    Bombardieri, M.2    Pitzalis, C.3    Vanhaesebroeck, B.4
  • 211
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood, L. D., Parsons, D. W., Jones, S., Lin, J., Sjöblom, T., Leary, R. J., et al. (2007). The genomic landscapes of human breast and colorectal cancers. Science 318, 1108-1113.
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3    Lin, J.4    Sjöblom, T.5    Leary, R.J.6
  • 212
    • 84867396426 scopus 로고    scopus 로고
    • Selective small molecule inhibitors of p110a and d isoforms of phosphoinosityl-3-kinase are cytotoxic to human acute myeloid leukemia progenitors
    • Xing, Y., Gerhard, B., and Hogge, D. E. (2012). Selective small molecule inhibitors of p110a and d isoforms of phosphoinosityl-3-kinase are cytotoxic to human acute myeloid leukemia progenitors. Exp. Hematol. 40, 922-933.
    • (2012) Exp. Hematol. , vol.40 , pp. 922-933
    • Xing, Y.1    Gerhard, B.2    Hogge, D.E.3
  • 213
    • 0042744837 scopus 로고    scopus 로고
    • Survival of acute myeloid leukemia cells requires PI3 kinase activation
    • Xu, Q., Simpson, S.-E., Scialla, T. J., Bagg, A., and Carroll, M. (2003). Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 102, 972-980.
    • (2003) Blood , vol.102 , pp. 972-980
    • Xu, Q.1    Simpson, S.-E.2    Scialla, T.J.3    Bagg, A.4    Carroll, M.5
  • 214
    • 0037018096 scopus 로고    scopus 로고
    • Essential immunoregulatory role for BCAP in B cell development and function
    • Yamazaki, T., Takeda, K., Gotoh, K., Takeshima, H., Akira, S., and Kurosaki, T. (2002). Essential immunoregulatory role for BCAP in B cell development and function. J. Exp. Med. 195, 535-545.
    • (2002) J. Exp. Med. , vol.195 , pp. 535-545
    • Yamazaki, T.1    Takeda, K.2    Gotoh, K.3    Takeshima, H.4    Akira, S.5    Kurosaki, T.6
  • 215
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: variations on a theme
    • Yuan, T. L., and Cantley, L. C. (2008). PI3K pathway alterations in cancer: variations on a theme. Oncogene 27, 5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 216
    • 51849128358 scopus 로고    scopus 로고
    • Class I PI3K in oncogenic cellular transformation
    • Zhao, L., and Vogt, P. K. (2008a). Class I PI3K in oncogenic cellular transformation. Oncogene 27, 5486-5496.
    • (2008) Oncogene , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 217
    • 40649096375 scopus 로고    scopus 로고
    • Helical domain and kinase domain mutations in p110a of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
    • Zhao, L., and Vogt, P. K. (2008b). Helical domain and kinase domain mutations in p110a of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc. Natl. Acad. Sci. U.S.A. 105, 2652-2657.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 2652-2657
    • Zhao, L.1    Vogt, P.K.2
  • 218
    • 1242285048 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias
    • Zhao, S., Konopleva, M., Cabreira-Hansen, M., Xie, Z., Hu, W., Milella, M., et al. (2003). Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia 18, 267-275.
    • (2003) Leukemia , vol.18 , pp. 267-275
    • Zhao, S.1    Konopleva, M.2    Cabreira-Hansen, M.3    Xie, Z.4    Hu, W.5    Milella, M.6
  • 219
    • 0034745353 scopus 로고    scopus 로고
    • Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
    • Zhou, B. P., Liao, Y., Xia, W., Spohn, B., Lee, M. H., and Hung, M. C. (2001). Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat. Cell Biol. 3, 245-252.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 245-252
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Spohn, B.4    Lee, M.H.5    Hung, M.C.6
  • 220
    • 48649083369 scopus 로고    scopus 로고
    • Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers
    • Zhu, Q., Youn, H., Tang, J., Tawfik, O., Dennis, K., Terranova, P. F., et al. (2008). Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers. Oncogene 27, 4569-4579.
    • (2008) Oncogene , vol.27 , pp. 4569-4579
    • Zhu, Q.1    Youn, H.2    Tang, J.3    Tawfik, O.4    Dennis, K.5    Terranova, P.F.6
  • 221
    • 84856544134 scopus 로고    scopus 로고
    • Functional CSF-1 receptors are located at the nuclear envelope and activated by the p110d isoform of PI 3-kinase
    • Zwaenepoel, O., Tzenaki, N., Vergetaki, K., Makrigiannakis, A., Vanhaesebroeck, B., and Papakonstanti, E. A. (2012). Functional CSF-1 receptors are located at the nuclear envelope and activated by the p110d isoform of PI 3-kinase. FASEB J. 26, 691-706.
    • (2012) FASEB J. , vol.26 , pp. 691-706
    • Zwaenepoel, O.1    Tzenaki, N.2    Vergetaki, K.3    Makrigiannakis, A.4    Vanhaesebroeck, B.5    Papakonstanti, E.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.