Phosphoinositide 3-kinase p110δ regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses

Journal of Immunology

Volumn 183, Issue 9, 2009, Pages 5673-5684

  Durand, Caylib A ^a   Hartvigsen, Karsten ^b   Fogelstrand, Linda ^b,e   Kim, Shin ^a   Iritani, Sally ^c,f   Vanhaesebroeck, Bart ^d   Witztum, Joseph L ^b   Puri, Kamal D ^c   Gold, Michael R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c Calistoga Pharmaceuticals Inc   (United States)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e UNIVERSITY OF GOTHENBURG   (Sweden)

^f ZYMOGENETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; B LYMPHOCYTE RECEPTOR; CXCL13 CHEMOKINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P110; SPHINGOSINE 1 PHOSPHATE; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; B 1 B CELL; B LYMPHOCYTE ACTIVATION; C57BL 6 MOUSE; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHEMOKINESIS; CHEMOTAXIS; CPG ISLAND; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE; MARGINAL ZONE B CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SPLEEN;

ADENINE; ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, BACTERIAL; AUTOANTIBODIES; B-LYMPHOCYTE SUBSETS; CELLS, CULTURED; FEMALE; GENE KNOCK-IN TECHNIQUES; HOMEOSTASIS; ISOANTIBODIES; MICE; MICE, INBRED C57BL; PERITONEUM; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; QUINAZOLINES; RATS; RATS, INBRED LEW; SPLEEN;

EID: 76349098519     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900432     Document Type: Article

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