p85β phosphoinositide 3-kinase subunit regulates tumor progression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 28, 2012, Pages 11318-11323

  Cortés, Isabel ^a   Sánchez Ruíz, Jesús ^a   Zuluaga, Susana ^a   Calvanese, Vincenzo ^a   Marqués, Miriam ^b   Hernández, Carmen ^a   Rivera, Teresa ^c   Kremer, Leonor ^a   González García, Ana ^a   Carrera, Ana C ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

^c HOSPITAL DE MÓSTOLES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE P85BETQ; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOMA; CANCER GROWTH; CELL INVASION; CELL MEMBRANE; CHROMOSOME ABERRATION; COLON CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MEMBRANE; COLONIC NEOPLASMS; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, SCID; MICE, TRANSGENIC; NEOPLASM TRANSPLANTATION; NIH 3T3 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 84863946244     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118138109     Document Type: Article

References (27)

1. García Z, Kumar A, Marques M, Cortes I, Carrera AC (2006) PI3K controls early and late events in mammalian cell division. EMBO J 25:655-661. (Pubitemid 43292428)
2. Marone R, Cmiljanovic V, Giese B, Wymann MP (2008) Targeting PI3K: Moving towards therapy. Biochim Biophys Acta 1784:159-185.
3. Kok K, Geering B, Vanhaesebroeck B (2009) Regulation of PI3K expression in health and disease. Trends Biochem Sci 34:115-127.
4. Fruman DA, Cantley LC, Carpenter CL (1996) Structural organization and alternative splicing of the murine PI3K p85 alpha gene. Genomics 37:113-121. (Pubitemid 26341841)
5. Ueki K, et al. (2002) Molecular balance between the regulatory and catalytic subunits of PI3K regulates cell signaling and survival. Mol Cell Biol 22:965-977. (Pubitemid 34053073)
6. Geering B, Cutillas PR, Nock G, Gharbi SI, Vanhaesebroeck B (2007) Class IA PI3K are obligate p85-p110 heterodimers. Proc Natl Acad Sci USA 104:7809-7814. (Pubitemid 47185833)
7. Alcazar I, et al. (2009) p85beta PI3K regulates CD28 coreceptor function. Blood 113:3198-3208.
8. Fruman DA, et al. (1999) Impaired B cell development and proliferation in absence of PI3K p85alpha. Science 283:393-397.
9. Yu J, et al. (1998) Regulation of the p85/p110 PI3K: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Mol Cell Biol 18:1379-1387. (Pubitemid 28100902)
10. Philp AJ, et al. (2001) The PI3K p85alpha gene is an oncogene in human ovarian and colon tumors. Cancer Res 61:7426-7429.
11. Vogt PK, Kang S, Elsliger MA, Gymnopoulos M (2007) Cancer-specific mutations in PI3K. Trends Biochem Sci 32:342-349.
12. Liu P, Cheng H, Roberts TM, Zhao JJ (2009) Targeting the PI3K pathway in cancer. Nat Rev Drug Discov 8:627-644.
13. Guertin DA, Sabatini DM (2007) Defining the role of mTOR in cancer. Cancer Cell 12:9-22. (Pubitemid 47001784)
14. DeVita VT, Hellman S, Rosenberg SA, eds (2005) Cancer: Principles and Practice of Oncology (Lippincott Williams and Wilkins, Philadelphia).
15. Bloom HJ, Richardson WW, Harries EJ (1962) Natural history of untreated breast cancer (1805-1933). Comparison of untreated and treated cases according to histological grade of malignancy. BMJ 2:213-221.
16. Sørlie T, et al. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98:10869-10874. (Pubitemid 32878711)
17. Guo C, et al. (2008) The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting PI3K signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer 47:939-946.
18. Lujambio A, et al. (2008) A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci USA 105:13556-13561.
19. Saito K, Scharenberg AM, Kinet JP (2001) Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk. J Biol Chem 276:16201-16206.
20. Myers MP, et al. (1998) The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci USA 95:13513-13518. (Pubitemid 28523003)
21. Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC (1989) PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57:167-175. (Pubitemid 19098878)
22. Brachmann SM, et al. (2005) Role of PI3K regulatory isoforms in development and actin rearrangement. Mol Cell Biol 25:2593-2606. (Pubitemid 40381624)
23. Genevestigator (2012) GENEVESTIGATOR Biomedical. Available at www.genevestigator.com. Accessed February 25, 2012.
24. Cheung LW, et al. (2011) High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov 1:170-185.
25. Oncomine (2012) Oncomine 4.4 Research Edition. Available at www.oncomine.org. Accessed May 25, 2012.
26. Luo J, et al. (2005) Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of PI3K. Proc Natl Acad Sci USA 102: 10238-10243. (Pubitemid 41023356)
27. Rabinovsky R, et al. (2009) p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. Mol Cell Biol 29:5377-5388.