Targeting PI3 kinase/AKT/mTOR signaling in cancer

Critical Reviews in Oncogenesis

Volumn 17, Issue 1, 2012, Pages 69-95

  Sheppard, Karen E ^a,b   Kinross, Kathryn M ^a   Solomon, Benjamin ^a,b   Pearson, Richard B ^a,b,c   Phillips, Wayne A ^a,b,c  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Anticancer drugs; Clinical trials; Combinational therapy; Kinase inhibitors; Phosphatidylinositol 3 kinase; Targeted therapeutics

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 4 (4 AMINO 5 (7 METHOXY 1H INDOL 2 YL)IMIDAZO[5,1 F][1,2,4]TRIAZIN 7 YL)CYCLOHEXANECARBOXYLIC ACID; ANASTROZOLE; ANTINEOPLASTIC AGENT; AZD 8055; CAPECITABINE; EVEROLIMUS; EXEMESTANE; FLUOROPYRIMIDINE; GDC 0980; GSK 2126458; INK 128; INTERFERON; IRINOTECAN; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PACLITAXEL; PF 04691502; PF 05212384; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; RAPAMYCIN; RIDAFOROLIMUS; TEMOZOLOMIDE; TEMSIROLIMUS; UNCLASSIFIED DRUG; UNINDEXED DRUG; XL 765; [1 (4 OXO 8 PHENYL 4H 1 BENZOPYRAN 2 YL)MORPHOLINIO]METHOXYSUCCINYLARGINYLGLYCYLASPARTYLSERINE ACETATE; MTOR PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; TARGET OF RAPAMYCIN KINASE;

ADVANCED CANCER; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER HORMONE THERAPY; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RESPONSE; ENDOMETRIUM CANCER; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GLIOMA; KIDNEY CARCINOMA; LUNG NON SMALL CELL CANCER; LYMPHOMA; MOLECULAR INTERACTION; MOLECULARLY TARGETED THERAPY; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SOLID TUMOR; TUMOR VASCULARIZATION; ANIMAL; BIOLOGICAL MODEL; DRUG ANTAGONISM; DRUG EFFECT; FEEDBACK SYSTEM; GENETICS; HUMAN; METABOLISM; METHODOLOGY; NEOPLASM; PHYSIOLOGY; REVIEW;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; FEEDBACK, PHYSIOLOGICAL; HUMANS; MODELS, BIOLOGICAL; MOLECULAR TARGETED THERAPY; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR CROSS-TALK; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84861515834     PISSN: 08939675     EISSN: 21626448     Source Type: Journal    
DOI: 10.1615/CritRevOncog.v17.i1.60     Document Type: Article

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