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Volumn 346, Issue 1, 2010, Pages 279-299

Taking PI3Kδ and PI3Kγ one step ahead: Dual active PI3Kδ/γ inhibitors for the treatment of immune-mediated inflammatory diseases

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GLUCOCORTICOID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PHOSPHATIDYLINOSITOL 3 KINASE DELTA INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 79952109496     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82-2010-79     Document Type: Article
Times cited : (23)

References (70)
  • 2
    • 42149091691 scopus 로고    scopus 로고
    • Isoform-specific functions of phosphoinositide 3-kinases p110 delta but not p110 gamma promotes optimal allergic responses in vivo
    • Ali K, Camps M, Pearce WP, Ji H, Rückle T, Kuehn N, Pasquali C, Chabert C, Rommel C, Vanhaesebroeck B (2008) Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo. J Immunol 180 (4):2538-2544
    • (2008) J Immunol , vol.180 , Issue.4 , pp. 2538-2544
    • Ali, K.1    Camps, M.2    Pearce, W.P.3    Ji, H.4    Rückle, T.5    Kuehn, N.6    Pasquali, C.7    Chabert, C.8    Rommel, C.9    Vanhaesebroeck, B.10
  • 3
    • 35148860072 scopus 로고    scopus 로고
    • PI3K class IB pathway in neutrophils
    • cm3
    • Andrews S, Stephens LR, Hawkins PT (2007) PI3K class IB pathway in neutrophils. Sci STKE 2007(407):cm3
    • (2007) Sci STKE , vol.2007 , Issue.407
    • Andrews, S.1    Stephens, L.R.2    Hawkins, P.T.3
  • 4
    • 0027432424 scopus 로고
    • Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor
    • Arcaro A, Wymann MP (1993) Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor. Biochem J 296:297-301
    • (1993) Biochem J , vol.296 , pp. 297-301
    • Arcaro, A.1    Wymann, M.P.2
  • 6
    • 30444439101 scopus 로고    scopus 로고
    • Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: Comparative analysis of genetic and pharmacologic interference with p110δ function in B cells
    • DOI 10.1182/blood-2005-07-3041
    • Bilancio A, Okkenhaug K, Camps M, Emery JL, Ruckle T, Rommel C, Vanhaesebroeck B (2006) Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. Blood 107(2):642-650 (Pubitemid 43076389)
    • (2006) Blood , vol.107 , Issue.2 , pp. 642-650
    • Bilancio, A.1    Okkenhaug, K.2    Camps, M.3    Emery, J.L.4    Ruckle, T.5    Rommel, C.6    Vanhaesebroeck, B.7
  • 10
    • 33751187650 scopus 로고    scopus 로고
    • Continuous signaling via PI3K isoforms b and g is required for platelet ADP receptor function in dynamic thrombus stabilization
    • Cosemans JM, Munnix IC, Wetzker R, Heller R, Jackson SP, Heemskerk JW (2006) Continuous signaling via PI3K isoforms b and g is required for platelet ADP receptor function in dynamic thrombus stabilization. Blood 108(9):3045-3052
    • (2006) Blood , vol.108 , Issue.9 , pp. 3045-3052
    • Cosemans, J.M.1    Munnix, I.C.2    Wetzker, R.3    Heller, R.4    Jackson, S.P.5    Heemskerk, J.W.6
  • 12
  • 13
    • 15944425792 scopus 로고    scopus 로고
    • An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model
    • DOI 10.1016/j.intimp.2004.10.015
    • Duan W (2005) Aguinaldo Datiles AM, Leung BP, Vlahos CJ, Wong WS. An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model. Int Immunopharmacol 5(3):495-502 (Pubitemid 40430757)
    • (2005) International Immunopharmacology , vol.5 , Issue.3 , pp. 495-502
    • Duan, W.1    Aguinaldo Datiles, A.M.K.2    Leung, B.P.3    Vlahos, C.J.4    Wong, W.S.F.5
  • 14
    • 76349098519 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase p110delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses
    • Durand CA, Hartvigsen K, Fogelstrand L, Kim S, Iritani S, Vanhaesebroeck B, Witztum JL, Puri KD, Gold MR (2009) Phosphoinositide 3-kinase p110delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses. J Immunol 183 (9):5673-5684
    • (2009) J Immunol , vol.183 , Issue.9 , pp. 5673-5684
    • Durand, C.A.1    Hartvigsen, K.2    Fogelstrand, L.3    Kim, S.4    Iritani, S.5    Vanhaesebroeck, B.6    Witztum, J.L.7    Puri, K.D.8    Gold, M.R.9
  • 15
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA (2009) Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 9(8):550-562
    • (2009) Nat Rev Cancer , vol.9 , Issue.8 , pp. 550-562
    • Engelman, J.A.1
  • 17
    • 58049217466 scopus 로고    scopus 로고
    • Rheumatoid arthritis in a mouse?
    • Firestein GS (2009) Rheumatoid arthritis in a mouse? Nat Clin Pract Rheumatol 5(1):1
    • (2009) Nat Clin Pract Rheumatol , vol.5 , Issue.1 , pp. 1
    • Firestein, G.S.1
  • 19
    • 61849126233 scopus 로고    scopus 로고
    • Fine tuning the immune response with PI3K
    • Fruman DA, Bismuth G (2009) Fine tuning the immune response with PI3K. Immunol Rev 228(1): 253-272
    • (2009) Immunol Rev , vol.228 , Issue.1 , pp. 253-272
    • Fruman, D.A.1    Bismuth, G.2
  • 22
    • 33749248536 scopus 로고    scopus 로고
    • Decompartmentalizing target validation - Thinking outside the pipeline boxes
    • DOI 10.1007/s00109-006-0080-2
    • Hooft van Huijsduijnen R, Rommel C (2006) Decompartmentalizing target validation-thinking outside the pipeline boxes. J Mol Med 84(10):802-813 (Pubitemid 44478864)
    • (2006) Journal of Molecular Medicine , vol.84 , Issue.10 , pp. 802-813
    • Hooft Van Huijsduijnen, R.1    Rommel, C.2
  • 23
    • 33947358942 scopus 로고    scopus 로고
    • Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease
    • DOI 10.1124/jpet.106.111674
    • Ito K, Caramori G, Adcock IM (2007) Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease. J Pharmacol Exp Ther 321(1):1-8 (Pubitemid 46456952)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.321 , Issue.1 , pp. 1-8
    • Ito, K.1    Caramori, G.2    Adcock, I.M.3
  • 28
    • 52049091239 scopus 로고    scopus 로고
    • The multiple roles of phosphoinositide 3-kinase in mast cell biology
    • Kim MS, Rådinger M, Gilfillan AM (2008) The multiple roles of phosphoinositide 3-kinase in mast cell biology. Trends Immunol 29(10):493-501
    • (2008) Trends Immunol , vol.29 , Issue.10 , pp. 493-501
    • Kim, M.S.1    Radinger, M.2    Gilfillan, A.M.3
  • 29
    • 34247163550 scopus 로고    scopus 로고
    • Chemically targeting the PI3K family
    • DOI 10.1042/BST0350245
    • Knight ZA, Shokat KM (2007a) Chemically targeting the PI3K family. Biochem Soc Trans 35 (pt 2):245-249 (Pubitemid 46596480)
    • (2007) Biochemical Society Transactions , vol.35 , Issue.2 , pp. 245-249
    • Knight, Z.A.1    Shokat, K.M.2
  • 30
    • 33846676987 scopus 로고    scopus 로고
    • Chemical genetics: Where genetics and pharmacology meet
    • DOI 10.1016/j.cell.2007.01.021, PII S0092867407001195
    • Knight ZA, Shokat KM (2007b) Chemical genetics: where genetics and pharmacology meet. Cell 128(3):425-430 (Pubitemid 46198904)
    • (2007) Cell , vol.128 , Issue.3 , pp. 425-430
    • Knight, Z.A.1    Shokat, K.M.2
  • 31
    • 62849114529 scopus 로고    scopus 로고
    • Regulation of phosphoinositide 3-kinase expression in health and disease
    • Kok K, Geering B, Vanhaesebroeck B (2009) Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem Sci 34(3):115-127
    • (2009) Trends Biochem Sci , vol.34 , Issue.3 , pp. 115-127
    • Kok, K.1    Geering, B.2    Vanhaesebroeck, B.3
  • 32
    • 57749086978 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation
    • Konrad S, Ali SR, Wiege K, Syed SN, Engling L, Piekorz RP, Hirsch E, Nürnberg B, Schmidt RE, Gessner JE (2008) Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation. J Biol Chem 283(48):33296-33303
    • (2008) J Biol Chem , vol.283 , Issue.48 , pp. 33296-33303
    • Konrad, S.1    Ali, S.R.2    Wiege, K.3    Syed, S.N.4    Engling, L.5    Piekorz, R.P.6    Hirsch, E.7    Nürnberg, B.8    Schmidt, R.E.9    Gessner, J.E.10
  • 33
  • 34
    • 33645827963 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase δ attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
    • DOI 10.1096/fj.05-5045com
    • Lee KS, Lee HK, Hayflick JS, Lee YC, Puri KD (2006) Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB J 20(3):455-465 (Pubitemid 44933322)
    • (2006) FASEB Journal , vol.20 , Issue.3 , pp. 455-465
    • Lee, K.S.1    Lee, H.K.2    Hayflick, J.S.3    Lee, Y.C.4    Puri, K.D.5
  • 35
    • 0034635221 scopus 로고    scopus 로고
    • Roles of PLC-β2 and -β3 and PI3kγ in chemoattractant- mediated signal transduction
    • DOI 10.1126/science.287.5455.1046
    • Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, Wu D (2000) Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 287(5455): 1046-1049 (Pubitemid 30094361)
    • (2000) Science , vol.287 , Issue.5455 , pp. 1046-1049
    • Li, Z.1    Jiang, H.2    Xie, W.3    Zhang, Z.4    Smrcka, A.V.5    Wu, D.6
  • 36
    • 59449099114 scopus 로고    scopus 로고
    • PI3K gamma-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling
    • Lim DH, Cho JY, Song DJ, Lee SY, Miller M, Broide DH (2009) PI3K gamma-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling. Am J Physiol Lung Cell Mol Physiol 296(2):L210-L219
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296 , Issue.2
    • Lim, D.H.1    Cho, J.Y.2    Song, D.J.3    Lee, S.Y.4    Miller, M.5    Broide, D.H.6
  • 37
    • 34548029399 scopus 로고    scopus 로고
    • Leukocyte PI3Kγ and PI3Kδ have temporally distinct roles for leukocyte recruitment in vivo
    • DOI 10.1182/blood-2006-11-060103
    • Liu L, Puri KD, Penninger JM, Kubes P (2007) Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood 110(4):1191-1198 (Pubitemid 47281416)
    • (2007) Blood , vol.110 , Issue.4 , pp. 1191-1198
    • Liu, L.1    Puri, K.D.2    Penninger, J.M.3    Kubes, P.4
  • 38
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu P, Cheng H, Roberts TM, Zhao JJ (2009) Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 8(8):627-644
    • (2009) Nat Rev Drug Discov , vol.8 , Issue.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3    Zhao, J.J.4
  • 39
    • 50049089619 scopus 로고    scopus 로고
    • Moving targets: Cell migration inhibitors as new anti-inflammatory therapies
    • Mackay CR (2008) Moving targets: cell migration inhibitors as new anti-inflammatory therapies. Nat Immunol 9(9):988-998
    • (2008) Nat Immunol , vol.9 , Issue.9 , pp. 988-998
    • Mackay, C.R.1
  • 40
    • 42149156057 scopus 로고    scopus 로고
    • Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase
    • Martin AL, Schwartz MD, Jameson SC, Shimizu Y (2008) Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase. J Immunol 180(4):2081-2088
    • (2008) J Immunol , vol.180 , Issue.4 , pp. 2081-2088
    • Martin, A.L.1    Schwartz, M.D.2    Jameson, S.C.3    Shimizu, Y.4
  • 44
    • 0038549067 scopus 로고    scopus 로고
    • PI3K in lymphocyte development, differentiation and activation
    • Okkenhaug K, Vanhaesebroeck B (2003) PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol 3(4):317-330 (Pubitemid 37328684)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.4 , pp. 317-330
    • Okkenhaug, K.1    Vanhaesebroeck, B.2
  • 46
    • 33846621025 scopus 로고    scopus 로고
    • Antigen receptor signalling: A distinctive role for the p110δ isoform of PI3K
    • DOI 10.1016/j.it.2006.12.007, PII S147149060600353X
    • Okkenhaug K, Ali K, Vanhaesebroeck B (2007) Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K. Trends Immunol 28(2):80-87 (Pubitemid 46176736)
    • (2007) Trends in Immunology , vol.28 , Issue.2 , pp. 80-87
    • Okkenhaug, K.1    Ali, K.2    Vanhaesebroeck, B.3
  • 47
    • 33847779788 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase (PI3K) signaling and regulation of the antibody response
    • Omori SA, Rickert RC (2007) Phosphatidylinositol 3-kinase (PI3K) signaling and regulation of the antibody response. Cell Cycle 6(4):397-402 (Pubitemid 46393440)
    • (2007) Cell Cycle , vol.6 , Issue.4 , pp. 397-402
    • Omori, S.A.1    Rickert, R.C.2
  • 49
    • 18244373430 scopus 로고    scopus 로고
    • Phosphoinositide-3 kinases critically regulate the recruitment and survival of eosinophils in vivo: Importance for the resolution of allergic inflammation
    • DOI 10.1189/jlb.0704386
    • Pinho V, Souza DG, Barsante MM, Hamer FP, De Freitas MS, Rossi AG, Teixeira MM (2005) Phosphoinositide-3 kinases critically regulate the recruitment and survival of eosinophils in vivo: importance for the resolution of allergic inflammation. J Leukoc Biol 77(5): 800-810 (Pubitemid 40628760)
    • (2005) Journal of Leukocyte Biology , vol.77 , Issue.5 , pp. 800-810
    • Pinho, V.1    Souza, D.G.2    Barsante, M.M.3    Hamer, F.P.4    De Freitas, M.S.5    Rossi, A.G.6    Teixeira, M.M.7
  • 52
    • 47049113462 scopus 로고    scopus 로고
    • Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils
    • Randis TM, Puri KD, Zhou H, Diacovo TG (2008) Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils. Eur J Immunol 38(5):1215-1224
    • (2008) Eur J Immunol , vol.38 , Issue.5 , pp. 1215-1224
    • Randis, T.M.1    Puri, K.D.2    Zhou, H.3    Diacovo, T.G.4
  • 53
    • 4043082729 scopus 로고    scopus 로고
    • Cutting edge: Differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing
    • Reif K, Okkenhaug K, Sasaki T, Penninger JM, Vanhaesebroeck B, Cyster JG (2004) Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol 173(4):2236
    • (2004) J Immunol , vol.173 , Issue.4 , pp. 2236
    • Reif, K.1    Okkenhaug, K.2    Sasaki, T.3    Penninger, J.M.4    Vanhaesebroeck, B.5    Cyster, J.G.6
  • 54
    • 33847239467 scopus 로고    scopus 로고
    • PI3K delta and PI3K gamma: Partners in crime in inflammation in rheumatoid arthritis and beyond?
    • Rommel C, Camps M, Ji H (2007) PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat Rev Immunol 7(3):191-201
    • (2007) Nat Rev Immunol , vol.7 , Issue.3 , pp. 191-201
    • Rommel, C.1    Camps, M.2    Ji, H.3
  • 55
    • 33750525089 scopus 로고    scopus 로고
    • PI3Kgamma inhibition: Towards an 'aspirin of the 21st century'?
    • Rückle T, Schwarz MK, Rommel C (2006) PI3Kgamma inhibition: towards an 'aspirin of the 21st century'? Nat Rev Drug Discov 5(11):903-918
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.11 , pp. 903-918
    • Rückle, T.1    Schwarz, M.K.2    Rommel, C.3
  • 56
    • 0037369696 scopus 로고    scopus 로고
    • Essential role of phosphoinositide 3-kinase δ in neutrophil directional movement
    • Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE (2003) Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol 170(5):2647-2654 (Pubitemid 36245657)
    • (2003) Journal of Immunology , vol.170 , Issue.5 , pp. 2647-2654
    • Sadhu, C.1    Masinovsky, B.2    Dick, K.3    Sowell, C.G.4    Staunton, D.E.5
  • 60
    • 33644765808 scopus 로고    scopus 로고
    • Essential role of PI3Kδ and PI3Kγ in thymocyte survival
    • DOI 10.1182/blood-2005-08-3300
    • Swat W, Montgrain V, Doggett TA, Douangpanya J, Puri K, Vermi W, Diacovo TG (2006) Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival. Blood 107(6):2415-2422 (Pubitemid 43345562)
    • (2006) Blood , vol.107 , Issue.6 , pp. 2415-2422
    • Swat, W.1    Montgrain, V.2    Doggett, T.A.3    Douangpanya, J.4    Puri, K.5    Vermi, W.6    Diacovo, T.G.7
  • 62
    • 34548039233 scopus 로고    scopus 로고
    • P110γ and p110δ Phosphoinositide 3-Kinase Signaling Pathways Synergize to Control Development and Functions of Murine NK Cells
    • DOI 10.1016/j.immuni.2007.07.014, PII S1074761307003792
    • Tassi I, Cella M, Gilfillan S, Turnbull I, Diacovo TG, Penninger JM, Colonna M (2007) p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells. Immunity 27(2):214-227 (Pubitemid 47284932)
    • (2007) Immunity , vol.27 , Issue.2 , pp. 214-227
    • Tassi, I.1    Cella, M.2    Gilfillan, S.3    Turnbull, I.4    Diacovo, T.G.5    Penninger, J.M.6    Colonna, M.7
  • 65
    • 4043067193 scopus 로고    scopus 로고
    • Gene targeting: Attention to detail
    • DOI 10.1016/j.cell.2004.07.018, PII S009286740400707X
    • Vanhaesebroeck B, Rohn JL, Waterfield MD (2004) Gene targeting: attention to detail. Cell 118 (3):274-276 (Pubitemid 39061107)
    • (2004) Cell , vol.118 , Issue.3 , pp. 274-276
    • Vanhaesebroeck, B.1    Rohn, J.L.2    Waterfield, M.D.3
  • 66
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3 kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos CJ et al (1994) A specific inhibitor of phosphatidylinositol 3 kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269(7):5241-5248
    • (1994) J Biol Chem , vol.269 , Issue.7 , pp. 5241-5248
    • Vlahos, C.J.1
  • 67
    • 0033634827 scopus 로고    scopus 로고
    • Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine
    • Walker EH, Pacold E, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL (2000) Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine. Mol Cell 6:909-919
    • (2000) Mol Cell , vol.6 , pp. 909-919
    • Walker, E.H.1    Pacold, E.2    Perisic, O.3    Stephens, L.4    Hawkins, P.T.5    Wymann, M.P.6    Williams, R.L.7
  • 68
    • 23844462453 scopus 로고    scopus 로고
    • Cutting edge: T cell development requires the combined activities of the p110γ and p110δ catalytic isoforms of phosphatidylinositol 3-kinase
    • Webb LM, Vigorito E, Wymann MP, Hirsch E, TurnerM(2005) Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase. J Immunol 175(5):2783-2787 (Pubitemid 41170493)
    • (2005) Journal of Immunology , vol.175 , Issue.5 , pp. 2783-2787
    • Webb, L.M.C.1    Vigorito, E.2    Wymann, M.P.3    Hirsch, E.4    Turner, M.5


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