CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

Blood

Volumn 117, Issue 2, 2011, Pages 591-594

  Lannutti, Brian J ^a   Meadows, Sarah A ^a   Herman, Sarah E M ^b   Kashishian, Adam ^a   Steiner, Bart ^a   Johnson, Amy J ^b   Byrd, John C ^b   Tyner, Jeffrey W ^c   Loriaux, Marc M ^c   Deininger, Mike ^c   Druker, Brian J ^c   Puri, Kamal D ^a   Ulrich, Roger G ^a   Giese, Neill A ^a  

^a Calistoga Pharmaceuticals Inc ^*  (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 FLUORO 3 PHENYL 2 [1 (9H PURIN 6 YLAMINO)PROPYL] 3H QUINAZOLIN 4 ONE; CASPASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CAL 101; ENZYME INHIBITOR; PURINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; B CELL LEUKEMIA; B CELL LYMPHOMA; CANCER CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL SEPARATION; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; METABOLISM; MOUSE; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SEPARATION; CELL SURVIVAL; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; LEUKEMIA, B-CELL; LYMPHOMA, B-CELL; MICE; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHATIDYLINOSITOL 3-KINASES; PURINES; QUINAZOLINONES; SIGNAL TRANSDUCTION;

EID: 78751553221     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-03-275305     Document Type: Article

References (14)

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