The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

Nature Immunology

Volumn 13, Issue 11, 2012, Pages 1045-1054

  Aksoy, Ezra ^a   Taboubi, Salma ^a   Torres, David ^b   Delbauve, Sandrine ^b   Hachani, Abderrahman ^c   Whitehead, Maria A ^a   Pearce, Wayne P ^a   Berenjeno Martin, Inma ^a   Nock, Gemma ^a   Filloux, Alain ^c   Beyaert, Rudi ^d,e   Flamand, Veronique ^b   Vanhaesebroeck, Bart ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b FREE UNIVERSITY OF BRUSSELS   (Belgium)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^e GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BETA INTERFERON; INTERLEUKIN 10; ISOENZYME; MYELOID DIFFERENTIATION FACTOR 88; P110 DELTA PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P110; TIRAP PROTEIN; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISSOCIATION; ENDOSOME; HOMEOSTASIS; INTERNALIZATION; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SEPTIC SHOCK;

ANIMALS; CALPAIN; CELL COMPARTMENTATION; CELL MEMBRANE; CELLS, CULTURED; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; DENDRITIC CELLS; ENDOSOMES; GENE EXPRESSION; INTERFERON-BETA; INTERLEUKIN-10; ISOENZYMES; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-1; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84867713025     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2426     Document Type: Article

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