-
1
-
-
0036791850
-
Focal adhesion kinase: Protein interactions and cellular functions
-
Abbi S, Guan JL (2002) Focal adhesion kinase: protein interactions and cellular functions. Histol Histopathol 17: 1163-1171.
-
(2002)
Histol Histopathol
, vol.17
, pp. 1163-1171
-
-
Abbi, S.1
Guan, J.L.2
-
2
-
-
0036077133
-
Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components
-
Actor B, Cobbers JM, Buschges R, Wolter M, Knobbe CB, Reifenberger G, Weber RG (2002) Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components. Genes Chromosomes Cancer 34: 416-427.
-
(2002)
Genes Chromosomes Cancer
, vol.34
, pp. 416-427
-
-
Actor, B.1
Cobbers, J.M.2
Buschges, R.3
Wolter, M.4
Knobbe, C.B.5
Reifenberger, G.6
Weber, R.G.7
-
3
-
-
0032443803
-
The akt kinase: Molecular determinants of oncogenicity
-
Aoki M, Batista O, Bellacosa A, Tsichlis P, Vogt PK (1998) The akt kinase: molecular determinants of oncogenicity. Proc Natl Acad Sci U S A 95: 14950-14955.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 14950-14955
-
-
Aoki, M.1
Batista, O.2
Bellacosa, A.3
Tsichlis, P.4
Vogt, P.K.5
-
4
-
-
0029127042
-
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
-
Bellacosa A, de Feo D, Godwin AK, Bell DW, Cheng JQ, Altomare DA, Wan M, Dubeau L, Scambia G, Masciullo V (1995) Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer 64: 280-285.
-
(1995)
Int J Cancer
, vol.64
, pp. 280-285
-
-
Bellacosa, A.1
De Feo, D.2
Godwin, A.K.3
Bell, D.W.4
Cheng, J.Q.5
Altomare, D.A.6
Wan, M.7
Dubeau, L.8
Scambia, G.9
Masciullo, V.10
-
5
-
-
0029890372
-
Increased expression of insulin receptor substrate-1 in human pancreatic cancer
-
Bergmann U, Funatomi H, Kornmann M, Beger HG, Korc M (1996) Increased expression of insulin receptor substrate-1 in human pancreatic cancer. Biochem Biophys Res Commun 220: 886-890.
-
(1996)
Biochem Biophys Res Commun
, vol.220
, pp. 886-890
-
-
Bergmann, U.1
Funatomi, H.2
Kornmann, M.3
Beger, H.G.4
Korc, M.5
-
6
-
-
0035017203
-
Mitogenic signalling and the relationship to cell cycle regulation in astrocytomas
-
Besson A, Yong VW (2001) Mitogenic signalling and the relationship to cell cycle regulation in astrocytomas. J Neurooncol 51: 245-264.
-
(2001)
J Neurooncol
, vol.51
, pp. 245-264
-
-
Besson, A.1
Yong, V.W.2
-
7
-
-
2642705040
-
Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q
-
Boström J, Cobbers JM, Wolter M, Tabatabai G, Weber RG, Lichter P, Collins VP, Reifenberger G (1998) Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q. Cancer Res 58: 29-33.
-
(1998)
Cancer Res
, vol.58
, pp. 29-33
-
-
Boström, J.1
Cobbers, J.M.2
Wolter, M.3
Tabatabai, G.4
Weber, R.G.5
Lichter, P.6
Collins, V.P.7
Reifenberger, G.8
-
8
-
-
0030725406
-
Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity
-
Burgaya F, Toutant M, Studler JM, Costa A, Le Bert M, Gelman M, Girault JA (1997) Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity. J Biol Chem 272: 28720-28725.
-
(1997)
J Biol Chem
, vol.272
, pp. 28720-28725
-
-
Burgaya, F.1
Toutant, M.2
Studler, J.M.3
Costa, A.4
Le Bert, M.5
Gelman, M.6
Girault, J.A.7
-
9
-
-
0037431435
-
Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma
-
Byun DS, Cho K, Ryu BK, Lee MG, Park JI, Chae KS, Kim HJ, Chi SG (2003) Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma. Int J Cancer 104: 318-327.
-
(2003)
Int J Cancer
, vol.104
, pp. 318-327
-
-
Byun, D.S.1
Cho, K.2
Ryu, B.K.3
Lee, M.G.4
Park, J.I.5
Chae, K.S.6
Kim, H.J.7
Chi, S.G.8
-
10
-
-
0035126321
-
PS6K amplification characterizes a small subset of anaplastic meningiomas
-
Cai DX, James CD, Scheithauer BW, Couch FJ, Perry A (2001) PS6K amplification characterizes a small subset of anaplastic meningiomas. Am J Clin Pathol 115: 213-218.
-
(2001)
Am J Clin Pathol
, vol.115
, pp. 213-218
-
-
Cai, D.X.1
James, C.D.2
Scheithauer, B.W.3
Couch, F.J.4
Perry, A.5
-
11
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296: 1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
12
-
-
0001872876
-
Diffusely infiltrating astrocytomas
-
Kleihues P and Cavenee WK (eds). Lyon, France: IARC Press
-
Cavenee WK, Furnari FB, Nagane M, Huang H-JS, Newcomb EW, Bigner, DD, Weller M, Berens ME, Plate KH, Israel MA, Noble MD, Kleihues P (2000). Diffusely infiltrating astrocytomas. In: Pathology and genetics of tumors of the nervous system. WHO classification of tumors. Kleihues P and Cavenee WK (eds). Lyon, France: IARC Press. pp. 10-21.
-
(2000)
Pathology and Genetics of Tumors of the Nervous System. WHO Classification of Tumors
, pp. 10-21
-
-
Cavenee, W.K.1
Furnari, F.B.2
Nagane, M.3
Huang, H.-J.S.4
Newcomb, E.W.5
Bigner, D.D.6
Weller, M.7
Berens, M.E.8
Plate, K.H.9
Israel, M.A.10
Noble, M.D.11
Kleihues, P.12
-
13
-
-
0036828097
-
Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: Therapeutic implications
-
Chang Q, Li Y, White MF, Fletcher JA, Xiao S (2002) Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications. Cancer Res 62: 6035-6038.
-
(2002)
Cancer Res
, vol.62
, pp. 6035-6038
-
-
Chang, Q.1
Li, Y.2
White, M.F.3
Fletcher, J.A.4
Xiao, S.5
-
14
-
-
0026667730
-
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
-
Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR (1992) AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci U S A 89: 9267-9271.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 9267-9271
-
-
Cheng, J.Q.1
Godwin, A.K.2
Bellacosa, A.3
Taguchi, T.4
Franke, T.F.5
Hamilton, T.C.6
Tsichlis, P.N.7
Testa, J.R.8
-
15
-
-
0038615946
-
Analysis of the phospatidylinositol 3′-kinase signalling pathway in glioblastoma patients in vivo
-
Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, Inge L, Smith BL, Sawyers CL, Mischel PS (2003) Analysis of the phospatidylinositol 3′-kinase signalling pathway in glioblastoma patients in vivo. Cancer Res 63: 2742-2746.
-
(2003)
Cancer Res
, vol.63
, pp. 2742-2746
-
-
Choe, G.1
Horvath, S.2
Cloughesy, T.F.3
Crosby, K.4
Seligson, D.5
Palotie, A.6
Inge, L.7
Smith, B.L.8
Sawyers, C.L.9
Mischel, P.S.10
-
16
-
-
0037114349
-
Cellular mechanisms targeted during astrocytoma progression
-
Collins VP (2002) Cellular mechanisms targeted during astrocytoma progression. Cancer Lett 188: 1-7.
-
(2002)
Cancer Lett
, vol.188
, pp. 1-7
-
-
Collins, V.P.1
-
17
-
-
0033119602
-
Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer
-
Couch FJ, Wang XY, Wu GJ, Qian J, Jenkins RB, James CD (1999) Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer. Cancer Res 59: 1408-1411.
-
(1999)
Cancer Res
, vol.59
, pp. 1408-1411
-
-
Couch, F.J.1
Wang, X.Y.2
Wu, G.J.3
Qian, J.4
Jenkins, R.B.5
James, C.D.6
-
18
-
-
0029024963
-
Transforming potential of the insulin receptor substrate 1
-
D'Ambrosio C, Keller SR, Morrione A, Lienhard GE, Baserga R, Surmacz E (1995) Transforming potential of the insulin receptor substrate 1. Cell Growth Differ 6: 557-562.
-
(1995)
Cell Growth Differ
, vol.6
, pp. 557-562
-
-
D'Ambrosio, C.1
Keller, S.R.2
Morrione, A.3
Lienhard, G.E.4
Baserga, R.5
Surmacz, E.6
-
19
-
-
0026793260
-
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors
-
Fleming TP, Saxena A, Clark WC, Robertson JT, Oldfield EH, Aaronson SA, Ali IU (1992) Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res 52: 4550-4553.
-
(1992)
Cancer Res
, vol.52
, pp. 4550-4553
-
-
Fleming, T.P.1
Saxena, A.2
Clark, W.C.3
Robertson, J.T.4
Oldfield, E.H.5
Aaronson, S.A.6
Ali, I.U.7
-
20
-
-
0034826541
-
Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase
-
Fujioka T, Kim JH, Adachi H, Saito K, Tsujimoto M, Yokoyama S, Ui M (2001) Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase. Eur J Biochem 268: 4158-4168.
-
(2001)
Eur J Biochem
, vol.268
, pp. 4158-4168
-
-
Fujioka, T.1
Kim, J.H.2
Adachi, H.3
Saito, K.4
Tsujimoto, M.5
Yokoyama, S.6
Ui, M.7
-
21
-
-
0036570357
-
Focal adhesion kinase enhances signalling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples
-
Hecker TP, Grammer JR, Gillespie GY, Stewart J Jr, Gladson CL (2002) Focal adhesion kinase enhances signalling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples. Cancer Res 62: 2699-2707.
-
(2002)
Cancer Res
, vol.62
, pp. 2699-2707
-
-
Hecker, T.P.1
Grammer, J.R.2
Gillespie, G.Y.3
Stewart Jr., J.4
Gladson, C.L.5
-
22
-
-
0034020459
-
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
-
Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, Fuller GN (2000) Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet 25: 55-57.
-
(2000)
Nat Genet
, vol.25
, pp. 55-57
-
-
Holland, E.C.1
Celestino, J.2
Dai, C.3
Schaefer, L.4
Sawaya, R.E.5
Fuller, G.N.6
-
23
-
-
0034998193
-
Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization
-
Hui AB, Lo KW, Yin XL, Poon WS, Ng HK (2001) Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization. Lab Invest 81: 717-723.
-
(2001)
Lab Invest
, vol.81
, pp. 717-723
-
-
Hui, A.B.1
Lo, K.W.2
Yin, X.L.3
Poon, W.S.4
Ng, H.K.5
-
25
-
-
0035423156
-
PTEN-independent induction of caspase-mediated cell death and reduced invasion by the focal adhesion targeting domain (FAT) in human astrocytic brain tumors which highly express focal adhesion kinase (FAK)
-
Jones G, Machado J Jr, Tolnay M, Merlo A (2001) PTEN-independent induction of caspase-mediated cell death and reduced invasion by the focal adhesion targeting domain (FAT) in human astrocytic brain tumors which highly express focal adhesion kinase (FAK). Cancer Res 61: 5688-5691.
-
(2001)
Cancer Res
, vol.61
, pp. 5688-5691
-
-
Jones, G.1
Machado Jr., J.2
Tolnay, M.3
Merlo, A.4
-
26
-
-
0033604585
-
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
-
Kandel ES, Hay N (1999) The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 253: 210-229.
-
(1999)
Exp Cell Res
, vol.253
, pp. 210-229
-
-
Kandel, E.S.1
Hay, N.2
-
27
-
-
0001843063
-
Glioblastoma
-
Kleihues P, Cavenee WK (eds). Lyon, France: IARC Press
-
Kleihues P, Burger PC, Collins VP, Newcomb EW, Ohgaki H, Cavenee WK (2000) Glioblastoma. In: Pathology and genetics of tumors of the nervous system. WHO classification of tumors. Kleihues P, Cavenee WK (eds). Lyon, France: IARC Press. pp. 29-39.
-
(2000)
Pathology and Genetics of Tumors of the Nervous System. WHO Classification of Tumors
, pp. 29-39
-
-
Kleihues, P.1
Burger, P.C.2
Collins, V.P.3
Newcomb, E.W.4
Ohgaki, H.5
Cavenee, W.K.6
-
29
-
-
0032189403
-
Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer
-
Kornmann M, Maruyama H, Bergmann U, Tangvoranuntakul P, Beger HG, White MF, Korc M (1998) Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. Cancer Res 58: 4250-4254.
-
(1998)
Cancer Res
, vol.58
, pp. 4250-4254
-
-
Kornmann, M.1
Maruyama, H.2
Bergmann, U.3
Tangvoranuntakul, P.4
Beger, H.G.5
White, M.F.6
Korc, M.7
-
30
-
-
0036073357
-
Comparative genomic hybridization in glioma: A meta-analysis of 509 cases
-
Koschny R, Koschny T, Froster UG, Krupp W, Zuber MA (2002) Comparative genomic hybridization in glioma: a meta-analysis of 509 cases. Cancer Genet Cytogenet 135: 147-159.
-
(2002)
Cancer Genet Cytogenet
, vol.135
, pp. 147-159
-
-
Koschny, R.1
Koschny, T.2
Froster, U.G.3
Krupp, W.4
Zuber, M.A.5
-
31
-
-
0032883773
-
SHIPs ahoy
-
Krystal G, Damen JE, Helgason CD, Huber M, Hughes MR, Kalesnikoff J, Lam V, Rosten P, Ware MD, Yew S, Humphries RK (1999) SHIPs ahoy. Int J Biochem Cell Biol 31: 1007-1010.
-
(1999)
Int J Biochem Cell Biol
, vol.31
, pp. 1007-1010
-
-
Krystal, G.1
Damen, J.E.2
Helgason, C.D.3
Huber, M.4
Hughes, M.R.5
Kalesnikoff, J.6
Lam, V.7
Rosten, P.8
Ware, M.D.9
Yew, S.10
Humphries, R.K.11
-
32
-
-
0035949707
-
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
-
Kwabi-Addo B, Giri D, Schmidt K, Podsypanina K, Parsons R, Greenberg N, Ittmann M (2001) Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression. Proc Natl Acad Sci U S A 98: 11563-11568.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 11563-11568
-
-
Kwabi-Addo, B.1
Giri, D.2
Schmidt, K.3
Podsypanina, K.4
Parsons, R.5
Greenberg, N.6
Ittmann, M.7
-
33
-
-
0030936323
-
PTEN, a putative tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R (1997) PTEN, a putative tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
34
-
-
0030724320
-
PTEN/MMAC1 mutations and EGFR amplification in glioblastomas
-
Liu W, James CD, Frederick L, Alderete BE, Jenkins RB (1997) PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. Cancer Res 57: 5254-5257.
-
(1997)
Cancer Res
, vol.57
, pp. 5254-5257
-
-
Liu, W.1
James, C.D.2
Frederick, L.3
Alderete, B.E.4
Jenkins, R.B.5
-
35
-
-
0034713390
-
PIK3CA as an oncogene in cervical cancer
-
Ma YY, Wei SJ, Lin YC, Lung JC, Chang TC, Whang-Peng J, Liu JM, Yang DM, Yang WK, and Shen CY (2000) PIK3CA as an oncogene in cervical cancer. Oncogene 19:2739-2744.
-
(2000)
Oncogene
, vol.19
, pp. 2739-2744
-
-
Ma, Y.Y.1
Wei, S.J.2
Lin, Y.C.3
Lung, J.C.4
Chang, T.C.5
Whang-Peng, J.6
Liu, J.M.7
Yang, D.M.8
Yang, W.K.9
Shen, C.Y.10
-
36
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
37
-
-
0034987702
-
Malignant glioma: Genetics and biology of a grave matter
-
Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA (2001) Malignant glioma: genetics and biology of a grave matter. Genes Dev 15: 1311-1333.
-
(2001)
Genes Dev
, vol.15
, pp. 1311-1333
-
-
Maher, E.A.1
Furnari, F.B.2
Bachoo, R.M.3
Rowitch, D.H.4
Louis, D.N.5
Cavenee, W.K.6
DePinho, R.A.7
-
39
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
-
Neshat MS, Mellinghoff IK, Tran C, Stiles B, Thomas G, Petersen R, Frost P, Gibbons JJ, Wu H, Sawyers CL (2001) Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A 98: 10314-10319.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
Stiles, B.4
Thomas, G.5
Petersen, R.6
Frost, P.7
Gibbons, J.J.8
Wu, H.9
Sawyers, C.L.10
-
40
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
Nicholson KM, Anderson NG (2002) The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14: 381-395.
-
(2002)
Cell Signal
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
41
-
-
0003028164
-
Gliosarcoma
-
Kleihues P, Cavenee WK (eds). Lyon, France: IARC Press
-
Ohgaki H, Biernat W, Reis R, Hegi M, Kleihues P (2000) Gliosarcoma. In: Pathology and genetics of tumors of the nervous system. WHO classification of tumors. Kleihues P, Cavenee WK (eds). Lyon, France: IARC Press. pp. 42-44.
-
(2000)
Pathology and Genetics of Tumors of the Nervous System. WHO Classification of Tumors
, pp. 42-44
-
-
Ohgaki, H.1
Biernat, W.2
Reis, R.3
Hegi, M.4
Kleihues, P.5
-
42
-
-
0001853021
-
Giant cell glioblastoma
-
Kleihues P, Cavenee WK (eds). Lyon, France: IARC Press
-
Ohgaki H, Peraud A, Nakazato Y, Watanabe K, von Deimling A (2000) Giant cell glioblastoma. In: Pathology and genetics of tumors of the nervous system. WHO classification of tumors. Kleihues P, Cavenee WK (eds). Lyon, France: IARC Press. pp. 40-41.
-
(2000)
Pathology and Genetics of Tumors of the Nervous System. WHO Classification of Tumors
, pp. 40-41
-
-
Ohgaki, H.1
Peraud, A.2
Nakazato, Y.3
Watanabe, K.4
Von Deimling, A.5
-
43
-
-
0034693854
-
Focal adhesion kinase: A regulator of focal adhesion dynamics and cell movement
-
Parsons JT, Martin KH, Slack JK, Taylor JM, Weed SA (2000) Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene 19: 5606-5613.
-
(2000)
Oncogene
, vol.19
, pp. 5606-5613
-
-
Parsons, J.T.1
Martin, K.H.2
Slack, J.K.3
Taylor, J.M.4
Weed, S.A.5
-
44
-
-
17944368972
-
+/- mice
-
+/- mice. Proc Natl Acad Sci U S A 98: 10320-10325.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10320-10325
-
-
Podsypanina, K.1
Lee, R.T.2
Politis, C.3
Hennessy, I.4
Crane, A.5
Puc, J.6
Neshat, M.7
Wang, H.8
Yang, L.9
Gibbons, J.10
Frost, P.11
Dreisbach, V.12
Blenis, J.13
Gaciong, Z.14
Fisher, P.15
Sawyers, C.16
Hedrick-Ellenson, L.17
Parsons, R.18
-
45
-
-
0012746941
-
Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas
-
Reifenberger J, Wolter M, Bostrom J, Buschges R, Schulte KW, Megahed M, Ruzicka T, Reifenberger G (2000) Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas. Virchows Arch 436: 487-493.
-
(2000)
Virchows Arch
, vol.436
, pp. 487-493
-
-
Reifenberger, J.1
Wolter, M.2
Bostrom, J.3
Buschges, R.4
Schulte, K.W.5
Megahed, M.6
Ruzicka, T.7
Reifenberger, G.8
-
46
-
-
0343819885
-
Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification
-
Riemenschneider MJ, Buschges R, Wolter M, Reifenberger J, Bostrom J, Kraus JA, Schlegel U, Reifenberger G (1999) Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification. Cancer Res 59: 6091-6096.
-
(1999)
Cancer Res
, vol.59
, pp. 6091-6096
-
-
Riemenschneider, M.J.1
Buschges, R.2
Wolter, M.3
Reifenberger, J.4
Bostrom, J.5
Kraus, J.A.6
Schlegel, U.7
Reifenberger, G.8
-
48
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T, Hall MN (2000) TOR, a central controller of cell growth. Cell 103: 253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
49
-
-
0032757347
-
Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts
-
Schmidt EE, Ichimura K, Goike HM, Moshref A, Liu L, Collins VP (1999) Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts. J Neuropathol Exp Neurol 58: 1170-1183.
-
(1999)
J Neuropathol Exp Neurol
, vol.58
, pp. 1170-1183
-
-
Schmidt, E.E.1
Ichimura, K.2
Goike, H.M.3
Moshref, A.4
Liu, L.5
Collins, V.P.6
-
50
-
-
0034693680
-
Down-regulation of insulin-like growth factor-I receptor and insulin receptor substrate-1 expression in advanced human breast cancer
-
Schnarr B, Strunz K, Ohsam J, Benner A, Wacker J, Mayer D (2000) Down-regulation of insulin-like growth factor-I receptor and insulin receptor substrate-1 expression in advanced human breast cancer. Int J Cancer 89: 506-513.
-
(2000)
Int J Cancer
, vol.89
, pp. 506-513
-
-
Schnarr, B.1
Strunz, K.2
Ohsam, J.3
Benner, A.4
Wacker, J.5
Mayer, D.6
-
51
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB, Gray JW (1999) PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 21: 99-102.
-
(1999)
Nat Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.L.3
Baldocchi, R.4
Godfrey, T.5
Collins, C.6
Pinkel, D.7
Powell, B.8
Mills, G.B.9
Gray, J.W.10
-
52
-
-
0034039961
-
Amplification of the platelet-derived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features
-
Smith JS, Wang XY, Qian J, Hosek SM, Scheithauer BW, Jenkins RB, James CD (2000) Amplification of the platelet-derived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features. J Neuropathol Exp Neurol 59: 495-503.
-
(2000)
J Neuropathol Exp Neurol
, vol.59
, pp. 495-503
-
-
Smith, J.S.1
Wang, X.Y.2
Qian, J.3
Hosek, S.M.4
Scheithauer, B.W.5
Jenkins, R.B.6
James, C.D.7
-
53
-
-
0035884505
-
Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma
-
Sonoda Y, Ozawa T, Aldape KD, Deen DF, Berger MS, Pieper RO (2001) Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. Cancer Res 61: 6674-6678.
-
(2001)
Cancer Res
, vol.61
, pp. 6674-6678
-
-
Sonoda, Y.1
Ozawa, T.2
Aldape, K.D.3
Deen, D.F.4
Berger, M.S.5
Pieper, R.O.6
-
54
-
-
0001582482
-
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
-
Staal SP (1987) Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A 84: 5034-5037.
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 5034-5037
-
-
Staal, S.P.1
-
55
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW (1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95:29-39.
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stambolic, V.1
Suzuki, A.2
De La Pompa, J.L.3
Brothers, G.M.4
Mirtsos, C.5
Sasaki, T.6
Ruland, J.7
Penninger, J.M.8
Siderovski, D.P.9
Mak, T.W.10
-
56
-
-
17144436629
-
Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV (1997) Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15:356-362.
-
(1997)
Nat Genet
, vol.15
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.4
Lin, H.5
Ligon, A.H.6
Langford, L.A.7
Baumgard, M.L.8
Hattier, T.9
Davis, T.10
Frye, C.11
Hu, R.12
Swedlund, B.13
Teng, D.H.14
Tavtigian, S.V.15
-
57
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
-
Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM (1998) Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280: 1614-1617.
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
Aota, S.4
Parsons, R.5
Yamada, K.M.6
-
58
-
-
0033811556
-
5′ phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells
-
Taylor V, Wong M, Brandts C, Reilly L, Dean NM, Cowsert LM, Moodie S, Stokoe D (2000) 5′ phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells. Mol Cell Biol 20: 6860-6871.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6860-6871
-
-
Taylor, V.1
Wong, M.2
Brandts, C.3
Reilly, L.4
Dean, N.M.5
Cowsert, L.M.6
Moodie, S.7
Stokoe, D.8
-
59
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
Testa JR, Bellacosa A (2001) AKT plays a central role in tumorigenesis. Proc Natl Acad Sci U S A 98: 10983-10985.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10983-10985
-
-
Testa, J.R.1
Bellacosa, A.2
-
60
-
-
0036632368
-
The phosphatidylinositol 3-Kinase/AKT pathway in human cancer
-
Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-Kinase/AKT pathway in human cancer. Nat Rev Cancer 2: 489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
61
-
-
0034532347
-
p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo
-
Wang D, Grammer JR, Cobbs CS, Stewart JE Jr, Liu Z, Rhoden R, Hecker TP, Ding Q, Gladson CL (2000) p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo. J Cell Sci 113 Pt 23: 4221-4230.
-
(2000)
J Cell Sci
, vol.113
, Issue.PART 23
, pp. 4221-4230
-
-
Wang, D.1
Grammer, J.R.2
Cobbs, C.S.3
Stewart Jr., J.E.4
Liu, Z.5
Rhoden, R.6
Hecker, T.P.7
Ding, Q.8
Gladson, C.L.9
-
62
-
-
0029736825
-
Characterization of genomic alterations associated with glioma progression by comparative genomic hybridization
-
Weber RG, Sabel M, Reifenberger J, Sommer C, Oberstrass J, Reifenberger G, Kiessling M, Cremer T (1996) Characterization of genomic alterations associated with glioma progression by comparative genomic hybridization. Oncogene 13: 983-994.
-
(1996)
Oncogene
, vol.13
, pp. 983-994
-
-
Weber, R.G.1
Sabel, M.2
Reifenberger, J.3
Sommer, C.4
Oberstrass, J.5
Reifenberger, G.6
Kiessling, M.7
Cremer, T.8
-
63
-
-
0032971251
-
Mutational analysis of the PTEN gene in gliomas: Molecular and pathological correlations
-
Zhou XP, Li YJ, Hoang-Xuan K, Laurent-Puig P, Mokhtari K, Longy M, Sanson M, Delattre JY, Thomas G, Hamelin R (1999) Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations. Int J Cancer 84: 150-154.
-
(1999)
Int J Cancer
, vol.84
, pp. 150-154
-
-
Zhou, X.P.1
Li, Y.J.2
Hoang-Xuan, K.3
Laurent-Puig, P.4
Mokhtari, K.5
Longy, M.6
Sanson, M.7
Delattre, J.Y.8
Thomas, G.9
Hamelin, R.10
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