CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification

Immunity

Volumn 13, Issue 1, 2000, Pages 47-57

  Fujimoto, Manabu ^a   Fujimoto, Yoko ^a   Poe, Jonathan C ^a   Jansen, Paul J ^a   Lowell, Clifford A ^b   DeFranco, Anthony L ^b   Tedder, Thomas F ^a  

^a DUKE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN FUNCTION; ARTICLE; B LYMPHOCYTE; CELL INTERACTION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE AMPLIFICATION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0033697728     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)00007-8     Document Type: Article

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16. CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation
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19. Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases
20. Impaired proliferation of peripheral cells and indication of autoimmune disease in Lyn-deficient mice
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26. The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation
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41. Polyacrylamide gel electrophoresis of small peptides
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44. Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B lymphocyte development