-
1
-
-
38949164409
-
Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase
-
DOI 10.1182/blood-2007-08-109769
-
Aiba Y, Kameyama M, Yamazaki T, Tedder TF, Kurosaki T (2008) Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood 111:1497-1503 (Pubitemid 351213438)
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1497-1503
-
-
Aiba, Y.1
Kameyama, M.2
Yamazaki, T.3
Tedder, T.F.4
Kurosaki, T.5
-
2
-
-
33846926759
-
Requirement for phosphoinositide 3-kinase p110δ signaling in B cell antigen receptor-mediated antigen presentation
-
Al-Alwan MM, Okkenhaug K, Vanhaesebroeck B, Hayflick JS, Marshall AJ (2007) Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation. J Immunol 178:2328-2335 (Pubitemid 46233431)
-
(2007)
Journal of Immunology
, vol.178
, Issue.4
, pp. 2328-2335
-
-
Al-Alwan, M.M.1
Okkenhaug, K.2
Vanhaesebroeck, B.3
Hayflick, J.S.4
Marshal, A.J.5
-
3
-
-
36549009460
-
Phosphoinositide 3-kinase γ participates in T cell receptor-induced T cell activation
-
DOI 10.1084/jem.20070366
-
Alcazar I, Marques M, Kumar A, Hirsch E, Wymann M, Carrera AC, Barber DF (2007) Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation. J Exp Med 204:2977-2987 (Pubitemid 350179565)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.12
, pp. 2977-2987
-
-
Alcazar, I.1
Marques, M.2
Kumar, A.3
Hirsch, E.4
Wymann, M.5
Carrera, A.C.6
Barber, D.F.7
-
4
-
-
65349138964
-
P85beta phosphoinositide 3-kinase regulates CD28 coreceptor function
-
Alcazar I, Cortes I, Zaballos A, Hernandez C, Fruman DA, Barber DF, Carrera AC (2009) p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function. Blood 113:3198-3208
-
(2009)
Blood
, vol.113
, pp. 3198-3208
-
-
Alcazar, I.1
Cortes, I.2
Zaballos, A.3
Hernandez, C.4
Fruman, D.A.5
Barber, D.F.6
Carrera, A.C.7
-
5
-
-
7244232917
-
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
-
DOI 10.1038/nature02991
-
Ali K, Bilancio A, Thomas M, Pearce W, Gilfillan AM, Tkaczyk C, Kuehn N, Gray A, Giddings J, Peskett E, Fox R, Bruce I, Walker C, Sawyer C, Okkenhaug K, Finan P, Vanhaesebroeck B (2004) Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature 431:1007-1011 (Pubitemid 39434424)
-
(2004)
Nature
, vol.431
, Issue.7011
, pp. 1007-1011
-
-
Ali, K.1
Bilancio, A.2
Thomas, M.3
Pearce, W.4
Gilfillan, A.M.5
Tkaczyk, C.6
Kuehn, N.7
Gray, A.8
Giddings, J.9
Peskett, E.10
Fox, R.11
Bruce, I.12
Walker, C.13
Sawyer, C.14
Okkenhaug, K.15
Finan, P.16
Vanhaesebroeck, B.17
-
6
-
-
42149091691
-
Isoform-specific functions of phosphoinositide 3-kinases: P110 delta but not p110 gamma promotes optimal allergic responses in vivo
-
Ali K, Camps M, Pearce WP, Ji H, Ruckle T, Kuehn N, Pasquali C, Chabert C, Rommel C, Vanhaesebroeck B (2008) Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo. J Immunol 180:2538-2544
-
(2008)
J Immunol
, vol.180
, pp. 2538-2544
-
-
Ali, K.1
Camps, M.2
Pearce, W.P.3
Ji, H.4
Ruckle, T.5
Kuehn, N.6
Pasquali, C.7
Chabert, C.8
Rommel, C.9
Vanhaesebroeck, B.10
-
7
-
-
44049091757
-
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
-
DOI 10.1038/ni.1612, PII NI.1612
-
Amin RH, Schlissel MS (2008) Foxo1 directly regulates the transcription of recombinationactivating genes during B cell development. Nat Immunol 9:613-622 (Pubitemid 351712632)
-
(2008)
Nature Immunology
, vol.9
, Issue.6
, pp. 613-622
-
-
Amin, R.H.1
Schlissel, M.S.2
-
8
-
-
34249085248
-
CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner
-
DOI 10.1084/jem.20062079
-
Asperti-Boursin F, Real E, Bismuth G, Trautmann A, Donnadieu E (2007) CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner. J Exp Med 204:1167-1179 (Pubitemid 46798159)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.5
, pp. 1167-1179
-
-
Asperti-Boursin, F.1
Real, E.2
Bismuth, G.3
Trautmann, A.4
Donnadieu, E.5
-
9
-
-
33845455093
-
Stromal cell networks regulate lymphocyte entry, migration, and territoriality in Lymph Nodes
-
DOI 10.1016/j.immuni.2006.10.011, PII S1074761306004833
-
Bajenoff M, Egen JG, Koo LY, Laugier JP, Brau F, Glaichenhaus N, Germain RN (2006) Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25:989-1001 (Pubitemid 44914055)
-
(2006)
Immunity
, vol.25
, Issue.6
, pp. 989-1001
-
-
Bajenoff, M.1
Egen, J.G.2
Koo, L.Y.3
Laugier, J.4
Brau, F.5
Glaichenhaus, N.6
Germain, R.N.7
-
10
-
-
24744449495
-
PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
-
DOI 10.1038/nm1291
-
Barber DF, Bartolome A, Hernandez C, Flores JM, Redondo C, Fernandez-Arias C, Camps M, Ruckle T, Schwarz MK, Rodriguez S, Martinez AC, Balomenos D, Rommel C, Carrera AC (2005) PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat Med 11:933-935 (Pubitemid 41294437)
-
(2005)
Nature Medicine
, vol.11
, Issue.9
, pp. 933-935
-
-
Barber, D.F.1
Bartolome, A.2
Hernandez, C.3
Flores, J.M.4
Redondo, C.5
Fernandez-Arias, C.6
Camps, M.7
Ruckle, T.8
Schwarz, M.K.9
Rodriguez, S.10
Martinez-A, C.11
Balomenos, D.12
Rommel, C.13
Carrera, A.C.14
-
11
-
-
29644443728
-
A-PI3K-induced systemic lupus but not T cell invasion
-
Barber DF, Bartolome A, Hernandez C, Flores JM, Fernandez-Arias C, Rodriguez-Borlado L, Hirsch E, Wymann M, Balomenos D, Carrera AC (2006) Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion. J Immunol 176:589-593 (Pubitemid 43023307)
-
(2006)
Journal of Immunology
, vol.176
, Issue.1
, pp. 589-593
-
-
Barber, D.F.1
Bartolome, A.2
Hernandez, C.3
Flores, J.M.4
Fernandez-Arias, C.5
Rodriguez-Borlado, L.6
Hirsch, E.7
Wymann, M.8
Balomenos, D.9
Carrera, A.C.10
-
12
-
-
11144357191
-
+ Regulatory T Cells
-
Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, Thompson CB, Burchill MA, Farrar MA, Turka LA (2004) Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol 172:5287-5296 (Pubitemid 38542026)
-
(2004)
Journal of Immunology
, vol.172
, Issue.9
, pp. 5287-5296
-
-
Bensinger, S.J.1
Walsh, P.T.2
Zhang, J.3
Carroll, M.4
Parsons, R.5
Rathmell, J.C.6
Thompson, C.B.7
Burchill, M.A.8
Farrar, M.A.9
Turka, L.A.10
-
13
-
-
30444439101
-
Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: Comparative analysis of genetic and pharmacologic interference with p110δ function in B cells
-
DOI 10.1182/blood-2005-07-3041
-
Bilancio A, Okkenhaug K, Camps M, Emery JL, Ruckle T, Rommel C, Vanhaesebroeck B (2006) Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. Blood 107:642-650 (Pubitemid 43076389)
-
(2006)
Blood
, vol.107
, Issue.2
, pp. 642-650
-
-
Bilancio, A.1
Okkenhaug, K.2
Camps, M.3
Emery, J.L.4
Ruckle, T.5
Rommel, C.6
Vanhaesebroeck, B.7
-
14
-
-
33644967813
-
CTLA4Ig: Bridging the basic immunology with clinical application
-
Bluestone JA, St Clair EW, Turka LA (2006) CTLA4Ig: bridging the basic immunology with clinical application. Immunity 24:233-238
-
(2006)
Immunity
, vol.24
, pp. 233-238
-
-
Bluestone, J.A.1
St Clair, E.W.2
Turka, L.A.3
-
15
-
-
0034194516
-
Differential regulation of B cell development, activation, and death by the Src homology 2 domain-containing 5' inositol phosphatase (SHIP)
-
DOI 10.1084/jem.191.9.1545
-
Brauweiler A, Tamir I, Dal Porto J, Benschop RJ, Helgason CD, Humphries RK, Freed JH, Cambier JC (2000) Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 50 inositol phosphatase (SHIP). J Exp Med 191:1545-1554 (Pubitemid 30257351)
-
(2000)
Journal of Experimental Medicine
, vol.191
, Issue.9
, pp. 1545-1554
-
-
Brauweiler, A.1
Tamir, I.2
Dal Porto, J.3
Benschop, R.J.4
Helgason, C.D.5
Humphries, R.K.6
Freed, J.H.7
Cambier, J.C.8
-
16
-
-
70449701417
-
Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy
-
Browne CD, Del Nagro CJ, Cato MH, Dengler HS, Rickert RC (2009) Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. Immunity 31:749-760
-
(2009)
Immunity
, vol.31
, pp. 749-760
-
-
Browne, C.D.1
Del Nagro, C.J.2
Cato, M.H.3
Dengler, H.S.4
Rickert, R.C.5
-
17
-
-
0032479864
-
T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide- linked dimer associated with the TCR-CD3-ζ complex, recruits intracellular signaling proteins to the plasma membrane
-
DOI 10.1084/jem.188.3.561
-
Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B (1998) T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane. J Exp Med 188:561-575 (Pubitemid 28369145)
-
(1998)
Journal of Experimental Medicine
, vol.188
, Issue.3
, pp. 561-575
-
-
Bruyns, E.1
Marie-Cardine, A.2
Kirchgessner, H.3
Sagolla, K.4
Shevchenko, A.5
Mann, M.6
Autschbach, F.7
Bensussan, A.8
Meuer, S.9
Schraven, B.10
-
18
-
-
0035340150
-
L
-
Burr JS, Savage ND, Messah GE, Kimzey SL, Shaw AS, Arch RH, Green JM (2001) Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL. J Immunol 166:5331-5335 (Pubitemid 32374151)
-
(2001)
Journal of Immunology
, vol.166
, Issue.9
, pp. 5331-5335
-
-
Burr, J.S.1
Savage, N.D.L.2
Messah, G.E.3
Kimzey, S.L.4
Shaw, A.S.5
Arch, R.H.6
Green, J.M.7
-
19
-
-
24744435115
-
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
-
DOI 10.1038/nm1284
-
Camps M, Ruckle T, Ji H, Ardissone V, Rintelen F, Shaw J, Ferrandi C, Chabert C, Gillieron C, Francon B, Martin T, Gretener D, Perrin D, LeroyD, Vitte PA, Hirsch E,Wymann MP, Cirillo R, Schwarz MK, Rommel C (2005) Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 11:936-943 (Pubitemid 41294438)
-
(2005)
Nature Medicine
, vol.11
, Issue.9
, pp. 936-943
-
-
Camps, M.1
Ruckle, T.2
Ji, H.3
Ardissone, V.4
Rintelen, F.5
Shaw, J.6
Ferrandi, C.7
Chabert, C.8
Gillieron, C.9
Francon, B.10
Martin, T.11
Gretener, D.12
Perrin, D.13
Leroy, D.14
Vitte, P.-A.15
Hirsch, E.16
Wymann, M.P.17
Cirillo, R.18
Schwarz, M.K.19
Rommel, C.20
more..
-
20
-
-
24944444760
-
Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism
-
DOI 10.1038/ni1234, PII N1234
-
Ciofani M, Zuniga-Pflucker JC (2005) Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat Immunol 6:881-888 (Pubitemid 43090442)
-
(2005)
Nature Immunology
, vol.6
, Issue.9
, pp. 881-888
-
-
Ciofani, M.1
Zuniga-Pflucker, J.C.2
-
21
-
-
0037119630
-
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation
-
Clayton E, Bardi G, Bell SE, Chantry D, Downes CP, Gray A, Humphries LA, Rawlings D, Reynolds H, Vigorito E, Turner M (2002) A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med 196:753-763
-
(2002)
J Exp Med
, vol.196
, pp. 753-763
-
-
Clayton, E.1
Bardi, G.2
Bell, S.E.3
Chantry, D.4
Downes, C.P.5
Gray, A.6
Humphries, L.A.7
Rawlings, D.8
Reynolds, H.9
Vigorito, E.10
Turner, M.11
-
22
-
-
8544265317
-
Forkhead-box transcription factors and their role in the immune system
-
DOI 10.1038/nri1488
-
Coffer PJ, Burgering BM (2004) Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol 4:889-899 (Pubitemid 39490764)
-
(2004)
Nature Reviews Immunology
, vol.4
, Issue.11
, pp. 889-899
-
-
Coffer, P.J.1
Burgering, B.M.T.2
-
23
-
-
35348926002
-
The PI3K inhibitor arsenal: choose your weapon!
-
DOI 10.1016/j.tibs.2007.09.001, PII S0968000407002113
-
Crabbe T, Welham MJ, Ward SG (2007) The PI3K inhibitor arsenal: choose your weapon! Trends Biochem Sci 32:450-456 (Pubitemid 47588944)
-
(2007)
Trends in Biochemical Sciences
, vol.32
, Issue.10
, pp. 450-456
-
-
Crabbe, T.1
Welham, M.J.2
Ward, S.G.3
-
24
-
-
33847397525
-
+ T regulatory cells
-
DOI 10.1182/blood-2006-07-035279
-
Crellin NK, Garcia RV, Levings MK (2007) Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells. Blood 109:2014-2022 (Pubitemid 46348201)
-
(2007)
Blood
, vol.109
, Issue.5
, pp. 2014-2022
-
-
Crellin, N.K.1
Garcia, R.V.2
Levings, M.K.3
-
25
-
-
2442719040
-
Enhanced T cell proliferation in mice lacking the p85β subunit of phosphoinositide 3-kinase
-
Deane JA, Trifilo MJ, Yballe CM, Choi S, Lane TE, Fruman DA (2004) Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase. J Immunol 172:6615-6625 (Pubitemid 38669096)
-
(2004)
Journal of Immunology
, vol.172
, Issue.11
, pp. 6615-6625
-
-
Deane, J.A.1
Trifilo, M.J.2
Yballe, C.M.3
Choi, S.4
Lane, T.E.5
Fruman, D.A.6
-
26
-
-
33947595612
-
T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling
-
DOI 10.1182/blood-2006-07-038620
-
Deane JA, Kharas MG, Oak JS, Stiles LN, Luo J, Moore TI, Ji H, Rommel C, Cantley LC, Lane TE, Fruman DA (2007) T cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood 109:2894-2902 (Pubitemid 46482086)
-
(2007)
Blood
, vol.109
, Issue.7
, pp. 2894-2902
-
-
Deane, J.A.1
Kharas, M.G.2
Oak, J.S.3
Stiles, L.N.4
Luo, J.5
Moore, T.I.6
Ji, H.7
Rommel, C.8
Cantley, L.C.9
Lane, T.E.10
Fruman, D.A.11
-
27
-
-
67651151038
-
Essential function for the GTPase TC21 in homeostatic antigen receptor signaling
-
Delgado P, Cubelos B, Calleja E, Martinez-Martin N, Cipres A, Merida I, Bellas C, Bustelo XR, Alarcon B (2009) Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Nat Immunol 10:880-888
-
(2009)
Nat Immunol
, vol.10
, pp. 880-888
-
-
Delgado, P.1
Cubelos, B.2
Calleja, E.3
Martinez-Martin, N.4
Cipres, A.5
Merida, I.6
Bellas, C.7
Bustelo, X.R.8
Alarcon, B.9
-
28
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, Worley PF, Kozma SC, Powell JD (2009) The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30:832-844
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
Zarek, P.E.4
Matthews, K.L.5
Xiao, B.6
Worley, P.F.7
Kozma, S.C.8
Powell, J.D.9
-
29
-
-
56349127778
-
Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
-
Dengler HS, Baracho GV, Omori SA, Bruckner S, Arden KC, Castrillon DH, DePinho RA, Rickert RC (2008) Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol 9:1388-1398
-
(2008)
Nat Immunol
, vol.9
, pp. 1388-1398
-
-
Dengler, H.S.1
Baracho, G.V.2
Omori, S.A.3
Bruckner, S.4
Arden, K.C.5
Castrillon, D.H.6
DePinho, R.A.7
Rickert, R.C.8
-
30
-
-
37349077033
-
CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand
-
DOI 10.1038/ni1547, PII NI1547
-
Depoil D, Fleire S, Treanor BL, Weber M, Harwood NE, Marchbank KL, Tybulewicz VL, Batista FD (2008) CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. Nat Immunol 9:63-72 (Pubitemid 350286205)
-
(2008)
Nature Immunology
, vol.9
, Issue.1
, pp. 63-72
-
-
Depoil, D.1
Fleire, S.2
Treanor, B.L.3
Weber, M.4
Harwood, N.E.5
Marchbank, K.L.6
Tybulewicz, V.L.J.7
Batista, F.D.8
-
31
-
-
0037015038
-
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation
-
DOI 10.1073/pnas.092284399
-
Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO (2002) Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci USA 99:11796-11801 (Pubitemid 34994478)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.18
, pp. 11796-11801
-
-
Diehn, M.1
Alizadeh, A.A.2
Rando, O.J.3
Liu, C.L.4
Stankunas, K.5
Botstein, D.6
Crabtree, G.R.7
Brown, P.O.8
-
32
-
-
41149103027
-
PI3K is a negative regulator of IgE production
-
DOI 10.1093/intimm/dxn009
-
Doi T, Obayashi K, Kadowaki T, Fujii H, Koyasu S (2008) PI3K is a negative regulator of IgE production. Int Immunol 20:499-508 (Pubitemid 351426044)
-
(2008)
International Immunology
, vol.20
, Issue.4
, pp. 499-508
-
-
Doi, T.1
Obayashi, K.2
Kadowaki, T.3
Fujii, H.4
Koyasu, S.5
-
33
-
-
35348852627
-
Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli
-
DOI 10.1002/eji.200737281
-
Donahue AC, Fruman DA (2007) Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli. Eur J Immunol 37:2923-2936 (Pubitemid 47578311)
-
(2007)
European Journal of Immunology
, vol.37
, Issue.10
, pp. 2923-2936
-
-
Donahue, A.C.1
Fruman, D.A.2
-
34
-
-
10844255780
-
Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85α
-
DOI 10.1093/intimm/dxh180
-
Donahue AC, Hess KL, Ng KL, Fruman DA (2004) Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha. Int Immunol 16:1789-1798 (Pubitemid 40003867)
-
(2004)
International Immunology
, vol.16
, Issue.12
, pp. 1789-1798
-
-
Donahue, A.C.1
Hess, K.L.2
Ng, K.L.3
Fruman, D.A.4
-
35
-
-
0032736029
-
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
-
Dong H, Zhu G, Tamada K, Chen L (1999) B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 5:1365-1369
-
(1999)
Nat Med
, vol.5
, pp. 1365-1369
-
-
Dong, H.1
Zhu, G.2
Tamada, K.3
Chen, L.4
-
36
-
-
33744462050
-
Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: Role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth
-
DOI 10.1182/blood-2005-12-4788
-
Doughty CA, Bleiman BF, Wagner DJ, Dufort FJ, Mataraza JM, Roberts MF, Chiles TC (2006) Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 107:4458-4465 (Pubitemid 43801373)
-
(2006)
Blood
, vol.107
, Issue.11
, pp. 4458-4465
-
-
Doughty, C.A.1
Bleiman, B.F.2
Wagner, D.J.3
Dufort, F.J.4
Mataraza, J.M.5
Roberts, M.F.6
Chiles, T.C.7
-
37
-
-
2542490265
-
B lymphocyte depletion therapy with rituximab in rheumatoid arthritis
-
DOI 10.1016/j.rdc.2004.01.006, PII S0889857X04000201
-
Edwards JC, Leandro MJ, Cambridge G (2004) B lymphocyte depletion therapy with rituximab in rheumatoid arthritis. Rheum Dis Clin North Am 30:393-403, viii (Pubitemid 38692569)
-
(2004)
Rheumatic Disease Clinics of North America
, vol.30
, Issue.2
, pp. 393-403
-
-
Edwards, J.C.W.1
Leandro, M.J.2
Cambridge, G.3
-
38
-
-
15444369929
-
Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control
-
Fabre S, Lang V, Harriague J, Jobart A, Unterman TG, Trautmann A, Bismuth G (2005) Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control. J Immunol 174:4161-4171 (Pubitemid 40395994)
-
(2005)
Journal of Immunology
, vol.174
, Issue.7
, pp. 4161-4171
-
-
Fabre, S.1
Lang, V.2
Harriague, J.3
Jobart, A.4
Unterman, T.G.5
Trautmann, A.6
Bismuth, G.7
-
39
-
-
51549111249
-
FOXO1 regulates L-selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase
-
Fabre S, Carrette F, Chen J, Lang V, Semichon M, Denoyelle C, Lazar V, Cagnard N, Dubart-Kupperschmitt A, Mangeney M, Fruman DA, Bismuth G (2008) FOXO1 regulates L-selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase. J Immunol 181:2980-2989
-
(2008)
J Immunol
, vol.181
, pp. 2980-2989
-
-
Fabre, S.1
Carrette, F.2
Chen, J.3
Lang, V.4
Semichon, M.5
Denoyelle, C.6
Lazar, V.7
Cagnard, N.8
Dubart-Kupperschmitt, A.9
Mangeney, M.10
Fruman, D.A.11
Bismuth, G.12
-
40
-
-
40149092093
-
Deletion of PKBalpha/ Akt1 affects thymic development
-
Fayard E, Gill J, Paolino M, Hynx D, Hollander GA, Hemmings BA (2007) Deletion of PKBalpha/ Akt1 affects thymic development. PLoS One 2:e992
-
(2007)
PLoS One
, vol.2
-
-
Fayard, E.1
Gill, J.2
Paolino, M.3
Hynx, D.4
Hollander, G.A.5
Hemmings, B.A.6
-
41
-
-
47249153519
-
Role of cytokines in rheumatoid arthritis: An education in pathophysiology and therapeutics
-
DOI 10.1111/j.1600-065X.2008.00626.x
-
Feldmann M, Maini SR (2008) Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics. Immunol Rev 223:7-19 (Pubitemid 351986171)
-
(2008)
Immunological Reviews
, vol.223
, Issue.1
, pp. 7-19
-
-
Feldmann, M.1
Maini, S.R.N.2
-
42
-
-
70449471819
-
Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes
-
Finlay DK, Sinclair LV, Feijoo C, Waugh CM, Hagenbeek TJ, Spits H, Cantrell DA (2009) Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes. J Exp Med 206:2441-2454
-
(2009)
J Exp Med
, vol.206
, pp. 2441-2454
-
-
Finlay, D.K.1
Sinclair, L.V.2
Feijoo, C.3
Waugh, C.M.4
Hagenbeek, T.J.5
Spits, H.6
Cantrell, D.A.7
-
43
-
-
27144549658
-
Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts
-
DOI 10.1038/nm1288, PII N1288
-
Floto RA, Clatworthy MR, Heilbronn KR, Rosner DR, MacAry PA, Rankin A, Lehner PJ, Ouwehand WH, Allen JM, Watkins NA, Smith KG (2005) Loss of function of a lupusassociated FcgammaRIIb polymorphism through exclusion from lipid rafts. Nat Med 11: 1056-1058 (Pubitemid 41486826)
-
(2005)
Nature Medicine
, vol.11
, Issue.10
, pp. 1056-1058
-
-
Floto, R.A.1
Clatworthy, M.R.2
Heilbronn, K.R.3
Rosner, D.R.4
MacAry, P.A.5
Rankin, A.6
Lehner, P.J.7
Ouwehand, W.H.8
Allen, J.M.9
Watkins, N.A.10
Smith, K.G.C.11
-
44
-
-
49649098826
-
ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse
-
Fos C, Salles A, Lang V, Carrette F, Audebert S, Pastor S, Ghiotto M, Olive D, Bismuth G, Nunes JA (2008) ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse. J Immunol 181:1969-1977
-
(2008)
J Immunol
, vol.181
, pp. 1969-1977
-
-
Fos, C.1
Salles, A.2
Lang, V.3
Carrette, F.4
Audebert, S.5
Pastor, S.6
Ghiotto, M.7
Olive, D.8
Bismuth, G.9
Nunes, J.A.10
-
45
-
-
13244278180
-
The Pim kinases control rapamycin-resistant T cell survival and activation
-
DOI 10.1084/jem.20042020
-
Fox CJ, Hammerman PS, Thompson CB (2005) The Pim kinases control rapamycin-resistant T cell survival and activation. J Exp Med 201:259-266 (Pubitemid 40189435)
-
(2005)
Journal of Experimental Medicine
, vol.201
, Issue.2
, pp. 259-266
-
-
Fox, C.J.1
Hammerman, P.S.2
Thompson, C.B.3
-
46
-
-
0036069699
-
The CD28 signaling pathway regulates glucose metabolism
-
DOI 10.1016/S1074-7613(02)00323-0
-
Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, Elstrom RL, June CH, Thompson CB (2002) The CD28 signaling pathway regulates glucose metabolism. Immunity 16:769-777 (Pubitemid 34786476)
-
(2002)
Immunity
, vol.16
, Issue.6
, pp. 769-777
-
-
Frauwirth, K.A.1
Riley, J.L.2
Harris, M.H.3
Parry, R.V.4
Rathmell, J.C.5
Plas, D.R.6
Elstrom, R.L.7
June, C.H.8
Thompson, C.B.9
-
47
-
-
61849126233
-
Fine tuning the immune response with PI3K
-
Fruman DA, Bismuth G (2009) Fine tuning the immune response with PI3K. Immunol Rev 228:253-272
-
(2009)
Immunol Rev
, vol.228
, pp. 253-272
-
-
Fruman, D.A.1
Bismuth, G.2
-
48
-
-
0033556333
-
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha
-
Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC (1999) Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science 283:393-397
-
(1999)
Science
, vol.283
, pp. 393-397
-
-
Fruman, D.A.1
Snapper, S.B.2
Yballe, C.M.3
Davidson, L.4
Yu, J.Y.5
Alt, F.W.6
Cantley, L.C.7
-
50
-
-
0036707521
-
PI3K-mediated negative feedback regulation of IL-12 production in DCs
-
Fukao T, Tanabe M, Terauchi Y, Ota T, Matsuda S, Asano T, Kadowaki T, Takeuchi T, Koyasu S (2002) PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 3:875-881
-
(2002)
Nat Immunol
, vol.3
, pp. 875-881
-
-
Fukao, T.1
Tanabe, M.2
Terauchi, Y.3
Ota, T.4
Matsuda, S.5
Asano, T.6
Kadowaki, T.7
Takeuchi, T.8
Koyasu, S.9
-
51
-
-
38949150779
-
CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer
-
DOI 10.1182/blood-2007-08-108050
-
Garcon F, Patton DT, Emery JL, Hirsch E, Rottapel R, Sasaki T, Okkenhaug K (2008) CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood 111:1464-1471 (Pubitemid 351213434)
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1464-1471
-
-
Garcon, F.1
Patton, D.T.2
Emery, J.L.3
Hirsch, E.4
Rottapel, R.5
Sasaki, T.6
Okkenhaug, K.7
-
52
-
-
73949090666
-
Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase
-
Gigoux M, Shang J, Pak Y, Xu M, Choe J, Mak TW, Suh WK (2009) Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. Proc Natl Acad Sci USA 106:20371-20376
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 20371-20376
-
-
Gigoux, M.1
Shang, J.2
Pak, Y.3
Xu, M.4
Choe, J.5
Mak, T.W.6
Suh, W.K.7
-
53
-
-
70149115741
-
CCL21 mediates CD4+ T cell costimulation via a DOCK2/Racdependent pathway
-
Gollmer K, Asperti-Boursin F, Tanaka Y, Okkenhaug K, Vanhaesebroeck B, Peterson JR, Fukui Y, Donnadieu E, Stein JV (2009) CCL21 mediates CD4+ T cell costimulation via a DOCK2/Racdependent pathway. Blood 114:580-588
-
(2009)
Blood
, vol.114
, pp. 580-588
-
-
Gollmer, K.1
Asperti-Boursin, F.2
Tanaka, Y.3
Okkenhaug, K.4
Vanhaesebroeck, B.5
Peterson, J.R.6
Fukui, Y.7
Donnadieu, E.8
Stein, J.V.9
-
54
-
-
33645733203
-
Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation
-
author reply 55
-
Gruber T, Freeley M, Thuille N, Heit I, Shaw S, Long A, Baier G (2006) Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation". Science 312:55, author reply 55
-
(2006)
Science
, vol.312
, pp. 55
-
-
Gruber, T.1
Freeley, M.2
Thuille, N.3
Heit, I.4
Shaw, S.5
Long, A.6
Baier, G.7
-
55
-
-
53349143413
-
The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation
-
Guo H, Samarakoon A, Vanhaesebroeck B, Malarkannan S (2008) The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation. J Exp Med 205:2419-2435
-
(2008)
J Exp Med
, vol.205
, pp. 2419-2435
-
-
Guo, H.1
Samarakoon, A.2
Vanhaesebroeck, B.3
Malarkannan, S.4
-
56
-
-
5444269438
-
The loss of PTEN allows TCR αβ lineage thymocytes to bypass IL-7 and pre-TCR-mediated signaling
-
DOI 10.1084/jem.20040495
-
Hagenbeek TJ, Naspetti M, Malergue F, Garcon F, Nunes JA, Cleutjens KB, Trapman J, Krimpenfort P, Spits H (2004) The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and pre-TCR-mediated signaling. J Exp Med 200:883-894 (Pubitemid 39362924)
-
(2004)
Journal of Experimental Medicine
, vol.200
, Issue.7
, pp. 883-894
-
-
Hagenbeek, T.J.1
Naspetti, M.2
Malergue, F.3
Garcon, F.4
Nunes, J.A.5
Cleutjens, K.B.J.M.6
Trapman, J.7
Krimpenfort, P.8
Spits, H.9
-
57
-
-
34250205544
-
The protean nature of cells in the B lymphocyte lineage
-
DOI 10.1016/j.immuni.2007.05.013, PII S1074761307002932
-
Hardy RR, Kincade PW, Dorshkind K (2007) The protean nature of cells in the B lymphocyte lineage. Immunity 26:703-714 (Pubitemid 46907671)
-
(2007)
Immunity
, vol.26
, Issue.6
, pp. 703-714
-
-
Hardy, R.R.1
Kincade, P.W.2
Dorshkind, K.3
-
59
-
-
59749099913
-
B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta
-
Henley T, Kovesdi D, Turner M (2008) B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta. Eur J Immunol 38:3543-3548
-
(2008)
Eur J Immunol
, vol.38
, pp. 3543-3548
-
-
Henley, T.1
Kovesdi, D.2
Turner, M.3
-
60
-
-
44049101651
-
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway
-
DOI 10.1038/ni.1616, PII NI.1616
-
Herzog S, Hug E, Meixlsperger S, Paik JH, DePinho RA, Reth M, Jumaa H (2008) SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat Immunol 9:623-631 (Pubitemid 351712633)
-
(2008)
Nature Immunology
, vol.9
, Issue.6
, pp. 623-631
-
-
Herzog, S.1
Hug, E.2
Meixlsperger, S.3
Paik, J.-H.4
DePinho, R.A.5
Reth, M.6
Jumaa, H.7
-
61
-
-
61349179407
-
Regulation of B-cell proliferation and differentiation by pre-Bcell receptor signalling
-
Herzog S, Reth M, Jumaa H (2009) Regulation of B-cell proliferation and differentiation by pre-Bcell receptor signalling. Nat Rev Immunol 9:195-205
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 195-205
-
-
Herzog, S.1
Reth, M.2
Jumaa, H.3
-
62
-
-
9244263536
-
Frontline: The p85α isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses
-
DOI 10.1002/eji.200425326
-
Hess KL, Donahue AC, Ng KL, Moore TI, Oak J, Fruman DA (2004) Frontline: the p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses. Eur J Immunol 34:2968-2976 (Pubitemid 39549376)
-
(2004)
European Journal of Immunology
, vol.34
, Issue.11
, pp. 2968-2976
-
-
Hess, K.L.1
Donahue, A.C.2
Ng, K.L.3
Moore, T.I.4
Oak, J.5
Fruman, D.A.6
-
63
-
-
2442681621
-
The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development
-
DOI 10.1038/ni1062
-
Hinton HJ, Alessi DR, Cantrell DA (2004) The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development. Nat Immunol 5:539-545 (Pubitemid 38660467)
-
(2004)
Nature Immunology
, vol.5
, Issue.5
, pp. 539-545
-
-
Hinton, H.J.1
Alessi, D.R.2
Cantrell, D.A.3
-
64
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
-
Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP (2000) Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287:1049-1053
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
Katanaev, V.L.2
Garlanda, C.3
Azzolino, O.4
Pirola, L.5
Silengo, L.6
Sozzani, S.7
Mantovani, A.8
Altruda, F.9
Wymann, M.P.10
-
65
-
-
0033590502
-
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
-
Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, Kroczek RA (1999) ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397:263-266
-
(1999)
Nature
, vol.397
, pp. 263-266
-
-
Hutloff, A.1
Dittrich, A.M.2
Beier, K.C.3
Eljaschewitsch, B.4
Kraft, R.5
Anagnostopoulos, I.6
Kroczek, R.A.7
-
66
-
-
0037148505
-
Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation
-
DOI 10.1084/jem.20011571
-
Inabe K, Ishiai M, Scharenberg AM, Freshney N, Downward J, Kurosaki T (2002) Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. J Exp Med 195:189-200 (Pubitemid 34461263)
-
(2002)
Journal of Experimental Medicine
, vol.195
, Issue.2
, pp. 189-200
-
-
Inabe, K.1
Ishiai, M.2
Scharenberg, A.M.3
Freshney, N.4
Downward, J.5
Kurosaki, T.6
-
67
-
-
65749103989
-
Regulatory lymphocytes and intestinal inflammation
-
Izcue A, Coombes JL, Powrie F (2009) Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 27:313-338
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 313-338
-
-
Izcue, A.1
Coombes, J.L.2
Powrie, F.3
-
68
-
-
17144422830
-
Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002
-
DOI 10.1074/jbc.M413155200
-
Jacobs MD, Black J, Futer O, Swenson L, Hare B, Fleming M, Saxena K (2005) Pim-1 ligandbound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002. J Biol Chem 280:13728-13734 (Pubitemid 40517268)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.14
, pp. 13728-13734
-
-
Jacobs, M.D.1
Black, J.2
Futer, O.3
Swenson, L.4
Hare, B.5
Fleming, M.6
Saxena, K.7
-
69
-
-
40449110080
-
The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells
-
Janas ML, Hodson D, Stamataki Z, Hill S, Welch K, Gambardella L, Trotman LC, Pandolfi PP, Vigorito E, TurnerM(2008) The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells. J Immunol 180:739-746
-
(2008)
J Immunol
, vol.180
, pp. 739-746
-
-
Janas, M.L.1
Hodson, D.2
Stamataki, Z.3
Hill, S.4
Welch, K.5
Gambardella, L.6
Trotman, L.C.7
Pandolfi, P.P.8
Vigorito, E.9
Turner, M.10
-
70
-
-
76149086153
-
Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4
-
Janas ML, Varano G, Gudmundsson K, Noda M, Nagasawa T, Turner M (2010) Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4. J Exp Med 207(247-261):S241-S242
-
(2010)
J Exp Med
, vol.207
, Issue.247-261
-
-
Janas, M.L.1
Varano, G.2
Gudmundsson, K.3
Noda, M.4
Nagasawa, T.5
Turner, M.6
-
71
-
-
40549116629
-
T cell receptor-induced phosphoinositide-3-kinase p110δ activity is required for T cell localization to antigenic tissue in mice
-
DOI 10.1172/JCI33267
-
Jarmin SJ, David R, Ma L, Chai JG, Dewchand H, Takesono A, Ridley AJ, Okkenhaug K, Marelli-Berg FM (2008) T cell receptor-induced phosphoinositide-3- kinase p110delta activity is required for T cell localization to antigenic tissue in mice. J Clin Invest 118:1154-1164 (Pubitemid 351364622)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.3
, pp. 1154-1164
-
-
Jarmin, S.J.1
David, R.2
Ma, L.3
Chai, J.-G.4
Dewchand, H.5
Takesono, A.6
Ridley, A.J.7
Okkenhaug, K.8
Marelli-Berg, F.M.9
-
72
-
-
35548996385
-
Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation
-
DOI 10.1182/blood-2007-04-086751
-
Ji H, Rintelen F, Waltzinger C, Bertschy Meier D, Bilancio A, Pearce W, Hirsch E, Wymann MP, Ruckle T, Camps M, Vanhaesebroeck B, Okkenhaug K, Rommel C (2007) Inactivation ofPI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation. Blood 110:2940-2947 (Pubitemid 350006947)
-
(2007)
Blood
, vol.110
, Issue.8
, pp. 2940-2947
-
-
Ji, H.1
Rintelen, F.2
Waltzinger, C.3
Meier, D.B.4
Bilancio, A.5
Pearce, W.6
Hirsch, E.7
Wymann, M.P.8
Ruckle, T.9
Camps, M.10
Vanhaesebroeck, B.11
Okkenhaug, K.12
Rommel, C.13
-
73
-
-
0034676001
-
Role of the PI3K regulatory subunit in the control of actin organization and cell migration
-
Jimenez C, Portela RA, Mellado M, Rodriguez-Frade JM, Collard J, Serrano A, Martinez AC, Avila J, Carrera AC (2000) Role of the PI3K regulatory subunit in the control of actin organization and cell migration. J Cell Biol 151:249-262
-
(2000)
J Cell Biol
, vol.151
, pp. 249-262
-
-
Jimenez, C.1
Portela, R.A.2
Mellado, M.3
Rodriguez-Frade, J.M.4
Collard, J.5
Serrano, A.6
Martinez, A.C.7
Avila, J.8
Carrera, A.C.9
-
74
-
-
0037695593
-
Essential, nonredundant role for the phosphoinositide 3-kinase p110δ in signaling by the B-cell receptor complex
-
DOI 10.1128/MCB.22.24.8580-8591.2002
-
Jou ST, Carpino N, Takahashi Y, Piekorz R, Chao JR, Carpino N, Wang D, Ihle JN (2002) Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol 22:8580-8591 (Pubitemid 35397173)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.24
, pp. 8580-8591
-
-
Jou, S.-T.1
Carpino, N.2
Takahashi, Y.3
Piekorz, R.4
Chao, J.-R.5
Carpino, N.6
Wang, D.7
Ihle, J.N.8
-
75
-
-
34547533470
-
Akt1 and Akt2 are required for αβ thymocyte survival and differentiation
-
DOI 10.1073/pnas.0705285104
-
Juntilla MM, Wofford JA, Birnbaum MJ, Rathmell JC, Koretzky GA (2007) Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc Natl Acad Sci USA 104:12105-12110 (Pubitemid 47185637)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.29
, pp. 12105-12110
-
-
Juntilla, M.M.1
Wofford, J.A.2
Birnbaum, M.J.3
Rathmell, J.C.4
Koretzky, G.A.5
-
76
-
-
0036316344
-
Akt-dependent phosphorylation specifically regulates Cot induction of NF-κB-dependent transcription
-
DOI 10.1128/MCB.22.16.5962-5974.2002
-
Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A (2002) Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Mol Cell Biol 22:5962-5974 (Pubitemid 34815843)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.16
, pp. 5962-5974
-
-
Kane, L.P.1
Mollenauer, M.N.2
Xu, Z.3
Turck, C.W.4
Weiss, A.5
-
77
-
-
34547208593
-
Notch-induced T cell development requires phosphoinositide-dependent kinase 1
-
DOI 10.1038/sj.emboj.7601761, PII 7601761
-
Kelly AP, Finlay DK, Hinton HJ, Clarke RG, Fiorini E, Radtke F, Cantrell DA (2007) Notchinduced T cell development requires phosphoinositide-dependent kinase 1. EMBO J 26: 3441-3450 (Pubitemid 47123527)
-
(2007)
EMBO Journal
, vol.26
, Issue.14
, pp. 3441-3450
-
-
Kelly, A.P.1
Finlay, D.K.2
Hinton, H.J.3
Clarke, R.G.4
Fiorini, E.5
Radtke, F.6
Cantrell, D.A.7
-
78
-
-
58449102260
-
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
-
Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM (2009) Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol 10:176-184
-
(2009)
Nat Immunol
, vol.10
, pp. 176-184
-
-
Kerdiles, Y.M.1
Beisner, D.R.2
Tinoco, R.3
Dejean, A.S.4
Castrillon, D.H.5
DePinho, R.A.6
Hedrick, S.M.7
-
79
-
-
33846485153
-
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
-
DOI 10.1038/ni1428, PII NI1428
-
Kim JM, Rasmussen JP, Rudensky AY (2007a) Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 8:191-197 (Pubitemid 46152650)
-
(2007)
Nature Immunology
, vol.8
, Issue.2
, pp. 191-197
-
-
Kim, J.M.1
Rasmussen, J.P.2
Rudensky, A.Y.3
-
80
-
-
36148992966
-
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion
-
DOI 10.1182/blood-2007-02-075366
-
Kim N, Saudemont A, Webb L, Camps M, Ruckle T, Hirsch E, Turner M, Colucci F (2007b) The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion. Blood 110:3202-3208 (Pubitemid 350106312)
-
(2007)
Blood
, vol.110
, Issue.9
, pp. 3202-3208
-
-
Kim, N.1
Saudemont, A.2
Webb, L.3
Camps, M.4
Ruckle, T.5
Hirsch, E.6
Turner, M.7
Colucci, F.8
-
81
-
-
34147139532
-
The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells
-
DOI 10.1182/blood-2006-07-038059
-
Kishimoto H, Ohteki T, Yajima N, Kawahara K, Natsui M, Kawarasaki S, Hamada K, Horie Y, Kubo Y, Arase S, Taniguchi M, Vanhaesebroeck B, Mak TW, Nakano T, Koyasu S, Sasaki T, Suzuki A (2007) The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood 109:3316-3324 (Pubitemid 46572519)
-
(2007)
Blood
, vol.109
, Issue.8
, pp. 3316-3324
-
-
Kishimoto, H.1
Ohteki, T.2
Yajima, N.3
Kawahara, K.4
Natsui, M.5
Kawarasaki, S.6
Hamada, K.7
Horie, Y.8
Kubo, Y.9
Arase, S.10
Taniguchi, M.11
Vanhaesebroeck, B.12
Tak, W.M.13
Nakano, T.14
Koyasu, S.15
Sasaki, T.16
Suzuki, A.17
-
82
-
-
33646234269
-
Normal T-cell development and immune functions in TRIM-deficient mice
-
Kolsch U, Arndt B, Reinhold D, Lindquist JA, Juling N, Kliche S, Pfeffer K, Bruyns E, Schraven B, Simeoni L (2006) Normal T-cell development and immune functions in TRIM-deficient mice. Mol Cell Biol 26:3639-3648
-
(2006)
Mol Cell Biol
, vol.26
, pp. 3639-3648
-
-
Kolsch, U.1
Arndt, B.2
Reinhold, D.3
Lindquist, J.A.4
Juling, N.5
Kliche, S.6
Pfeffer, K.7
Bruyns, E.8
Schraven, B.9
Simeoni, L.10
-
83
-
-
33747150625
-
CXCR4 physically associates with the T cell receptor to signal in T cells
-
DOI 10.1016/j.immuni.2006.06.015, PII S1074761306003529
-
Kumar A, Humphreys TD, Kremer KN, Bramati PS, Bradfield L, Edgar CE, Hedin KE (2006) CXCR4 physically associates with the T cell receptor to signal in T cells. Immunity 25: 213-224 (Pubitemid 44224150)
-
(2006)
Immunity
, vol.25
, Issue.2
, pp. 213-224
-
-
Kumar, A.1
Humphreys, T.D.2
Kremer, K.N.3
Bramati, P.S.4
Bradfield, L.5
Edgar, C.E.6
Hedin, K.E.7
-
84
-
-
15944410614
-
PDK1 nucleates T cell receptor-induced signaling complex for NF-κB activation
-
DOI 10.1126/science.1107107
-
Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S (2005) PDK1 nucleates T cell receptorinduced signaling complex for NF-kappaB activation. Science 308:114-118 (Pubitemid 40471010)
-
(2005)
Science
, vol.308
, Issue.5718
, pp. 114-118
-
-
Lee, K.-Y.1
D'Acquisto, F.2
Hayden, M.S.3
Shim, J.-H.4
Ghosh, S.5
-
85
-
-
33645827963
-
Inhibition of phosphoinositide 3-kinase δ attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
-
DOI 10.1096/fj.05-5045com
-
Lee KS, Lee HK, Hayflick JS, Lee YC, Puri KD (2006) Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB J 20:455-465 (Pubitemid 44933322)
-
(2006)
FASEB Journal
, vol.20
, Issue.3
, pp. 455-465
-
-
Lee, K.S.1
Lee, H.K.2
Hayflick, J.S.3
Lee, Y.C.4
Puri, K.D.5
-
86
-
-
48449086316
-
TGF-beta: A master of all T cell trades
-
Li MO, Flavell RA (2008) TGF-beta: a master of all T cell trades. Cell 134:392-404
-
(2008)
Cell
, vol.134
, pp. 392-404
-
-
Li, M.O.1
Flavell, R.A.2
-
87
-
-
0034635221
-
Roles of PLC-β2 and -β3 and PI3kγ in chemoattractant- mediated signal transduction
-
DOI 10.1126/science.287.5455.1046
-
Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, Wu D (2000) Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 287:1046-1049 (Pubitemid 30094361)
-
(2000)
Science
, vol.287
, Issue.5455
, pp. 1046-1049
-
-
Li, Z.1
Jiang, H.2
Xie, W.3
Zhang, Z.4
Smrcka, A.V.5
Wu, D.6
-
88
-
-
4143129696
-
Regulation of NF-κB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a
-
DOI 10.1016/j.immuni.2004.06.016, PII S1074761304002055
-
Lin L, Hron JD, Peng SL (2004) Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity 21:203-213 (Pubitemid 39094050)
-
(2004)
Immunity
, vol.21
, Issue.2
, pp. 203-213
-
-
Lin, L.1
Hron, J.D.2
Peng, S.L.3
-
89
-
-
35548975191
-
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
-
DOI 10.1038/ni1513, PII NI1513
-
Link A, Vogt TK, Favre S, Britschgi MR, Acha-Orbea H, Hinz B, Cyster JG, Luther SA (2007) Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol 8:1255-1265 (Pubitemid 350011765)
-
(2007)
Nature Immunology
, vol.8
, Issue.11
, pp. 1255-1265
-
-
Link, A.1
Vogt, T.K.2
Favre, S.3
Britschgi, M.R.4
Acha-Orbea, H.5
Hinz, B.6
Cyster, J.G.7
Luther, S.A.8
-
90
-
-
68149100422
-
The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells
-
Liu D, Zhang T, Marshall AJ, Okkenhaug K, Vanhaesebroeck B, Uzonna JE (2009) The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells. J Immunol 183:1921-1933
-
(2009)
J Immunol
, vol.183
, pp. 1921-1933
-
-
Liu, D.1
Zhang, T.2
Marshall, A.J.3
Okkenhaug, K.4
Vanhaesebroeck, B.5
Uzonna, J.E.6
-
91
-
-
33846895443
-
Cutting edge: The PI3K p110δ is required for down-regulation of RAG expression in immature B cells
-
Llorian M, Stamataki Z, Hill S, Turner M, Martensson IL (2007) The PI3K p110delta is required for down-regulation of RAG expression in immature B cells. J Immunol 178:1981-1985 (Pubitemid 46233393)
-
(2007)
Journal of Immunology
, vol.178
, Issue.4
, pp. 1981-1985
-
-
Llorian, M.1
Stamataki, Z.2
Hill, S.3
Turner, M.4
Martensson, I.-L.5
-
92
-
-
70249138405
-
SHIP regulates the reciprocal development of T regulatory and Th17 cells
-
Locke NR, Patterson SJ, Hamilton MJ, Sly LM, Krystal G, Levings MK (2009) SHIP regulates the reciprocal development of T regulatory and Th17 cells. J Immunol 183:975-983
-
(2009)
J Immunol
, vol.183
, pp. 975-983
-
-
Locke, N.R.1
Patterson, S.J.2
Hamilton, M.J.3
Sly, L.M.4
Krystal, G.5
Levings, M.K.6
-
93
-
-
34247627902
-
Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition
-
Mao C, Tili EG, Dose M, Haks MC, Bear SE, Maroulakou I, Horie K, Gaitanaris GA, Fidanza V, Ludwig T, Wiest DL, Gounari F, Tsichlis PN (2007) Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. J Immunol 178:5443-5453 (Pubitemid 46674338)
-
(2007)
Journal of Immunology
, vol.178
, Issue.9
, pp. 5443-5453
-
-
Mao, C.1
Till, E.G.2
Dose, M.3
Haks, M.C.4
Bear, S.E.5
Maroulakou, I.6
Horie, K.7
Gaitanaris, G.A.8
Fidanza, V.9
Ludwig, T.10
Wiest, D.L.11
Gounari, F.12
Tsichlis, P.N.13
-
94
-
-
42149156057
-
Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase
-
Martin AL, Schwartz MD, Jameson SC, Shimizu Y (2008) Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase. J Immunol 180:2081-2088
-
(2008)
J Immunol
, vol.180
, pp. 2081-2088
-
-
Martin, A.L.1
Schwartz, M.D.2
Jameson, S.C.3
Shimizu, Y.4
-
95
-
-
34848887428
-
Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node
-
Matheu MP, Deane JA, Parker I, Fruman DA, Cahalan MD (2007) Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. J Immunol 179:2261-2269
-
(2007)
J Immunol
, vol.179
, pp. 2261-2269
-
-
Matheu, M.P.1
Deane, J.A.2
Parker, I.3
Fruman, D.A.4
Cahalan, M.D.5
-
96
-
-
33947599936
-
Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28
-
DOI 10.1182/blood-2006-10-050724
-
Mirenda V, Jarmin SJ, David R, Dyson J, Scott D, Gu Y, Lechler RI, Okkenhaug K, Marelli-Berg FM (2007) Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28. Blood 109:2968-2977 (Pubitemid 46482095)
-
(2007)
Blood
, vol.109
, Issue.7
, pp. 2968-2977
-
-
Mirenda, V.1
Jarmin, S.J.2
David, R.3
Dyson, J.4
Scott, D.5
Gu, Y.6
Lechler, R.I.7
Okkenhaug, K.8
Marelli-Berg, F.M.9
-
97
-
-
18244389686
-
T cell costimulation by chemokine receptors
-
DOI 10.1038/ni1191
-
Molon B, Gri G, Bettella M, Gomez-Mouton C, Lanzavecchia A, Martinez AC, Manes S, Viola A (2005) T cell costimulation by chemokine receptors. Nat Immunol 6:465-471 (Pubitemid 41716759)
-
(2005)
Nature Immunology
, vol.6
, Issue.5
, pp. 465-471
-
-
Molon, B.1
Gri, G.2
Bettella, M.3
Gomez-Mouton, C.4
Lanzavecchia, A.5
Martinez-A, C.6
Manes, S.7
Viola, A.8
-
98
-
-
33644772836
-
CARMA1 is required for Akt-mediated NF-κB activation in T cells
-
DOI 10.1128/MCB.26.6.2327-2336.2006
-
Narayan P, Holt B, Tosti R, Kane LP (2006) CARMA1 is required for Akt-mediated NF-kappaB activation in T cells. Mol Cell Biol 26:2327-2336 (Pubitemid 43346932)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.6
, pp. 2327-2336
-
-
Narayan, P.1
Holt, B.2
Tosti, R.3
Kane, L.P.4
-
99
-
-
33947729717
-
Role of the phosphoinositide 3-kinase p110δ in generation of type 2 cytokine responses and allergic airway inflammation
-
DOI 10.1002/eji.200636401
-
Nashed BF, Zhang T, Al-Alwan M, Srinivasan G, Halayko AJ, Okkenhaug K, Vanhaesebroeck B, Hayglass KT, Marshall AJ (2007) Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation. Eur J Immunol 37:416-424 (Pubitemid 46915581)
-
(2007)
European Journal of Immunology
, vol.37
, Issue.2
, pp. 416-424
-
-
Nashed, B.F.1
Zhang, T.2
Al-Alwan, M.3
Srinivasan, G.4
Halayko, A.J.5
Okkenhaug, K.6
Vanhaesebroeck, B.7
HayGlass, K.T.8
Marshal, A.J.9
-
100
-
-
4444335344
-
Differential requirements for DOCK2 and phosphoinositide-3-kinase γ during T and B lymphocyte homing
-
DOI 10.1016/j.immuni.2004.07.012, PII S1074761304001992
-
Nombela-Arrieta C, Lacalle RA, Montoya MC, Kunisaki Y, Megias D, Marques M, Carrera AC, Manes S, Fukui Y, Martinez AC, Stein JV (2004) Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing. Immunity 21:429-441 (Pubitemid 39208343)
-
(2004)
Immunity
, vol.21
, Issue.3
, pp. 429-441
-
-
Nombela-Arrieta, C.1
Lacalle, R.A.2
Montoya, M.C.3
Kunisaki, Y.4
Megias, D.5
Marques, M.6
Carrera, A.C.7
Manes, S.8
Fukui, Y.9
Martinez-A, C.10
Stein, J.V.11
-
101
-
-
33947411398
-
A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress
-
DOI 10.1084/jem.20061780
-
Nombela-Arrieta C, Mempel TR, Soriano SF, Mazo I, Wymann MP, Hirsch E, Martinez AC, Fukui Y, von Andrian UH, Stein JV (2007) A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med 204:497-510 (Pubitemid 46457074)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.3
, pp. 497-510
-
-
Nombela-Arrieta, C.1
Mempel, T.R.2
Soriano, S.F.3
Mazo, I.4
Wymann, M.P.5
Hirsch, E.6
Martinez, A.C.7
Fukui, Y.8
Von Andrian, U.H.9
Stein, J.V.10
-
102
-
-
33750963809
-
Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase
-
DOI 10.1073/pnas.0607984103
-
Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA (2006) Sjogren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proc Natl Acad Sci USA 103:16882-16887 (Pubitemid 44737347)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.45
, pp. 16882-16887
-
-
Oak, J.S.1
Deane, J.A.2
Kharas, M.G.3
Luo, J.4
Lane, T.E.5
Cantley, L.C.6
Fruman, D.A.7
-
103
-
-
70749116852
-
The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells
-
Oak JS, Chen J, Peralta RQ, Deane JA, Fruman DA (2009) The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells. Autoimmunity 442:447-458
-
(2009)
Autoimmunity
, vol.442
, pp. 447-458
-
-
Oak, J.S.1
Chen, J.2
Peralta, R.Q.3
Deane, J.A.4
Fruman, D.A.5
-
104
-
-
0035319244
-
A point mutation in CD28 distinguishes proliferative signals from survival signals
-
DOI 10.1038/86327
-
Okkenhaug K,Wu L, Garza KM, La Rose J, KhooW, Odermatt B,Mak TW, Ohashi PS, Rottapel R (2001) A point mutation in CD28 distinguishes proliferative signals from survival signals. Nat Immunol 2:325-332 (Pubitemid 33706343)
-
(2001)
Nature Immunology
, vol.2
, Issue.4
, pp. 325-332
-
-
Okkenhaug, K.1
Wu, L.2
Garza, K.M.3
La Rose, J.4
Khoo, W.5
Odermatt, B.6
Mak, T.W.7
Ohashi, P.S.8
Rottapel, R.9
-
105
-
-
0037047590
-
Impaired B and T cell antigen receptor signaling in p110δ PI 3-kinase mutant mice
-
DOI 10.1126/science.1073560
-
Okkenhaug K, Bilancio A, FarjotG, Priddle H, Sancho S, Peskett E, PearceW,Meek SE, Salpekar A, Waterfield MD, Smith AJ, Vanhaesebroeck B (2002) Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 297:1031-1034 (Pubitemid 34856039)
-
(2002)
Science
, vol.297
, Issue.5583
, pp. 1031-1034
-
-
Okkenhaug, K.1
Bilancio, A.2
Farjot, G.3
Priddle, H.4
Sancho, S.5
Peskett, E.6
Pearce, W.7
Meek, S.E.8
Salpekar, A.9
Waterfield, M.D.10
Smith, A.J.H.11
Vanhaesebroeck, B.12
-
106
-
-
33749515632
-
The p110δ isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells
-
Okkenhaug K, Patton DT, Bilancio A, Garcon F, Rowan WC, Vanhaesebroeck B (2006) The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells. J Immunol 177:5122-5128 (Pubitemid 44527583)
-
(2006)
Journal of Immunology
, vol.177
, Issue.8
, pp. 5122-5128
-
-
Okkenhaug, K.1
Patton, D.T.2
Bilancio, A.3
Garcon, F.4
Rowan, W.C.5
Vanhaesebroeck, B.6
-
107
-
-
33846621025
-
Antigen receptor signalling: A distinctive role for the p110δ isoform of PI3K
-
DOI 10.1016/j.it.2006.12.007, PII S147149060600353X
-
Okkenhaug K, Ali K, Vanhaesebroeck B (2007) Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K. Trends Immunol 28:80-87 (Pubitemid 46176736)
-
(2007)
Trends in Immunology
, vol.28
, Issue.2
, pp. 80-87
-
-
Okkenhaug, K.1
Ali, K.2
Vanhaesebroeck, B.3
-
108
-
-
33749685322
-
Regulation of Class-Switch Recombination and Plasma Cell Differentiation by Phosphatidylinositol 3-Kinase Signaling
-
DOI 10.1016/j.immuni.2006.08.015, PII S1074761306004249
-
Omori SA, Cato MH, Anzelon-Mills A, Puri KD, Shapiro-Shelef M, Calame K, Rickert RC (2006) Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling. Immunity 25:545-557 (Pubitemid 44550181)
-
(2006)
Immunity
, vol.25
, Issue.4
, pp. 545-557
-
-
Omori, S.A.1
Cato, M.H.2
Anzelon-Mills, A.3
Puri, K.D.4
Shapiro-Shelef, M.5
Calame, K.6
Rickert, R.C.7
-
109
-
-
62049086102
-
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance
-
Ouyang W, Beckett O, Flavell RA, Li MO (2009) An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity 30:358-371
-
(2009)
Immunity
, vol.30
, pp. 358-371
-
-
Ouyang, W.1
Beckett, O.2
Flavell, R.A.3
Li, M.O.4
-
110
-
-
34948908663
-
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
-
DOI 10.1038/nm1636, PII NM1636
-
Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, BassoG, CastilloM,Nagase S, Cordon-Cardo C, Parsons R, Zuniga-Pflucker JC, Dominguez M, Ferrando AA (2007) Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med 13:1203-1210 (Pubitemid 47530629)
-
(2007)
Nature Medicine
, vol.13
, Issue.10
, pp. 1203-1210
-
-
Palomero, T.1
Sulis, M.L.2
Cortina, M.3
Real, P.J.4
Barnes, K.5
Ciofani, M.6
Caparros, E.7
Buteau, J.8
Brown, K.9
Perkins, S.L.10
Bhagat, G.11
Agarwal, A.M.12
Basso, G.13
Castillo, M.14
Nagase, S.15
Cordon-Cardo, C.16
Parsons, R.17
Zuniga-Pflucker, J.C.18
Dominguez, M.19
Ferrando, A.A.20
more..
-
111
-
-
58549094896
-
The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells
-
Park SG, Schulze-Luehrman J, Hayden MS, Hashimoto N, Ogawa W, Kasuga M, Ghosh S (2009) The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells. Nat Immunol 10:158-166
-
(2009)
Nat Immunol
, vol.10
, pp. 158-166
-
-
Park, S.G.1
Schulze-Luehrman, J.2
Hayden, M.S.3
Hashimoto, N.4
Ogawa, W.5
Kasuga, M.6
Ghosh, S.7
-
112
-
-
0038545370
-
L, and IL-2 expression in primary human CD4 T lymphocytes
-
Parry RV, Rumbley CA, Vandenberghe LH, June CH, Riley JL (2003) CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary human CD4 T lymphocytes. J Immunol 171:166-174 (Pubitemid 36745285)
-
(2003)
Journal of Immunology
, vol.171
, Issue.1
, pp. 166-174
-
-
Parry, R.V.1
Rumbley, C.A.2
Vandenberghe, L.H.3
June, C.H.4
Riley, J.L.5
-
113
-
-
75349096225
-
Fine tuning T lymphocytes: A role for the lipid phosphatase SHIP-1
-
Parry RV, Harris SJ, Ward SG (2010) Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1. Biochim Biophys Acta 1804:592-597
-
(2010)
Biochim Biophys Acta
, vol.1804
, pp. 592-597
-
-
Parry, R.V.1
Harris, S.J.2
Ward, S.G.3
-
114
-
-
33750807672
-
+ regulatory T cells
-
Patton DT, Garden OA, Pearce WP, Clough LE, Monk CR, Leung E, Rowan WC, Sancho S, Walker LS, Vanhaesebroeck B, Okkenhaug K (2006) Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function ofCD4+CD25+Foxp3+ regulatoryTcells. J Immunol 177:6598-6602 (Pubitemid 44715022)
-
(2006)
Journal of Immunology
, vol.177
, Issue.10
, pp. 6598-6602
-
-
Patton, D.T.1
Garden, O.A.2
Pearce, W.P.3
Clough, L.E.4
Monk, C.R.5
Leung, E.6
Rowan, W.C.7
Sancho, S.8
Walker, L.S.K.9
Vanhaesebroeck, B.10
Okkenhaug, K.11
-
115
-
-
0035193064
-
Visualization of negative signaling in B cells by quantitative confocal microscopy
-
DOI 10.1128/MCB.21.24.8615-8625.2001
-
Phee H, Rodgers W, Coggeshall KM (2001) Visualization of negative signaling in B cells by quantitative confocal microscopy. Mol Cell Biol 21:8615-8625 (Pubitemid 33108618)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.24
, pp. 8615-8625
-
-
Phee, H.1
Rodgers, W.2
Coggeshall, K.M.3
-
116
-
-
77953008362
-
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation
-
Pierau M, Engelmann S, Reinhold D, Lapp T, Schraven B, Bommhardt UH (2009) Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation. J Immunol 183:6124-6134
-
(2009)
J Immunol
, vol.183
, pp. 6124-6134
-
-
Pierau, M.1
Engelmann, S.2
Reinhold, D.3
Lapp, T.4
Schraven, B.5
Bommhardt, U.H.6
-
117
-
-
47049113462
-
Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils
-
Randis TM, Puri KD, Zhou H, Diacovo TG (2008) Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils. Eur J Immunol 38: 1215-1224
-
(2008)
Eur J Immunol
, vol.38
, pp. 1215-1224
-
-
Randis, T.M.1
Puri, K.D.2
Zhou, H.3
Diacovo, T.G.4
-
118
-
-
4043082729
-
Cuttin edge: Differential roles for phosphoinositide 3-kinases, p110γ and p110δ, lymphocyte chemotaxis and homing
-
Reif K, Okkenhaug K, Sasaki T, Penninger JM, Vanhaesebroeck B, Cyster JG (2004) Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol 173:2236-2240 (Pubitemid 39063077)
-
(2004)
Journal of Immunology
, vol.173
, Issue.4
, pp. 2236-2240
-
-
Reif, K.1
Okkenhaug, K.2
Sasaki, T.3
Penninger, J.M.4
Vanhaesebroeck, B.5
Cyster, J.G.6
-
119
-
-
0037015055
-
Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors
-
DOI 10.1073/pnas.162359999
-
Riley JL, Mao M, Kobayashi S, Biery M, Burchard J, Cavet G, Gregson BP, June CH, Linsley PS (2002) Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc Natl Acad Sci USA 99:11790-11795 (Pubitemid 34994477)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.18
, pp. 11790-11795
-
-
Riley, J.L.1
Mao, M.2
Kobayashi, S.3
Biery, M.4
Burchard, J.5
Cavet, G.6
Gregson, B.P.7
June, C.H.8
Linsley, P.S.9
-
120
-
-
79952109738
-
Comparing the roles of the p110a and p110b isoforms of PI3K in signaling and cancer
-
doi 10.1007/82-2010-63
-
Roberts TM, Ilić N (2010) Comparing the roles of the p110a and p110b isoforms of PI3K in signaling and cancer. Curr Top Microbiol Immunol doi 10.1007/82-2010-63
-
(2010)
Curr Top Microbiol Immunol
-
-
Roberts, T.M.1
Ilić, N.2
-
121
-
-
0242416992
-
Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio
-
Rodriguez-Borlado L, Barber DF, Hernandez C, Rodriguez-Marcos MA, Sanchez A, Hirsch E, Wymann M, Martinez AC, Carrera AC (2003) Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio. J Immunol 170:4475-4482 (Pubitemid 36519952)
-
(2003)
Journal of Immunology
, vol.170
, Issue.9
, pp. 4475-4482
-
-
Rodriguez-Borlado, L.1
Barber, D.F.2
Hernandez, C.3
Rodriguez-Marcos, M.A.4
Sanchez, A.5
Hirsch, E.6
Wymann, M.7
Martinez-A, C.8
Carrera, A.C.9
-
122
-
-
33847239467
-
PI3K delta and PI3K gamma: Partners in crime in inflammation in rheumatoid arthritis and beyond?
-
Rommel C, Camps M, Ji H (2007) PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat Rev Immunol 7:191-201
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 191-201
-
-
Rommel, C.1
Camps, M.2
Ji, H.3
-
123
-
-
33750525089
-
PI3Kgamma inhibition: Towards an 'aspirin of the 21st century'?
-
Ruckle T, Schwarz MK, Rommel C (2006) PI3Kgamma inhibition: towards an 'aspirin of the 21st century'? Nat Rev Drug Discov 5:903-918
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 903-918
-
-
Ruckle, T.1
Schwarz, M.K.2
Rommel, C.3
-
124
-
-
0142259712
-
Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
-
DOI 10.1038/nri1131
-
Rudd CE, Schneider H (2003) Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat Rev Immunol 3:544-556 (Pubitemid 37328674)
-
(2003)
Nature Reviews Immunology
, vol.3
, Issue.7
, pp. 544-556
-
-
Rudd, C.E.1
Schneider, H.2
-
125
-
-
43949105866
-
Regulatory T cells and immune tolerance
-
DOI 10.1016/j.cell.2008.05.009, PII S0092867408006247
-
Sakaguchi S, Yamaguchi T, Nomura T, Ono M (2008) Regulatory T cells and immune tolerance. Cell 133:775-787 (Pubitemid 351707693)
-
(2008)
Cell
, vol.133
, Issue.5
, pp. 775-787
-
-
Sakaguchi, S.1
Yamaguchi, T.2
Nomura, T.3
Ono, M.4
-
126
-
-
10344237020
-
Cutting edge: CD28-mediated transcriptional and posttranscriptional regulation of IL-2 expression are controlled through different signalling pathways
-
Sanchez-Lockhart M, Marin E, Graf B, Abe R, Harada Y, Sedwick CE, Miller J (2004) Cutting edge: CD28-mediated transcriptional and posttranscriptional regulation of IL-2 expression are controlled through different signaling pathways. J Immunol 173:7120-7124 (Pubitemid 39628145)
-
(2004)
Journal of Immunology
, vol.173
, Issue.12
, pp. 7120-7124
-
-
Sanchez-Lockhart, M.1
Marin, E.2
Graf, B.3
Abe, R.4
Harada, Y.5
Sedwick, C.E.6
Miller, J.7
-
127
-
-
71849111698
-
Signals and sequences that control CD28 localization to the central region of the immunological synapse
-
Sanchez-Lockhart M, Graf B, Miller J (2008) Signals and sequences that control CD28 localization to the central region of the immunological synapse. J Immunol 181:7639-7648
-
(2008)
J Immunol
, vol.181
, pp. 7639-7648
-
-
Sanchez-Lockhart, M.1
Graf, B.2
Miller, J.3
-
128
-
-
0034635264
-
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
-
Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM (2000) Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 287:1040-1046
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
Irie-Sasaki, J.2
Jones, R.G.3
Oliveira-Dos-Santos, A.J.4
Stanford, W.L.5
Bolon, B.6
Wakeham, A.7
Itie, A.8
Bouchard, D.9
Kozieradzki, I.10
Joza, N.11
Mak, T.W.12
Ohashi, P.S.13
Suzuki, A.14
Penninger, J.M.15
-
129
-
-
65249191411
-
P110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease
-
Saudemont A, Garcon F, Yadi H, Roche-Molina M, Kim N, Segonds-Pichon A, Martin-Fontecha A, Okkenhaug K, Colucci F (2009) p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease. Proc Natl Acad Sci USA 106:5795-5800
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 5795-5800
-
-
Saudemont, A.1
Garcon, F.2
Yadi, H.3
Roche-Molina, M.4
Kim, N.5
Segonds-Pichon, A.6
Martin-Fontecha, A.7
Okkenhaug, K.8
Colucci, F.9
-
130
-
-
45549098562
-
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
-
DOI 10.1073/pnas.0800928105
-
Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, Shokat KM, Fisher AG, Merkenschlager M (2008) T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci USA 105: 7797-7802 (Pubitemid 351872718)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.22
, pp. 7797-7802
-
-
Sauer, S.1
Bruno, L.2
Hertweck, A.3
Finlay, D.4
Leleu, M.5
Spivakov, M.6
Knight, Z.A.7
Cobb, B.S.8
Cantrell, D.9
O'Connor, E.10
Shokat, K.M.11
Fisher, A.G.12
Merkenschlager, M.13
-
131
-
-
77649214306
-
Function of the nucleotide exchange activity of vav1 in T cell development and activation
-
ra83
-
Saveliev A, Vanes L, Ksionda O, Rapley J, Smerdon SJ, Rittinger K, Tybulewicz VLJ (2009) Function of the nucleotide exchange activity of vav1 in T cell development and activation. Sci Signal 2:ra83
-
(2009)
Sci Signal
, vol.2
-
-
Saveliev, A.1
Vanes, L.2
Ksionda, O.3
Rapley, J.4
Smerdon, S.J.5
Rittinger, K.6
Tybulewicz, V.L.J.7
-
132
-
-
33846228444
-
Antigen-Receptor Signaling to Nuclear Factor κB
-
DOI 10.1016/j.immuni.2006.10.010, PII S1074761306004821
-
Schulze-Luehrmann J, Ghosh S (2006) Antigen-receptor signaling to nuclear factor kappa B. Immunity 25:701-715 (Pubitemid 46107295)
-
(2006)
Immunity
, vol.25
, Issue.5
, pp. 701-715
-
-
Schulze-Luehrmann, J.1
Ghosh, S.2
-
133
-
-
39449087305
-
Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns
-
DOI 10.1038/ni1565, PII NI1565
-
Sebzda E, Zou Z, Lee JS, Wang T, Kahn ML (2008) Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Nat Immunol 9:292-300 (Pubitemid 351267326)
-
(2008)
Nature Immunology
, vol.9
, Issue.3
, pp. 292-300
-
-
Sebzda, E.1
Zou, Z.2
Lee, J.S.3
Wang, T.4
Kahn, M.L.5
-
134
-
-
33846513615
-
The p85α regulatory subunit of class IA phosphoinositide 3-kinase regulates β-selection in thymocyte development
-
Shiroki F, Matsuda S, Doi T, Fujiwara M, Mochizuki Y, Kadowaki T, Suzuki H, Koyasu S (2007) The p85alpha regulatory subunit of class IA phosphoinositide 3-kinase regulates beta-selection in thymocyte development. J Immunol 178:1349-1356 (Pubitemid 46154604)
-
(2007)
Journal of Immunology
, vol.178
, Issue.3
, pp. 1349-1356
-
-
Shiroki, F.1
Matsuda, S.2
Doi, T.3
Fujiwara, M.4
Mochizuki, Y.5
Kadowaki, T.6
Suzuki, H.7
Koyasu, S.8
-
135
-
-
42449110816
-
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
-
DOI 10.1038/ni.1603, PII NI.1603
-
SinclairLV, FinlayD, FeijooC,CornishGH,GrayA,AgerA,Okkenhaug K, Hagenbeek TJ, SpitsH, Cantrell DA (2008) Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol 9:513-521 (Pubitemid 351560520)
-
(2008)
Nature Immunology
, vol.9
, Issue.5
, pp. 513-521
-
-
Sinclair, L.V.1
Finlay, D.2
Feijoo, C.3
Cornish, G.H.4
Gray, A.5
Ager, A.6
Okkenhaug, K.7
Hagenbeek, T.J.8
Spits, H.9
Cantrell, D.A.10
-
136
-
-
45749110212
-
Bam32: A novel mediator of Erk activation in T cells
-
DOI 10.1093/intimm/dxn039
-
Sommers CL, Gurson JM, Surana R, Barda-Saad M, Lee J, Kishor A, Li W, Gasser AJ, Barr VA, Miyaji M, Love PE, Samelson LE (2008) Bam32: a novel mediator of Erk activation in T cells. Int Immunol 20:811-818 (Pubitemid 351865857)
-
(2008)
International Immunology
, vol.20
, Issue.7
, pp. 811-818
-
-
Sommers, C.L.1
Gurson, J.M.2
Surana, R.3
Barda-Saad, M.4
Lee, J.5
Kishor, A.6
Li, W.7
Gasser, A.J.8
Barr, V.A.9
Miyaji, M.10
Love, P.E.11
Samelson, L.E.12
-
137
-
-
77950457187
-
PI3K p110{delta} regulates T cell cytokine production during primary and secondary immune responses in mice and humans
-
Soond DR, Bjorgo E, Moltu K, Dale VQ, Patton DT, Torgersen KM, Galleway F, Twomey B, Clark J, Gaston JH, Tasken K, Bunyard P, Okkenhaug K (2010) PI3K p110{delta} regulates T cell cytokine production during primary and secondary immune responses in mice and humans. Blood 115:2203-2213
-
(2010)
Blood
, vol.115
, pp. 2203-2213
-
-
Soond, D.R.1
Bjorgo, E.2
Moltu, K.3
Dale, V.Q.4
Patton, D.T.5
Torgersen, K.M.6
Galleway, F.7
Twomey, B.8
Clark, J.9
Gaston, J.H.10
Tasken, K.11
Bunyard, P.12
Okkenhaug, K.13
-
138
-
-
70350304558
-
PI3 kinase signals BCR-dependent mature B cell survival
-
Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K (2009) PI3 kinase signals BCR-dependent mature B cell survival. Cell 139:573-586
-
(2009)
Cell
, vol.139
, pp. 573-586
-
-
Srinivasan, L.1
Sasaki, Y.2
Calado, D.P.3
Zhang, B.4
Paik, J.H.5
DePinho, R.A.6
Kutok, J.L.7
Kearney, J.F.8
Otipoby, K.L.9
Rajewsky, K.10
-
139
-
-
57849147589
-
Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation
-
Sriskantharajah S, Belich MP, Papoutsopoulou S, Janzen J, Tybulewicz V, Seddon B, Ley SC (2009) Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation. Nat Immunol 10:38-47
-
(2009)
Nat Immunol
, vol.10
, pp. 38-47
-
-
Sriskantharajah, S.1
Belich, M.P.2
Papoutsopoulou, S.3
Janzen, J.4
Tybulewicz, V.5
Seddon, B.6
Ley, S.C.7
-
140
-
-
0033555829
-
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
-
Suzuki H, Terauchi Y, Fujiwara M, Aizawa S, Yazaki Y, Kadowaki T, Koyasu S (1999) Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science 283:390-392
-
(1999)
Science
, vol.283
, pp. 390-392
-
-
Suzuki, H.1
Terauchi, Y.2
Fujiwara, M.3
Aizawa, S.4
Yazaki, Y.5
Kadowaki, T.6
Koyasu, S.7
-
141
-
-
0037341617
-
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction
-
DOI 10.1038/ni890
-
Suzuki H,Matsuda S, TerauchiY, FujiwaraM,Ohteki T,Asano T, Behrens TW, Kouro T, Takatsu K, Kadowaki T, Koyasu S (2003) PI3K and Btk differentially regulate B cell antigen receptormediated signal transduction. Nat Immunol 4:280-286 (Pubitemid 36322139)
-
(2003)
Nature Immunology
, vol.4
, Issue.3
, pp. 280-286
-
-
Suzuki, H.1
Matsuda, S.2
Terauchi, Y.3
Fujiwara, M.4
Ohteki, T.5
Asano, T.6
Behrens, T.W.7
Kouro, T.8
Takatsu, K.9
Kadowaki, T.10
Koyasu, S.11
-
142
-
-
33644765808
-
Essential role of PI3Kδ and PI3Kγ in thymocyte survival
-
DOI 10.1182/blood-2005-08-3300
-
Swat W, Montgrain V, Doggett TA, Douangpanya J, Puri K, Vermi W, Diacovo TG (2006) Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival. Blood 107:2415-2422 (Pubitemid 43345562)
-
(2006)
Blood
, vol.107
, Issue.6
, pp. 2415-2422
-
-
Swat, W.1
Montgrain, V.2
Doggett, T.A.3
Douangpanya, J.4
Puri, K.5
Vermi, W.6
Diacovo, T.G.7
-
143
-
-
34548303252
-
FcγRIIB as a modulator of autoimmune disease susceptibility
-
DOI 10.1080/08916930701464665, PII 781664210, Signal Transduction
-
Tarasenko T, Dean JA, Bolland S (2007a) FcgammaRIIB as a modulator of autoimmune disease susceptibility. Autoimmunity 40:409-417 (Pubitemid 47343352)
-
(2007)
Autoimmunity
, vol.40
, Issue.6
, pp. 409-417
-
-
Tarasenko, T.1
Dean, J.A.2
Bolland, S.3
-
144
-
-
34547402441
-
T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses
-
DOI 10.1073/pnas.0704853104
-
Tarasenko T, Kole HK, Chi AW, Mentink-Kane MM, Wynn TA, Bolland S (2007b) T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc Natl Acad Sci USA 104:11382-11387 (Pubitemid 47175149)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.27
, pp. 11382-11387
-
-
Tarasenko, T.1
Kole, H.K.2
Chi, A.W.3
Mentink-Kane, M.M.4
Wynn, T.A.5
Bolland, S.6
-
145
-
-
34548039233
-
P110γ and p110δ Phosphoinositide 3-Kinase Signaling Pathways Synergize to Control Development and Functions of Murine NK Cells
-
DOI 10.1016/j.immuni.2007.07.014, PII S1074761307003792
-
Tassi I, Cella M, Gilfillan S, Turnbull I, Diacovo TG, Penninger JM, Colonna M (2007) p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells. Immunity 27:214-227 (Pubitemid 47284932)
-
(2007)
Immunity
, vol.27
, Issue.2
, pp. 214-227
-
-
Tassi, I.1
Cella, M.2
Gilfillan, S.3
Turnbull, I.4
Diacovo, T.G.5
Penninger, J.M.6
Colonna, M.7
-
146
-
-
50849122062
-
The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites
-
Thomas MS, Mitchell JS, DeNucci CC, Martin AL, Shimizu Y (2008) The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites. J Leukoc Biol 84:814-823
-
(2008)
J Leukoc Biol
, vol.84
, pp. 814-823
-
-
Thomas, M.S.1
Mitchell, J.S.2
DeNucci, C.C.3
Martin, A.L.4
Shimizu, Y.5
-
147
-
-
2442612540
-
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
-
ThomeM(2004) CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat Rev Immunol 4:348-359 (Pubitemid 38649277)
-
(2004)
Nature Reviews Immunology
, vol.4
, Issue.5
, pp. 348-359
-
-
Thome, M.1
-
148
-
-
42949137559
-
Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells
-
DOI 10.1073/pnas.0708381104
-
Tsatsanis C, Vaporidi K, Zacharioudaki V, Androulidaki A, Sykulev Y, Margioris AN, Tsichlis PN (2008) Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells. Proc Natl Acad Sci USA 105:2987-2992 (Pubitemid 351723655)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.8
, pp. 2987-2992
-
-
Tsatsanis, C.1
Vaporidi, K.2
Zacharioudaki, V.3
Androulidaki, A.4
Sykulev, Y.5
Margioris, A.N.6
Tsichlis, P.N.7
-
149
-
-
20944435721
-
Basal immunoglobulin signaling actively maintains developmental stage in immature B cells
-
Tze LE, SchramBR, LamKP, HogquistKA, HippenKL, Liu J, Shinton SA,OtipobyKL, Rodine PR, Vegoe AL, Kraus M, Hardy RR, Schlissel MS, Rajewsky K, Behrens TW (2005) Basal immunoglobulin signaling actively maintains developmental stage in immature B cells. PLoS Biol 3:e82
-
(2005)
PLoS Biol
, vol.3
-
-
Tze, L.E.1
Schram, B.R.2
Lam, K.P.3
Hogquist, K.A.4
Hippen, K.L.5
Liu, J.6
Shinton, S.A.7
Otipoby, K.L.8
Rodine, P.R.9
Vegoe, A.L.10
Kraus, M.11
Hardy, R.R.12
Schlissel, M.S.13
Rajewsky, K.14
Behrens, T.W.15
-
150
-
-
34248216554
-
Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection
-
Verkoczy L, Duong B, Skog P, Ait-Azzouzene D, Puri K, Vela JL, Nemazee D (2007) Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cellpositive selection. J Immunol 178:6332-6341 (Pubitemid 46717417)
-
(2007)
Journal of Immunology
, vol.178
, Issue.10
, pp. 6332-6341
-
-
Verkoczy, L.1
Duong, B.2
Skog, P.3
Ait-Azzouzene, D.4
Puri, K.5
Vela, J.L.6
Nemazee, D.7
-
151
-
-
4344671730
-
Vav-dependent and Vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus
-
Vigorito E, Bardi G, Glassford J, Lam EW, Clayton E, Turner M (2004) Vav-dependent and vavindependent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus. J Immunol 173:3209-3214 (Pubitemid 39142028)
-
(2004)
Journal of Immunology
, vol.173
, Issue.5
, pp. 3209-3214
-
-
Vigorito, E.1
Bardi, G.2
Glassford, J.3
Lam, E.W.-F.4
Clayton, E.5
Turner, M.6
-
152
-
-
0033105611
-
Regulation of B cell receptor-mediated MHC class II antigen processing by FcγRIIB1
-
Wagle NM, Faassen AE, Kim JH, Pierce SK (1999) Regulation of B cell receptor-mediated MHC class II antigen processing by FcgammaRIIB1. J Immunol 162:2732-2740 (Pubitemid 29309296)
-
(1999)
Journal of Immunology
, vol.162
, Issue.5
, pp. 2732-2740
-
-
Wagle, N.M.1
Faassen, A.E.2
Kim, J.H.3
Pierce, S.K.4
-
153
-
-
0142116231
-
Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling
-
DOI 10.1126/science.1089709
-
Walmsley MJ, Ooi SK, Reynolds LF, Smith SH, Ruf S, Mathiot A, Vanes L, Williams DA, Cancro MP, Tybulewicz VL (2003) Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 302:459-462 (Pubitemid 37296274)
-
(2003)
Science
, vol.302
, Issue.5644
, pp. 459-462
-
-
Walmsley, M.J.1
Ooi, S.K.T.2
Reynolds, L.F.3
Smith, S.H.4
Ruf, S.5
Mathiot, A.6
Vanes, L.7
Williams, D.A.8
Cancro, M.P.9
Tybulewicz, V.L.J.10
-
154
-
-
33748335576
-
+ Tregs
-
DOI 10.1172/JCI28057
-
Walsh PT, Buckler JL, Zhang J, Gelman AE, Dalton NM, Taylor DK, Bensinger SJ, HancockWW, Turka LA (2006) PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest 116:2521-2531 (Pubitemid 44330151)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.9
, pp. 2521-2531
-
-
Walsh, P.T.1
Buckler, J.L.2
Zhang, J.3
Gelman, A.E.4
Dalton, N.M.5
Taylor, D.K.6
Bensinger, S.J.7
Hancock, W.W.8
Turka, L.A.9
-
155
-
-
70350523607
-
Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide- dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation
-
Waugh C, Sinclair L, Finlay D, Bayascas JR, Cantrell D (2009) Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation. Mol Cell Biol 29:5952-5962
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5952-5962
-
-
Waugh, C.1
Sinclair, L.2
Finlay, D.3
Bayascas, J.R.4
Cantrell, D.5
-
156
-
-
23844462453
-
Cutting edge: T cell development requires the combined activities of the p110γ and p110δ catalytic isoforms of phosphatidylinositol 3-kinase
-
Webb LM, Vigorito E, Wymann MP, Hirsch E, TurnerM(2005) Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase. J Immunol 175:2783-2787 (Pubitemid 41170493)
-
(2005)
Journal of Immunology
, vol.175
, Issue.5
, pp. 2783-2787
-
-
Webb, L.M.C.1
Vigorito, E.2
Wymann, M.P.3
Hirsch, E.4
Turner, M.5
-
157
-
-
42249090333
-
Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
-
DOI 10.1084/jem.20072619
-
Weber M, Treanor B, Depoil D, Shinohara H, Harwood NE, Hikida M, Kurosaki T, Batista FD (2008) Phospholipase C-gamma2 and vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J Exp Med 205:853-868 (Pubitemid 351549883)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.4
, pp. 853-868
-
-
Weber, M.1
Treanor, B.2
Depoil, D.3
Shinohara, H.4
Harwood, N.E.5
Hikida, M.6
Kurosaki, T.7
Batista, F.D.8
-
158
-
-
54949103906
-
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation
-
Yokosuka T, Kobayashi W, Sakata-Sogawa K, Takamatsu M, Hashimoto-Tane A, Dustin ML, Tokunaga M, Saito T (2008) Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity 29:589-601
-
(2008)
Immunity
, vol.29
, pp. 589-601
-
-
Yokosuka, T.1
Kobayashi, W.2
Sakata-Sogawa, K.3
Takamatsu, M.4
Hashimoto-Tane, A.5
Dustin, M.L.6
Tokunaga, M.7
Saito, T.8
-
159
-
-
58149398769
-
Leukemic challenge unmasks a requirement for PI3Kdelta in NK cell-mediated tumor surveillance
-
Zebedin E, Simma O, Schuster C, Putz EM, Fajmann S, Warsch W, Eckelhart E, Stoiber D, Weisz E, Schmid JA, Pickl WF, Baumgartner C, Valent P, Piekorz RP, Freissmuth M, Sexl V (2008) Leukemic challenge unmasks a requirement for PI3Kdelta in NK cell-mediated tumor surveillance. Blood 112:4655-4664
-
(2008)
Blood
, vol.112
, pp. 4655-4664
-
-
Zebedin, E.1
Simma, O.2
Schuster, C.3
Putz, E.M.4
Fajmann, S.5
Warsch, W.6
Eckelhart, E.7
Stoiber, D.8
Weisz, E.9
Schmid, J.A.10
Pickl, W.F.11
Baumgartner, C.12
Valent, P.13
Piekorz, R.P.14
Freissmuth, M.15
Sexl, V.16
-
160
-
-
53049098169
-
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production
-
Zhang TT, Okkenhaug K, Nashed BF, Puri KD, Knight ZA, Shokat KM, Vanhaesebroeck B, Marshall AJ (2008) Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. J Allergy Clin Immunol 122(811-819):e812
-
(2008)
J Allergy Clin Immunol
, vol.122
, Issue.811-819
-
-
Zhang, T.T.1
Okkenhaug, K.2
Nashed, B.F.3
Puri, K.D.4
Knight, Z.A.5
Shokat, K.M.6
Vanhaesebroeck, B.7
Marshall, A.J.8
-
161
-
-
34247277666
-
Foxp3 in control of the regulatory T cell lineage
-
DOI 10.1038/ni1455, PII NI1455
-
Zheng Y, Rudensky AY (2007) Foxp3 in control of the regulatory T cell lineage. Nat Immunol 8:457-462 (Pubitemid 46605910)
-
(2007)
Nature Immunology
, vol.8
, Issue.5
, pp. 457-462
-
-
Zheng, Y.1
Rudensky, A.Y.2
-
162
-
-
0038276047
-
NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases
-
DOI 10.1038/ni930
-
Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz VL, Di Santo JP, Lanier LL, Colucci F (2003) NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat Immunol 4:565-572 (Pubitemid 36701340)
-
(2003)
Nature Immunology
, vol.4
, Issue.6
, pp. 565-572
-
-
Zompi, S.1
Hamerman, J.A.2
Ogasawara, K.3
Schweighoffer, E.4
Tybulewicz, V.L.J.5
Di Santo, J.P.6
Lanier, L.L.7
Colucci, F.8
|