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Volumn 346, Issue 1, 2010, Pages 57-85

PI3Ks in lymphocyte signaling and development

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN RECEPTOR; B LYMPHOCYTE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUCOSE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN P110; PROTEIN P110 DELTA; PROTEIN P110 GAMMA; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 79952110284     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82-2010-45     Document Type: Article
Times cited : (55)

References (162)
  • 1
    • 38949164409 scopus 로고    scopus 로고
    • Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase
    • DOI 10.1182/blood-2007-08-109769
    • Aiba Y, Kameyama M, Yamazaki T, Tedder TF, Kurosaki T (2008) Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood 111:1497-1503 (Pubitemid 351213438)
    • (2008) Blood , vol.111 , Issue.3 , pp. 1497-1503
    • Aiba, Y.1    Kameyama, M.2    Yamazaki, T.3    Tedder, T.F.4    Kurosaki, T.5
  • 2
    • 33846926759 scopus 로고    scopus 로고
    • Requirement for phosphoinositide 3-kinase p110δ signaling in B cell antigen receptor-mediated antigen presentation
    • Al-Alwan MM, Okkenhaug K, Vanhaesebroeck B, Hayflick JS, Marshall AJ (2007) Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation. J Immunol 178:2328-2335 (Pubitemid 46233431)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 2328-2335
    • Al-Alwan, M.M.1    Okkenhaug, K.2    Vanhaesebroeck, B.3    Hayflick, J.S.4    Marshal, A.J.5
  • 6
    • 42149091691 scopus 로고    scopus 로고
    • Isoform-specific functions of phosphoinositide 3-kinases: P110 delta but not p110 gamma promotes optimal allergic responses in vivo
    • Ali K, Camps M, Pearce WP, Ji H, Ruckle T, Kuehn N, Pasquali C, Chabert C, Rommel C, Vanhaesebroeck B (2008) Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo. J Immunol 180:2538-2544
    • (2008) J Immunol , vol.180 , pp. 2538-2544
    • Ali, K.1    Camps, M.2    Pearce, W.P.3    Ji, H.4    Ruckle, T.5    Kuehn, N.6    Pasquali, C.7    Chabert, C.8    Rommel, C.9    Vanhaesebroeck, B.10
  • 7
    • 44049091757 scopus 로고    scopus 로고
    • Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
    • DOI 10.1038/ni.1612, PII NI.1612
    • Amin RH, Schlissel MS (2008) Foxo1 directly regulates the transcription of recombinationactivating genes during B cell development. Nat Immunol 9:613-622 (Pubitemid 351712632)
    • (2008) Nature Immunology , vol.9 , Issue.6 , pp. 613-622
    • Amin, R.H.1    Schlissel, M.S.2
  • 8
    • 34249085248 scopus 로고    scopus 로고
    • CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner
    • DOI 10.1084/jem.20062079
    • Asperti-Boursin F, Real E, Bismuth G, Trautmann A, Donnadieu E (2007) CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner. J Exp Med 204:1167-1179 (Pubitemid 46798159)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.5 , pp. 1167-1179
    • Asperti-Boursin, F.1    Real, E.2    Bismuth, G.3    Trautmann, A.4    Donnadieu, E.5
  • 9
    • 33845455093 scopus 로고    scopus 로고
    • Stromal cell networks regulate lymphocyte entry, migration, and territoriality in Lymph Nodes
    • DOI 10.1016/j.immuni.2006.10.011, PII S1074761306004833
    • Bajenoff M, Egen JG, Koo LY, Laugier JP, Brau F, Glaichenhaus N, Germain RN (2006) Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25:989-1001 (Pubitemid 44914055)
    • (2006) Immunity , vol.25 , Issue.6 , pp. 989-1001
    • Bajenoff, M.1    Egen, J.G.2    Koo, L.Y.3    Laugier, J.4    Brau, F.5    Glaichenhaus, N.6    Germain, R.N.7
  • 13
    • 30444439101 scopus 로고    scopus 로고
    • Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: Comparative analysis of genetic and pharmacologic interference with p110δ function in B cells
    • DOI 10.1182/blood-2005-07-3041
    • Bilancio A, Okkenhaug K, Camps M, Emery JL, Ruckle T, Rommel C, Vanhaesebroeck B (2006) Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. Blood 107:642-650 (Pubitemid 43076389)
    • (2006) Blood , vol.107 , Issue.2 , pp. 642-650
    • Bilancio, A.1    Okkenhaug, K.2    Camps, M.3    Emery, J.L.4    Ruckle, T.5    Rommel, C.6    Vanhaesebroeck, B.7
  • 14
    • 33644967813 scopus 로고    scopus 로고
    • CTLA4Ig: Bridging the basic immunology with clinical application
    • Bluestone JA, St Clair EW, Turka LA (2006) CTLA4Ig: bridging the basic immunology with clinical application. Immunity 24:233-238
    • (2006) Immunity , vol.24 , pp. 233-238
    • Bluestone, J.A.1    St Clair, E.W.2    Turka, L.A.3
  • 16
    • 70449701417 scopus 로고    scopus 로고
    • Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy
    • Browne CD, Del Nagro CJ, Cato MH, Dengler HS, Rickert RC (2009) Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. Immunity 31:749-760
    • (2009) Immunity , vol.31 , pp. 749-760
    • Browne, C.D.1    Del Nagro, C.J.2    Cato, M.H.3    Dengler, H.S.4    Rickert, R.C.5
  • 17
    • 0032479864 scopus 로고    scopus 로고
    • T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide- linked dimer associated with the TCR-CD3-ζ complex, recruits intracellular signaling proteins to the plasma membrane
    • DOI 10.1084/jem.188.3.561
    • Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B (1998) T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane. J Exp Med 188:561-575 (Pubitemid 28369145)
    • (1998) Journal of Experimental Medicine , vol.188 , Issue.3 , pp. 561-575
    • Bruyns, E.1    Marie-Cardine, A.2    Kirchgessner, H.3    Sagolla, K.4    Shevchenko, A.5    Mann, M.6    Autschbach, F.7    Bensussan, A.8    Meuer, S.9    Schraven, B.10
  • 20
    • 24944444760 scopus 로고    scopus 로고
    • Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism
    • DOI 10.1038/ni1234, PII N1234
    • Ciofani M, Zuniga-Pflucker JC (2005) Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat Immunol 6:881-888 (Pubitemid 43090442)
    • (2005) Nature Immunology , vol.6 , Issue.9 , pp. 881-888
    • Ciofani, M.1    Zuniga-Pflucker, J.C.2
  • 22
    • 8544265317 scopus 로고    scopus 로고
    • Forkhead-box transcription factors and their role in the immune system
    • DOI 10.1038/nri1488
    • Coffer PJ, Burgering BM (2004) Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol 4:889-899 (Pubitemid 39490764)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.11 , pp. 889-899
    • Coffer, P.J.1    Burgering, B.M.T.2
  • 23
    • 35348926002 scopus 로고    scopus 로고
    • The PI3K inhibitor arsenal: choose your weapon!
    • DOI 10.1016/j.tibs.2007.09.001, PII S0968000407002113
    • Crabbe T, Welham MJ, Ward SG (2007) The PI3K inhibitor arsenal: choose your weapon! Trends Biochem Sci 32:450-456 (Pubitemid 47588944)
    • (2007) Trends in Biochemical Sciences , vol.32 , Issue.10 , pp. 450-456
    • Crabbe, T.1    Welham, M.J.2    Ward, S.G.3
  • 24
    • 33847397525 scopus 로고    scopus 로고
    • + T regulatory cells
    • DOI 10.1182/blood-2006-07-035279
    • Crellin NK, Garcia RV, Levings MK (2007) Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells. Blood 109:2014-2022 (Pubitemid 46348201)
    • (2007) Blood , vol.109 , Issue.5 , pp. 2014-2022
    • Crellin, N.K.1    Garcia, R.V.2    Levings, M.K.3
  • 25
    • 2442719040 scopus 로고    scopus 로고
    • Enhanced T cell proliferation in mice lacking the p85β subunit of phosphoinositide 3-kinase
    • Deane JA, Trifilo MJ, Yballe CM, Choi S, Lane TE, Fruman DA (2004) Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase. J Immunol 172:6615-6625 (Pubitemid 38669096)
    • (2004) Journal of Immunology , vol.172 , Issue.11 , pp. 6615-6625
    • Deane, J.A.1    Trifilo, M.J.2    Yballe, C.M.3    Choi, S.4    Lane, T.E.5    Fruman, D.A.6
  • 30
    • 37349077033 scopus 로고    scopus 로고
    • CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand
    • DOI 10.1038/ni1547, PII NI1547
    • Depoil D, Fleire S, Treanor BL, Weber M, Harwood NE, Marchbank KL, Tybulewicz VL, Batista FD (2008) CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. Nat Immunol 9:63-72 (Pubitemid 350286205)
    • (2008) Nature Immunology , vol.9 , Issue.1 , pp. 63-72
    • Depoil, D.1    Fleire, S.2    Treanor, B.L.3    Weber, M.4    Harwood, N.E.5    Marchbank, K.L.6    Tybulewicz, V.L.J.7    Batista, F.D.8
  • 33
    • 35348852627 scopus 로고    scopus 로고
    • Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli
    • DOI 10.1002/eji.200737281
    • Donahue AC, Fruman DA (2007) Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli. Eur J Immunol 37:2923-2936 (Pubitemid 47578311)
    • (2007) European Journal of Immunology , vol.37 , Issue.10 , pp. 2923-2936
    • Donahue, A.C.1    Fruman, D.A.2
  • 34
    • 10844255780 scopus 로고    scopus 로고
    • Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85α
    • DOI 10.1093/intimm/dxh180
    • Donahue AC, Hess KL, Ng KL, Fruman DA (2004) Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha. Int Immunol 16:1789-1798 (Pubitemid 40003867)
    • (2004) International Immunology , vol.16 , Issue.12 , pp. 1789-1798
    • Donahue, A.C.1    Hess, K.L.2    Ng, K.L.3    Fruman, D.A.4
  • 35
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    • Dong H, Zhu G, Tamada K, Chen L (1999) B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 5:1365-1369
    • (1999) Nat Med , vol.5 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3    Chen, L.4
  • 36
    • 33744462050 scopus 로고    scopus 로고
    • Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: Role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth
    • DOI 10.1182/blood-2005-12-4788
    • Doughty CA, Bleiman BF, Wagner DJ, Dufort FJ, Mataraza JM, Roberts MF, Chiles TC (2006) Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 107:4458-4465 (Pubitemid 43801373)
    • (2006) Blood , vol.107 , Issue.11 , pp. 4458-4465
    • Doughty, C.A.1    Bleiman, B.F.2    Wagner, D.J.3    Dufort, F.J.4    Mataraza, J.M.5    Roberts, M.F.6    Chiles, T.C.7
  • 37
    • 2542490265 scopus 로고    scopus 로고
    • B lymphocyte depletion therapy with rituximab in rheumatoid arthritis
    • DOI 10.1016/j.rdc.2004.01.006, PII S0889857X04000201
    • Edwards JC, Leandro MJ, Cambridge G (2004) B lymphocyte depletion therapy with rituximab in rheumatoid arthritis. Rheum Dis Clin North Am 30:393-403, viii (Pubitemid 38692569)
    • (2004) Rheumatic Disease Clinics of North America , vol.30 , Issue.2 , pp. 393-403
    • Edwards, J.C.W.1    Leandro, M.J.2    Cambridge, G.3
  • 38
    • 15444369929 scopus 로고    scopus 로고
    • Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control
    • Fabre S, Lang V, Harriague J, Jobart A, Unterman TG, Trautmann A, Bismuth G (2005) Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control. J Immunol 174:4161-4171 (Pubitemid 40395994)
    • (2005) Journal of Immunology , vol.174 , Issue.7 , pp. 4161-4171
    • Fabre, S.1    Lang, V.2    Harriague, J.3    Jobart, A.4    Unterman, T.G.5    Trautmann, A.6    Bismuth, G.7
  • 41
    • 47249153519 scopus 로고    scopus 로고
    • Role of cytokines in rheumatoid arthritis: An education in pathophysiology and therapeutics
    • DOI 10.1111/j.1600-065X.2008.00626.x
    • Feldmann M, Maini SR (2008) Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics. Immunol Rev 223:7-19 (Pubitemid 351986171)
    • (2008) Immunological Reviews , vol.223 , Issue.1 , pp. 7-19
    • Feldmann, M.1    Maini, S.R.N.2
  • 42
    • 70449471819 scopus 로고    scopus 로고
    • Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes
    • Finlay DK, Sinclair LV, Feijoo C, Waugh CM, Hagenbeek TJ, Spits H, Cantrell DA (2009) Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes. J Exp Med 206:2441-2454
    • (2009) J Exp Med , vol.206 , pp. 2441-2454
    • Finlay, D.K.1    Sinclair, L.V.2    Feijoo, C.3    Waugh, C.M.4    Hagenbeek, T.J.5    Spits, H.6    Cantrell, D.A.7
  • 45
    • 13244278180 scopus 로고    scopus 로고
    • The Pim kinases control rapamycin-resistant T cell survival and activation
    • DOI 10.1084/jem.20042020
    • Fox CJ, Hammerman PS, Thompson CB (2005) The Pim kinases control rapamycin-resistant T cell survival and activation. J Exp Med 201:259-266 (Pubitemid 40189435)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.2 , pp. 259-266
    • Fox, C.J.1    Hammerman, P.S.2    Thompson, C.B.3
  • 47
    • 61849126233 scopus 로고    scopus 로고
    • Fine tuning the immune response with PI3K
    • Fruman DA, Bismuth G (2009) Fine tuning the immune response with PI3K. Immunol Rev 228:253-272
    • (2009) Immunol Rev , vol.228 , pp. 253-272
    • Fruman, D.A.1    Bismuth, G.2
  • 49
    • 0033712984 scopus 로고    scopus 로고
    • Xid-like phenotypes: A B cell signalosome takes shape
    • Fruman DA, Satterthwaite AB, Witte ON (2000) Xid-like phenotypes: a B cell signalosome takes shape. Immunity 13:1-3
    • (2000) Immunity , vol.13 , pp. 1-3
    • Fruman, D.A.1    Satterthwaite, A.B.2    Witte, O.N.3
  • 51
    • 38949150779 scopus 로고    scopus 로고
    • CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer
    • DOI 10.1182/blood-2007-08-108050
    • Garcon F, Patton DT, Emery JL, Hirsch E, Rottapel R, Sasaki T, Okkenhaug K (2008) CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood 111:1464-1471 (Pubitemid 351213434)
    • (2008) Blood , vol.111 , Issue.3 , pp. 1464-1471
    • Garcon, F.1    Patton, D.T.2    Emery, J.L.3    Hirsch, E.4    Rottapel, R.5    Sasaki, T.6    Okkenhaug, K.7
  • 52
    • 73949090666 scopus 로고    scopus 로고
    • Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase
    • Gigoux M, Shang J, Pak Y, Xu M, Choe J, Mak TW, Suh WK (2009) Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. Proc Natl Acad Sci USA 106:20371-20376
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20371-20376
    • Gigoux, M.1    Shang, J.2    Pak, Y.3    Xu, M.4    Choe, J.5    Mak, T.W.6    Suh, W.K.7
  • 54
    • 33645733203 scopus 로고    scopus 로고
    • Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation
    • author reply 55
    • Gruber T, Freeley M, Thuille N, Heit I, Shaw S, Long A, Baier G (2006) Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation". Science 312:55, author reply 55
    • (2006) Science , vol.312 , pp. 55
    • Gruber, T.1    Freeley, M.2    Thuille, N.3    Heit, I.4    Shaw, S.5    Long, A.6    Baier, G.7
  • 55
    • 53349143413 scopus 로고    scopus 로고
    • The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation
    • Guo H, Samarakoon A, Vanhaesebroeck B, Malarkannan S (2008) The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation. J Exp Med 205:2419-2435
    • (2008) J Exp Med , vol.205 , pp. 2419-2435
    • Guo, H.1    Samarakoon, A.2    Vanhaesebroeck, B.3    Malarkannan, S.4
  • 57
    • 34250205544 scopus 로고    scopus 로고
    • The protean nature of cells in the B lymphocyte lineage
    • DOI 10.1016/j.immuni.2007.05.013, PII S1074761307002932
    • Hardy RR, Kincade PW, Dorshkind K (2007) The protean nature of cells in the B lymphocyte lineage. Immunity 26:703-714 (Pubitemid 46907671)
    • (2007) Immunity , vol.26 , Issue.6 , pp. 703-714
    • Hardy, R.R.1    Kincade, P.W.2    Dorshkind, K.3
  • 59
    • 59749099913 scopus 로고    scopus 로고
    • B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta
    • Henley T, Kovesdi D, Turner M (2008) B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta. Eur J Immunol 38:3543-3548
    • (2008) Eur J Immunol , vol.38 , pp. 3543-3548
    • Henley, T.1    Kovesdi, D.2    Turner, M.3
  • 60
    • 44049101651 scopus 로고    scopus 로고
    • SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway
    • DOI 10.1038/ni.1616, PII NI.1616
    • Herzog S, Hug E, Meixlsperger S, Paik JH, DePinho RA, Reth M, Jumaa H (2008) SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat Immunol 9:623-631 (Pubitemid 351712633)
    • (2008) Nature Immunology , vol.9 , Issue.6 , pp. 623-631
    • Herzog, S.1    Hug, E.2    Meixlsperger, S.3    Paik, J.-H.4    DePinho, R.A.5    Reth, M.6    Jumaa, H.7
  • 61
    • 61349179407 scopus 로고    scopus 로고
    • Regulation of B-cell proliferation and differentiation by pre-Bcell receptor signalling
    • Herzog S, Reth M, Jumaa H (2009) Regulation of B-cell proliferation and differentiation by pre-Bcell receptor signalling. Nat Rev Immunol 9:195-205
    • (2009) Nat Rev Immunol , vol.9 , pp. 195-205
    • Herzog, S.1    Reth, M.2    Jumaa, H.3
  • 62
    • 9244263536 scopus 로고    scopus 로고
    • Frontline: The p85α isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses
    • DOI 10.1002/eji.200425326
    • Hess KL, Donahue AC, Ng KL, Moore TI, Oak J, Fruman DA (2004) Frontline: the p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses. Eur J Immunol 34:2968-2976 (Pubitemid 39549376)
    • (2004) European Journal of Immunology , vol.34 , Issue.11 , pp. 2968-2976
    • Hess, K.L.1    Donahue, A.C.2    Ng, K.L.3    Moore, T.I.4    Oak, J.5    Fruman, D.A.6
  • 63
    • 2442681621 scopus 로고    scopus 로고
    • The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development
    • DOI 10.1038/ni1062
    • Hinton HJ, Alessi DR, Cantrell DA (2004) The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development. Nat Immunol 5:539-545 (Pubitemid 38660467)
    • (2004) Nature Immunology , vol.5 , Issue.5 , pp. 539-545
    • Hinton, H.J.1    Alessi, D.R.2    Cantrell, D.A.3
  • 67
    • 65749103989 scopus 로고    scopus 로고
    • Regulatory lymphocytes and intestinal inflammation
    • Izcue A, Coombes JL, Powrie F (2009) Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 27:313-338
    • (2009) Annu Rev Immunol , vol.27 , pp. 313-338
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 68
    • 17144422830 scopus 로고    scopus 로고
    • Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002
    • DOI 10.1074/jbc.M413155200
    • Jacobs MD, Black J, Futer O, Swenson L, Hare B, Fleming M, Saxena K (2005) Pim-1 ligandbound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002. J Biol Chem 280:13728-13734 (Pubitemid 40517268)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.14 , pp. 13728-13734
    • Jacobs, M.D.1    Black, J.2    Futer, O.3    Swenson, L.4    Hare, B.5    Fleming, M.6    Saxena, K.7
  • 70
    • 76149086153 scopus 로고    scopus 로고
    • Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4
    • Janas ML, Varano G, Gudmundsson K, Noda M, Nagasawa T, Turner M (2010) Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4. J Exp Med 207(247-261):S241-S242
    • (2010) J Exp Med , vol.207 , Issue.247-261
    • Janas, M.L.1    Varano, G.2    Gudmundsson, K.3    Noda, M.4    Nagasawa, T.5    Turner, M.6
  • 74
    • 0037695593 scopus 로고    scopus 로고
    • Essential, nonredundant role for the phosphoinositide 3-kinase p110δ in signaling by the B-cell receptor complex
    • DOI 10.1128/MCB.22.24.8580-8591.2002
    • Jou ST, Carpino N, Takahashi Y, Piekorz R, Chao JR, Carpino N, Wang D, Ihle JN (2002) Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol 22:8580-8591 (Pubitemid 35397173)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.24 , pp. 8580-8591
    • Jou, S.-T.1    Carpino, N.2    Takahashi, Y.3    Piekorz, R.4    Chao, J.-R.5    Carpino, N.6    Wang, D.7    Ihle, J.N.8
  • 76
    • 0036316344 scopus 로고    scopus 로고
    • Akt-dependent phosphorylation specifically regulates Cot induction of NF-κB-dependent transcription
    • DOI 10.1128/MCB.22.16.5962-5974.2002
    • Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A (2002) Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Mol Cell Biol 22:5962-5974 (Pubitemid 34815843)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.16 , pp. 5962-5974
    • Kane, L.P.1    Mollenauer, M.N.2    Xu, Z.3    Turck, C.W.4    Weiss, A.5
  • 77
    • 34547208593 scopus 로고    scopus 로고
    • Notch-induced T cell development requires phosphoinositide-dependent kinase 1
    • DOI 10.1038/sj.emboj.7601761, PII 7601761
    • Kelly AP, Finlay DK, Hinton HJ, Clarke RG, Fiorini E, Radtke F, Cantrell DA (2007) Notchinduced T cell development requires phosphoinositide-dependent kinase 1. EMBO J 26: 3441-3450 (Pubitemid 47123527)
    • (2007) EMBO Journal , vol.26 , Issue.14 , pp. 3441-3450
    • Kelly, A.P.1    Finlay, D.K.2    Hinton, H.J.3    Clarke, R.G.4    Fiorini, E.5    Radtke, F.6    Cantrell, D.A.7
  • 79
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • DOI 10.1038/ni1428, PII NI1428
    • Kim JM, Rasmussen JP, Rudensky AY (2007a) Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 8:191-197 (Pubitemid 46152650)
    • (2007) Nature Immunology , vol.8 , Issue.2 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 80
    • 36148992966 scopus 로고    scopus 로고
    • The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion
    • DOI 10.1182/blood-2007-02-075366
    • Kim N, Saudemont A, Webb L, Camps M, Ruckle T, Hirsch E, Turner M, Colucci F (2007b) The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion. Blood 110:3202-3208 (Pubitemid 350106312)
    • (2007) Blood , vol.110 , Issue.9 , pp. 3202-3208
    • Kim, N.1    Saudemont, A.2    Webb, L.3    Camps, M.4    Ruckle, T.5    Hirsch, E.6    Turner, M.7    Colucci, F.8
  • 83
    • 33747150625 scopus 로고    scopus 로고
    • CXCR4 physically associates with the T cell receptor to signal in T cells
    • DOI 10.1016/j.immuni.2006.06.015, PII S1074761306003529
    • Kumar A, Humphreys TD, Kremer KN, Bramati PS, Bradfield L, Edgar CE, Hedin KE (2006) CXCR4 physically associates with the T cell receptor to signal in T cells. Immunity 25: 213-224 (Pubitemid 44224150)
    • (2006) Immunity , vol.25 , Issue.2 , pp. 213-224
    • Kumar, A.1    Humphreys, T.D.2    Kremer, K.N.3    Bramati, P.S.4    Bradfield, L.5    Edgar, C.E.6    Hedin, K.E.7
  • 84
    • 15944410614 scopus 로고    scopus 로고
    • PDK1 nucleates T cell receptor-induced signaling complex for NF-κB activation
    • DOI 10.1126/science.1107107
    • Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S (2005) PDK1 nucleates T cell receptorinduced signaling complex for NF-kappaB activation. Science 308:114-118 (Pubitemid 40471010)
    • (2005) Science , vol.308 , Issue.5718 , pp. 114-118
    • Lee, K.-Y.1    D'Acquisto, F.2    Hayden, M.S.3    Shim, J.-H.4    Ghosh, S.5
  • 85
    • 33645827963 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase δ attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
    • DOI 10.1096/fj.05-5045com
    • Lee KS, Lee HK, Hayflick JS, Lee YC, Puri KD (2006) Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB J 20:455-465 (Pubitemid 44933322)
    • (2006) FASEB Journal , vol.20 , Issue.3 , pp. 455-465
    • Lee, K.S.1    Lee, H.K.2    Hayflick, J.S.3    Lee, Y.C.4    Puri, K.D.5
  • 86
    • 48449086316 scopus 로고    scopus 로고
    • TGF-beta: A master of all T cell trades
    • Li MO, Flavell RA (2008) TGF-beta: a master of all T cell trades. Cell 134:392-404
    • (2008) Cell , vol.134 , pp. 392-404
    • Li, M.O.1    Flavell, R.A.2
  • 87
    • 0034635221 scopus 로고    scopus 로고
    • Roles of PLC-β2 and -β3 and PI3kγ in chemoattractant- mediated signal transduction
    • DOI 10.1126/science.287.5455.1046
    • Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, Wu D (2000) Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 287:1046-1049 (Pubitemid 30094361)
    • (2000) Science , vol.287 , Issue.5455 , pp. 1046-1049
    • Li, Z.1    Jiang, H.2    Xie, W.3    Zhang, Z.4    Smrcka, A.V.5    Wu, D.6
  • 88
    • 4143129696 scopus 로고    scopus 로고
    • Regulation of NF-κB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a
    • DOI 10.1016/j.immuni.2004.06.016, PII S1074761304002055
    • Lin L, Hron JD, Peng SL (2004) Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity 21:203-213 (Pubitemid 39094050)
    • (2004) Immunity , vol.21 , Issue.2 , pp. 203-213
    • Lin, L.1    Hron, J.D.2    Peng, S.L.3
  • 90
    • 68149100422 scopus 로고    scopus 로고
    • The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells
    • Liu D, Zhang T, Marshall AJ, Okkenhaug K, Vanhaesebroeck B, Uzonna JE (2009) The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells. J Immunol 183:1921-1933
    • (2009) J Immunol , vol.183 , pp. 1921-1933
    • Liu, D.1    Zhang, T.2    Marshall, A.J.3    Okkenhaug, K.4    Vanhaesebroeck, B.5    Uzonna, J.E.6
  • 91
    • 33846895443 scopus 로고    scopus 로고
    • Cutting edge: The PI3K p110δ is required for down-regulation of RAG expression in immature B cells
    • Llorian M, Stamataki Z, Hill S, Turner M, Martensson IL (2007) The PI3K p110delta is required for down-regulation of RAG expression in immature B cells. J Immunol 178:1981-1985 (Pubitemid 46233393)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 1981-1985
    • Llorian, M.1    Stamataki, Z.2    Hill, S.3    Turner, M.4    Martensson, I.-L.5
  • 94
    • 42149156057 scopus 로고    scopus 로고
    • Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase
    • Martin AL, Schwartz MD, Jameson SC, Shimizu Y (2008) Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase. J Immunol 180:2081-2088
    • (2008) J Immunol , vol.180 , pp. 2081-2088
    • Martin, A.L.1    Schwartz, M.D.2    Jameson, S.C.3    Shimizu, Y.4
  • 95
    • 34848887428 scopus 로고    scopus 로고
    • Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node
    • Matheu MP, Deane JA, Parker I, Fruman DA, Cahalan MD (2007) Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. J Immunol 179:2261-2269
    • (2007) J Immunol , vol.179 , pp. 2261-2269
    • Matheu, M.P.1    Deane, J.A.2    Parker, I.3    Fruman, D.A.4    Cahalan, M.D.5
  • 96
    • 33947599936 scopus 로고    scopus 로고
    • Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28
    • DOI 10.1182/blood-2006-10-050724
    • Mirenda V, Jarmin SJ, David R, Dyson J, Scott D, Gu Y, Lechler RI, Okkenhaug K, Marelli-Berg FM (2007) Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28. Blood 109:2968-2977 (Pubitemid 46482095)
    • (2007) Blood , vol.109 , Issue.7 , pp. 2968-2977
    • Mirenda, V.1    Jarmin, S.J.2    David, R.3    Dyson, J.4    Scott, D.5    Gu, Y.6    Lechler, R.I.7    Okkenhaug, K.8    Marelli-Berg, F.M.9
  • 98
    • 33644772836 scopus 로고    scopus 로고
    • CARMA1 is required for Akt-mediated NF-κB activation in T cells
    • DOI 10.1128/MCB.26.6.2327-2336.2006
    • Narayan P, Holt B, Tosti R, Kane LP (2006) CARMA1 is required for Akt-mediated NF-kappaB activation in T cells. Mol Cell Biol 26:2327-2336 (Pubitemid 43346932)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.6 , pp. 2327-2336
    • Narayan, P.1    Holt, B.2    Tosti, R.3    Kane, L.P.4
  • 103
    • 70749116852 scopus 로고    scopus 로고
    • The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells
    • Oak JS, Chen J, Peralta RQ, Deane JA, Fruman DA (2009) The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells. Autoimmunity 442:447-458
    • (2009) Autoimmunity , vol.442 , pp. 447-458
    • Oak, J.S.1    Chen, J.2    Peralta, R.Q.3    Deane, J.A.4    Fruman, D.A.5
  • 106
    • 33749515632 scopus 로고    scopus 로고
    • The p110δ isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells
    • Okkenhaug K, Patton DT, Bilancio A, Garcon F, Rowan WC, Vanhaesebroeck B (2006) The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells. J Immunol 177:5122-5128 (Pubitemid 44527583)
    • (2006) Journal of Immunology , vol.177 , Issue.8 , pp. 5122-5128
    • Okkenhaug, K.1    Patton, D.T.2    Bilancio, A.3    Garcon, F.4    Rowan, W.C.5    Vanhaesebroeck, B.6
  • 107
    • 33846621025 scopus 로고    scopus 로고
    • Antigen receptor signalling: A distinctive role for the p110δ isoform of PI3K
    • DOI 10.1016/j.it.2006.12.007, PII S147149060600353X
    • Okkenhaug K, Ali K, Vanhaesebroeck B (2007) Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K. Trends Immunol 28:80-87 (Pubitemid 46176736)
    • (2007) Trends in Immunology , vol.28 , Issue.2 , pp. 80-87
    • Okkenhaug, K.1    Ali, K.2    Vanhaesebroeck, B.3
  • 108
    • 33749685322 scopus 로고    scopus 로고
    • Regulation of Class-Switch Recombination and Plasma Cell Differentiation by Phosphatidylinositol 3-Kinase Signaling
    • DOI 10.1016/j.immuni.2006.08.015, PII S1074761306004249
    • Omori SA, Cato MH, Anzelon-Mills A, Puri KD, Shapiro-Shelef M, Calame K, Rickert RC (2006) Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling. Immunity 25:545-557 (Pubitemid 44550181)
    • (2006) Immunity , vol.25 , Issue.4 , pp. 545-557
    • Omori, S.A.1    Cato, M.H.2    Anzelon-Mills, A.3    Puri, K.D.4    Shapiro-Shelef, M.5    Calame, K.6    Rickert, R.C.7
  • 109
    • 62049086102 scopus 로고    scopus 로고
    • An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance
    • Ouyang W, Beckett O, Flavell RA, Li MO (2009) An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity 30:358-371
    • (2009) Immunity , vol.30 , pp. 358-371
    • Ouyang, W.1    Beckett, O.2    Flavell, R.A.3    Li, M.O.4
  • 111
    • 58549094896 scopus 로고    scopus 로고
    • The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells
    • Park SG, Schulze-Luehrman J, Hayden MS, Hashimoto N, Ogawa W, Kasuga M, Ghosh S (2009) The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells. Nat Immunol 10:158-166
    • (2009) Nat Immunol , vol.10 , pp. 158-166
    • Park, S.G.1    Schulze-Luehrman, J.2    Hayden, M.S.3    Hashimoto, N.4    Ogawa, W.5    Kasuga, M.6    Ghosh, S.7
  • 112
    • 0038545370 scopus 로고    scopus 로고
    • L, and IL-2 expression in primary human CD4 T lymphocytes
    • Parry RV, Rumbley CA, Vandenberghe LH, June CH, Riley JL (2003) CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary human CD4 T lymphocytes. J Immunol 171:166-174 (Pubitemid 36745285)
    • (2003) Journal of Immunology , vol.171 , Issue.1 , pp. 166-174
    • Parry, R.V.1    Rumbley, C.A.2    Vandenberghe, L.H.3    June, C.H.4    Riley, J.L.5
  • 113
    • 75349096225 scopus 로고    scopus 로고
    • Fine tuning T lymphocytes: A role for the lipid phosphatase SHIP-1
    • Parry RV, Harris SJ, Ward SG (2010) Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1. Biochim Biophys Acta 1804:592-597
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 592-597
    • Parry, R.V.1    Harris, S.J.2    Ward, S.G.3
  • 115
    • 0035193064 scopus 로고    scopus 로고
    • Visualization of negative signaling in B cells by quantitative confocal microscopy
    • DOI 10.1128/MCB.21.24.8615-8625.2001
    • Phee H, Rodgers W, Coggeshall KM (2001) Visualization of negative signaling in B cells by quantitative confocal microscopy. Mol Cell Biol 21:8615-8625 (Pubitemid 33108618)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.24 , pp. 8615-8625
    • Phee, H.1    Rodgers, W.2    Coggeshall, K.M.3
  • 116
    • 77953008362 scopus 로고    scopus 로고
    • Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation
    • Pierau M, Engelmann S, Reinhold D, Lapp T, Schraven B, Bommhardt UH (2009) Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation. J Immunol 183:6124-6134
    • (2009) J Immunol , vol.183 , pp. 6124-6134
    • Pierau, M.1    Engelmann, S.2    Reinhold, D.3    Lapp, T.4    Schraven, B.5    Bommhardt, U.H.6
  • 117
    • 47049113462 scopus 로고    scopus 로고
    • Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils
    • Randis TM, Puri KD, Zhou H, Diacovo TG (2008) Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils. Eur J Immunol 38: 1215-1224
    • (2008) Eur J Immunol , vol.38 , pp. 1215-1224
    • Randis, T.M.1    Puri, K.D.2    Zhou, H.3    Diacovo, T.G.4
  • 118
    • 4043082729 scopus 로고    scopus 로고
    • Cuttin edge: Differential roles for phosphoinositide 3-kinases, p110γ and p110δ, lymphocyte chemotaxis and homing
    • Reif K, Okkenhaug K, Sasaki T, Penninger JM, Vanhaesebroeck B, Cyster JG (2004) Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol 173:2236-2240 (Pubitemid 39063077)
    • (2004) Journal of Immunology , vol.173 , Issue.4 , pp. 2236-2240
    • Reif, K.1    Okkenhaug, K.2    Sasaki, T.3    Penninger, J.M.4    Vanhaesebroeck, B.5    Cyster, J.G.6
  • 120
    • 79952109738 scopus 로고    scopus 로고
    • Comparing the roles of the p110a and p110b isoforms of PI3K in signaling and cancer
    • doi 10.1007/82-2010-63
    • Roberts TM, Ilić N (2010) Comparing the roles of the p110a and p110b isoforms of PI3K in signaling and cancer. Curr Top Microbiol Immunol doi 10.1007/82-2010-63
    • (2010) Curr Top Microbiol Immunol
    • Roberts, T.M.1    Ilić, N.2
  • 122
    • 33847239467 scopus 로고    scopus 로고
    • PI3K delta and PI3K gamma: Partners in crime in inflammation in rheumatoid arthritis and beyond?
    • Rommel C, Camps M, Ji H (2007) PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat Rev Immunol 7:191-201
    • (2007) Nat Rev Immunol , vol.7 , pp. 191-201
    • Rommel, C.1    Camps, M.2    Ji, H.3
  • 123
    • 33750525089 scopus 로고    scopus 로고
    • PI3Kgamma inhibition: Towards an 'aspirin of the 21st century'?
    • Ruckle T, Schwarz MK, Rommel C (2006) PI3Kgamma inhibition: towards an 'aspirin of the 21st century'? Nat Rev Drug Discov 5:903-918
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 903-918
    • Ruckle, T.1    Schwarz, M.K.2    Rommel, C.3
  • 124
    • 0142259712 scopus 로고    scopus 로고
    • Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
    • DOI 10.1038/nri1131
    • Rudd CE, Schneider H (2003) Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat Rev Immunol 3:544-556 (Pubitemid 37328674)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.7 , pp. 544-556
    • Rudd, C.E.1    Schneider, H.2
  • 125
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • DOI 10.1016/j.cell.2008.05.009, PII S0092867408006247
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M (2008) Regulatory T cells and immune tolerance. Cell 133:775-787 (Pubitemid 351707693)
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 126
    • 10344237020 scopus 로고    scopus 로고
    • Cutting edge: CD28-mediated transcriptional and posttranscriptional regulation of IL-2 expression are controlled through different signalling pathways
    • Sanchez-Lockhart M, Marin E, Graf B, Abe R, Harada Y, Sedwick CE, Miller J (2004) Cutting edge: CD28-mediated transcriptional and posttranscriptional regulation of IL-2 expression are controlled through different signaling pathways. J Immunol 173:7120-7124 (Pubitemid 39628145)
    • (2004) Journal of Immunology , vol.173 , Issue.12 , pp. 7120-7124
    • Sanchez-Lockhart, M.1    Marin, E.2    Graf, B.3    Abe, R.4    Harada, Y.5    Sedwick, C.E.6    Miller, J.7
  • 127
    • 71849111698 scopus 로고    scopus 로고
    • Signals and sequences that control CD28 localization to the central region of the immunological synapse
    • Sanchez-Lockhart M, Graf B, Miller J (2008) Signals and sequences that control CD28 localization to the central region of the immunological synapse. J Immunol 181:7639-7648
    • (2008) J Immunol , vol.181 , pp. 7639-7648
    • Sanchez-Lockhart, M.1    Graf, B.2    Miller, J.3
  • 132
    • 33846228444 scopus 로고    scopus 로고
    • Antigen-Receptor Signaling to Nuclear Factor κB
    • DOI 10.1016/j.immuni.2006.10.010, PII S1074761306004821
    • Schulze-Luehrmann J, Ghosh S (2006) Antigen-receptor signaling to nuclear factor kappa B. Immunity 25:701-715 (Pubitemid 46107295)
    • (2006) Immunity , vol.25 , Issue.5 , pp. 701-715
    • Schulze-Luehrmann, J.1    Ghosh, S.2
  • 133
    • 39449087305 scopus 로고    scopus 로고
    • Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns
    • DOI 10.1038/ni1565, PII NI1565
    • Sebzda E, Zou Z, Lee JS, Wang T, Kahn ML (2008) Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Nat Immunol 9:292-300 (Pubitemid 351267326)
    • (2008) Nature Immunology , vol.9 , Issue.3 , pp. 292-300
    • Sebzda, E.1    Zou, Z.2    Lee, J.S.3    Wang, T.4    Kahn, M.L.5
  • 134
    • 33846513615 scopus 로고    scopus 로고
    • The p85α regulatory subunit of class IA phosphoinositide 3-kinase regulates β-selection in thymocyte development
    • Shiroki F, Matsuda S, Doi T, Fujiwara M, Mochizuki Y, Kadowaki T, Suzuki H, Koyasu S (2007) The p85alpha regulatory subunit of class IA phosphoinositide 3-kinase regulates beta-selection in thymocyte development. J Immunol 178:1349-1356 (Pubitemid 46154604)
    • (2007) Journal of Immunology , vol.178 , Issue.3 , pp. 1349-1356
    • Shiroki, F.1    Matsuda, S.2    Doi, T.3    Fujiwara, M.4    Mochizuki, Y.5    Kadowaki, T.6    Suzuki, H.7    Koyasu, S.8
  • 140
    • 0033555829 scopus 로고    scopus 로고
    • Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
    • Suzuki H, Terauchi Y, Fujiwara M, Aizawa S, Yazaki Y, Kadowaki T, Koyasu S (1999) Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science 283:390-392
    • (1999) Science , vol.283 , pp. 390-392
    • Suzuki, H.1    Terauchi, Y.2    Fujiwara, M.3    Aizawa, S.4    Yazaki, Y.5    Kadowaki, T.6    Koyasu, S.7
  • 142
    • 33644765808 scopus 로고    scopus 로고
    • Essential role of PI3Kδ and PI3Kγ in thymocyte survival
    • DOI 10.1182/blood-2005-08-3300
    • Swat W, Montgrain V, Doggett TA, Douangpanya J, Puri K, Vermi W, Diacovo TG (2006) Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival. Blood 107:2415-2422 (Pubitemid 43345562)
    • (2006) Blood , vol.107 , Issue.6 , pp. 2415-2422
    • Swat, W.1    Montgrain, V.2    Doggett, T.A.3    Douangpanya, J.4    Puri, K.5    Vermi, W.6    Diacovo, T.G.7
  • 143
    • 34548303252 scopus 로고    scopus 로고
    • FcγRIIB as a modulator of autoimmune disease susceptibility
    • DOI 10.1080/08916930701464665, PII 781664210, Signal Transduction
    • Tarasenko T, Dean JA, Bolland S (2007a) FcgammaRIIB as a modulator of autoimmune disease susceptibility. Autoimmunity 40:409-417 (Pubitemid 47343352)
    • (2007) Autoimmunity , vol.40 , Issue.6 , pp. 409-417
    • Tarasenko, T.1    Dean, J.A.2    Bolland, S.3
  • 145
    • 34548039233 scopus 로고    scopus 로고
    • P110γ and p110δ Phosphoinositide 3-Kinase Signaling Pathways Synergize to Control Development and Functions of Murine NK Cells
    • DOI 10.1016/j.immuni.2007.07.014, PII S1074761307003792
    • Tassi I, Cella M, Gilfillan S, Turnbull I, Diacovo TG, Penninger JM, Colonna M (2007) p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells. Immunity 27:214-227 (Pubitemid 47284932)
    • (2007) Immunity , vol.27 , Issue.2 , pp. 214-227
    • Tassi, I.1    Cella, M.2    Gilfillan, S.3    Turnbull, I.4    Diacovo, T.G.5    Penninger, J.M.6    Colonna, M.7
  • 146
    • 50849122062 scopus 로고    scopus 로고
    • The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites
    • Thomas MS, Mitchell JS, DeNucci CC, Martin AL, Shimizu Y (2008) The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites. J Leukoc Biol 84:814-823
    • (2008) J Leukoc Biol , vol.84 , pp. 814-823
    • Thomas, M.S.1    Mitchell, J.S.2    DeNucci, C.C.3    Martin, A.L.4    Shimizu, Y.5
  • 147
    • 2442612540 scopus 로고    scopus 로고
    • CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
    • ThomeM(2004) CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat Rev Immunol 4:348-359 (Pubitemid 38649277)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.5 , pp. 348-359
    • Thome, M.1
  • 150
    • 34248216554 scopus 로고    scopus 로고
    • Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection
    • Verkoczy L, Duong B, Skog P, Ait-Azzouzene D, Puri K, Vela JL, Nemazee D (2007) Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cellpositive selection. J Immunol 178:6332-6341 (Pubitemid 46717417)
    • (2007) Journal of Immunology , vol.178 , Issue.10 , pp. 6332-6341
    • Verkoczy, L.1    Duong, B.2    Skog, P.3    Ait-Azzouzene, D.4    Puri, K.5    Vela, J.L.6    Nemazee, D.7
  • 151
    • 4344671730 scopus 로고    scopus 로고
    • Vav-dependent and Vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus
    • Vigorito E, Bardi G, Glassford J, Lam EW, Clayton E, Turner M (2004) Vav-dependent and vavindependent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus. J Immunol 173:3209-3214 (Pubitemid 39142028)
    • (2004) Journal of Immunology , vol.173 , Issue.5 , pp. 3209-3214
    • Vigorito, E.1    Bardi, G.2    Glassford, J.3    Lam, E.W.-F.4    Clayton, E.5    Turner, M.6
  • 152
    • 0033105611 scopus 로고    scopus 로고
    • Regulation of B cell receptor-mediated MHC class II antigen processing by FcγRIIB1
    • Wagle NM, Faassen AE, Kim JH, Pierce SK (1999) Regulation of B cell receptor-mediated MHC class II antigen processing by FcgammaRIIB1. J Immunol 162:2732-2740 (Pubitemid 29309296)
    • (1999) Journal of Immunology , vol.162 , Issue.5 , pp. 2732-2740
    • Wagle, N.M.1    Faassen, A.E.2    Kim, J.H.3    Pierce, S.K.4
  • 155
    • 70350523607 scopus 로고    scopus 로고
    • Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide- dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation
    • Waugh C, Sinclair L, Finlay D, Bayascas JR, Cantrell D (2009) Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation. Mol Cell Biol 29:5952-5962
    • (2009) Mol Cell Biol , vol.29 , pp. 5952-5962
    • Waugh, C.1    Sinclair, L.2    Finlay, D.3    Bayascas, J.R.4    Cantrell, D.5
  • 156
    • 23844462453 scopus 로고    scopus 로고
    • Cutting edge: T cell development requires the combined activities of the p110γ and p110δ catalytic isoforms of phosphatidylinositol 3-kinase
    • Webb LM, Vigorito E, Wymann MP, Hirsch E, TurnerM(2005) Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase. J Immunol 175:2783-2787 (Pubitemid 41170493)
    • (2005) Journal of Immunology , vol.175 , Issue.5 , pp. 2783-2787
    • Webb, L.M.C.1    Vigorito, E.2    Wymann, M.P.3    Hirsch, E.4    Turner, M.5
  • 157
    • 42249090333 scopus 로고    scopus 로고
    • Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
    • DOI 10.1084/jem.20072619
    • Weber M, Treanor B, Depoil D, Shinohara H, Harwood NE, Hikida M, Kurosaki T, Batista FD (2008) Phospholipase C-gamma2 and vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J Exp Med 205:853-868 (Pubitemid 351549883)
    • (2008) Journal of Experimental Medicine , vol.205 , Issue.4 , pp. 853-868
    • Weber, M.1    Treanor, B.2    Depoil, D.3    Shinohara, H.4    Harwood, N.E.5    Hikida, M.6    Kurosaki, T.7    Batista, F.D.8
  • 161
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • DOI 10.1038/ni1455, PII NI1455
    • Zheng Y, Rudensky AY (2007) Foxp3 in control of the regulatory T cell lineage. Nat Immunol 8:457-462 (Pubitemid 46605910)
    • (2007) Nature Immunology , vol.8 , Issue.5 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2


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