-
1
-
-
0037374815
-
The role of PI3K in immune cells
-
Koyasu S. The role of PI3K in immune cells. Nat Immunol. 4:2003;313-319
-
(2003)
Nat Immunol
, vol.4
, pp. 313-319
-
-
Koyasu, S.1
-
2
-
-
0038549067
-
PI3K in lymphocyte development, differentiation and activation
-
Okkenhaug K., Vanhaesebroeck B. PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol. 3:2003;317-330
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 317-330
-
-
Okkenhaug, K.1
Vanhaesebroeck, B.2
-
3
-
-
1342292522
-
Phosphoinositide 3-kinase: Diverse roles in immune cell activation
-
in press.
-
Deane JA, Fruman DA: Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu Rev Immunol 2004, in press.
-
(2004)
Annu Rev Immunol
-
-
Deane, J.A.1
Fruman, D.A.2
-
4
-
-
0036595050
-
T-cell signalling and autoimmunity: Molecular mechanisms of disease
-
Ohashi P.S. T-cell signalling and autoimmunity: molecular mechanisms of disease. Nat Rev Immunol. 2:2002;427-438
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 427-438
-
-
Ohashi, P.S.1
-
5
-
-
0037310664
-
Physiological functions of pten in mouse tissues
-
Kishimoto H., Hamada K., Saunders M., Backman S., Sasaki T., Nakano T., Mak T.W., Suzuki A. Physiological functions of pten in mouse tissues. Cell Struct Funct. 28:2003;11-21
-
(2003)
Cell Struct Funct
, vol.28
, pp. 11-21
-
-
Kishimoto, H.1
Hamada, K.2
Saunders, M.3
Backman, S.4
Sasaki, T.5
Nakano, T.6
Mak, T.W.7
Suzuki, A.8
-
6
-
-
0034911881
-
Synthesis and function of 3-phosphorylated inositol lipids
-
Vanhaesebroeck B., Leevers S.J., Ahmadi K., Timms J., Katso R., Driscoll P.C., Woscholski R., Parker P.J., Waterfield M.D. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem. 70:2001;535-602
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 535-602
-
-
Vanhaesebroeck, B.1
Leevers, S.J.2
Ahmadi, K.3
Timms, J.4
Katso, R.5
Driscoll, P.C.6
Woscholski, R.7
Parker, P.J.8
Waterfield, M.D.9
-
7
-
-
1342321748
-
PI3K signaling controls cell fate at many points in B lymphocyte development and activation
-
Donahue A.C., Fruman D.A. PI3K signaling controls cell fate at many points in B lymphocyte development and activation. Semin Cell Dev Biol. 15:2004;183-197
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 183-197
-
-
Donahue, A.C.1
Fruman, D.A.2
-
8
-
-
0033712984
-
Xid-like phenotypes: A B cell signalosome takes shape
-
Fruman D.A., Satterthwaite A.B., Witte O.N. Xid-like phenotypes: a B cell signalosome takes shape. Immunity. 13:2000;1-3
-
(2000)
Immunity
, vol.13
, pp. 1-3
-
-
Fruman, D.A.1
Satterthwaite, A.B.2
Witte, O.N.3
-
9
-
-
0032055476
-
Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation
-
Fluckiger A.C., Li Z., Kato R.M., Wahl M.I., Ochs H.D., Longnecker R., Kinet J.P., Witte O.N., Scharenberg A.M., Rawlings D.J. Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation. EMBO J. 17:1998;1973-1985
-
(1998)
EMBO J
, vol.17
, pp. 1973-1985
-
-
Fluckiger, A.C.1
Li, Z.2
Kato, R.M.3
Wahl, M.I.4
Ochs, H.D.5
Longnecker, R.6
Kinet, J.P.7
Witte, O.N.8
Scharenberg, A.M.9
Rawlings, D.J.10
-
10
-
-
0032055484
-
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory signals
-
Scharenberg A.M., El-Hillal O., Fruman D.A., Beitz L.O., Li Z., Lin S., Gout I., Cantley L.C., Rawlings D.J., Kinet J.P. Phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns-3, 4, 5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J. 17:1998;1961-1972
-
(1998)
EMBO J
, vol.17
, pp. 1961-1972
-
-
Scharenberg, A.M.1
El-Hillal, O.2
Fruman, D.A.3
Beitz, L.O.4
Li, Z.5
Lin, S.6
Gout, I.7
Cantley, L.C.8
Rawlings, D.J.9
Kinet, J.P.10
-
11
-
-
0028847329
-
Defective B cell development and function in Btk-deficient mice
-
Khan W.N., Alt F.W., Gerstein R.M., Malynn B.A., Larsson I., Rathbun G., Davidson L., Muller S., Kantor A.B., Herzenberg L.A., et al. Defective B cell development and function in Btk-deficient mice. Immunity. 3:1995;283-299
-
(1995)
Immunity
, vol.3
, pp. 283-299
-
-
Khan, W.N.1
Alt, F.W.2
Gerstein, R.M.3
Malynn, B.A.4
Larsson, I.5
Rathbun, G.6
Davidson, L.7
Muller, S.8
Kantor, A.B.9
Herzenberg, L.A.10
-
12
-
-
0032147181
-
Btk function in B cell development and response
-
Satterthwaite A.B., Li Z., Witte O.N. Btk function in B cell development and response. Semin Immunol. 10:1998;309-316
-
(1998)
Semin Immunol
, vol.10
, pp. 309-316
-
-
Satterthwaite, A.B.1
Li, Z.2
Witte, O.N.3
-
13
-
-
0037119630
-
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation
-
Clayton E., Bardi G., Bell S.E., Chantry D., Downes C.P., Gray A., Humphries L.A., Rawlings D., Reynolds H., Vigorito E., et al. A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med. 196:2002;753-763
-
(2002)
J Exp Med
, vol.196
, pp. 753-763
-
-
Clayton, E.1
Bardi, G.2
Bell, S.E.3
Chantry, D.4
Downes, C.P.5
Gray, A.6
Humphries, L.A.7
Rawlings, D.8
Reynolds, H.9
Vigorito, E.10
-
14
-
-
0037695593
-
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex
-
Jou S.T., Carpino N., Takahashi Y., Piekorz R., Chao J.R., Wang D., Ihle J.N. Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol. 22:2002;8580-8591
-
(2002)
Mol Cell Biol
, vol.22
, pp. 8580-8591
-
-
Jou, S.T.1
Carpino, N.2
Takahashi, Y.3
Piekorz, R.4
Chao, J.R.5
Wang, D.6
Ihle, J.N.7
-
15
-
-
0037341617
-
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction
-
The authors demonstrate that PI3K activation is not required for the phosphorylation nor activation of Btk, and propose that PI3K and Btk function independently. The data might also be consistent with PI3K regulating a kinase-independent function of Btk at the membrane.
-
Suzuki H., Matsuda S., Terauchi Y., Fujiwara M., Ohteki T., Asano T., Behrens T.W., Kouro T., Takatsu K., Kadowaki T., et al. PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction. Nat Immunol. 4:2003;280-286 The authors demonstrate that PI3K activation is not required for the phosphorylation nor activation of Btk, and propose that PI3K and Btk function independently. The data might also be consistent with PI3K regulating a kinase-independent function of Btk at the membrane.
-
(2003)
Nat Immunol
, vol.4
, pp. 280-286
-
-
Suzuki, H.1
Matsuda, S.2
Terauchi, Y.3
Fujiwara, M.4
Ohteki, T.5
Asano, T.6
Behrens, T.W.7
Kouro, T.8
Takatsu, K.9
Kadowaki, T.10
-
16
-
-
0345138995
-
BTK regulates PtdIns-4,5-P2 synthesis important for calcium signaling and PI3K activity
-
2+ flux.
-
2+ flux.
-
(2003)
Immunity
, vol.19
, pp. 669-678
-
-
Saito, K.1
Tolias, K.F.2
Saci, A.3
Koon, H.B.4
Humphries, L.A.5
Scharenberg, A.M.6
Rawlings, D.J.7
Kinet, J.P.8
Carpenter, C.L.9
-
17
-
-
0029739626
-
Immunodeficiency in protein kinase cbeta-deficient mice
-
Leitges M., Schmedt C., Guinamard R., Davoust J., Schaal S., Stabel S., Tarakhovsky A. Immunodeficiency in protein kinase cbeta-deficient mice. Science. 273:1996;788-791
-
(1996)
Science
, vol.273
, pp. 788-791
-
-
Leitges, M.1
Schmedt, C.2
Guinamard, R.3
Davoust, J.4
Schaal, S.5
Stabel, S.6
Tarakhovsky, A.7
-
18
-
-
0038671744
-
BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells
-
Glassford J., Soeiro I., Skarell S.M., Banerji L., Holman M., Klaus G.G., Kadowaki T., Koyasu S., Lam E.W. BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells. Oncogene. 22:2003;2248-2259
-
(2003)
Oncogene
, vol.22
, pp. 2248-2259
-
-
Glassford, J.1
Soeiro, I.2
Skarell, S.M.3
Banerji, L.4
Holman, M.5
Klaus, G.G.6
Kadowaki, T.7
Koyasu, S.8
Lam, E.W.9
-
19
-
-
0001766539
-
Bruton's tyrosine-kinase-deficient murine B lymphocytes fail to enter S phase when stimulated with anti-immunoglobulin plus interleukin-4
-
Forssell J., Nilsson A., Sideras P. Bruton's tyrosine-kinase-deficient murine B lymphocytes fail to enter S phase when stimulated with anti-immunoglobulin plus interleukin-4. Scand J Immunol. 49:1999;155-161
-
(1999)
Scand J Immunol
, vol.49
, pp. 155-161
-
-
Forssell, J.1
Nilsson, A.2
Sideras, P.3
-
21
-
-
0036344276
-
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
-
The authors show that PKCβ enhances NFκB activity by promoting IKKα phosphorylation and recruitment to lipid rafts.
-
Su T.T., Guo B., Kawakami Y., Sommer K., Chae K., Humphries L.A., Kato R.M., Kang S., Patrone L., Wall R., et al. PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol. 3:2002;780-786 The authors show that PKCβ enhances NFκB activity by promoting IKKα phosphorylation and recruitment to lipid rafts.
-
(2002)
Nat Immunol
, vol.3
, pp. 780-786
-
-
Su, T.T.1
Guo, B.2
Kawakami, Y.3
Sommer, K.4
Chae, K.5
Humphries, L.A.6
Kato, R.M.7
Kang, S.8
Patrone, L.9
Wall, R.10
-
22
-
-
0036928333
-
B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-kappaB regulated c-myc transcription
-
This paper shows that BCR-elicited cell-size increases are impaired in B cells lacking the NFκB components c-rel and NFκB1, or treated with PI3K inhibitors. This block in cell growth correlates with failure to upregulate the NFκB target gene c-myc.
-
Grumont R.J., Strasser A., Gerondakis S. B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-kappaB regulated c-myc transcription. Mol Cell. 10:2002;1283-1294 This paper shows that BCR-elicited cell-size increases are impaired in B cells lacking the NFκB components c-rel and NFκB1, or treated with PI3K inhibitors. This block in cell growth correlates with failure to upregulate the NFκB target gene c-myc.
-
(2002)
Mol Cell
, vol.10
, pp. 1283-1294
-
-
Grumont, R.J.1
Strasser, A.2
Gerondakis, S.3
-
23
-
-
2642617810
-
Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells
-
Solvason N., Wu W.W., Kabra N., Lund-Johansen F., Roncarolo M.G., Behrens T.W., Grillot D.A., Nunez G., Lees E., Howard M. Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells. J Exp Med. 187:1998;1081-1091
-
(1998)
J Exp Med
, vol.187
, pp. 1081-1091
-
-
Solvason, N.1
Wu, W.W.2
Kabra, N.3
Lund-Johansen, F.4
Roncarolo, M.G.5
Behrens, T.W.6
Grillot, D.A.7
Nunez, G.8
Lees, E.9
Howard, M.10
-
25
-
-
0034092567
-
Tec family kinases in lymphocyte signaling and function
-
Schaeffer E.M., Schwartzberg P.L. Tec family kinases in lymphocyte signaling and function. Curr Opin Immunol. 12:2000;282-288
-
(2000)
Curr Opin Immunol
, vol.12
, pp. 282-288
-
-
Schaeffer, E.M.1
Schwartzberg, P.L.2
-
26
-
-
10744228513
-
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP
-
Labno C.M., Lewis C.M., You D., Leung D.W., Takesono A., Kamberos N., Seth A., Finkelstein L.D., Rosen M.K., Schwartzberg P.L., et al. Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Curr Biol. 13:2003;1619-1624
-
(2003)
Curr Biol
, vol.13
, pp. 1619-1624
-
-
Labno, C.M.1
Lewis, C.M.2
You, D.3
Leung, D.W.4
Takesono, A.5
Kamberos, N.6
Seth, A.7
Finkelstein, L.D.8
Rosen, M.K.9
Schwartzberg, P.L.10
-
27
-
-
0037446773
-
Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor
-
Grasis J.A., Browne C.D., Tsoukas C.D. Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor. J Immunol. 170:2003;3971-3976
-
(2003)
J Immunol
, vol.170
, pp. 3971-3976
-
-
Grasis, J.A.1
Browne, C.D.2
Tsoukas, C.D.3
-
28
-
-
0344064944
-
Amplifying Btk's signal
-
Schwartzberg P.L. Amplifying Btk's signal. Immunity. 19:2003;634-636
-
(2003)
Immunity
, vol.19
, pp. 634-636
-
-
Schwartzberg, P.L.1
-
29
-
-
0036200194
-
Protein kinase B (Akt) regulation and function in T lymphocytes
-
Cantrell D. Protein kinase B (Akt) regulation and function in T lymphocytes. Semin Immunol. 14:2002;19-26
-
(2002)
Semin Immunol
, vol.14
, pp. 19-26
-
-
Cantrell, D.1
-
30
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I., Sawyers C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2:2002;489-501
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
31
-
-
0035846955
-
Cd19-dependent activation of Akt kinase in B-lymphocytes
-
Otero D.C., Omori S.A., Rickert R.C. Cd19-dependent activation of Akt kinase in B-lymphocytes. J Biol Chem. 276:2001;1474-1478
-
(2001)
J Biol Chem
, vol.276
, pp. 1474-1478
-
-
Otero, D.C.1
Omori, S.A.2
Rickert, R.C.3
-
32
-
-
0034658320
-
Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo
-
Jones R.G., Parsons M., Bonnard M., Chan V.S., Yeh W.C., Woodgett J.R., Ohashi P.S. Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J Exp Med. 191:2000;1721-1734
-
(2000)
J Exp Med
, vol.191
, pp. 1721-1734
-
-
Jones, R.G.1
Parsons, M.2
Bonnard, M.3
Chan, V.S.4
Yeh, W.C.5
Woodgett, J.R.6
Ohashi, P.S.7
-
33
-
-
0035399612
-
Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation
-
Parsons M.J., Jones R.G., Tsao M.S., Odermatt B., Ohashi P.S., Woodgett J.R. Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation. J Immunol. 167:2001;42-48
-
(2001)
J Immunol
, vol.167
, pp. 42-48
-
-
Parsons, M.J.1
Jones, R.G.2
Tsao, M.S.3
Odermatt, B.4
Ohashi, P.S.5
Woodgett, J.R.6
-
34
-
-
0041975825
-
Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma
-
The authors study T cells expressing membrane-targeted Akt and report similar results to those in [32], but also show increased basal size and glycolytic rate.
-
Rathmell J.C., Elstrom R.L., Cinalli R.M., Thompson C.B. Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. Eur J Immunol. 33:2003;2223-2232 The authors study T cells expressing membrane-targeted Akt and report similar results to those in [32], but also show increased basal size and glycolytic rate.
-
(2003)
Eur J Immunol
, vol.33
, pp. 2223-2232
-
-
Rathmell, J.C.1
Elstrom, R.L.2
Cinalli, R.M.3
Thompson, C.B.4
-
35
-
-
0035221568
-
Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines
-
Kane L.P., Andres P.G., Howland K.C., Abbas A.K., Weiss A. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat Immunol. 2:2001;37-44
-
(2001)
Nat Immunol
, vol.2
, pp. 37-44
-
-
Kane, L.P.1
Andres, P.G.2
Howland, K.C.3
Abbas, A.K.4
Weiss, A.5
-
36
-
-
0038578823
-
The PI-3 kinase/Akt pathway and T cell activation: Pleiotropic pathways downstream of PIP3
-
Kane L.P., Weiss A. The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunol Rev. 192:2003;7-20
-
(2003)
Immunol Rev
, vol.192
, pp. 7-20
-
-
Kane, L.P.1
Weiss, A.2
-
37
-
-
0034600901
-
Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3
-
Ohteki T., Parsons M., Zakarian A., Jones R.G., Nguyen L.T., Woodgett J.R., Ohashi P.S. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J Exp Med. 192:2000;99-104
-
(2000)
J Exp Med
, vol.192
, pp. 99-104
-
-
Ohteki, T.1
Parsons, M.2
Zakarian, A.3
Jones, R.G.4
Nguyen, L.T.5
Woodgett, J.R.6
Ohashi, P.S.7
-
38
-
-
0035554933
-
'Decisions, decisions.': Beta-catenin-mediated activation of TCF-1 and Lef-1 influences the fate of developing T cells
-
Wu L., Strasser A. 'Decisions, decisions.': beta-catenin-mediated activation of TCF-1 and Lef-1 influences the fate of developing T cells. Nat Immunol. 2:2001;823-824
-
(2001)
Nat Immunol
, vol.2
, pp. 823-824
-
-
Wu, L.1
Strasser, A.2
-
39
-
-
0346121607
-
Deletion of beta-catenin impairs T cell development
-
Xu Y., Banerjee D., Huelsken J., Birchmeier W., Sen J.M. Deletion of beta-catenin impairs T cell development. Nat Immunol. 4:2003;1177-1182
-
(2003)
Nat Immunol
, vol.4
, pp. 1177-1182
-
-
Xu, Y.1
Banerjee, D.2
Huelsken, J.3
Birchmeier, W.4
Sen, J.M.5
-
40
-
-
0036629251
-
Cell cycle and death control: Long live Forkheads
-
Burgering B.M., Kops G.J. Cell cycle and death control: long live Forkheads. Trends Biochem Sci. 27:2002;352-360
-
(2002)
Trends Biochem Sci
, vol.27
, pp. 352-360
-
-
Burgering, B.M.1
Kops, G.J.2
-
41
-
-
0037094096
-
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2
-
The authors demonstrate that FOXO1 is phosphorylated following stimulation of human T cells with anti-CD3 plus IL-2, and that expression of a PI3K/Akt-independent FOXO3a promotes cell-cycle arrest and death in an IL-2-dependent T-cell line. This paper is the first to demonstrate a function for FOXO proteins in mature nontransformed lymphocytes.
-
Stahl M., Dijkers P.F., Kops G.J., Lens S.M., Coffer P.J., Burgering B.M., Medema R.H. The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol. 168:2002;5024-5031 The authors demonstrate that FOXO1 is phosphorylated following stimulation of human T cells with anti-CD3 plus IL-2, and that expression of a PI3K/Akt-independent FOXO3a promotes cell-cycle arrest and death in an IL-2-dependent T-cell line. This paper is the first to demonstrate a function for FOXO proteins in mature nontransformed lymphocytes.
-
(2002)
J Immunol
, vol.168
, pp. 5024-5031
-
-
Stahl, M.1
Dijkers, P.F.2
Kops, G.J.3
Lens, S.M.4
Coffer, P.J.5
Burgering, B.M.6
Medema, R.H.7
-
42
-
-
2342622123
-
Optimal B cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors
-
in press.
-
Yusuf I, Zhu X, Kharas MG, Chen J, Fruman DA: Optimal B cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors. Blood 2004, in press.
-
(2004)
Blood
-
-
Yusuf, I.1
Zhu, X.2
Kharas, M.G.3
Chen, J.4
Fruman, D.A.5
-
44
-
-
0036550053
-
3′-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling
-
Storz P., Toker A. 3′-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling. Front Biosci. 7:2002;d886-d902
-
(2002)
Front Biosci
, vol.7
-
-
Storz, P.1
Toker, A.2
-
46
-
-
0036316344
-
Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription
-
The authors establish that the MAP3K family member Cot is a direct Akt substrate, and provide evidence that Cot links Akt to the NFκB pathway.
-
Kane L.P., Mollenauer M.N., Xu Z., Turck C.W., Weiss A. Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Mol Cell Biol. 22:2002;5962-5974 The authors establish that the MAP3K family member Cot is a direct Akt substrate, and provide evidence that Cot links Akt to the NFκB pathway.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5962-5974
-
-
Kane, L.P.1
Mollenauer, M.N.2
Xu, Z.3
Turck, C.W.4
Weiss, A.5
-
47
-
-
0038644122
-
Regulation of quiescence in lymphocytes
-
Yusuf I., Fruman D.A. Regulation of quiescence in lymphocytes. Trends Immunol. 24:2003;380-386
-
(2003)
Trends Immunol
, vol.24
, pp. 380-386
-
-
Yusuf, I.1
Fruman, D.A.2
-
48
-
-
0038281331
-
Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation
-
Donahue A.C., Fruman D.A. Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation. J Immunol. 170:2003;5851-5860
-
(2003)
J Immunol
, vol.170
, pp. 5851-5860
-
-
Donahue, A.C.1
Fruman, D.A.2
-
49
-
-
0036853106
-
Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse
-
3 rapidly accumulates and is sustained at the site of T-cell contact with APC. In addition, the authors show that late addition of PI3K inhibitors blocks T-cell proliferation, indicating that sustained PI3K activation is likely to be functionally important.
-
3 rapidly accumulates and is sustained at the site of T-cell contact with APC. In addition, the authors show that late addition of PI3K inhibitors blocks T-cell proliferation, indicating that sustained PI3K activation is likely to be functionally important.
-
(2002)
Nat Immunol
, vol.3
, pp. 1082-1089
-
-
Costello, P.S.1
Gallagher, M.2
Cantrell, D.A.3
-
50
-
-
0036069699
-
The CD28 signaling pathway regulates glucose metabolism
-
•].
-
•].
-
(2002)
Immunity
, vol.16
, pp. 769-777
-
-
Frauwirth, K.A.1
Riley, J.L.2
Harris, M.H.3
Parry, R.V.4
Rathmell, J.C.5
Plas, D.R.6
Elstrom, R.L.7
June, C.H.8
Thompson, C.B.9
-
51
-
-
0344927167
-
Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1
-
Niiro H., Clark E.A. Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1. Immunity. 19:2003;637-640
-
(2003)
Immunity
, vol.19
, pp. 637-640
-
-
Niiro, H.1
Clark, E.A.2
|