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Volumn 116, Issue 14, 2010, Pages 2513-2521

Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

4,5,6,7 TETRABROMO 1H BENZOTRIAZOLE; 5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; APIGENIN; BENZOTRIAZOLE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

EID: 77957739848     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-10-248054     Document Type: Article
Times cited : (105)

References (50)
  • 1
    • 52449121246 scopus 로고    scopus 로고
    • Novel insights in chronic lymphocytic leukemia: Are we getting closer to understanding the pathogenesis of the disease?
    • Caligaris-Cappio F, Ghia P. Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? J Clin Oncol. 2008;26(27):4497-4503.
    • (2008) J Clin Oncol , vol.26 , Issue.27 , pp. 4497-4503
    • Caligaris-Cappio, F.1    Ghia, P.2
  • 2
    • 36148983111 scopus 로고    scopus 로고
    • Emerging therapy for chronic lymphocytic leukaemia
    • DOI 10.1111/j.1365-2141.2007.06877.x
    • Auer RL, Gribben J, Cotter FE. Emerging therapy for chronic lymphocytic leukaemia. Br J Haematol. 2007;139(5):635-644. (Pubitemid 350115738)
    • (2007) British Journal of Haematology , vol.139 , Issue.5 , pp. 635-644
    • Auer, R.L.1    Gribben, J.2    Cotter, F.E.3
  • 4
    • 0033377032 scopus 로고    scopus 로고
    • Adhesion to bone marrow stroma inhibits apoptosis of chronic lymphocytic leukemia cells
    • Lagneaux L, Delforge A, De Bruyn C, Bernier M, Bron D. Adhesion to bone marrow stroma inhibits apoptosis of chronic lymphocytic leukemia cells. Leuk Lymphoma. 1999;35(5-6):445-453. (Pubitemid 30015644)
    • (1999) Leukemia and Lymphoma , vol.35 , Issue.5-6 , pp. 445-453
    • Lagneaux, L.1    Delforge, A.2    De Bruyn, C.3    Bernier, M.4    Bron, D.5
  • 5
    • 0030048565 scopus 로고    scopus 로고
    • Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
    • Panayiotidis P, Jones D, Ganeshaguru K, Foroni L, Hoffbrand AV. Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br J Haematol. 1996;92(1):97-103. (Pubitemid 26018774)
    • (1996) British Journal of Haematology , vol.92 , Issue.1 , pp. 97-103
    • Panayiotidis, P.1    Jones, D.2    Ganeshaguru, K.3    Foroni, L.4    Hoffbrand, A.V.5
  • 6
    • 73349126115 scopus 로고    scopus 로고
    • Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: Development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance
    • Kurtova A, Balakrishnan K, Chen R, et al. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood. 2009;114(20):4441-4450.
    • (2009) Blood , vol.114 , Issue.20 , pp. 4441-4450
    • Kurtova, A.1    Balakrishnan, K.2    Chen, R.3
  • 7
    • 0034667624 scopus 로고    scopus 로고
    • Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
    • Burger JA, Tsukada N, Burger M, Zvaifler NJ, Dell'Aquila M, Kipps TJ. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood. 2000;96(8):2655-2663.
    • (2000) Blood , vol.96 , Issue.8 , pp. 2655-2663
    • Burger, J.A.1    Tsukada, N.2    Burger, M.3    Zvaifler, N.J.4    Dell'Aquila, M.5    Kipps, T.J.6
  • 9
    • 59449095496 scopus 로고    scopus 로고
    • AT-101 induces apoptosis in CLL B-cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance
    • Balakrishnan K, Burger JA, Wierda WG, Gandhi V. AT-101 induces apoptosis in CLL B-cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood. 2009;113(1): 149-153.
    • (2009) Blood , vol.113 , Issue.1 , pp. 149-153
    • Balakrishnan, K.1    Burger, J.A.2    Wierda, W.G.3    Gandhi, V.4
  • 10
    • 0034051534 scopus 로고    scopus 로고
    • The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms
    • Ghia P, Caligaris-Cappio F. The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms. Adv Cancer Res. 2000;79:157-173. (Pubitemid 30228123)
    • (2000) Advances in Cancer Research , vol.79 , pp. 157-173
    • Ghia, P.1    Caligaris-Cappio, F.2
  • 11
    • 11444259307 scopus 로고    scopus 로고
    • Microenvironmental interactions and survival of CLL B-cells
    • DOI 10.1080/10428190412331272703
    • Munk Pedersen I, Reed J. Microenvironmental interactions and survival of CLL B-cells. Leuk Lymphoma. 2004;45(12):2365-2372. (Pubitemid 40081179)
    • (2004) Leukemia and Lymphoma , vol.45 , Issue.12 , pp. 2365-2372
    • Pedersen, I.M.1    Reed, J.C.2
  • 13
    • 33644845081 scopus 로고    scopus 로고
    • Microenvironmental niches in the bone marrow required for B-cell development
    • DOI 10.1038/nri1780, PII N1780
    • Nagasawa T. Microenvironmental niches in the bone marrow required for B-cell development. Nat Rev Immunol. 2006;6(2):107-116. (Pubitemid 43361586)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.2 , pp. 107-116
    • Nagasawa, T.1
  • 14
    • 58149175555 scopus 로고    scopus 로고
    • The life of a cell: Apoptosis regulation by the PI3K/PKB pathway
    • Duronio V. The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem J. 2008; 415(3):333-344.
    • (2008) Biochem J , vol.415 , Issue.3 , pp. 333-344
    • Duronio, V.1
  • 15
    • 59849098801 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells
    • Su CC, Lin YP, Cheng YJ, et al. Phosphatidylinositol 3-kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells. J Immunol. 2007;179(7):4589-4597.
    • (2007) J Immunol , vol.179 , Issue.7 , pp. 4589-4597
    • Su, C.C.1    Lin, Y.P.2    Cheng, Y.J.3
  • 16
    • 38349107623 scopus 로고    scopus 로고
    • The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
    • Longo PG, Laurenti L, Gobessi S, Sica S, Leone G, Efremov DG. The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood. 2008;111(2): 846-855.
    • (2008) Blood , vol.111 , Issue.2 , pp. 846-855
    • Longo, P.G.1    Laurenti, L.2    Gobessi, S.3    Sica, S.4    Leone, G.5    Efremov, D.G.6
  • 17
    • 0035846955 scopus 로고    scopus 로고
    • Cd19-dependent activation of Akt kinase in B-lymphocytes
    • Otero DC, Omori SA, Rickert RC. Cd19-dependent activation of Akt kinase in B-lymphocytes. J Biol Chem. 2001;276(2):1474-1478.
    • (2001) J Biol Chem , vol.276 , Issue.2 , pp. 1474-1478
    • Otero, D.C.1    Omori, S.A.2    Rickert, R.C.3
  • 18
    • 0031936619 scopus 로고    scopus 로고
    • Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes
    • Gringhuis SI, de Leij LF, Coffer PJ, Vellenga E. Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes. Mol Cell Biol. 1998;18(3):1725-1735. (Pubitemid 28100938)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.3 , pp. 1725-1735
    • Gringhuis, S.I.1    De Leij, L.F.M.H.2    Coffer, P.J.3    Vellenga, E.4
  • 19
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2002;2(7):489-501. (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 20
    • 68249128423 scopus 로고    scopus 로고
    • Insights into the PI3-KPKB- MTOR signalling pathway from small molecules
    • Gunn RM, Hailes HC. Insights into the PI3-KPKB- mTOR signalling pathway from small molecules. J Chem Biol. 2008;1(1-4):49-62.
    • (2008) J Chem Biol , vol.1 , Issue.1-4 , pp. 49-62
    • Gunn, R.M.1    Hailes, H.C.2
  • 21
    • 70349391226 scopus 로고    scopus 로고
    • Advances in development of phosphatidylinositol 3-kinase inhibitors
    • Kong D, Yamori T. Advances in development of phosphatidylinositol 3-kinase inhibitors. Curr Med Chem. 2009;16(22):2839-2854.
    • (2009) Curr Med Chem , vol.16 , Issue.22 , pp. 2839-2854
    • Kong, D.1    Yamori, T.2
  • 22
    • 51849084360 scopus 로고    scopus 로고
    • The PTEN-PI3K pathway: Of feedbacks and cross-talks
    • Carracedo A, Pandolfi PP. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene. 2008;27(41):5527-5541.
    • (2008) Oncogene , vol.27 , Issue.41 , pp. 5527-5541
    • Carracedo, A.1    Pandolfi, P.P.2
  • 23
    • 0038549067 scopus 로고    scopus 로고
    • PI3K in lymphocyte development, differentiation and activation
    • Okkenhaug K, Vanhaesebroeck B. PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol. 2003;3(4):317-330. (Pubitemid 37328684)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.4 , pp. 317-330
    • Okkenhaug, K.1    Vanhaesebroeck, B.2
  • 25
    • 0037111661 scopus 로고    scopus 로고
    • Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: Association with protein kinase Cdelta
    • DOI 10.1182/blood-2002-02-0539
    • Ringshausen I, Schneller F, Bogner C, et al. Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta. Blood. 2002;100(10):3741-3748. (Pubitemid 35303946)
    • (2002) Blood , vol.100 , Issue.10 , pp. 3741-3748
    • Ringshausen, I.1    Schneller, F.2    Bogner, C.3    Hipp, S.4    Duyster, J.5    Peschel, C.6    Decker, T.7
  • 27
    • 33845526567 scopus 로고    scopus 로고
    • The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease
    • DOI 10.1038/sj.leu.2404417, PII 2404417
    • Longo PG, Laurenti L, Gobessi S, et al. The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease. Leukemia. 2007;21(1):110-120. (Pubitemid 44921842)
    • (2007) Leukemia , vol.21 , Issue.1 , pp. 110-120
    • Longo, P.G.1    Laurenti, L.2    Gobessi, S.3    Petlickovski, A.4    Pelosi, M.5    Chiusolo, P.6    Sica, S.7    Leone, G.8    Efremov, D.G.9
  • 28
    • 67049137382 scopus 로고    scopus 로고
    • Isoform-selective phosphoinositide 3′-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: A novel therapeutic approach
    • Niedermeier M, Hennessy BT, Knight ZA, et al. Isoform-selective phosphoinositide 3′-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood. 2009;113(22):5549-5557.
    • (2009) Blood , vol.113 , Issue.22 , pp. 5549-5557
    • Niedermeier, M.1    Hennessy, B.T.2    Knight, Z.A.3
  • 29
    • 0032080433 scopus 로고    scopus 로고
    • Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin
    • Christodoulopoulos G, Muller C, Salles B, Kazmi R, Panasci L. Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin. Cancer Res. 1998;58(9): 1789-1792. (Pubitemid 28217447)
    • (1998) Cancer Research , vol.58 , Issue.9 , pp. 1789-1792
    • Christodoulopoulos, G.1    Muller, C.2    Salles, B.3    Kazmi, R.4    Panasci, L.5
  • 31
    • 33947218937 scopus 로고    scopus 로고
    • Covalent Reactions of Wortmannin under Physiological Conditions
    • DOI 10.1016/j.chembiol.2007.02.007, PII S1074552107000749
    • Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L. Covalent reactions of wortmannin under physiological conditions. Chem Biol. 2007; 14(3):321-328. (Pubitemid 46428147)
    • (2007) Chemistry and Biology , vol.14 , Issue.3 , pp. 321-328
    • Yuan, H.1    Barnes, K.R.2    Weissleder, R.3    Cantley, L.4    Josephson, L.5
  • 32
    • 42249098543 scopus 로고    scopus 로고
    • Oncogenic signaling of class I PI3K isoforms
    • DOI 10.1038/sj.onc.1210918, PII 1210918
    • Denley A, Kang S, Karst U, Vogt PK. Oncogenic signaling of class I PI3K isoforms. Oncogene. 2008;27(18):2561-2574. (Pubitemid 351550883)
    • (2008) Oncogene , vol.27 , Issue.18 , pp. 2561-2574
    • Denley, A.1    Kang, S.2    Karst, U.3    Vogt, P.K.4
  • 33
  • 34
    • 0033199841 scopus 로고    scopus 로고
    • Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo
    • DOI 10.1042/0264-6021:3420287
    • Casamayor A, Morrice NA, Alessi DR. Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. Biochem J. 1999;342(Pt 2):287-292. (Pubitemid 29425348)
    • (1999) Biochemical Journal , vol.342 , Issue.2 , pp. 287-292
    • Casamayor, A.1    Morrice, N.A.2    Alessi, D.R.3
  • 35
    • 0033946740 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail regulates protein stability and function
    • DOI 10.1128/MCB.20.14.5010-5018.2000
    • Vazquez F, Ramaswamy S, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol. 2000; 20(14):5010-5018. (Pubitemid 30431555)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.14 , pp. 5010-5018
    • Vazquez, F.1    Ramaswamy, S.2    Nakamura, N.3    Sellers, W.R.4
  • 36
    • 0035847102 scopus 로고    scopus 로고
    • The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation
    • DOI 10.1074/jbc.M009134200
    • Torres J, Pulido R. The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome- mediated degradation. J Biol Chem. 2001;276(2):993-998. (Pubitemid 32096519)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.2 , pp. 993-998
    • Torres, J.1    Pulido, R.2
  • 37
    • 0037269847 scopus 로고    scopus 로고
    • Protein kinase CK2: Structure, regulation and role in cellular decisions of life and death
    • Litchfield DW. Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J. 2003;369(Pt 1):1-15.
    • (2003) Biochem J , vol.369 , Issue.PART 1 , pp. 1-15
    • Litchfield, D.W.1
  • 39
    • 0032572792 scopus 로고    scopus 로고
    • DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site
    • Blaydes JP, Hupp TR. DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site. Oncogene. 1998;17(8):1045-1052.
    • (1998) Oncogene , vol.17 , Issue.8 , pp. 1045-1052
    • Blaydes, J.P.1    Hupp, T.R.2
  • 40
    • 0035805108 scopus 로고    scopus 로고
    • Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2')
    • DOI 10.1016/S0014-5793(01)02404-8, PII S0014579301024048
    • Sarno S, Reddy H, Meggio F, et al. Selectivity of 4,5,6,7- tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2′). FEBS Lett. 2001;496(1):44-48. (Pubitemid 32436419)
    • (2001) FEBS Letters , vol.496 , Issue.1 , pp. 44-48
    • Sarno, S.1    Reddy, H.2    Meggio, F.3    Ruzzene, M.4    Davies, S.P.5    Donella-Deana, A.6    Shugar, D.7    Pinna, L.A.8
  • 42
    • 66149141021 scopus 로고    scopus 로고
    • PTEN and the PI3-kinase pathway in cancer
    • Chalhoub N, Baker SJ. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol. 2009;4:127-150.
    • (2009) Annu Rev Pathol , vol.4 , pp. 127-150
    • Chalhoub, N.1    Baker, S.J.2
  • 43
    • 0037393911 scopus 로고    scopus 로고
    • Disparate expression of the PTEN gene: A novel finding in B-cell chronic lymphocytic leukaemia (B-CLL)
    • DOI 10.1046/j.1365-2141.2003.04227.x
    • Leupin N, Cenni B, Novak U, et al. Disparate expression of the PTEN gene: a novel finding in Bcell chronic lymphocytic leukaemia (B-CLL). Br J Haematol. 2003;121(1):97-100. (Pubitemid 36461273)
    • (2003) British Journal of Haematology , vol.121 , Issue.1 , pp. 97-100
    • Leupin, N.1    Cenni, B.2    Novak, U.3    Hugli, B.4    Graber, H.U.5    Tobler, A.6    Fey, M.F.7
  • 44
    • 38349030742 scopus 로고    scopus 로고
    • New insights into PTEN
    • Tamguney T, Stokoe D. New insights into PTEN. J Cell Sci. 2007;120(Pt 23):4071-4079.
    • (2007) J Cell Sci , vol.120 , Issue.PART 23 , pp. 4071-4079
    • Tamguney, T.1    Stokoe, D.2
  • 45
    • 24944568790 scopus 로고    scopus 로고
    • Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis
    • DOI 10.1158/0008-5472.CAN-05-1888
    • Chung JH, Eng C. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res. 2005;65(18):8096-8100. (Pubitemid 41330571)
    • (2005) Cancer Research , vol.65 , Issue.18 , pp. 8096-8100
    • Chung, J.-H.1    Eng, C.2
  • 47
    • 55849138418 scopus 로고    scopus 로고
    • PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability
    • Silva A, Yunes JA, Cardoso BA, et al. PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. J Clin Invest. 2008;118(11):3762-3774.
    • (2008) J Clin Invest , vol.118 , Issue.11 , pp. 3762-3774
    • Silva, A.1    Yunes, J.A.2    Cardoso, B.A.3
  • 48
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B-cell malignancies: A target for new treatment strategies
    • Burger J, Ghia P, Rosenwald A, Caligaris-Cappio F. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood. 2009;114(16):3367-3375.
    • (2009) Blood , vol.114 , Issue.16 , pp. 3367-3375
    • Burger, J.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 49
    • 55249096769 scopus 로고    scopus 로고
    • Protein kinase CK2 inhibitors: Emerging anticancer therapeutic agents?
    • Bortolato A, Cozza G, Moro S. Protein kinase CK2 inhibitors: emerging anticancer therapeutic agents? Anticancer Agents Med Chem. 2008; 8(7):798-806.
    • (2008) Anticancer Agents Med Chem , vol.8 , Issue.7 , pp. 798-806
    • Bortolato, A.1    Cozza, G.2    Moro, S.3
  • 50
    • 43749120732 scopus 로고    scopus 로고
    • The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
    • DOI 10.2174/156800908784293659
    • Carnero A, Blanco-Aparicio C, Renner O, Link W, Leal JF. The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets. 2008;8(3):187-198. (Pubitemid 351688437)
    • (2008) Current Cancer Drug Targets , vol.8 , Issue.3 , pp. 187-198
    • Carnero, A.1    Blanco-Aparicio, C.2    Renner, O.3    Link, W.4    Leal, J.F.M.5


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