High levels of p110δ PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110δ inhibitors through PTEN activation

FASEB Journal

Volumn 26, Issue 6, 2012, Pages 2498-2508

  Tzenaki, Niki ^a   Andreou, Margarita ^a   Stratigi, Kalliopi ^a   Vergetaki, Aikaterini ^a   Makrigiannakis, Antonis ^a   Vanhaesebroeck, Bart ^b   Papakonstanti, Evangelia A ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Breast; Prostate

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; DIMETHYL SULFOXIDE; P110DELTA PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN KINASE B; PROTEIN P110; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKOCYTE; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SOLID TUMOR; UTERINE CERVIX CANCER;

ADENINE; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; FEMALE; MALE; MICE; NIH 3T3 CELLS; PROSTATIC NEOPLASMS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; QUINAZOLINES;

EID: 84861763406     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-198192     Document Type: Article

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