Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 1, 2012, Pages 273-278

  Troutman, Ty Dale ^a   Hu, Wei ^a   Fulenchek, Stephanie ^a   Yamazaki, Tetsuo ^b   Kurosaki, Tomohiro ^c   Bazand, J Fernando ^d,e   Pasare, Chandrashekhar ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c RIKEN Center for Integrative Medical Sciences   (Japan)

^d GENENTECH INC   (United States)

^e NeuroScience Inc   (United States)

Author keywords

Inflammation; Innate immunity; Macrophage; Negative regulator; Pattern recognition receptors

Indexed keywords

B CELL ADAPTER FOR PI3K; DEXTRAN SULFATE; INTERLEUKIN 12; INTERLEUKIN 6; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE PI3K; SCAFFOLD PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; COLITIS; CONTROLLED STUDY; IN VIVO STUDY; INFECTION; INFLAMMATION; INFLAMMATORY CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; INFLAMMATION; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84856008042     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118579109     Document Type: Article

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