메뉴 건너뛰기




Volumn 1, Issue 36, 2008, Pages

Phosphoinositide 3-kinase p110β activity: Key role in metabolism and mammary gland cancer but not development

Author keywords

[No Author keywords available]

Indexed keywords

1 PHOSPHATIDYLINOSITOL 3 KINASE P110 SUBUNIT, MOUSE; 1-PHOSPHATIDYLINOSITOL 3-KINASE P110 SUBUNIT, MOUSE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 55649084906     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.1161577     Document Type: Article
Times cited : (213)

References (38)
  • 1
    • 15044338824 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase in disease: Timing, location, and scaffolding
    • M. P. Wymann, R. Marone, Phosphoinositide 3-kinase in disease: Timing, location, and scaffolding. Curr. Opin. Cell Biol. 17, 141-149 (2005).
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 141-149
    • Wymann, M.P.1    Marone, R.2
  • 2
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • J. A. Engelman, J. Luo, L. C. Cantley, The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7, 606-619 (2006).
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 3
    • 34547895443 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases as a common platform for multi-hormone signaling
    • E. Hirsch, C. Costa, E. Ciraolo, Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. J. Endocrinol. 194, 243-256 (2007).
    • (2007) J. Endocrinol. , vol.194 , pp. 243-256
    • Hirsch, E.1    Costa, C.2    Ciraolo, E.3
  • 8
    • 0036185944 scopus 로고    scopus 로고
    • Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
    • L. Bi, I. Okabe, D. J. Bernard, R. L. Nussbaum, Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm. Genome 13, 169-172 (2002).
    • (2002) Mamm. Genome , vol.13 , pp. 169-172
    • Bi, L.1    Okabe, I.2    Bernard, D.J.3    Nussbaum, R.L.4
  • 9
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • A. G. Bader, S. Kang, L. Zhao, P. K. Vogt, Oncogenic PI3K deregulates transcription and translation. Nat. Rev. Cancer 5, 921-929 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3    Vogt, P.K.4
  • 10
    • 31944444234 scopus 로고    scopus 로고
    • Cancer-specific mutations in PIK3CA are oncogenic in vivo
    • A. G. Bader, S. Kang, P. K. Vogt, Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc. Natl. Acad. Sci. U.S.A. 103, 1475-1479 (2006).
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 1475-1479
    • Bader, A.G.1    Kang, S.2    Vogt, P.K.3
  • 11
    • 14144252004 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
    • S. Kang, A. G. Bader, P. K. Vogt, Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc. Natl. Acad. Sci. U.S.A. 102, 802-807 (2005).
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 802-807
    • Kang, S.1    Bader, A.G.2    Vogt, P.K.3
  • 12
    • 29444449785 scopus 로고    scopus 로고
    • The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
    • J. J. Zhao, Z. Liu, L. Wang, E. Shin, M. F. Loda, T. M. Roberts, The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 102, 18443-18448 (2005).
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 18443-18448
    • Zhao, J.J.1    Liu, Z.2    Wang, L.3    Shin, E.4    Loda, M.F.5    Roberts, T.M.6
  • 13
    • 31944448780 scopus 로고    scopus 로고
    • Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
    • S. Kang, A. Denley, B. Vanhaesebroeck, P. K. Vogt, Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. Proc. Natl. Acad. Sci. U.S.A. 103, 1289-1294 (2006).
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 1289-1294
    • Kang, S.1    Denley, A.2    Vanhaesebroeck, B.3    Vogt, P.K.4
  • 14
    • 0034687278 scopus 로고    scopus 로고
    • A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells
    • C. Benistant, H. Chapuis, S. Roche, A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. Oncogene 19, 5083-5090 (2000).
    • (2000) Oncogene , vol.19 , pp. 5083-5090
    • Benistant, C.1    Chapuis, H.2    Roche, S.3
  • 18
    • 0032828890 scopus 로고    scopus 로고
    • Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma
    • U. Maier, A. Babich, B. Nurnberg, Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma. J. Biol. Chem. 274, 29311-29317 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 29311-29317
    • Maier, U.1    Babich, A.2    Nurnberg, B.3
  • 19
    • 0034697121 scopus 로고    scopus 로고
    • A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt
    • C. Murga, S. Fukuhara, J. S. Gutkind, A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt. J. Biol. Chem. 275, 12069-12073 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 12069-12073
    • Murga, C.1    Fukuhara, S.2    Gutkind, J.S.3
  • 20
    • 2442650416 scopus 로고    scopus 로고
    • Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases
    • L. Lanzetti, A. Palamidessi, L. Areces, G. Scita, P. P. Di Fiore, Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases. Nature 429, 309-314 (2004).
    • (2004) Nature , vol.429 , pp. 309-314
    • Lanzetti, L.1    Palamidessi, A.2    Areces, L.3    Scita, G.4    Di Fiore, P.P.5
  • 21
  • 23
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • R. Nahta, D. Yu, M. C. Hung, G. N. Hortobagyi, F. J. Esteva, Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer. Nat. Clin. Pract. Oncol. 3, 269-280 (2006).
    • (2006) Nat. Clin. Pract. Oncol. , vol.3 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 26
    • 33645551286 scopus 로고    scopus 로고
    • Signaling through PI3Kgamma: A common platform for leukocyte, platelet and cardiovascular stress sensing
    • E. Hirsch, G. Lembo, G. Montrucchio, C. Rommel, C. Costa, L. Barberis, Signaling through PI3Kgamma: A common platform for leukocyte, platelet and cardiovascular stress sensing. Thromb. Haemost. 95, 29-35 (2006).
    • (2006) Thromb. Haemost. , vol.95 , pp. 29-35
    • Hirsch, E.1    Lembo, G.2    Montrucchio, G.3    Rommel, C.4    Costa, C.5    Barberis, L.6
  • 29
    • 33645982255 scopus 로고    scopus 로고
    • From mice to men: Insights into the insulin resistance syndromes
    • S. B. Biddinger, C. R. Kahn, From mice to men: Insights into the insulin resistance syndromes. Annu. Rev. Physiol. 68, 123-158 (2006).
    • (2006) Annu. Rev. Physiol. , vol.68 , pp. 123-158
    • Biddinger, S.B.1    Kahn, C.R.2
  • 30
    • 33750902947 scopus 로고    scopus 로고
    • Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight: Potential link to increased risk of diabetes?
    • S. E. Ozanne, C. B. Jensen, K. J. Tingey, M. S. Martin-Gronert, L. Grunnet, C. Brons, H. Storgaard, A. A. Vaag, Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight: Potential link to increased risk of diabetes? Diabetologia 49, 2993-2999 (2006).
    • (2006) Diabetologia , vol.49 , pp. 2993-2999
    • Ozanne, S.E.1    Jensen, C.B.2    Tingey, K.J.3    Martin-Gronert, M.S.4    Grunnet, L.5    Brons, C.6    Storgaard, H.7    Vaag, A.A.8
  • 31
    • 1642499409 scopus 로고    scopus 로고
    • Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo
    • L. C. Foukas, C. A. Beeton, J. Jensen, W. A. Phillips, P. R. Shepherd, Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo. Mol. Cell Biol. 24, 966-975 (2004).
    • (2004) Mol. Cell Biol. , vol.24 , pp. 966-975
    • Foukas, L.C.1    Beeton, C.A.2    Jensen, J.3    Phillips, W.A.4    Shepherd, P.R.5
  • 32
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • N. E. Hynes, H. A. Lane, ERBB receptors and cancer: The complexity of targeted inhibitors. Nat. Rev. Cancer 5, 341-354 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 35
    • 14144250240 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice
    • S. M. Brachmann, K. Ueki, J. A. Engelman, R. C. Kahn, L. C. Cantley, Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Mol. Cell Biol. 25, 1596-1607 (2005).
    • (2005) Mol. Cell Biol. , vol.25 , pp. 1596-1607
    • Brachmann, S.M.1    Ueki, K.2    Engelman, J.A.3    Kahn, R.C.4    Cantley, L.C.5
  • 36
    • 33646148946 scopus 로고    scopus 로고
    • Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta
    • C. M. Taniguchi, T. Kondo, M. Sajan, J. Luo, R. Bronson, T. Asano, R. Farese, L. C. Cantley, C. R. Kahn, Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab. 3, 343-353 (2006).
    • (2006) Cell Metab. , vol.3 , pp. 343-353
    • Taniguchi, C.M.1    Kondo, T.2    Sajan, M.3    Luo, J.4    Bronson, R.5    Asano, T.6    Farese, R.7    Cantley, L.C.8    Kahn, C.R.9
  • 37
    • 13444252573 scopus 로고    scopus 로고
    • Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure
    • A. Mora, C. Lipina, F. Tronche, C. Sutherland, D. R. Alessi, Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure. Biochem. J. 385, 639-648 (2005).
    • (2005) Biochem. J. , vol.385 , pp. 639-648
    • Mora, A.1    Lipina, C.2    Tronche, F.3    Sutherland, C.4    Alessi, D.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.